LOCUS       NM_010080               4440 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus dentin sialophosphoprotein (Dspp), mRNA.
ACCESSION   NM_010080 XM_986747 XM_986777
VERSION     NM_010080.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4440)
  AUTHORS   Yoshida,Y., Inubushi,T., Yokoyama,M., Nag,P., Sasaki,J.I., Oka,A.,
            Murotani,T., Kani,R., Shiraishi,Y., Kurosaka,H., Takahata,Y.,
            Nishimura,R., Imazato,S., Papagerakis,P. and Yamashiro,T.
  TITLE     Slc26a2-mediated sulfate metabolism is important in tooth
            development
  JOURNAL   Dis Model Mech 17 (12) (2024)
   PUBMED   39508796
REFERENCE   2  (bases 1 to 4440)
  AUTHORS   Chen,Y., Petho,A., Ganapathy,A. and George,A.
  TITLE     DPP an extracellular matrix molecule induces Wnt5a mediated
            signaling to promote the differentiation of adult stem cells into
            odontogenic lineage
  JOURNAL   Sci Rep 14 (1), 26187 (2024)
   PUBMED   39478025
  REMARK    GeneRIF: DPP an extracellular matrix molecule induces Wnt5a
            mediated signaling to promote the differentiation of adult stem
            cells into odontogenic lineage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4440)
  AUTHORS   Li,Y., Lin,Y., Guo,J., Huang,D., Zuo,H., Zhang,H., Yuan,G., Liu,H.
            and Chen,Z.
  TITLE     CREB3L1 deficiency impairs odontoblastic differentiation and molar
            dentin deposition partially through the TMEM30B
  JOURNAL   Int J Oral Sci 16 (1), 59 (2024)
   PUBMED   39384739
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4440)
  AUTHORS   Liu,Q., Zhao,Y., Shi,H., Xiang,D., Wu,C., Song,L., Ma,N. and Sun,H.
  TITLE     Long-term haplodeficency of DSPP causes temporomandibular joint
            osteoarthritis in mice
  JOURNAL   BMC Oral Health 24 (1), 569 (2024)
   PUBMED   38745274
  REMARK    GeneRIF: Long-term haplodeficency of DSPP causes temporomandibular
            joint osteoarthritis in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4440)
  AUTHORS   Zhu,Q., Gibson,M.P., Liu,Q., Liu,Y., Lu,Y., Wang,X., Feng,J.Q. and
            Qin,C.
  TITLE     Proteolytic processing of dentin sialophosphoprotein (DSPP) is
            essential to dentinogenesis
  JOURNAL   J Biol Chem 287 (36), 30426-30435 (2012)
   PUBMED   22798071
  REMARK    GeneRIF: the proteolytic processing of DSPP is an activation step
            essential to its biological function in dentinogenesis.
REFERENCE   6  (bases 1 to 4440)
  AUTHORS   Begue-Kirn,C., Ruch,J.V., Ridall,A.L. and Butler,W.T.
  TITLE     Comparative analysis of mouse DSP and DPP expression in
            odontoblasts, preameloblasts, and experimentally induced
            odontoblast-like cells
  JOURNAL   Eur J Oral Sci 106 Suppl 1, 254-259 (1998)
   PUBMED   9541234
REFERENCE   7  (bases 1 to 4440)
  AUTHORS   D'Souza,R.N., Cavender,A., Sunavala,G., Alvarez,J., Ohshima,T.,
            Kulkarni,A.B. and MacDougall,M.
  TITLE     Gene expression patterns of murine dentin matrix protein 1 (Dmp1)
            and dentin sialophosphoprotein (DSPP) suggest distinct
            developmental functions in vivo
  JOURNAL   J Bone Miner Res 12 (12), 2040-2049 (1997)
   PUBMED   9421236
REFERENCE   8  (bases 1 to 4440)
  AUTHORS   Ritchie,H.H., Berry,J.E., Somerman,M.J., Hanks,C.T.,
            Bronckers,A.L., Hotton,D., Papagerakis,P., Berdal,A. and
            Butler,W.T.
  TITLE     Dentin sialoprotein (DSP) transcripts: developmentally-sustained
            expression in odontoblasts and transient expression in
            pre-ameloblasts
  JOURNAL   Eur J Oral Sci 105 (5 Pt 1), 405-413 (1997)
   PUBMED   9395101
REFERENCE   9  (bases 1 to 4440)
  AUTHORS   MacDougall,M., Simmons,D., Luan,X., Nydegger,J., Feng,J. and
            Gu,T.T.
  TITLE     Dentin phosphoprotein and dentin sialoprotein are cleavage products
            expressed from a single transcript coded by a gene on human
            chromosome 4. Dentin phosphoprotein DNA sequence determination
  JOURNAL   J Biol Chem 272 (2), 835-842 (1997)
   PUBMED   8995371
REFERENCE   10 (bases 1 to 4440)
  AUTHORS   Ritchie,H.H., Shigeyama,Y., Somerman,M.J. and Butler,W.T.
  TITLE     Partial cDNA sequencing of mouse dentine sialoprotein and detection
            of its specific expression by odontoblasts
  JOURNAL   Arch Oral Biol 41 (6), 571-575 (1996)
   PUBMED   8937648
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC164587.5 and BC116173.1.
            
            On Feb 4, 2016 this sequence version replaced NM_010080.2.
            
            Summary: This gene encodes a member of the small integrin-binding
            ligand N-linked glycoprotein (SIBLING) family of proteins. The
            encoded preproprotein is secreted by odontoblasts and
            proteolytically processed to generate two principal proteins of the
            dentin extracellular matrix of the tooth, dentin sialoprotein and
            dentin phosphoprotein. These two protein products may play distinct
            but related roles in dentin mineralization. Mice lacking the
            encoded protein exhibit hypomineralization defects in dentin,
            similar to human dentinogenesis imperfecta. [provided by RefSeq,
            Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U67916.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN01164131,
                                           SAMN01164132 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC164587.5         123424-123432
            10-373              BC116173.1         1-364
            374-1171            AC164587.5         128002-128799
            1172-4440           AC164587.5         129580-132848
FEATURES             Location/Qualifiers
     source          1..4440
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.59 cM"
     gene            1..4440
                     /gene="Dspp"
                     /gene_synonym="Dmp2; Dmp3; Dpp; Dsp"
                     /note="dentin sialophosphoprotein"
                     /db_xref="GeneID:666279"
                     /db_xref="MGI:MGI:109172"
     exon            1..66
                     /gene="Dspp"
                     /gene_synonym="Dmp2; Dmp3; Dpp; Dsp"
                     /inference="alignment:Splign:2.1.0"
     exon            67..142
                     /gene="Dspp"
                     /gene_synonym="Dmp2; Dmp3; Dpp; Dsp"
                     /inference="alignment:Splign:2.1.0"
     exon            143..229
                     /gene="Dspp"
                     /gene_synonym="Dmp2; Dmp3; Dpp; Dsp"
                     /inference="alignment:Splign:2.1.0"
     exon            230..1171
                     /gene="Dspp"
                     /gene_synonym="Dmp2; Dmp3; Dpp; Dsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..4440
                     /gene="Dspp"
                     /gene_synonym="Dmp2; Dmp3; Dpp; Dsp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactctcagc ctggaaagag agataaggaa atctggattt tcaaagtccc ctcggaggct
       61 ttgaagacat tgattactac tcataatgaa aatgaagata attatatata tatgcatttg
      121 ggcaactgcc tgggccattc cggttcccca gttagtacca ctggaaagag acattgttga
      181 aaactctgtg gctgtgcctc ttctaacaca tccaggaact gcagcacaga atgagttatc
      241 tatcaacagc accactagca acagcaacga ctccccagat ggcagtgaga taggagagca
      301 ggtacttagc gaggatggtt acaaaagaga tgggaatggc tccgagtcaa tacatgtagg
      361 agggaaggat tttcctactc agcccatttt agtaaacgaa caggggaaca ctgctgaaga
      421 acacaatgac atagaaacat acggtcatga tggggtacat gcgagaggag agaacagcac
      481 agcaaatggc atcaggagcc aggtaggcat cgttgaaaat gcggaggaag cagagagcag
      541 tgtccacgga caggctggtc agaatacaaa atctggaggt gctagtgatg taagccagaa
      601 tggagatgcg acccttgtcc aggaaaatga gcctccagaa gctagcatca agaatagcac
      661 caaccatgag gctggaatac acgggagtgg ggttgctaca catgaaacga cgcctcagag
      721 agaagggctg gggagtgaga accaggggac tgaggtgaca ccaagcatcg gggaagatgc
      781 aggtttggat gatactgatg ggagtcctag cgggaacggg gtagaggagg atgaagatac
      841 aggctctggt gatggtgagg gtgcagaagc aggagatgga agggagagcc atgatggcac
      901 taagggccag gggggccaat ctcatggggg aaacactgac cacagaggtc agagttcagt
      961 tagtactgaa gatgatgatt ctaaagaaca agaaggcttc ccaaatggac acaatggaga
     1021 caacagcagt gaggaaaacg gtgttgaaga aggcgacagt acccaggcaa cgcaggacaa
     1081 ccaaaagctc agccccaaag acacccgaga tgcagagggt gggatcatca gccagtcaga
     1141 agcatgtcct tctgggaaga gccaagatca gggaatagaa actgaaggtc ccaacaaagg
     1201 caacaaaagt attattacca aagaatctgg gaaactcagt ggaagtaaag atagcaatgg
     1261 acaccaagga gtggagctgg acaaaaggaa tagcccaaag caaggggagt ctgacaagcc
     1321 tcaaggcact gctgagaaat cagctgccca cagtaacctg ggacacagca ggataggtag
     1381 cagcagcaat agtgatgggc atgacagtta cgagttcgat gacgagtcca tgcaaggaga
     1441 tgatcccaag agcagcgacg aatctaacgg aagtgacgaa agtgacacta actctgaaag
     1501 cgccaatgag agtggcagcc gtggagatgc ttcttacaca tctgatgaat caagtgatga
     1561 tgacaatgac agtgactcac atgcgggaga agacgatagc agtgatgact catctgatac
     1621 agatgacagt gacagtaatg gtgatggtga cagtgacagt aatggtgatg gtgacagcga
     1681 gagtgaggac aaggacgaat ctgacagcag tgaccatgac aacagcagtg acagtgagag
     1741 caaatcagac agcagtgaca gtagtgacga cagcagtgac agcagcgaca gtagtgacag
     1801 cagtgacagc agtgacagta gtgacagtag tgacagcagc gacagcagtg acagcagcga
     1861 cagcaacagt agtagtgaca gcagcgacag cagcagtagt agtgacagca gcgacagcag
     1921 tgacagcagt gacagcagtg acagcagcga tagcagtgac agcagtgaca gcagtgacag
     1981 cagcgatagc agtgacagca gtgacagtag tgacagcagt gacagcagcg acagcagcag
     2041 tagtagtgac agcagcgaca gcagcagtag tagtgacagc agcgacagca gtgacagcag
     2101 tgacagcagc gatagcagtg acagcagtga cagcagcagc agcgacagca gcagcagtag
     2161 caacagcagt gacagtagtg acagcagtga cagcagcagc agcagcgaca gcagcaacag
     2221 cagcgacagc agtgacagta gtgacagcag tgacagtagt gacagcagtg acagcagcaa
     2281 cagtagtgac agcagcgaca gcagcagtag tagtgacagc agcgacagca gcagtagtag
     2341 tgacagcagt gacagtagtg acagtagtga cagcagtgag agcagtgaga gcagcgacag
     2401 cagcaacagc agtgacagca gcgacagtag tgacagcagt gacagtagcg acagcagcga
     2461 cagtagtgac agtagcgaca gcagtgacag tagcaacagt agcgacagca gtgacagcag
     2521 tgacagcagc gacagtagtg acagcagcaa cagtagtgac agcagtgaca gtagcgacag
     2581 tagtgacagc agtgacagca gtgacagcag cgacagtagt gacagcagtg acagtagtga
     2641 cagcagcgac agtagtgaca gcagtgacag cagtgacagc agtgacagca gcgacagcag
     2701 cgacagcagt gacagcagcg acagcagcga cagcagtgac agcagcgaca gcagcaacag
     2761 cagtgacagc agtgacagtg acagcaagga tagcagttct gacagcagtg atggtgacag
     2821 caagtctggt aatggcaaca gtgacagcaa cagtgacagc aacagtgaca gtgacagtga
     2881 cagtgaaggc agtgacagta accactcaac cagtgatgat tagatcagag agaacccatg
     2941 atatcctctg tgtgacctct tggtgagtga tgggaaggca gtgaaggttc ctaacccaat
     3001 gatgacagga gagatgtgca gactgtgtgg aacccatgga gctcataggg agtggagccg
     3061 agctccagct ctctcagaga gaatctgggt gtaccacctt tggtacatgt gtgttaaaat
     3121 atattcatgt tcagaaaata tttttaaaag gataaatcta aacaatactt taacaggaac
     3181 tgaagaaatc actaagacac atagcttcga tttgaatggc gggtgcttta aagagcagag
     3241 ctagcaatgt cacagcctgc tgcagcctcc tccctcagtg ctccgggcac cagagagcta
     3301 gtcttcatgt tgtgcagtga gtaatgctgt tctgtgacat tcaactcaac tactctgtca
     3361 tttatttatt ccggggaaaa ttacatttag ggcataatca aaacaccgct gcaactactg
     3421 gccctatcca aggtgctgag ataatctttg tgatgagaca atagctatac attatgaaaa
     3481 ttccgaagaa tgaatgagaa aagagcccca aggatggctt gggcaggatc tgacacatgc
     3541 ggttaaattt ctgcatggga tggatatgta ctaagtcccc aacccctgca ctttgaacag
     3601 tgtctccctt ccagcagtgg ccctcaaacc ttaaataaac gagcaacacg gatggatgat
     3661 ttcgggaggt gggatcatat tctgagctct ccatgtacca ctgtgttatt agttttcttc
     3721 gaatcacagc tcaaacagtt taatcaagag ttgtaaggct gtgcgtgaca agagtgggac
     3781 cctgtttggg ctctagggct cctctgaaag caagagaggt aatgagaata aaccacacca
     3841 agacaggagg tgtgaactgg gattgtctca agaaaacctt aaccctcaag ccttaaggat
     3901 atttttgaag atttagggtt ttcctttgtc atttccctat ttccccacat aggcagttat
     3961 gccaaatttg ggttaaatag aaactattaa atacattata atgataatct actctattct
     4021 cattttaggc ttattttacc cagagtttca gaagagtttc ttttctcagg tgctcacctc
     4081 cttttgtgag agtttctgag ttaaggaata ttgctgaggc tttcacacgc tgctatctgt
     4141 aaacgcgttg taacgcccac actgtaaagc tccaggcttc tgagctgcca cagctgtgac
     4201 gtgactccag acccctcacc agaaagtaaa ggttcagtct ttgccttcta ctagacccca
     4261 aactctcctt tgtttgctgt aacttatgaa gcacctgcct ctagtaaccc gccacaccca
     4321 ctcatcgagg ttgtgatcac taaagccatg ggtagaaaac tcatcgtaaa ctgtgtaaga
     4381 aatgtaaagg aagagataat gaacttcagt attataataa acatctattt atacaattgc
//
