LOCUS       NM_023842               9592 bp    mRNA    linear   ROD 10-MAR-2023
DEFINITION  Mus musculus desmoplakin (Dsp), mRNA.
ACCESSION   NM_023842 XM_484245
VERSION     NM_023842.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9592)
  AUTHORS   Wu T, Xu Y, Zhang L, Liang Z, Zhou X, Evans SM and Chen J.
  TITLE     Filamin C is Essential for mammalian myocardial integrity
  JOURNAL   PLoS Genet 19 (1), e1010630 (2023)
   PUBMED   36706168
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9592)
  AUTHORS   Xie W, Gao S, Yang Y, Li H, Zhou J, Chen M, Yang S, Zhang Y, Zhang
            L, Meng X, Xie S, Liu M, Li D, Chen Y and Zhou J.
  TITLE     CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting
            and gap junction assembly in the heart
  JOURNAL   Cell Rep 41 (13), 111864 (2022)
   PUBMED   36577382
REFERENCE   3  (bases 1 to 9592)
  AUTHORS   Piprek RP, Rams-Pociecha I, Zdanowski R, Kloc M and Kubiak JZ.
  TITLE     Desmoplakin (Dsp) conditional knockout in NR5A1+ somatic cells
            affects germ cell survival in developing mouse gonads
  JOURNAL   Reproduction 163 (4), 199-207 (2022)
   PUBMED   35119382
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9592)
  AUTHORS   Godsel LM, Roth-Carter QR, Koetsier JL, Tsoi LC, Huffine AL,
            Broussard JA, Fitz GN, Lloyd SM, Kweon J, Burks HE, Hegazy M,
            Amagai S, Harms PW, Xing X, Kirma J, Johnson JL, Urciuoli G, Doglio
            LT, Swindell WR, Awatramani R, Sprecher E, Bao X, Cohen-Barak E,
            Missero C, Gudjonsson JE and Green KJ.
  TITLE     Translational implications of Th17-skewed inflammation due to
            genetic deficiency of a cadherin stress sensor
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34905516
REFERENCE   5  (bases 1 to 9592)
  AUTHORS   Vallverdu-Prats M, Brugada R and Alcalde M.
  TITLE     Premature Termination Codon in 5' Region of Desmoplakin and
            Plakoglobin Genes May Escape Nonsense-Mediated Decay through the
            Reinitiation of Translation
  JOURNAL   Int J Mol Sci 23 (2), 656 (2022)
   PUBMED   35054841
  REMARK    GeneRIF: Premature Termination Codon in 5' Region of Desmoplakin
            and Plakoglobin Genes May Escape Nonsense-Mediated Decay through
            the Reinitiation of Translation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9592)
  AUTHORS   Bierkamp C, Schwarz H, Huber O and Kemler R.
  TITLE     Desmosomal localization of beta-catenin in the skin of plakoglobin
            null-mutant mice
  JOURNAL   Development 126 (2), 371-381 (1999)
   PUBMED   9847250
REFERENCE   7  (bases 1 to 9592)
  AUTHORS   Ruhrberg C, Hajibagheri MA, Parry DA and Watt FM.
  TITLE     Periplakin, a novel component of cornified envelopes and desmosomes
            that belongs to the plakin family and forms complexes with
            envoplakin
  JOURNAL   J Cell Biol 139 (7), 1835-1849 (1997)
   PUBMED   9412476
REFERENCE   8  (bases 1 to 9592)
  AUTHORS   Hieda Y, Iwai K, Morita T and Nakanishi Y.
  TITLE     Mouse embryonic submandibular gland epithelium loses its tissue
            integrity during early branching morphogenesis
  JOURNAL   Dev Dyn 207 (4), 395-403 (1996)
   PUBMED   8950514
REFERENCE   9  (bases 1 to 9592)
  AUTHORS   Ruiz P, Brinkmann V, Ledermann B, Behrend M, Grund C, Thalhammer C,
            Vogel F, Birchmeier C, Gunthert U, Franke WW and Birchmeier W.
  TITLE     Targeted mutation of plakoglobin in mice reveals essential
            functions of desmosomes in the embryonic heart
  JOURNAL   J Cell Biol 135 (1), 215-225 (1996)
   PUBMED   8858175
REFERENCE   10 (bases 1 to 9592)
  AUTHORS   Proetzel G, Pawlowski SA, Wiles MV, Yin M, Boivin GP, Howles PN,
            Ding J, Ferguson MW and Doetschman T.
  TITLE     Transforming growth factor-beta 3 is required for secondary palate
            fusion
  JOURNAL   Nat Genet 11 (4), 409-414 (1995)
   PUBMED   7493021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140331.2.
            
            [WARNING] On Apr 12, 2023 this sequence was replaced by
            NM_023842.3.
            
            On Jun 12, 2008 this sequence version replaced NM_023842.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-501               AC140331.2         128609-129109
            502-604             AC140331.2         142079-142181
            605-753             AC140331.2         144831-144979
            754-928             AC140331.2         145921-146095
            929-1057            AC140331.2         150094-150222
            1058-1108           AC140331.2         151133-151183
            1109-1270           AC140331.2         152383-152544
            1271-1375           AC140331.2         153711-153815
            1376-1471           AC140331.2         154502-154597
            1472-1597           AC140331.2         155749-155874
            1598-1750           AC140331.2         156363-156515
            1751-1905           AC140331.2         158413-158567
            1906-2032           AC140331.2         159517-159643
            2033-2234           AC140331.2         160430-160631
            2235-2461           AC140331.2         161261-161487
            2462-2628           AC140331.2         162411-162577
            2629-2767           AC140331.2         162888-163026
            2768-2961           AC140331.2         163910-164103
            2962-3124           AC140331.2         165056-165218
            3125-3208           AC140331.2         165765-165848
            3209-3316           AC140331.2         166861-166968
            3317-3415           AC140331.2         167710-167808
            3416-5710           AC140331.2         168676-170970
            5711-9592           AC140331.2         172011-175892
FEATURES             Location/Qualifiers
     source          1..9592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     gene            1..9592
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /note="desmoplakin"
                     /db_xref="GeneID:109620"
                     /db_xref="MGI:MGI:109611"
     exon            1..501
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..8947
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /note="desmosomal cytoskeletal connector molecule;
                     desmoplakin I/II"
                     /codon_start=1
                     /product="desmoplakin"
                     /protein_id="NP_076331.2"
                     /db_xref="CCDS:CCDS49239.1"
                     /db_xref="GeneID:109620"
                     /db_xref="MGI:MGI:109611"
                     /translation="MSCNGGSHPRINTLGRMTRAESGPDLRYEMTYSGGGGGGGGGGG
                     GGTSRTFYSHSRRCTVNDQNSDGYCQTGTMSRHQNQNTIQEMLQNCSDCLMRAELIAQ
                     PELKFGEGMQLAWNRELDEYFTQANDQMEIIDGLIREMRQMGQPCDAYQKRLLQLQEQ
                     MRALYKAISVPRVRRASSKGAGGYTCQSGSGWDEFTKRLTGECLGWMRQQREEMDLMA
                     WGVDAGSVEQHINSHRSIHNTIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFE
                     RMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVK
                     EKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQ
                     FFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKIIEYKRQVQNL
                     VNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVT
                     GPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCM
                     IDIEKIRAMTIAKLKTMRQEDYMKTIEDLELHYQDFIKNSQGSEMFGDDDKRRMQSQF
                     TDAQKHYQTLVIQLPGHPQHQTVTKTEITHLGTCQDVNHNKVIETNRENDKQETWLLM
                     ELQKIRRQMEHCEARMTLKNLLLAEQGSTHHITVKINELKSVQNDSQALAEVLNQLKD
                     MLANFRGSEKYCYLQNEIFGLFQKLENINGVSDGYLNSLCSVRALLQAILQTEDMLKV
                     YEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQSSQ
                     QYPLYDLDLGKFTEKVTQLTDRWQKIDKQIDFRLWDLEKQIKQLRNYRDNYQSFCKWL
                     YDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVHKIAELCANSIKD
                     YELQLASYTSGLETLLNIPIKRTMVQSPSGVILQEAADIHARYIELLTRSGDYYRFLS
                     EMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKL
                     VSLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKTVEDRFDQ
                     QKNDYDQLQKARQCEKENLSWQKLESEKAIKEKEYEIERLRVLLQEEGARKREYENEL
                     AKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQMDRLSRENRDLK
                     DEIVRLNDSILQATEQRRRAEENALQQKACGSETMQKKQRLEIELKQVIQQRSEDNAR
                     HKQSLEEAAKTIQDKNKEIERLKAEYQEEAKRRWEYENELSKVRNSYDEEIISLKNQF
                     ETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLCEEVKRLKNTLAQTTENLR
                     RVEENAQQQKATGSEMSQRKQQLEIELRQVTQMRTEESMRYKQSLDDAAKTIQDKNKE
                     IERLKQLVDKETNERKCLEDENSKLQRVQYDLQKANNSATEAMSKLKVQEQELTRLRI
                     DYERVSQERTVKDQDITRIQSSLKDLQLQKQKAEEELSRLKRTASDESSKRKMLEEEL
                     EAMRRSLKEQAVKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHVREKQRTQEELRR
                     LSLDVEALRRQLVQEQENVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLT
                     KEHLMLEEELRNLRLEYDDLRRGRSEADSDKNSTISELRSQLQISNNRTLELQGLIND
                     LQRERENLRQEIEKFQKQALEASNRIQESKSQCTQVVQERESLLVKIKVLEQDKARLQ
                     RLEDELNRAKATLEAESRVKQRLECEKQQIQNDLNQWKTQYSRKEETIRKIESEREKS
                     EREKNSLRSEIERLQAEIKRIEERCRRKLEDSSRETQSQLESERCRLQKEIEKLRQRP
                     YGSHRETQTEYEWTVDSSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV
                     ASEIQPFLRGAGAIAGASASPKEKYSLVEAKRKKFITPESTVMLLEAQAATGGIIDPH
                     RNEKLTVDNAVARDLIDFDDRQQIYTAEKAITGFDDPFSGKTVSVSEAIKKNLIDRET
                     GMRLLEAQLASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPITK
                     KKVSYMQLRERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNEL
                     ESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEA
                     QAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ
                     AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDMAYKRGYFNEELSEILSDPSD
                     DTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVI
                     VDPETNKEMSVQEAYKKGLIDYDTFKELCEQECEWEEITITGSDGSTRVVLVDRKTGS
                     QYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGNSSGLGGSVNDDVFSS
                     SRHDSVSKISTISSVRNLTIRSSSLSDPLEESSPIAAIFDTENLEKISIAEGIERGIV
                     DSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVNQGLIDQDMATRLKPAQKAFIGFEG
                     VKGKKKMSAAEAVKEKWLPYEAGQRFLEFQFLTGGLVDPEVHGRISTEEAIRKGFIDG
                     RAAQRLQDISSYAKILTCPKTKLKISYKDAMNRSMVEDITGLRLLEAASVSSKGLPSP
                     YNMSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGGY"
     exon            502..604
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            605..753
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            754..928
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1057
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1108
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1270
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1375
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1471
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1597
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1750
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1905
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2032
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2234
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2461
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2628
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2767
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2961
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3124
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3208
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3316
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3415
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..5710
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
     exon            5711..9592
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccaggtgt ggcctgggcg ccgggtgcca gcggggagga gactcgcacc gcctcgacca
       61 acaccaacac ccaggcgcga cccagctcct ctgagccctc gctgccctcc gagccacagc
      121 tccactccgg ttcccgcgcc tagccagtcg ccgtccccgt ctccgccctg ctggagcgct
      181 gagccctcgc cagtcctccg cgttccgcgc tcctctcccg gagtccctcg cgtgctccga
      241 ggcgacgcct cgcgtatgcc gcggcgctga gcggctctct tgagtgaccg cagacatgag
      301 ctgcaacggc ggctcccacc cgcggatcaa cacgctgggt cgcatgaccc gcgcggagtc
      361 cggcccggac ctgcgctacg agatgaccta cagcggtggc ggcggcgggg gcggcggggg
      421 cggcggcggg ggcaccagca ggacgttcta ctcccactcc cggcgctgca ccgtcaacga
      481 ccagaactcc gacggctact gtcaaaccgg caccatgtct agacatcaga atcagaacac
      541 catccaagaa atgctgcaaa attgctcaga ctgtctgatg cgggcggagc tgatcgcgca
      601 gccggaactg aaattcggag aagggatgca gctggcatgg aaccgagagc tggatgagta
      661 ttttacacaa gccaacgatc agatggaaat catagacggc ttgatccgag agatgaggca
      721 gatgggccag ccctgtgatg cgtatcagaa aagactgctt cagctccagg aacaaatgcg
      781 agccctttac aaggccatca gcgtccctcg ggtccgaaga gccagctcca agggagccgg
      841 agggtacact tgccagagtg gatccggctg ggacgagttc accaaacgcc tcacgggcga
      901 gtgtctgggc tggatgaggc agcagaggga ggaaatggac ctgatggcct ggggtgtgga
      961 cgctggttca gtggaacagc acatcaatag ccacaggagc atccacaaca ccattgggga
     1021 ctaccgctgg cagctggaca agatcaaagc agacctgcgt gagaagtcag caatctacca
     1081 gttggaggag gaatatgaaa acctgctgaa agcctccttc gagaggatgg accacctgcg
     1141 ccagctgcag aacatcatcc aggccacctc tcgagagatc atgtggatca atgactgcga
     1201 ggaggaggag ctgctctatg actggagcga caagaacacc aacatcgctc agaagcagga
     1261 ggccttctct atacgcatga gtcaactgga ggtcaaggaa aaggaactca ataagcttaa
     1321 acaagaaagt gaccagcttg tcctcaatca gcatccagct tcagacaaaa ttgaggcata
     1381 catggacact cttcagacgc agtggagctg gattctgcag atcaccaagt gcattgatgt
     1441 ccatctcaaa gaaaacgctg cttacttcca gttttttgaa gaggctcagt caactgaagc
     1501 ctacctgaag ggcctgcagg actccatcag gaagaaatac ccctgtgaca agaatatgcc
     1561 tctccagcac ctgctggagc agatcaaaga gctggagaaa gaacgggaga agatcattga
     1621 atacaagcgt caggtgcaga acttggtaaa caagtccaag aagatcgtgc agctgaaacc
     1681 tcggaaccca gactacagga gcaacaagcc cattatcctc agggctctct gcgactacaa
     1741 acaagaccag aaaatcgtac acaaagggga tgagtgtatt ctgaaggaca acaacgagcg
     1801 cagcaagtgg tacgtgacgg gcccaggagg cgtggacatg cttgtccctt ccgtgggcct
     1861 gatcatcccg cctccgaacc cactggctgt ggacctttct tgcaagattg agcagtacta
     1921 tgaagccatc ttggctctgt ggaaccagct ctacatcaac atgaagagcc tggtgtcttg
     1981 gcactactgc atgattgaca tcgagaagat cagagccatg actattgcca agctgaaaac
     2041 gatgagacaa gaagattaca tgaagaccat cgaagacctt gagctccatt accaagactt
     2101 catcaagaac agccaaggct cggagatgtt tggagacgac gacaagcggc ggatgcagtc
     2161 ccagttcacc gatgcccaga agcattacca gaccctggtc attcagcttc ctggccaccc
     2221 ccagcaccag acagtcacca aaaccgaaat cactcacctg ggtacctgcc aagatgtcaa
     2281 ccacaataaa gtgatcgaaa cgaaccgaga aaacgacaaa caggagacat ggttgctgat
     2341 ggagctgcag aagatccgca ggcagatgga gcattgtgag gccaggatga cgcttaaaaa
     2401 tctcctgctg gcagagcaag gctctacaca ccacatcacc gtgaaaatca acgagctcaa
     2461 gagcgtacag aacgactccc aagccctggc cgaggttctc aatcagctta aagacatgct
     2521 tgccaacttc cgaggctctg aaaagtactg ctacctgcag aatgagatat ttggactgtt
     2581 tcagaagctg gaaaatatca atggtgtctc ggatggctac ttaaacagcc tgtgttccgt
     2641 gagagccctt ctccaggcta ttctgcaaac ggaagacatg ctgaaggtct atgaagcgag
     2701 gctgacggaa gaggaaactg tctgtctgga cctggataaa gtagaggctt accgctgcgg
     2761 gctgaagaaa ataaaaaatg acttgaactt gaaaaagtcg ctgttggcca ccatgaagac
     2821 ggagctgcag aaggcacagc agatccactc ccagtcctct cagcagtacc cgctctatga
     2881 cctggacctg ggcaaattca ctgagaaagt gacccagctg acggaccgct ggcaaaagat
     2941 agataaacag atagacttca gattgtggga cctggagaaa caaatcaaac aactgaggaa
     3001 ttatcgggac aactatcaga gcttctgcaa gtggctatat gatgccaaac gccgccagga
     3061 ctctttagag tccatgaagt ttggagattc caacacagtc atgcggtttt tgaatgagca
     3121 gaagaacctg cacagtgaaa tatctggcaa acgagacaaa tcagaagaag tgcataaaat
     3181 cgctgaactt tgcgcaaact caattaagga ttatgaactg cagctggcat cgtacacctc
     3241 agggctggaa actctactga acatacctat caagaggacc atggttcagt ccccatccgg
     3301 ggtgattctg caagaggctg cggacattca tgcgagatac attgaactgc ttacgaggtc
     3361 tggagactac tacagattcc taagtgagat gttgaagagt ctggaagatc taaagctgaa
     3421 aaacaccaag attgaagttt tggaagagga gctaagactg gcccgggatg ccaactcgga
     3481 aaattgcaat aagaataagt tcctagatca gaacctgcag aaataccagg cagagtgttc
     3541 ccagttcaag gccaagcttg tgagcctgga ggagctcaag agacaagctg agctcgatgg
     3601 aaagtcagcc aagcaaaacc tagacaagtg ctacggtcag atcaaggaac tcaacgagaa
     3661 gatcacccgg ctgacctatg agatcgaaga cgagaagcgc cggagaaaga ccgtggagga
     3721 caggttcgac caacagaaga atgactatga tcagctgcag aaggcaaggc agtgtgagaa
     3781 ggagaacctc agctggcaga agctggagtc tgagaaagcc atcaaggaga aggagtacga
     3841 gatagagagg ttgagggttc tgctgcagga agagggcgcc cggaagagag agtatgaaaa
     3901 tgagctggca aaggtaagaa accactataa tgaggagatg agtaatttaa ggaacaagta
     3961 tgaaacagag attaacatca ccaagaccac catcaaggag atatccatgc agaaggaaga
     4021 cgattccaag aatctcagaa accagatgga cagactctcc cgggagaacc gagatcttaa
     4081 ggatgagata gtcaggctca atgacagcat cttgcaggcc acggagcagc gaaggagagc
     4141 cgaggagaac gccctgcagc agaaagcctg tggctcggaa accatgcaga agaagcagcg
     4201 cctggagatt gaactgaagc aggtcatcca gcagcgctca gaggacaacg ccaggcacaa
     4261 gcagtccctg gaggaggctg ccaagaccat ccaggacaag aacaaagaga tcgaaaggct
     4321 caaagctgag tatcaggagg aggccaagcg gcgctgggaa tacgaaaatg aactgagtaa
     4381 ggtaaggaac agttacgatg aggagatcat tagcttaaaa aaccagttcg agaccgagat
     4441 caacatcacc aagaccacga tccaccagct gaccatgcag aaggaagagg acaccagtgg
     4501 ctaccgagcg cagatagaca atctcacccg agaaaacagg agcttgtgtg aggaggtcaa
     4561 gaggctgaag aacactctag cccagaccac cgagaacctc aggagggtcg aagagaacgc
     4621 ccagcagcag aaggccactg gctcagagat gtctcagagg aaacagcagt tggagatcga
     4681 gctccgacag gtcactcaga tgcgaactga agagagcatg aggtacaagc agtccctcga
     4741 tgacgctgcc aagaccatcc aggataagaa caaggagatc gaaaggctca aacagctggt
     4801 cgacaaagaa accaatgaga ggaagtgcct ggaggacgaa aattccaagt tgcagagagt
     4861 ccagtatgac ctgcagaaag ccaacaacag cgccacggag gccatgagca aactgaaggt
     4921 tcaggaacag gagttaacgc gcctacggat tgactatgag agggtgtccc aggagaggac
     4981 cgtgaaggat caggacatca cgaggatcca gagctccctg aaggatctgc agctgcagaa
     5041 gcagaaagcg gaagaggagc tgagtaggct gaagagaaca gcctccgacg agtcctccaa
     5101 gaggaagatg ctggaggagg aactggaggc catgaggagg tctttgaaag agcaagccgt
     5161 caaaatcacc aacctgaccc agcagctgga gcaggcgtcc attgttaaga agaggagcga
     5221 ggatgacctc aggcagcaga gggatgtgct ggatggccac gtgagggaga agcagaggac
     5281 ccaggaggag ctgaggaggc tctccttgga tgtcgaggcc ctccggcggc agctggtcca
     5341 ggaacaggag aatgtcaagc aggctcactt gaggaatgag catttccaga aggccataga
     5401 agacaaaagc aggagcctca atgagagtaa aatagagatc gaaaggctac agtcgctcac
     5461 ggagaacctg accaaggaac acttgatgct ggaggaagag ctgaggaacc tgaggctgga
     5521 gtacgacgac ctgcggaggg gccggagtga agcggacagc gataaaaact caaccatctc
     5581 cgagctaagg agccaactgc agatcagcaa caatcgaacc ctcgagctgc aggggctgat
     5641 taatgattta cagagagaga gggaaaattt gagacaggaa attgagaaat tccaaaagca
     5701 ggctttagag gcatctaata ggatccagga gtcaaagagt cagtgcactc aagttgttca
     5761 ggagagagag agcctgctgg tgaagatcaa agtcctggag caagacaagg cgaggctgca
     5821 gcggctggag gatgagctga accgtgccaa agcaacgctg gaggcagaaa gccgggtgaa
     5881 acagcgtctg gagtgtgaga agcagcagat ccagaacgac ctgaaccagt ggaaaactca
     5941 gtattcccgc aaggaggaga ccattaggaa gatagagtcg gaaagagaga agagcgagcg
     6001 agaaaagaac agtctcagga gtgagatcga gaggctccag gcggagatca agaggatcga
     6061 agagagatgc aggaggaagc tagaggattc ttctagggag actcagtccc agctggaatc
     6121 cgaacgctgc aggcttcaga aggagatcga gaaactcagg cagcgcccct acgggtccca
     6181 tcgggagacc cagacggaat acgagtggac cgttgattcc tccaagctgg tatttgatgg
     6241 gctgaggaag aaggtgacgg caatgcagct ctatgagtgc cagctgatcg acaagacgac
     6301 gctagacaag ctgttgaagg ggaagaagtc agtggaggag gtggcctcag agatccagcc
     6361 tttcctgcgc ggcgcaggcg ccatcgccgg ggcttccgct tctcccaagg aaaagtactc
     6421 tttggtggag gccaagagaa agaaattcat caccccagaa tccactgtca tgcttctgga
     6481 ggcccaggca gccaccggtg gtatcatcga tccccatcgg aatgagaagc tcactgtgga
     6541 caatgccgta gcccgggatc tcatcgactt cgacgaccgc caacagatct acacagcgga
     6601 gaaagccatc actggtttcg atgacccgtt ttcgggcaag acggtctctg tttcagaagc
     6661 catcaagaag aatttgatcg acagagaaac cggaatgcgc ctgctggaag cccagcttgc
     6721 ttcagggggt gtagttgatc cagtcaacag tgtcttcttg ccaaaagatg tcgccttggc
     6781 ccgtgggctg attgatagag atttgtatcg ctccttgaac gatccccgag atagtcagaa
     6841 gaacttcgtg gatccaatca ccaagaagaa ggtcagctac atgcagctga gagaaaggtg
     6901 cagaatcgaa ccccacacgg gtctgctcct gctgtcagta cagaagagaa gcatgtcctt
     6961 ccagggaatc agacaacccg tgaccgtcac cgaactggtt gattctggca tattgagacc
     7021 gtccactgta aacgaactgg aatccggtca gatttcctat gatgaggttg gggagagaat
     7081 caaggacttc ctccagggtt caagctgcat agcaggcata tataatgaga ccactaagca
     7141 gaagctgggc atctatgagg ccatgaaaat aggcttagtt cgacctggta ccgccctgga
     7201 gttgctggaa gcccaagcag ctactggctt tattgtggat cccgtcagca atttaaggct
     7261 acctgtggag gaagcctaca agagaggtct ggtgggcatt gagttcaaag agaagcttct
     7321 gtctgcggaa cgagccgtca ctggctacaa cgatcctgag accggaaaca tcatctcttt
     7381 attccaagca atgaacaagg agctcatcga aaagggccat ggcattcgct tgctggaggc
     7441 acagatcgca accggcggca tcatcgaccc gaaggagagc catcggttac cggttgacat
     7501 ggcgtataag aggggttatt ttaatgagga gcttagcgaa atcctctcag acccaagtga
     7561 tgataccaaa ggctttttcg atccaaacac agaagaaaac ctcacctatc tgcaactgaa
     7621 ggagagatgc atcaaagatg aggaaacagg gctctgcctg ctgcccctga aagagaagaa
     7681 gaaacaggtg cagacttctc agaagaacac gctcagaaag cggcgggtgg tcatagttga
     7741 cccggaaacc aataaggaga tgtctgttca ggaggcctac aagaaaggtc tcattgatta
     7801 tgacaccttc aaggagctat gtgaacaaga gtgcgaatgg gaagaaataa ccatcacagg
     7861 atcagacggc tccaccaggg tggtcttagt ggacaggaag accggcagtc agtatgacat
     7921 tcaagatgct attgacaagg gcctcgttga caggaagttc ttcgatcaat accgatcagg
     7981 cagccttagc ctcacacagt ttgctgacat gatctccttg aaaaacggcg tcggcaacag
     8041 cagcggcttg ggtgggagtg tcaacgatga tgtttttagc agctcccgac acgactccgt
     8101 gagtaagatt tccaccatat ccagtgtcag aaatctaacc atccgaagca gctctctgtc
     8161 agaccctctg gaggagtcaa gccccattgc ggccatcttt gacacagaga acctggagaa
     8221 aatctcgatc gcagaaggta tagagcgggg cattgtggat agcatcaccg gtcagaggct
     8281 tctggaggct caggcctgca ctggtggcat cattcaccct accactggtc agaagctctc
     8341 ccttcaagat gcagtcaacc agggtctcat tgaccaagac atggccacca ggctgaagcc
     8401 tgcccagaag gccttcatcg gctttgaagg ggtaaaagga aagaagaaga tgtcggcagc
     8461 agaggcagtc aaagagaaat ggcttcccta cgaggcaggc cagcgcttcc tggagttcca
     8521 gttcctcacg ggaggccttg ttgacccgga agtgcatggg aggatcagca ccgaagaagc
     8581 catccgcaaa ggtttcatcg atggccgtgc agctcagagg ttgcaggaca tcagcagcta
     8641 tgccaaaatc ctcacctgcc ccaaaaccaa gttaaaaatc tcctacaagg atgccatgaa
     8701 tcgctccatg gtggaagaca tcactgggtt gcgccttctg gaagccgcct ccgtgtcctc
     8761 gaagggtttg cctagccctt ataacatgtc agccccaggc tcccgctctg gttcaaggtc
     8821 cggatctcgc tcaggctccc gctctggctc ccgcagcggg tctcggagag gaagcttcga
     8881 tgctacgggc aattcttctt actcctattc ctattcattt agcagtagct ccattggggg
     8941 gtactagtgg tcagaagtag ttaccgtacc ttaggatcat ttgtatgtct actttatctt
     9001 aacaaagaaa acctggtgct tgcagtatag ctgtagaatt ttctatgttc aagacgtagc
     9061 tgcaataaaa tcccagtagt aaaggctcat ttagctctgt agctttcggc tcaattaatg
     9121 tacttcctta tagtgaatga gaagtggtag tcatttgtaa ggatagcaca cattgaattt
     9181 ggaatttatt tcttccatgt tttgatcaat tctctgtaac ttttcttggc ttataaggtc
     9241 caatttctgt gtctggaggt ataaaaaaat tacactgact actggtggct tagtacttta
     9301 tgttgtctct cacctaaata gttccacttt ctgcattagg agaaaactgc tcccctcccc
     9361 aagtatttta gtccaagttt cctttagttt gagaacatag attgtatcac ccatatattc
     9421 ttgaatacac ttgtttggtt tggtattact ttgactatgt ccacaatagc agcaatcttg
     9481 gctttttgtt agccaaagtg ttctgtttat ttggcttgtc attttccgtg tgctttaaaa
     9541 aggtgttgtt atgaagtttg ctgttctggc aataaacttg cagaccttgg aa
//
