LOCUS       NP_076331               2883 aa            linear   ROD 01-MAY-2025
DEFINITION  desmoplakin isoform 1 [Mus musculus].
ACCESSION   NP_076331 XP_484245
VERSION     NP_076331.2
DBSOURCE    REFSEQ: accession NM_023842.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2883)
  AUTHORS   Xu,T., Herkens,L., Jia,T., Klinkhammer,B.M., Kant,S., Krusche,C.A.,
            Buhl,E.M., Hayat,S., Floege,J., Strnad,P., Kramann,R., Djudjaj,S.
            and Boor,P.
  TITLE     The role of desmoglein-2 in kidney disease
  JOURNAL   Kidney Int 105 (5), 1035-1048 (2024)
   PUBMED   38395410
REFERENCE   2  (residues 1 to 2883)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 2883)
  AUTHORS   Griffin,E.N., Jucius,T., Sim,S.E., Harris,B.S., Heinz,S. and
            Ackerman,S.L.
  TITLE     RREB1 regulates neuronal proteostasis and the microtubule network
  JOURNAL   Sci Adv 10 (2), eadh3929 (2024)
   PUBMED   38198538
REFERENCE   4  (residues 1 to 2883)
  AUTHORS   Olcum,M., Fan,S., Rouhi,L., Cheedipudi,S., Cathcart,B., Jeong,H.H.,
            Zhao,Z., Gurha,P. and Marian,A.J.
  TITLE     Genetic inactivation of beta-catenin is salubrious, whereas its
            activation is deleterious in desmoplakin cardiomyopathy
  JOURNAL   Cardiovasc Res 119 (17), 2712-2728 (2023)
   PUBMED   37625794
  REMARK    GeneRIF: Genetic inactivation of beta-catenin is salubrious,
            whereas its activation is deleterious in desmoplakin
            cardiomyopathy.
REFERENCE   5  (residues 1 to 2883)
  AUTHORS   He,Q., Zuo,Z., Song,K., Wang,W., Yu,L., Tang,Z., Hu,S., Li,L.,
            Luo,H., Chen,Z., Liu,J., Lin,B., Luo,J., Jiang,Y., Huang,Q. and
            Guo,X.
  TITLE     Keratin7 and Desmoplakin are involved in acute lung injury induced
            by sepsis through RAGE
  JOURNAL   Int Immunopharmacol 124 (Pt A), 110867 (2023)
   PUBMED   37660597
  REMARK    GeneRIF: Keratin7 and Desmoplakin are involved in acute lung injury
            induced by sepsis through RAGE.
REFERENCE   6  (residues 1 to 2883)
  AUTHORS   Bierkamp,C., Schwarz,H., Huber,O. and Kemler,R.
  TITLE     Desmosomal localization of beta-catenin in the skin of plakoglobin
            null-mutant mice
  JOURNAL   Development 126 (2), 371-381 (1999)
   PUBMED   9847250
REFERENCE   7  (residues 1 to 2883)
  AUTHORS   Ruhrberg,C., Hajibagheri,M.A., Parry,D.A. and Watt,F.M.
  TITLE     Periplakin, a novel component of cornified envelopes and desmosomes
            that belongs to the plakin family and forms complexes with
            envoplakin
  JOURNAL   J Cell Biol 139 (7), 1835-1849 (1997)
   PUBMED   9412476
REFERENCE   8  (residues 1 to 2883)
  AUTHORS   Hieda,Y., Iwai,K., Morita,T. and Nakanishi,Y.
  TITLE     Mouse embryonic submandibular gland epithelium loses its tissue
            integrity during early branching morphogenesis
  JOURNAL   Dev Dyn 207 (4), 395-403 (1996)
   PUBMED   8950514
REFERENCE   9  (residues 1 to 2883)
  AUTHORS   Ruiz,P., Brinkmann,V., Ledermann,B., Behrend,M., Grund,C.,
            Thalhammer,C., Vogel,F., Birchmeier,C., Gunthert,U., Franke,W.W.
            and Birchmeier,W.
  TITLE     Targeted mutation of plakoglobin in mice reveals essential
            functions of desmosomes in the embryonic heart
  JOURNAL   J Cell Biol 135 (1), 215-225 (1996)
   PUBMED   8858175
REFERENCE   10 (residues 1 to 2883)
  AUTHORS   Proetzel,G., Pawlowski,S.A., Wiles,M.V., Yin,M., Boivin,G.P.,
            Howles,P.N., Ding,J., Ferguson,M.W. and Doetschman,T.
  TITLE     Transforming growth factor-beta 3 is required for secondary palate
            fusion
  JOURNAL   Nat Genet 11 (4), 409-414 (1995)
   PUBMED   7493021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140331.2.
            
            On Jun 12, 2008 this sequence version replaced NP_076331.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.12545.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2883
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 18.0 cM"
     Protein         1..2883
                     /product="desmoplakin isoform 1"
                     /note="desmosomal cytoskeletal connector molecule;
                     desmoplakin I/II"
                     /calculated_mol_wt=332783
     Region          1..1068
                     /region_name="Globular 1"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q557.1)"
     Region          1..596
                     /region_name="Interaction with PKP1, JUP, PKP2.
                     /evidence=ECO:0000250|UniProtKB:P15924"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q557.1)"
     Region          1..21
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            22
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            59
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            65
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            68
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            73
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            177
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            178
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            188
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Region          202..378
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            282..286
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          297..462
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            387..392
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          459..525
                     /region_name="SH3_10"
                     /note="SH3 domain; pfam17902"
                     /db_xref="CDD:407754"
     Region          560..637
                     /region_name="Spectrin_like"
                     /note="Spectrin like domain; pfam18373"
                     /db_xref="CDD:465730"
     Region          1069..1957
                     /region_name="Central fibrous rod domain"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q557.1)"
     Region          1134..1924
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            1670
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            1720
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Region          1958..2882
                     /region_name="Globular 2"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q557.1)"
     Region          1972..2220
                     /region_name="4.5 X 38 AA tandem repeats (Domain A)"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2036
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Region          2060..2098
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          2096..2133
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          2136..2174
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Site            2219
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2221
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2237
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Region          2256..2458
                     /region_name="4.5 X 38 AA tandem repeats (Domain B)"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q557.1)"
     Region          2263..2300
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          2303..2341
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          2340..2376
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          2379..2417
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          <2480..2508
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          2621..2833
                     /region_name="4.5 X 38 AA tandem repeats (Domain C)"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q557.1)"
     Region          2623..2659
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          2662..2700
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          2738..2776
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          2822..2883
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2822
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2827
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2829
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2832
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Region          2835..2858
                     /region_name="6 X 4 AA tandem repeats of G-S-R-[SR]"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2836
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2837
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2858
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2860
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2864
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     Site            2879
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15924; propagated from
                     UniProtKB/Swiss-Prot (E9Q557.1)"
     CDS             1..2883
                     /gene="Dsp"
                     /gene_synonym="2300002E22Rik; 5730453H04Rik; DP; rul"
                     /coded_by="NM_023842.3:209..8860"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS49239.1"
                     /db_xref="GeneID:109620"
                     /db_xref="MGI:MGI:109611"
ORIGIN      
        1 mscnggshpr intlgrmtra esgpdlryem tysggggggg ggggggtsrt fyshsrrctv
       61 ndqnsdgycq tgtmsrhqnq ntiqemlqnc sdclmraeli aqpelkfgeg mqlawnreld
      121 eyftqandqm eiidglirem rqmgqpcday qkrllqlqeq mralykaisv prvrrasskg
      181 aggytcqsgs gwdeftkrlt geclgwmrqq reemdlmawg vdagsveqhi nshrsihnti
      241 gdyrwqldki kadlreksai yqleeeyenl lkasfermdh lrqlqniiqa tsreimwind
      301 ceeeellydw sdkntniaqk qeafsirmsq levkekelnk lkqesdqlvl nqhpasdkie
      361 aymdtlqtqw swilqitkci dvhlkenaay fqffeeaqst eaylkglqds irkkypcdkn
      421 mplqhlleqi kelekereki ieykrqvqnl vnkskkivql kprnpdyrsn kpiilralcd
      481 ykqdqkivhk gdecilkdnn erskwyvtgp ggvdmlvpsv gliipppnpl avdlsckieq
      541 yyeailalwn qlyinmkslv swhycmidie kiramtiakl ktmrqedymk tiedlelhyq
      601 dfiknsqgse mfgdddkrrm qsqftdaqkh yqtlviqlpg hpqhqtvtkt eithlgtcqd
      661 vnhnkvietn rendkqetwl lmelqkirrq mehcearmtl knlllaeqgs thhitvkine
      721 lksvqndsqa laevlnqlkd mlanfrgsek ycylqneifg lfqklening vsdgylnslc
      781 svrallqail qtedmlkvye arlteeetvc ldldkveayr cglkkikndl nlkksllatm
      841 ktelqkaqqi hsqssqqypl ydldlgkfte kvtqltdrwq kidkqidfrl wdlekqikql
      901 rnyrdnyqsf ckwlydakrr qdslesmkfg dsntvmrfln eqknlhseis gkrdkseevh
      961 kiaelcansi kdyelqlasy tsgletllni pikrtmvqsp sgvilqeaad iharyiellt
     1021 rsgdyyrfls emlksledlk lkntkievle eelrlardan sencnknkfl dqnlqkyqae
     1081 csqfkaklvs leelkrqael dgksakqnld kcygqikeln ekitrltyei edekrrrktv
     1141 edrfdqqknd ydqlqkarqc ekenlswqkl esekaikeke yeierlrvll qeegarkrey
     1201 enelakvrnh yneemsnlrn kyeteinitk ttikeismqk eddsknlrnq mdrlsrenrd
     1261 lkdeivrlnd silqateqrr raeenalqqk acgsetmqkk qrleielkqv iqqrsednar
     1321 hkqsleeaak tiqdknkeie rlkaeyqeea krrweyenel skvrnsydee iislknqfet
     1381 einitkttih qltmqkeedt sgyraqidnl trenrslcee vkrlkntlaq ttenlrrvee
     1441 naqqqkatgs emsqrkqqle ielrqvtqmr teesmrykqs lddaaktiqd knkeierlkq
     1501 lvdketnerk cledensklq rvqydlqkan nsateamskl kvqeqeltrl ridyervsqe
     1561 rtvkdqditr iqsslkdlql qkqkaeeels rlkrtasdes skrkmleeel eamrrslkeq
     1621 avkitnltqq leqasivkkr seddlrqqrd vldghvrekq rtqeelrrls ldvealrrql
     1681 vqeqenvkqa hlrnehfqka iedksrslne skieierlqs ltenltkehl mleeelrnlr
     1741 leyddlrrgr seadsdknst iselrsqlqi snnrtlelqg lindlqrere nlrqeiekfq
     1801 kqaleasnri qesksqctqv vqeresllvk ikvleqdkar lqrledelnr akatleaesr
     1861 vkqrlecekq qiqndlnqwk tqysrkeeti rkiesereks ereknslrse ierlqaeikr
     1921 ieercrrkle dssretqsql esercrlqke ieklrqrpyg shretqteye wtvdssklvf
     1981 dglrkkvtam qlyecqlidk ttldkllkgk ksveevasei qpflrgagai agasaspkek
     2041 yslveakrkk fitpestvml leaqaatggi idphrneklt vdnavardli dfddrqqiyt
     2101 aekaitgfdd pfsgktvsvs eaikknlidr etgmrlleaq lasggvvdpv nsvflpkdva
     2161 larglidrdl yrslndprds qknfvdpitk kkvsymqlre rcriephtgl lllsvqkrsm
     2221 sfqgirqpvt vtelvdsgil rpstvneles gqisydevge rikdflqgss ciagiynett
     2281 kqklgiyeam kiglvrpgta lelleaqaat gfivdpvsnl rlpveeaykr glvgiefkek
     2341 llsaeravtg yndpetgnii slfqamnkel iekghgirll eaqiatggii dpkeshrlpv
     2401 dmaykrgyfn eelseilsdp sddtkgffdp nteenltylq lkercikdee tglcllplke
     2461 kkkqvqtsqk ntlrkrrvvi vdpetnkems vqeaykkgli dydtfkelce qeceweeiti
     2521 tgsdgstrvv lvdrktgsqy diqdaidkgl vdrkffdqyr sgslsltqfa dmislkngvg
     2581 nssglggsvn ddvfsssrhd svskistiss vrnltirsss lsdpleessp iaaifdtenl
     2641 ekisiaegie rgivdsitgq rlleaqactg giihpttgqk lslqdavnqg lidqdmatrl
     2701 kpaqkafigf egvkgkkkms aaeavkekwl pyeagqrfle fqfltgglvd pevhgriste
     2761 eairkgfidg raaqrlqdis syakiltcpk tklkisykda mnrsmvedit glrlleaasv
     2821 sskglpspyn msapgsrsgs rsgsrsgsrs gsrsgsrrgs fdatgnssys ysysfssssi
     2881 ggy
//
