LOCUS       NM_025853               2283 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus DSN1 homolog, MIS12 kinetochore complex component
            (Dsn1), mRNA.
ACCESSION   NM_025853
VERSION     NM_025853.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2283)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2283)
  AUTHORS   Li,Y., Yuan,J., Chen,F., Zhang,S., Zhao,Y., Chen,X., Lu,L.,
            Zhou,L., Chu,C.Y., Sun,H. and Wang,H.
  TITLE     Long noncoding RNA SAM promotes myoblast proliferation through
            stabilizing Sugt1 and facilitating kinetochore assembly
  JOURNAL   Nat Commun 11 (1), 2725 (2020)
   PUBMED   32483152
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2283)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   4  (bases 1 to 2283)
  AUTHORS   Sarkar,S., Shenoy,R.T., Dalgaard,J.Z., Newnham,L., Hoffmann,E.,
            Millar,J.B. and Arumugam,P.
  TITLE     Monopolin subunit Csm1 associates with MIND complex to establish
            monopolar attachment of sister kinetochores at meiosis I
  JOURNAL   PLoS Genet 9 (7), e1003610 (2013)
   PUBMED   23861669
  REMARK    GeneRIF: we demonstrate that interaction of monopolin subunit Csm1
            with the N-terminal domain of MIND complex subunit Dsn1, is
            essential for both the association of monopolin with kinetochores
            and for monopolar attachment of sister kinetochores during meiosis
REFERENCE   5  (bases 1 to 2283)
  AUTHORS   Varma,D. and Salmon,E.D.
  TITLE     The KMN protein network--chief conductors of the kinetochore
            orchestra
  JOURNAL   J Cell Sci 125 (Pt 24), 5927-5936 (2012)
   PUBMED   23418356
  REMARK    Review article
REFERENCE   6  (bases 1 to 2283)
  AUTHORS   Lampert,F. and Westermann,S.
  TITLE     A blueprint for kinetochores - new insights into the molecular
            mechanics of cell division
  JOURNAL   Nat Rev Mol Cell Biol 12 (7), 407-412 (2011)
   PUBMED   21633384
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2283)
  AUTHORS   Hutchins,J.R., Toyoda,Y., Hegemann,B., Poser,I., Heriche,J.K.,
            Sykora,M.M., Augsburg,M., Hudecz,O., Buschhorn,B.A., Bulkescher,J.,
            Conrad,C., Comartin,D., Schleiffer,A., Sarov,M., Pozniakovsky,A.,
            Slabicki,M.M., Schloissnig,S., Steinmacher,I., Leuschner,M.,
            Ssykor,A., Lawo,S., Pelletier,L., Stark,H., Nasmyth,K.,
            Ellenberg,J., Durbin,R., Buchholz,F., Mechtler,K., Hyman,A.A. and
            Peters,J.M.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
REFERENCE   8  (bases 1 to 2283)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 2283)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 2283)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006246.1, BC046807.1 and CK333431.1.
            
            On Jul 21, 2009 this sequence version replaced NM_025853.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006246.1, AK017740.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1089              AK006246.1         2-1090
            1090-2068           BC046807.1         1051-2029
            2069-2283           CK333431.1         313-527
FEATURES             Location/Qualifiers
     source          1..2283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.89 cM"
     gene            1..2283
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /note="DSN1 homolog, MIS12 kinetochore complex component"
                     /db_xref="GeneID:66934"
                     /db_xref="MGI:MGI:1914184"
     exon            1..101
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            102..127
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1149
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /note="DSN1, MIND kinetochore complex component, homolog"
                     /codon_start=1
                     /product="kinetochore-associated protein DSN1 homolog"
                     /protein_id="NP_080129.2"
                     /db_xref="CCDS:CCDS16972.1"
                     /db_xref="GeneID:66934"
                     /db_xref="MGI:MGI:1914184"
                     /translation="MTSVTRSEDQEPTMSETQDRPLQPSLKPLEALPQSSAYQEMMTQ
                     GVSEEKNHLGSNPGEGESCGADHQEGSQLRSFHLSPQEQSIRPQDRRQSWRRASMKEV
                     NRRKSLAPFHPGITELCRSISVKLAQSQRLGALLLSSFQFSVEKLEPFLKNTKDFSLE
                     CFRAKASSLSEELKHFTDRLGNDGTLQKCFVEDSKEKAADFSLEASVAEVKEYITKFS
                     LERQAWDRLLLQYQNEVPPEEMPRGSTETRITEVKVDPAAYLRSSQKEVLSTKPDYQR
                     IVQDQNQVFAYVELVMDELQGSVKQLQALMDESTQYLQKVSVQLKKRSMDQLDSSPAR
                     KLLKLPLQSSPSTQ"
     exon            128..451
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            452..525
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            526..598
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            599..689
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            690..749
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            750..827
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            828..975
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1063
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..2283
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2046..2051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2068
                     /gene="Dsn1"
                     /gene_synonym="1700022L09Rik"
                     /note="major polyA site"
ORIGIN      
        1 agttgttcgg cgggagtttc gtaagtagcg gaggcagcgg ggaaccccga accggactga
       61 cgcgggagag gaccttctgc ggcgacgccg agtttgcaga ggatgacgtc agtgaccaga
      121 tcagaagacc aggaacccac gatgtccgag actcaggatc gtccattgca gccaagtctc
      181 aagcctttgg aagcattgcc tcaatcctct gcctaccagg aaatgatgac gcaaggcgtt
      241 tcagaggaaa aaaaccacct tggctcgaac cctggagagg gggaaagttg tggtgccgac
      301 caccaggagg gatctcagtt gaggtccttt catttgtccc ctcaagaaca gtctatccgt
      361 cctcaagaca gaaggcagtc ctggagacga gcaagcatga aagaagtaaa ccggcggaag
      421 tcattggctc ccttccaccc aggcatcaca gagctctgca ggtccatcag tgtgaagtta
      481 gcccagagcc aacggctggg cgccctcctg ctctccagct tccagttctc tgttgaaaaa
      541 cttgaacctt tcttaaagaa cactaaggac ttcagccttg aatgttttag agcgaaagca
      601 tcttctctct ctgaagaatt gaaacatttt acagacaggc tgggaaatga tggaacactg
      661 caaaaatgtt ttgttgaaga ttcaaaagaa aaagcagcag atttttcact ggaagcatca
      721 gtagctgagg tgaaagaata tataacaaag ttttctttag agcgtcaggc ctgggatcgg
      781 ctcttactgc agtaccagaa cgaggttcca cctgaagaga tgcccagagg atcaactgaa
      841 accagaatca ctgaagtcaa ggtggatcct gcagcctacc tcaggtcttc ccagaaggaa
      901 gttcttagca cgaagccaga ctaccagaga atagtacaag atcagaacca agtctttgcc
      961 tacgtggagt tagtgatgga tgagctccaa ggatcagtga agcagctgca agccctcatg
     1021 gatgagagta ctcagtacct ccagaaggtg tcagtacagc tcaagaagag aagtatggac
     1081 caattagact cttcacctgc tcggaaactg ctcaagctcc ccctccagag ctcaccttcc
     1141 acgcagtgat gaggatcctg tcagggaccc tacctcacag cagtcagctg gaatgtccca
     1201 gctctacagc acttcactgt tgccgagtga cagcatgtat gtatccagaa gagtgtgtta
     1261 aggacacttt ttgtcgggat gtgcacgatg ctcaaaatgg ccttcagaac cagtcgtccg
     1321 ttgctcctaa catcctcatg gtcagcgctt ttcatcccat aaaataatcc agagacatct
     1381 aaaaccaacc tcaaggaaat gttttagagg ccaaggtggg ttgttgccat aaaagactga
     1441 cgctaaagtt tgtgagtgtg ggactgaagg tggattatag gatgttgtca cataacgggt
     1501 atgtgtggac actttacagc atgcccattt tctgaagtgt cctaatctct gtagagtgct
     1561 ttagttttta atattgaatt gacttcctgg aatctaaatt catgacaaga aaaggctgtg
     1621 ccaatttaat tttttccttt gggaattacc cctgcctccc taagaattga ccccagagct
     1681 ttgtgggtgc tagggaagca ccctcaagaa gctgcacctt tagtccccat attttggggt
     1741 ttttaatatt ttttttaagt tctgttagtg aatggcgtgt tatttaaaaa ccgtgtgttg
     1801 tcatttcctg gggctgagat agagttattt aacctcttat ctcgaacatt agatggatgt
     1861 tagaatctat gtcgtaagga cactgtgagg atttgtttaa agagtaaaag cctagaacaa
     1921 tgttatagtt tgttgttgaa gacttaataa aatgagtata ctgtagttaa tgaggtggga
     1981 aagctactat ctcatatgga ataccacatg gagaactcaa gcagatacat aaagtctgga
     2041 ttagaaataa acttacaagt tttgcctagt tgttgaagtg tacactatgt gacagtgtgt
     2101 ctctgccctt ccttgccttc ctaaaaagca ccttgtgact ggttaagata aaaagcctgt
     2161 agcctgtagc agaaggctgg atactaacgt agtacatcca gaaagaggaa ctctgggaag
     2221 gagtcaggta caggagagtt gccacccaaa gtgtcaacct cacccaaact gaggagaggt
     2281 gac
//
