LOCUS       NM_030596               4138 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus desmoglein 3 (Dsg3), mRNA.
ACCESSION   NM_030596 XM_984295
VERSION     NM_030596.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4138)
  AUTHORS   Takahashi,H., Iriki,H. and Asahina,Y.
  TITLE     T cell autoimmunity and immune regulation to desmoglein 3, a
            pemphigus autoantigen
  JOURNAL   J Dermatol 50 (2), 112-123 (2023)
   PUBMED   36539957
  REMARK    GeneRIF: T cell autoimmunity and immune regulation to desmoglein 3,
            a pemphigus autoantigen.
            Review article
REFERENCE   2  (bases 1 to 4138)
  AUTHORS   Hudemann,C., Exner,Y., Pollmann,R., Schneider,K., Zakrzewicz,A.,
            Feldhoff,S., Schmidt,T., Spindler,V., Rafei-Shamsabadi,D.,
            Vollner,F., Waschke,J., Tikkanen,R., Hertl,M. and Eming,R.
  TITLE     IgG against the Membrane-Proximal Portion of the Desmoglein 3
            Ectodomain Induces Loss of Keratinocyte Adhesion, a Hallmark in
            Pemphigus Vulgaris
  JOURNAL   J Invest Dermatol 143 (2), 254-263 (2023)
   PUBMED   36089007
REFERENCE   3  (bases 1 to 4138)
  AUTHORS   Zheng,X., Huang,W., He,Z., Li,Y., Li,S. and Song,Y.
  TITLE     Effects of Fam83h truncation mutation on enamel developmental
            defects in male C57/BL6J mice
  JOURNAL   Bone 166, 116595 (2023)
   PUBMED   36272714
REFERENCE   4  (bases 1 to 4138)
  AUTHORS   Nomura,H., Wada,N., Takahashi,H., Kase,Y., Yamagami,J., Egami,S.,
            Iriki,H., Mukai,M., Kamata,A., Ito,H., Fujii,H., Ishikura,T.,
            Koseki,H., Watanabe,T., Yamada,T., Ohara,O., Koyasu,S. and
            Amagai,M.
  TITLE     IgM to IgG Class Switching Is a Necessary Step for Pemphigus
            Phenotype Induction in Desmoglein 3-Specific B Cell Receptor
            Knock-in Mouse
  JOURNAL   J Immunol 208 (3), 582-593 (2022)
   PUBMED   34996836
  REMARK    GeneRIF: IgM to IgG Class Switching Is a Necessary Step for
            Pemphigus Phenotype Induction in Desmoglein 3-Specific B Cell
            Receptor Knock-in Mouse.
REFERENCE   5  (bases 1 to 4138)
  AUTHORS   Godsel,L.M., Roth-Carter,Q.R., Koetsier,J.L., Tsoi,L.C.,
            Huffine,A.L., Broussard,J.A., Fitz,G.N., Lloyd,S.M., Kweon,J.,
            Burks,H.E., Hegazy,M., Amagai,S., Harms,P.W., Xing,X., Kirma,J.,
            Johnson,J.L., Urciuoli,G., Doglio,L.T., Swindell,W.R.,
            Awatramani,R., Sprecher,E., Bao,X., Cohen-Barak,E., Missero,C.,
            Gudjonsson,J.E. and Green,K.J.
  TITLE     Translational implications of Th17-skewed inflammation due to
            genetic deficiency of a cadherin stress sensor
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34905516
REFERENCE   6  (bases 1 to 4138)
  AUTHORS   Ishikawa,H., Li,K., Tamai,K., Sawamura,D. and Uitto,J.
  TITLE     Cloning of the mouse desmoglein 3 gene (Dsg3): interspecies
            conservation within the cadherin superfamily
  JOURNAL   Exp Dermatol 9 (4), 229-239 (2000)
   PUBMED   10949543
REFERENCE   7  (bases 1 to 4138)
  AUTHORS   Hogan,M.E., King,L.E. Jr. and Sundberg,J.P.
  TITLE     Defects of pelage hairs in 20 mouse mutations
  JOURNAL   J Invest Dermatol 104 (5 Suppl), 31S-32S (1995)
   PUBMED   7738386
REFERENCE   8  (bases 1 to 4138)
  AUTHORS   Collins,J.E., Lorimer,J.E., Garrod,D.R., Pidsley,S.C., Buxton,R.S.
            and Fleming,T.P.
  TITLE     Regulation of desmocollin transcription in mouse preimplantation
            embryos
  JOURNAL   Development 121 (3), 743-753 (1995)
   PUBMED   7536656
REFERENCE   9  (bases 1 to 4138)
  AUTHORS   Ishikawa,H., Silos,S.A., Tamai,K., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Uitto,J.
  TITLE     cDNA cloning and chromosomal assignment of the mouse gene for
            desmoglein 3 (Dsg3), the pemphigus vulgaris antigen
  JOURNAL   Mamm Genome 5 (12), 803-804 (1994)
   PUBMED   7894164
REFERENCE   10 (bases 1 to 4138)
  AUTHORS   Davisson,M.T., Cook,S.A., Johnson,K.R. and Eicher,E.M.
  TITLE     Balding: a new mutation on mouse chromosome 18 causing hair loss
            and immunological defects
  JOURNAL   J Hered 85 (2), 134-136 (1994)
   PUBMED   8182278
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK037142.1 and AK148657.1.
            
            On Feb 3, 2016 this sequence version replaced NM_030596.3.
            
            Summary: This gene encodes a member of the cadherin family of
            proteins that forms an integral transmembrane component of
            desmosomes, the multiprotein complexes involved in cell adhesion,
            organization of the cytoskeleton, cell sorting and cell signaling.
            The encoded preproprotein undergoes proteolytic processing to
            generate a mature, functional protein. Mice lacking the encoded
            protein exhibit loss of keratinocyte cell adhesion resulting in a
            phenotype that resembles that of patients with pemphigus vulgaris.
            This gene is located in a cluster of desmosomal cadherin genes on
            chromosome 18. [provided by RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148657.1, AK037142.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AK037142.1         2-31
            31-4138             AK148657.1         2-4109
FEATURES             Location/Qualifiers
     source          1..4138
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.39 cM"
     gene            1..4138
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /note="desmoglein 3"
                     /db_xref="GeneID:13512"
                     /db_xref="MGI:MGI:99499"
     exon            1..149
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            150..185
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            186..317
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            318..473
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            474..618
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            619..785
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            786..914
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1100
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1372
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1512
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1740
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1995
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2138
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2202
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2423
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..4138
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3560..3565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /note="hexamer: AATAAA"
     polyA_site      3579
                     /gene="Dsg3"
                     /gene_synonym="bal"
                     /note="major polyA site"
ORIGIN      
        1 accactgcca gaagggagct tcagacaccc agatatacag acacccaggt gaggagctgc
       61 agcaagaagc ttggatttat tcaccagaca caccagcaac aatgacctgc ctcttcccta
      121 gagccttggg gtctctggcc ctcctgatgg tggtgctgct ggtacagggg gaactgcatg
      181 tgaagccggg aggacagcac agagaagatg ggacagcatt gcagctggcc aaaagaaggt
      241 acaaacgtga atgggtgaaa tttgcaaaac cctgcagaga aagagaagac aactcaagac
      301 gaaacccaat tgccaagatc acttcagatt tccaaaaaaa ccagaaaatt acctaccgca
      361 tttctggagt gggaattgat cagcctccct ttgggatctt tgttgttgac ccaaacaatg
      421 gtgatatcaa cataacagcc atagttgatc gtgaggaaac cccaagcttc ctgatcacat
      481 gccgtgcact aaatgccctg ggacaggatg tagagagacc acttatatta acagtgaaaa
      541 ttttagacgt caatgataac cctccaatat tttcacaaac catattcaag ggtgaaattg
      601 aagaaaatag tgcttcaaat tccctggtaa tgatcctaaa tgccacggat gcagatgaac
      661 caaaccatat gaactctaaa attgccttca aaattgtctc ccaggagccc gcaggcatgt
      721 ccatgttcct catcagcaga aacaccggag aagtccgcac tttgaccagt tctcttgatc
      781 gagagcaaat tagtagctac catctggttg tgagcggtgc agacaacgat ggaacaggac
      841 tgtcaactca gtgtgaatgt agtattaaaa ttaaagatgt caatgacaac ttcccagtgc
      901 tcagagagtc tcagtattca gcacgtattg aagaaaatac tttgaatgca gagctactcc
      961 gatttcaagt gacagactgg gatgaagaat acacagataa ttggttggct gtgtatttct
     1021 tcacctctgg gaatgagggg aattggtttg aaattgaaac agatcctaga accaatgaag
     1081 gcatcctgaa ggtggttaag gctctggatt atgaacaagt gcagagtatg cagtttagta
     1141 ttgctgtcag aaacaaagct gagttccacc agtcagtgat ctctcagtac cgagtgcagt
     1201 caacgccagt cacaattcaa gtcattgatg tccgagaggg aatctcattc cgtcctcctt
     1261 ccaagacatt tactgtgcaa aggggtgtaa gcactaacaa attagttggt tacatcctgg
     1321 ggacatacca agctactgat gaggacacgg gtaaagctgc ctcctctgtc agatatgtcc
     1381 tgggtcgtaa tgatggtggt ttgcttgtta ttgattcaaa gactgctcag atcaaatttg
     1441 tcaaaaacat cgaccgagat tctactttca tagttaacaa gacaatttct gctgaggttc
     1501 tggccataga cgaaaacact ggtaagacct ccacaggcac aatatatgtg gaagtgccca
     1561 gttttaatga aaactgcccg tcagttgtcc tcgagaagaa agacatctgt acttcctcac
     1621 cttctgtgac cctctcagtg agaaccctgg acaggggtaa atacactggc ccctacacag
     1681 tgtccctgga ggagcagcca ctgaagctgc cagtcatgtg gaccatcacg acgctgaatg
     1741 ctacatcagc tcttctacaa gcccagcagc aagtgtctcc aggagtgtac aatgtcccag
     1801 tcatcgtgaa ggacaatcag gatgggctgt gtgacacacc agagagcttg accctgacag
     1861 tgtgtcaatg tgatgaccgg agcatgtgca gagcccctat cccgagcaga gagcctaaca
     1921 catatgggga gtcatcctgg aggctggggc ctgctgccat tggcttgatc ctgctaggac
     1981 tcctgatgtt gctattggcc ccacttctgc ttctgacctg tgactgtggg tcaggtccca
     2041 ttggaggagc agcgacaggt ggctttatcc cagtgcccga tggttcggaa ggtacaattc
     2101 atcagtgggg aatcgaagga gctcagcccg aagacaagga aatcacaaat atttgtgttc
     2161 ctccagttac aaccaatgga gccgatttta tggaaagctc tgaagtttgc acaaatacat
     2221 atgctggtgg gaccatggta gaaggtgctt caggaatgga aatgattacc aagctgggag
     2281 gagctactgg agctacagcg gcacttggtc cctgttcctt gggttattca ggaacaatga
     2341 gaacaaggca ttccactgga gggaccttga aggactatgc tgcgccagtc aacatgactt
     2401 tcctaggctc ctatttctct cagaaatcac tcgcctatgc cgaggaagag gatgagcgcg
     2461 aagtgaacga ctgtttgctg atctacgatg atgaaggcga ggatgctgcc ccccactccc
     2521 ccaccctcag ctcctgcagc atttttgccg atgacctaga cgacaacttc ttggattccc
     2581 ttggccccaa atttaaaaag cttgcagaga tctgtctcgg tattgatgac gaagccaagc
     2641 aagcaaagcc aggccctaaa gacagtggtt ctggggctga tacctgcgct cgctctatgg
     2701 aagtccctca gtcaggttct aacaggtacc agactttgcc tggcagtctg gaagtcaccc
     2761 aaacgggttc taaaatatgc cacacgctgt caggcaacca agaaacttct gttatgtcca
     2821 cttctgggtc tgtccaccct gctgttgcca tccctgaccc tctacagctt gggaactact
     2881 tgctcacaga aacttactca acttcaggtt cctttgcaca acccaccact gttacctttg
     2941 acccccatgt cacacaaaat gtcactgtaa cagaaagggt catttgtccc cttcctagtg
     3001 cctccagcag tatagtggct cccacagaac tgcgaggctc atacaatatg ctctatacaa
     3061 aagaaacctg ttcccatcta tgaccaaagc aaactggaaa aacataccag gcaaatttgg
     3121 atgtgtgtac ctacatatct ttttttaata tagcaatgct agcactgttg gactaatttg
     3181 gctcttagtg gataatctct gatcataaga ataattcaaa ttttctgatt catatatgaa
     3241 agctgggtat gttgtcattt ctaattatct gattttttca agcagagtaa acctgtatat
     3301 atatatatat ttttaattat ctaagatgtt agacaggtat atttcccaag catcttcaca
     3361 tttctacatt atcgacaaca aagggagatg ctgttgcctt aaaatgcagt gtgggttagc
     3421 agattggctg ccttcttaaa gttcacattt ctgtttctac cacccattct gtttctacca
     3481 tccatgaata aggatatgag agtattatta ataacaatgg gaatttgagg tgctcaatgt
     3541 agcttacagg gcaacttgga ataaagacat taaatgcaac tggggatttt tggtttgggg
     3601 atttttggtt tggtttggtt tggtttggtt tggtttggtt tggtttggtt tggtttggtt
     3661 tggtttggtt tctcttcttg gtgatggaac tcaaagcata tcttttgctc aagtccaggg
     3721 ttgtgagtaa acctgtttaa tttgcaatat ctatatgctg tgtatcttca aaataaggca
     3781 attttaaaat gcaagtatca taaaacatgt aagaaaattt agtatggcat aaataatacg
     3841 cagtgtgtac tttgatctag cccaagaaaa atacaatgaa cttcctcatt gacactcctc
     3901 tgaaactgat cctgtgtcag tctttaacaa agaaatcctt attttgtaag tgccagggag
     3961 tagaaatgac tcaaaagatg tgcagtgagg ttcgttatgt taaccgtgtc taacagggtt
     4021 tgtgggaata gatagcatgc cttctcttct aagcaaaaag gtctatggcc taaaataaca
     4081 tggagagaag tgtgtgaatg tacatcattt taggaaaatg atgaagtaaa tttcaagt
//
