LOCUS       NM_181680               4088 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus desmoglein 1 gamma (Dsg1c), mRNA.
ACCESSION   NM_181680
VERSION     NM_181680.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4088)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4088)
  AUTHORS   Godsel,L.M., Roth-Carter,Q.R., Koetsier,J.L., Tsoi,L.C.,
            Huffine,A.L., Broussard,J.A., Fitz,G.N., Lloyd,S.M., Kweon,J.,
            Burks,H.E., Hegazy,M., Amagai,S., Harms,P.W., Xing,X., Kirma,J.,
            Johnson,J.L., Urciuoli,G., Doglio,L.T., Swindell,W.R.,
            Awatramani,R., Sprecher,E., Bao,X., Cohen-Barak,E., Missero,C.,
            Gudjonsson,J.E. and Green,K.J.
  TITLE     Translational implications of Th17-skewed inflammation due to
            genetic deficiency of a cadherin stress sensor
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34905516
REFERENCE   3  (bases 1 to 4088)
  AUTHORS   Kugelmann,D., Radeva,M.Y., Spindler,V. and Waschke,J.
  TITLE     Desmoglein 1 Deficiency Causes Lethal Skin Blistering
  JOURNAL   J Invest Dermatol 139 (7), 1596-1599 (2019)
   PUBMED   30660666
REFERENCE   4  (bases 1 to 4088)
  AUTHORS   Lecland,N., Hsu,C.Y., Chemin,C., Merdes,A. and Bierkamp,C.
  TITLE     Epidermal development requires ninein for spindle orientation and
            cortical microtubule organization
  JOURNAL   Life Sci Alliance 2 (2), e201900373 (2019)
   PUBMED   30923192
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4088)
  AUTHORS   Inoue,S.I., Takahara,S., Yoshikawa,T., Niihori,T., Yanai,K.,
            Matsubara,Y. and Aoki,Y.
  TITLE     Activated Braf induces esophageal dilation and gastric epithelial
            hyperplasia in mice
  JOURNAL   Hum Mol Genet 26 (23), 4715-4727 (2017)
   PUBMED   28973166
REFERENCE   6  (bases 1 to 4088)
  AUTHORS   Brennan,D., Hu,Y., Kljuic,A., Choi,Y., Joubeh,S., Bashkin,M.,
            Wahl,J., Fertala,A., Pulkkinen,L., Uitto,J., Christiano,A.M.,
            Panteleyev,A. and Mahoney,M.G.
  TITLE     Differential structural properties and expression patterns suggest
            functional significance for multiple mouse desmoglein 1 isoforms
  JOURNAL   Differentiation 72 (8), 434-449 (2004)
   PUBMED   15606502
REFERENCE   7  (bases 1 to 4088)
  AUTHORS   Cheng,X., Mihindukulasuriya,K., Den,Z., Kowalczyk,A.P.,
            Calkins,C.C., Ishiko,A., Shimizu,A. and Koch,P.J.
  TITLE     Assessment of splice variant-specific functions of desmocollin 1 in
            the skin
  JOURNAL   Mol Cell Biol 24 (1), 154-163 (2004)
   PUBMED   14673151
REFERENCE   8  (bases 1 to 4088)
  AUTHORS   Whittock,N.V.
  TITLE     Genomic sequence analysis of the mouse desmoglein cluster reveals
            evidence for six distinct genes: characterization of mouse DSG4,
            DSG5, and DSG6
  JOURNAL   J Invest Dermatol 120 (6), 970-980 (2003)
   PUBMED   12787123
  REMARK    GeneRIF: Desmogleins 4, 5, and 6 are all expressed in the epidermis
            but are expressed during different times of mouse development.
REFERENCE   9  (bases 1 to 4088)
  AUTHORS   Ciani,L., Patel,A., Allen,N.D. and ffrench-Constant,C.
  TITLE     Mice lacking the giant protocadherin mFAT1 exhibit renal slit
            junction abnormalities and a partially penetrant cyclopia and
            anophthalmia phenotype
  JOURNAL   Mol Cell Biol 23 (10), 3575-3582 (2003)
   PUBMED   12724416
REFERENCE   10 (bases 1 to 4088)
  AUTHORS   Kljuic,A. and Christiano,A.M.
  TITLE     A novel mouse desmosomal cadherin family member, desmoglein 1 gamma
  JOURNAL   Exp Dermatol 12 (1), 20-29 (2003)
   PUBMED   12631243
  REMARK    GeneRIF: Expressed in brain, skeletal muscle, and liver, among
            other tissues. Similar to Dsg2 in its tissue distribution.
            Orthologous Dsg1 gamma was not found in human genome, suggesting
            desmosomal cadherin gene cluster contracted during mammalian
            evolution.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY192159.1, AK034104.1 and
            AC108943.4.
            
            On Jan 29, 2016 this sequence version replaced NM_181680.1.
            
            Summary: This gene encodes a member of the cadherin family of
            proteins that forms an integral transmembrane component of
            desmosomes, the multiprotein complexes involved in cell adhesion,
            organization of the cytoskeleton, cell sorting and cell signaling.
            The encoded preproprotein undergoes proteolytic processing to
            generate a mature, functional protein. This gene is located in a
            cluster of desmosomal cadherin genes on chromosome 18. [provided by
            RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY192159.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AY192159.1         1-148
            149-1475            AK034104.1         92-1418
            1476-1476           AC108943.4         74672-74672         c
            1477-4088           AK034104.1         1420-4031
FEATURES             Location/Qualifiers
     source          1..4088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.26 cM"
     gene            1..4088
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /note="desmoglein 1 gamma"
                     /db_xref="GeneID:211924"
                     /db_xref="MGI:MGI:2664358"
     exon            1..148
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2836
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /note="desmoglein 6"
                     /codon_start=1
                     /product="desmoglein-1-gamma preproprotein"
                     /protein_id="NP_859008.1"
                     /db_xref="CCDS:CCDS29079.1"
                     /db_xref="GeneID:211924"
                     /db_xref="MGI:MGI:2664358"
                     /translation="MDWHSFRIAALLLTSLVVLEVNSEFQIQVRDHNAKNGTIKWHSI
                     RRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQPVTYRISGVGIDQPPYGIFII
                     NQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDINDNPPVFSMT
                     TFLGQIEENSNANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFTINRKTGEI
                     RTMNNFLDREQYSQYSLVVRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDI
                     TIEENTLHSQLLQIRVIDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVV
                     KPLDYEAVKNLQLCIGVRNVAEFHQSIISQYRLTVTLITVTVLNVVKGCVFQPGSKTF
                     IVDSRMEANHTVGEFLATDCETGQATNKFKNVRYRYVMGNNPENLLVVDSGIITLRNR
                     VTMEQYERLNKRYEGTVLSIHDSLQRTCTGTIIMVLCGFWTTTEHPTTSTEKPVTLSI
                     TPNVDNVHFGPAGIGLLIMGFLVLGLVPFLLISCDCGGAPGGGAGFEPVPECSDGAIH
                     TWAVEGPQPGGITTICVPQMPPGNANVIEYIDNSGVYTNEYCGREMQDLGGGERTTGF
                     ELMDGVKTSAAPEICQEYSGTLRRNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGR
                     PSNDCLLIYDIEGVGSPAGSVGCCSFIEDLDESFLDTLGPKFKKLADISLGKEIDSYP
                     DPDPSWPPQSTEPICPQHMEQLASGHPSISPHFGKTTVISENAYPSGPGVQHPMLIPD
                     PLGYGNITVRESYTTSGTLKPSVHFHDNQQASNVVVTERVVGPISGADLHGMLEIPAL
                     RDGTNVIVTERVIAPGSSLPNSLTIPNPRETSNVVVTERVIQPTSGMIGNLSIPP"
     exon            149..184
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            185..316
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            317..472
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            473..617
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            618..784
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            785..919
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1105
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1374
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1514
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1700
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1828
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1901
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2110
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..4088
                     /gene="Dsg1c"
                     /gene_synonym="dsg1g; Dsg1gamma; Dsg6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatcttctg gaaaattaat tgaatcaaac acctgcaagc tagcagagaa gagcaaagaa
       61 actgccttga tcgtggacgt aacagaagcc agctgcagcg atggactggc actccttcag
      121 gatagctgcc ctgctgctca cttccctggt ggtgcttgaa gttaacagtg aatttcaaat
      181 ccaggtaaga gatcataacg ccaaaaatgg taccatcaag tggcattcca tcagaaggca
      241 gaaacgagaa tggatcaagt ttgctgcagc ctgtcgcgaa ggtgaagaca actcaaagag
      301 aaacccaatt gccaaaattc attcagactg tgctgcaaac caaccagtga cataccgcat
      361 ctcgggagtg ggaattgacc agccacctta tggaatcttc attattaacc aaaaaactgg
      421 tgaaatcaat ataacatcca ttgttgatcg tgaagtcacc ccctttttca ttatctattg
      481 ccgagcactg aatgcacaag gtcaagactt ggagaatcca ctggagctta gagttagagt
      541 gatggatata aacgacaacc ctcctgtgtt ttcaatgact acatttctag gacaaataga
      601 agaaaattct aatgcaaaca cactggtaat gaaactcaat gctaccgatg ccgatgagcc
      661 aaataacttg aactcaatga tagccttcaa gatcataaga caggagcctt ctgactcacc
      721 aatgttcacc atcaacagga aaactggaga aatcagaaca atgaataact ttctagacag
      781 agagcaatat agccagtatt cccttgtggt gagaggctca gaccgggacg gtggagcaga
      841 cggcatgtct gcagagagcg agtgcagcat caccatcctg gatgtcaatg acaacatccc
      901 atacttggag cagtcatctt atgacatcac aattgaagaa aacacacttc actcccaact
      961 attgcagatc agagtcattg atttggatga agaattctca gacaactgga aggcaatcat
     1021 tttctttatc tctggaaatg agggaaattg gtttgaaata gaaatgaatg aaagaacaaa
     1081 tgtaggaact ctgaaggttg tcaagcccct agattatgaa gccgtgaaga atctacagct
     1141 ttgtattggt gttcgaaatg tagctgaatt ccaccagtca attatttctc aatatagact
     1201 cacagtaact ttgatcactg tgactgtgtt aaatgttgtc aagggctgtg tgttccagcc
     1261 aggttcaaag acatttatag tagacagtag aatggaagca aatcacacag tgggagagtt
     1321 tttagctaca gactgtgaaa caggtcaagc tacaaacaag ttcaaaaatg ttagatacag
     1381 atatgtaatg ggaaataacc cagagaacct gctggttgtt gactcaggca taataacttt
     1441 aagaaacaga gttactatgg aacaatacga aaggcttaat aagagatatg aaggaacagt
     1501 gctatcaata catgattccc ttcagaggac ctgcacaggg acaatcatca tggtactttg
     1561 tggcttctgg acaactactg aacatcccac aacatccact gagaaacctg tgactctatc
     1621 catcactcca aacgtagaca atgttcactt cggtcctgca ggcatcgggc tgctcatcat
     1681 ggggttccta gtcttaggat tggttccatt cctgctgatc tcctgtgatt gtggaggggc
     1741 ccctggtggt ggagctggat ttgaacctgt tccagaatgt tctgatggag caattcacac
     1801 gtgggctgta gaagggccac agcctggtgg gataaccacc atctgtgtgc cacaaatgcc
     1861 acctggtaat gccaatgtta tagaatatat tgacaactca ggagtttata caaatgaata
     1921 ttgtggcaga gaaatgcaag atctgggagg aggagaacga accacaggat ttgaactaat
     1981 ggatggagtt aaaacatcag ctgcacctga gatatgccaa gaatattcag gaacattaag
     2041 aagaaattca atgagagaat gtagagatgg gggtctcaac atgaatttta tggaaagtta
     2101 cttctgccag aaagcctatg cttatgcgga tgaagatgaa ggacgtccat ccaatgactg
     2161 tttgctcatc tatgacatcg aaggtgtggg ttcccctgca ggctccgtgg gctgttgcag
     2221 tttcattgaa gatctagatg agagtttcct ggataccttg gggcccaagt ttaagaagtt
     2281 ggcagatatc agcctgggaa aagaaataga ctcataccca gatcctgatc cttcttggcc
     2341 tcctcagagc actgaaccaa tttgcccaca gcatatggag caacttgcta gtggacaccc
     2401 aagcatatcc ccacattttg gcaagaccac agtaatttct gagaatgcct acccctctgg
     2461 ccctggagta cagcatccta tgctaattcc tgatcctctg ggctatggta atatcactgt
     2521 gagggagtcc tatactacct ctggcactct gaaaccctct gtccactttc atgataacca
     2581 gcaagcttca aatgtggtgg tgacagagag agtggtgggc cccatctctg gtgctgattt
     2641 gcatggcatg ttagagatac ctgccttaag agatggaaca aatgttatag tgacagaaag
     2701 ggtaatagca ccaggctcaa gtttacccaa ttctctaacc attcctaacc ctcgagagac
     2761 ctcaaatgta gttgtgacag aaagagtgat ccaaccaacc tctggcatga taggcaacct
     2821 gagcatcccc ccctgagtta tcaagtgccc acaacgtgat tgtgacagag agagtggttt
     2881 ctggtgctgg tatgagtgga attgctggca ccgctgagtt aggtggggtt ggaggcatag
     2941 gcagcagtgg cattgttagc accaccatgg gtgttggtgg cactgggctg agcatgggag
     3001 ggacagccac tattggccac atgaggagtg cctctgacca tcactttagc tagacagttg
     3061 gatctgcctc ccccaacatg gctcgaagtc aaatcacaaa gtatagtaca gtacagtata
     3121 ccaagtagtc atgatcacag agtattgttc accgccatct cagtgactta catccaactc
     3181 ctcctcatcc tcaatctaac agtccaattt ataatgcaga acaggctatg ggagacctgt
     3241 ggagtaagga agagccacag tgatagtaac acatggaaac atcaccatga ggaagagtgc
     3301 tccctagcat tggtaaactt ttttcttata ttaacactga tgaaataatg aaggtgaact
     3361 tgaggtagaa ttttaagctt ggggcgattt tagattagaa gaaatgatta agacttattg
     3421 aatccagcta ttattttaat tccatattca gggagatggt aattttgctg tcacaatatt
     3481 tacatgtttt cattcttctt tcttagcttc cacttattct atgttactgg ctggactcct
     3541 cttccaaatg tctcctagtg acattacaga gcacacatac agataaaaac agtgataaag
     3601 ctttcatttt aaacgttttc agagacagtg gttcctattt acagatataa ttctgtacca
     3661 agaatgctaa aatagcaata aatcaggcat caggcctaaa tgtattgcac gccctccact
     3721 caatgcctgg cactttctga gaaccacata aatgagaata ttagctttgt ggacagtgaa
     3781 ggttcctaga tcctgcatcc ctgtcatcta cattctcacc tcagcaactg taagcctatg
     3841 aggtggtcct catgaactat cccgtgattc aattgaaatt ccttagcaac catttagggt
     3901 aataacttca taatctaccc aatcctgcca actgttattg taaaaagcat ggagtacatg
     3961 tatctctttg agaagcccac acccatcctt tctggagtac cgtattcttt cccctaatat
     4021 ccctgtctgg gaactgatat tcttaaattt atttaaaaat gtcttttaat aaacttcagc
     4081 tctacttc
//
