LOCUS       NM_181682               5952 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus desmoglein 1 beta (Dsg1b), mRNA.
ACCESSION   NM_181682
VERSION     NM_181682.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5952)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5952)
  AUTHORS   Godsel,L.M., Roth-Carter,Q.R., Koetsier,J.L., Tsoi,L.C.,
            Huffine,A.L., Broussard,J.A., Fitz,G.N., Lloyd,S.M., Kweon,J.,
            Burks,H.E., Hegazy,M., Amagai,S., Harms,P.W., Xing,X., Kirma,J.,
            Johnson,J.L., Urciuoli,G., Doglio,L.T., Swindell,W.R.,
            Awatramani,R., Sprecher,E., Bao,X., Cohen-Barak,E., Missero,C.,
            Gudjonsson,J.E. and Green,K.J.
  TITLE     Translational implications of Th17-skewed inflammation due to
            genetic deficiency of a cadherin stress sensor
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34905516
REFERENCE   3  (bases 1 to 5952)
  AUTHORS   Kugelmann,D., Radeva,M.Y., Spindler,V. and Waschke,J.
  TITLE     Desmoglein 1 Deficiency Causes Lethal Skin Blistering
  JOURNAL   J Invest Dermatol 139 (7), 1596-1599 (2019)
   PUBMED   30660666
REFERENCE   4  (bases 1 to 5952)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5952)
  AUTHORS   Lecland,N., Hsu,C.Y., Chemin,C., Merdes,A. and Bierkamp,C.
  TITLE     Epidermal development requires ninein for spindle orientation and
            cortical microtubule organization
  JOURNAL   Life Sci Alliance 2 (2), e201900373 (2019)
   PUBMED   30923192
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5952)
  AUTHORS   Brennan,D., Hu,Y., Kljuic,A., Choi,Y., Joubeh,S., Bashkin,M.,
            Wahl,J., Fertala,A., Pulkkinen,L., Uitto,J., Christiano,A.M.,
            Panteleyev,A. and Mahoney,M.G.
  TITLE     Differential structural properties and expression patterns suggest
            functional significance for multiple mouse desmoglein 1 isoforms
  JOURNAL   Differentiation 72 (8), 434-449 (2004)
   PUBMED   15606502
REFERENCE   7  (bases 1 to 5952)
  AUTHORS   Cheng,X., Mihindukulasuriya,K., Den,Z., Kowalczyk,A.P.,
            Calkins,C.C., Ishiko,A., Shimizu,A. and Koch,P.J.
  TITLE     Assessment of splice variant-specific functions of desmocollin 1 in
            the skin
  JOURNAL   Mol Cell Biol 24 (1), 154-163 (2004)
   PUBMED   14673151
REFERENCE   8  (bases 1 to 5952)
  AUTHORS   Whittock,N.V.
  TITLE     Genomic sequence analysis of the mouse desmoglein cluster reveals
            evidence for six distinct genes: characterization of mouse DSG4,
            DSG5, and DSG6
  JOURNAL   J Invest Dermatol 120 (6), 970-980 (2003)
   PUBMED   12787123
  REMARK    GeneRIF: Desmogleins 4, 5, and 6 are all expressed in the epidermis
            but are expressed during different times of mouse development.
REFERENCE   9  (bases 1 to 5952)
  AUTHORS   Ciani,L., Patel,A., Allen,N.D. and ffrench-Constant,C.
  TITLE     Mice lacking the giant protocadherin mFAT1 exhibit renal slit
            junction abnormalities and a partially penetrant cyclopia and
            anophthalmia phenotype
  JOURNAL   Mol Cell Biol 23 (10), 3575-3582 (2003)
   PUBMED   12724416
REFERENCE   10 (bases 1 to 5952)
  AUTHORS   Pulkkinen,L., Choi,Y.W., Kljuic,A., Uitto,J. and Mahoney,M.G.
  TITLE     Novel member of the mouse desmoglein gene family: Dsg1-beta
  JOURNAL   Exp Dermatol 12 (1), 11-19 (2003)
   PUBMED   12631242
  REMARK    GeneRIF: Cloned and characterized a novel member of the mouse
            desmoglein gene family, Dsg1-beta.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK036986.1 and AC164648.3.
            
            On Jan 29, 2016 this sequence version replaced NM_181682.1.
            
            Summary: This gene encodes a member of the cadherin family of
            proteins that forms an integral transmembrane component of
            desmosomes, the multiprotein complexes involved in cell adhesion,
            organization of the cytoskeleton, cell sorting and cell signaling.
            The encoded preproprotein undergoes proteolytic processing to
            generate a mature, functional protein. This gene is located in a
            cluster of desmosomal cadherin genes on chromosome 18. [provided by
            RefSeq, Jan 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036986.1, AY192158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AK036986.1         3-58
            57-57               AC164648.3         62927-62927         c
            58-2680             AK036986.1         60-2682
            2681-5952           AC164648.3         27529-30800         c
FEATURES             Location/Qualifiers
     source          1..5952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.32 cM"
     gene            1..5952
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /note="desmoglein 1 beta"
                     /db_xref="GeneID:225256"
                     /db_xref="MGI:MGI:2664357"
     exon            1..254
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..3389
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /note="desmoglein 5"
                     /codon_start=1
                     /product="desmoglein-1-beta preproprotein"
                     /protein_id="NP_859010.1"
                     /db_xref="CCDS:CCDS29081.1"
                     /db_xref="GeneID:225256"
                     /db_xref="MGI:MGI:2664357"
                     /translation="MDWHSFRIAALLLTSLVVLEVNSEFQIQVRDHNAKNGTIKWHSI
                     RRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQPVTYRISGVGIDQPPYGIFII
                     NQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDINDNPPVFSMT
                     TFLGQIEENSNANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEI
                     RTMNNFLDREQYSQYSLVVRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDI
                     EIEENALHSQLVQIRVIDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVV
                     KPLDYEAMKNLQLSIGVRNVAEFHQSIISQYRLTATMVTVTVLNVIEGSVFRPGSKTF
                     VVDSRMEANHRVGEFVATDLDTGRASTNVRYEMGNNPENLLVVDSRTGIITLRNRVTM
                     EQYQRLNGEYKGTVLSIDDSLQRTCTGTIVIELSGTGWVPGSDGGGSSSGSGGNRDPV
                     TNGYQGTSTVGPQRVTGSGGVTSSGGGSGVNNTPGRQNPLDEPEPEPFDITEDNVHFG
                     PAGIGLLIMGFLVLGLVPFLLICCDCGGAPGGGAGFEPVPECSDGAIHTWAIEGPQPE
                     PHDGITTICVPQMPPGNANVIEYIDNSGVYTNEYCGREMQDLGGGERTTGFELMDGVK
                     TSAAPEICQEYSGTLRRNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLL
                     IYDIEGVGSPAGSVGCCSFIGEDLDESFLDTLGPKFKKLADISLGKEIDSYPDPDSSW
                     PPQSTEPMCPQSTEPLGSGYPPISPHFGTTTVISENAYPSGPGVQHPLPIPDPLGYGN
                     VTVRESYATSGTLKPSVHFHDNQQASNVVVTERVVGPVPGADLHGMLEIPDLRDGTNV
                     IVTERVIAPGSSLPTSLTIPNPRETSNVVVTERVIQPTSGMIGNLSMTPELSSAQNVI
                     VTERVVSGAGMSGIAGTAGLGGVGGIGSSGLVSTTMGAAGTGLNMGGTATIGHMRSSS
                     DHHFSQTIGSASPNMARSRITKYSTVQYSK"
     exon            255..290
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            291..422
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            423..578
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            579..723
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            724..890
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1025
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1211
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1471
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1611
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1950
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2087
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2160
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2369
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..5952
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3777..3782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /note="hexamer: ATTAAA"
     polyA_site      3798
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /note="major polyA site"
     regulatory      3952..3957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /note="hexamer: AATAAA"
     polyA_site      3973
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
     regulatory      5932..5937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
                     /note="hexamer: AATAAA"
     polyA_site      5949
                     /gene="Dsg1b"
                     /gene_synonym="dsg1-beta; Dsg5"
ORIGIN      
        1 aagtttttag ggtggagatc caactggtta tacgtacctt ccctccttct cccagtggaa
       61 ggcagaaaca cctcaaagcc tgcatgtaag aacatctact gagaaattat tttaatcaga
      121 caccagcaaa gtgggagaaa gcaagctagc agagaagagc aaagaaactg ccttgatcgt
      181 ggatgtaaca gaagccagct gcagcgatgg actggcactc cttcaggata gctgccctgc
      241 tgctcacttc cctggtggtg cttgaagtta acagtgaatt tcaaatccag gtaagagatc
      301 ataacgccaa aaatggtacc atcaagtggc actccatcag aaggcagaaa agagaatgga
      361 tcaagtttgc tgcagcctgt cgcgaaggtg aagacaactc aaagagaaac ccaattgcca
      421 aaattcattc agattgtgct gcaaaccaac cagtaacata ccgcatctcg ggagtgggaa
      481 ttgaccagcc accttatgga atcttcatta ttaaccaaaa aactggtgaa atcaatataa
      541 catccattgt tgatcgtgaa gtcaccccct ttttcattat ctactgccga gcactgaatg
      601 cacaaggtca agacttggag aatccactgg agcttagagt cagagtgatg gatataaacg
      661 acaaccctcc tgtgttttca atgactacat ttctaggaca aatagaagaa aattctaatg
      721 caaacacact ggtaatgaaa ctcaatgcta ccgatgccga tgagccaaat aacttgaact
      781 caatgatagc cttcaagatc ataagacagg agccttctga ctcaccaatg ttcatcatca
      841 acaggaaaac tggagaaatc agaacaatga ataactttct agacagagag caatatagcc
      901 agtattccct tgtggtgaga ggctcagacc gggacggtgg agcagacggc atgtctgcag
      961 agagcgagtg cagcatcacc atcctggatg tcaatgacaa catcccatac ttggagcagt
     1021 catcttatga catcgaaatt gaagaaaatg cacttcactc acagctagtg cagatcagag
     1081 tcattgattt ggatgaagaa ttctcagaca actggaaggc aatcattttc tttatctctg
     1141 gaaatgaggg aaattggttt gaaatagaaa tgaatgaaag aacaaatgta ggaactctga
     1201 aggttgtcaa gcccctagat tatgaagcca tgaagaatct acagcttagt attggtgttc
     1261 gaaatgtagc tgaattccac cagtcaatta tttctcaata cagactcaca gcaactatgg
     1321 tcactgtgac tgtgttaaat gtcatcgagg gctctgtgtt ccgtccaggt tcaaagacat
     1381 ttgtagtaga cagtagaatg gaagcaaatc acagagtggg agagtttgta gctacagacc
     1441 tggacacagg tcgagcttcc acaaatgtta gatatgaaat gggaaataac ccagagaacc
     1501 tgctggttgt tgactcaaga acaggcataa taacgttaag aaacagagtt actatggaac
     1561 aataccaaag gcttaatggg gaatataaag gaacagtgct atcaatagat gattcccttc
     1621 agaggacctg cacggggaca atcgtcattg aacttagtgg cactggctgg gtaccaggtt
     1681 cagatggtgg tggcagttcc agtggcagtg gtggtaatcg tgacccagtg actaatggat
     1741 atcaaggcac ttctactgtg ggcccgcaac gcgtcacagg atcaggggga gtcacttcaa
     1801 gtggtggagg cagtggagtt aacaacactc ccggtaggca aaatccctta gacgaaccgg
     1861 aacccgagcc ctttgacatc acagaagaca acgttcactt cggtcctgca ggcatcgggc
     1921 tgctcatcat ggggttccta gtcttaggat tggttccatt cctgctgatc tgctgtgatt
     1981 gtggaggggc ccctggtggt ggagctggat ttgaacctgt tccagaatgt tctgatggag
     2041 caattcacac gtgggccata gaagggccac agcctgaacc ccacgatggg ataaccacca
     2101 tctgtgtgcc acaaatgcca cctggtaatg ccaatgttat agaatatatt gacaactcag
     2161 gagtttacac aaatgaatat tgtggcagag aaatgcaaga tctgggagga ggagaaagaa
     2221 ccacaggatt tgaactaatg gatggagtta aaacatcagc tgcacctgag atatgccaag
     2281 aatattcagg aacattaaga agaaattcaa tgagagaatg tagagatggg ggtctcaaca
     2341 tgaatttcat ggaaagttac ttctgccaga aagcctatgc ttatgcggat gaagatgaag
     2401 gacgtccatc caatgactgt ttgctcatct atgacatcga aggtgtgggt tcccctgcag
     2461 gctccgtggg ctgttgcagt ttcattggag aagatctaga tgagagcttc ctggatacct
     2521 tggggcccaa gtttaagaag ttggcagata tcagcctggg aaaagaaata gactcatacc
     2581 cagatcctga ttcttcttgg cctcctcaga gcactgaacc gatgtgtccc cagagtacag
     2641 agcccctggg tagtggatat ccacctatat ccccacattt tggtacgacc acagtaattt
     2701 ctgagaatgc ctacccttct ggccctggag tacagcatcc tttgccaatt cctgatcctc
     2761 tgggctatgg caatgtcact gtaagggagt cctatgccac ctctggcact ctgaagccct
     2821 ctgtccactt tcatgataac cagcaggctt caaatgtggt ggtgacagag agggtggtgg
     2881 gccccgtccc tggtgctgat ttgcatggca tgttagagat acctgactta agagatggaa
     2941 caaatgttat agtgacagaa agggtaatag caccaggctc aagtctaccc acttctctga
     3001 ccattcctaa ccctcgagag acctcaaatg tagttgtgac agaaagagtg atccaaccaa
     3061 cctctggcat gataggcaat ctgagcatga cccctgagtt atcaagtgcc caaaacgtga
     3121 ttgtgacaga gagagtggtt tctggtgctg gtatgagtgg aattgctggc actgccgggt
     3181 taggtggggt tggaggcata ggcagcagtg gccttgttag caccaccatg ggtgctgctg
     3241 gcactgggct gaatatggga ggaacagcca ctattggcca catgaggagt tcctctgacc
     3301 atcactttag tcagacaatt ggatctgcct cccccaacat ggctcgaagt cgaatcacaa
     3361 agtacagtac ggtacagtat agcaagtagt catggtccca gagtattgtt cactaccatc
     3421 tcagtgactt acatccaact cctccccacc ctcaatctaa cagtgcaatt tatgatgcag
     3481 agcaggctat gggagacctg tggagtaagg aagagccaca gtgatagtaa cccatggaaa
     3541 catcaccatg gggaagagtg ctccctagca ttggtaaact tttttctttt ttcttttttc
     3601 cgtttttttc ttctttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt
     3661 ctttttttcc tggtttttca agacagggtt tctctgtata gccctggcta tcctggaact
     3721 cactttgtag acctcaaact cagaaatcca cctgcctctg tttcccgagt cctgagatta
     3781 aaggcatgcg ccaccacacc cagctggtaa actttttctt atattaacac taatgaaata
     3841 atgaaggtga acttgaggta caatcttatc tgtggctgtg tggtccacag gtttgttttt
     3901 ggttttatgt ttttaatgtt gccttctagg gtatcagcag catgttgaat aaataaaaca
     3961 tggctacata caagcactgg ctttaaatgg caatgagaag aattcttatt gctgttcaga
     4021 aattaacaaa aaaggtttga ataagcttga gcacacatag gtgaggaaaa tctgacattt
     4081 ccttcccata tgccttgtct gtttcacagg gaatacaaat taaaaatcat tccacagatt
     4141 caggctaagg ttaataaaat tctaactaca aagttatgta cgtaagatac cagttattat
     4201 tactgtgacc acatttaaac tacattggat ggaataattt tcaaattaag aaatatgtcc
     4261 tggtagaaaa gtctatagac agtaacatta ttgtgagatt cgtttggcac aaactgacac
     4321 tgaatctcaa gatgtggttt tgttaagtcc cctgtggagt tgggaacttt cctggctccc
     4381 actgtgtttc atgggtgtga ctttgaagaa tattgcttac tgggtggatg aagggcacca
     4441 tgctcatttt tgcctttacc actgtagttg aagggagagt tgcaaatgac acatgacatg
     4501 gctgccctcc caagtgttaa atctcctccc aagtacagac aggacagtat tatctcttaa
     4561 gtctaagcag taaggcatac tcatttctgt gcagctcttt aaggcataaa ttcatagtta
     4621 agataatgta cctaagctga gatggtggga agaagctcac agtatggcta agcattgggg
     4681 taatttttca gggagatctg aggaagggga actgttttta gaacatgaaa actgtcttaa
     4741 gtgggaaatg ttagaaaata attgttcagt aaaggaaaac catataatga gatatagttg
     4801 agattagtgt catcatttga atgaccctct gctgccattt ggaagtgatt aaacaaccct
     4861 ttactagaat tgatattact ttagaaagga tgaagtagtt actagacaaa gctattcctt
     4921 atctaaaatg tgttatgcac acaactttga ggtttctctt tgatttgtta ataatgtctt
     4981 ggcttctaag cattctaact taaagacagt ttacaagtta taatatgata tatttttcta
     5041 gccttgtaat ttagtaatgt gctatttatg atgtgttgtt tctgtatttt tgtcaactgg
     5101 tgttccccgg tttaaaacct ctcagaagaa tcaaactttc gaggtgacag gtacatttac
     5161 tattgcaggg tagaagaatc ttttcttact tttaaatcaa tgttaaaata agctcactat
     5221 agtagaatca catatatata tatatatata catatatata tatatggcaa aataggaaca
     5281 tggaaaatac tggtcctgag ttgtgaatta tgcacagctt ttaaagatgt gttcatacac
     5341 tgcctattca tttcttaggg tgtcacaaaa tcacaacatt tatcaaagac caggaatgat
     5401 tgattattcc agcaaaagct aatttgttct atatagcagt ggatatggca aatattttaa
     5461 aggccacaat atgaccaatt ttaactgtac agaacatgta caattttgtt aacatgtagg
     5521 aagccaaaat gcagaggcag aaataaagtc acataaggga gtctttcttt tattgtgttc
     5581 taaaatgtag ggtaacacat tgaggatatg gtttgggtat tggtttttgt ttttctgagc
     5641 ttttttattt ttagaaataa actcaaaagg tatttgttga aatatacttg aagatgccta
     5701 ggtttgaaag ttttgaacag atagaaataa ttaatagttt tccttccttc ctttgttcat
     5761 tcattcatcc aaaggcaagt gtacttgttg ccctaatgtg ctatactctg gctatatctt
     5821 tgcttcgatg cctgatgaat cctaaatatt tttttcattg cctaacaagt ggcaatatgg
     5881 caatctttaa taaatgtgat caacattcat cagttatata aggcctggga aaataaaact
     5941 ttaaatgaag aa
//
