LOCUS       NM_010079               5627 bp    mRNA    linear   ROD 05-MAR-2023
DEFINITION  Mus musculus desmoglein 1 alpha (Dsg1a), mRNA.
ACCESSION   NM_010079 XM_484705 XM_904434 XM_978431 XM_980693
VERSION     NM_010079.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5627)
  AUTHORS   Hegazy M, Koetsier JL, Huffine AL, Broussard JA, Godsel BM,
            Cohen-Barak E, Sprecher E, Wolfgeher DJ, Kron SJ, Godsel LM and
            Green KJ.
  TITLE     Epidermal stratification requires retromer-mediated desmoglein-1
            recycling
  JOURNAL   Dev Cell 57 (24), 2683-2698 (2022)
   PUBMED   36495876
REFERENCE   2  (bases 1 to 5627)
  AUTHORS   Godsel LM, Roth-Carter QR, Koetsier JL, Tsoi LC, Huffine AL,
            Broussard JA, Fitz GN, Lloyd SM, Kweon J, Burks HE, Hegazy M,
            Amagai S, Harms PW, Xing X, Kirma J, Johnson JL, Urciuoli G, Doglio
            LT, Swindell WR, Awatramani R, Sprecher E, Bao X, Cohen-Barak E,
            Missero C, Gudjonsson JE and Green KJ.
  TITLE     Translational implications of Th17-skewed inflammation due to
            genetic deficiency of a cadherin stress sensor
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34905516
  REMARK    GeneRIF: Translational implications of Th17-skewed inflammation due
            to genetic deficiency of a cadherin stress sensor.
REFERENCE   3  (bases 1 to 5627)
  AUTHORS   Kashgari G, Meinecke L, Gordon W, Ruiz B, Yang J, Ma AL, Xie Y, Ho
            H, Plikus MV, Nie Q, Jester JV and Andersen B.
  TITLE     Epithelial Migration and Non-adhesive Periderm Are Required for
            Digit Separation during Mammalian Development
  JOURNAL   Dev Cell 52 (6), 764-778 (2020)
   PUBMED   32109382
REFERENCE   4  (bases 1 to 5627)
  AUTHORS   Quispe Calla NE, Vicetti Miguel RD, Aceves KM, Torres A and Cherpes
            TL.
  TITLE     Depot-medroxyprogesterone acetate reduces genital cell-cell
            adhesion molecule expression and increases genital herpes simplex
            virus type 2 infection susceptibility in a dose-dependent fashion
  JOURNAL   Contraception 100 (5), 397-401 (2019)
   PUBMED   31302121
  REMARK    GeneRIF: Depot-medroxyprogesterone acetate reduces genital
            cell-cell adhesion molecule expression and increases genital herpes
            simplex virus type 2 infection susceptibility in a dose-dependent
            fashion.
REFERENCE   5  (bases 1 to 5627)
  AUTHORS   Lecland N, Hsu CY, Chemin C, Merdes A and Bierkamp C.
  TITLE     Epidermal development requires ninein for spindle orientation and
            cortical microtubule organization
  JOURNAL   Life Sci Alliance 2 (2), e201900373 (2019)
   PUBMED   30923192
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5627)
  AUTHORS   Mahoney MG, Simpson A, Aho S, Uitto J and Pulkkinen L.
  TITLE     Interspecies conservation and differential expression of mouse
            desmoglein gene family
  JOURNAL   Exp Dermatol 11 (2), 115-125 (2002)
   PUBMED   11994138
REFERENCE   7  (bases 1 to 5627)
  AUTHORS   Collins JE, Lorimer JE, Garrod DR, Pidsley SC, Buxton RS and
            Fleming TP.
  TITLE     Regulation of desmocollin transcription in mouse preimplantation
            embryos
  JOURNAL   Development 121 (3), 743-753 (1995)
   PUBMED   7536656
REFERENCE   8  (bases 1 to 5627)
  AUTHORS   Ishikawa H, Silos SA, Tamai K, Copeland NG, Gilbert DJ, Jenkins NA
            and Uitto J.
  TITLE     cDNA cloning and chromosomal assignment of the mouse gene for
            desmoglein 3 (Dsg3), the pemphigus vulgaris antigen
  JOURNAL   Mamm Genome 5 (12), 803-804 (1994)
   PUBMED   7894164
REFERENCE   9  (bases 1 to 5627)
  AUTHORS   Buxton RS, Wheeler GN, Pidsley SC, Marsden MD, Adams MJ, Jenkins
            NA, Gilbert DJ and Copeland NG.
  TITLE     Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely
            linked in the proximal region of chromosome 18
  JOURNAL   Genomics 21 (3), 510-516 (1994)
   PUBMED   7959727
REFERENCE   10 (bases 1 to 5627)
  AUTHORS   Buxton RS, Cowin P, Franke WW, Garrod DR, Green KJ, King IA, Koch
            PJ, Magee AI, Rees DA, Stanley JR et al.
  TITLE     Nomenclature of the desmosomal cadherins
  JOURNAL   J Cell Biol 121 (3), 481-483 (1993)
   PUBMED   8486729
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC154410.1 and AC108943.4.
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_010079.3.
            
            On or before Mar 2, 2008 this sequence version replaced
            XM_904434.2, XM_978431.1, XM_484705.3, XM_980693.1, NM_010079.1.
            
            Summary: This gene encodes a member of the cadherin family of
            proteins that forms an integral transmembrane component of
            desmosomes, the multiprotein complexes involved in cell adhesion,
            organization of the cytoskeleton, cell sorting and cell signaling.
            The encoded preproprotein undergoes proteolytic processing to
            generate a mature, functional protein. This gene is located in a
            cluster of desmosomal cadherin genes on chromosome 18. [provided by
            RefSeq, Jan 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC154410.1, SRR9219382.77515.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3501              BC154410.1         1-3501
            3502-5627           AC108943.4         6590-8715           c
FEATURES             Location/Qualifiers
     source          1..5627
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.29 cM"
     gene            1..5627
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /note="desmoglein 1 alpha"
                     /db_xref="GeneID:13510"
                     /db_xref="MGI:MGI:94930"
     exon            1..193
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..3319
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /note="desmosomal glycoprotein I"
                     /codon_start=1
                     /product="desmoglein-1-alpha preproprotein"
                     /protein_id="NP_034209.2"
                     /db_xref="CCDS:CCDS50231.1"
                     /db_xref="GeneID:13510"
                     /db_xref="MGI:MGI:94930"
                     /translation="MDWHSFRIAALLLTSLVVLEVNSEFQIQVRDHNAKNGTIKWHSI
                     RRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQPVTYRISGVGIDQPPYGIFII
                     NQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDINDNPPVFSMT
                     TFLGQIEENSNANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEI
                     RTMNNFLDREQYSQYSLVVRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDI
                     TIEENALHSQLVQIRVIDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVV
                     KPLDYEAMKNLQLSIGVRNVAEFHQSIISQYRLTATMVTVTVLNVIEGSVFRPGSKTF
                     VVDSRMEANHRVGEFVATDLDTGRASTNVRYEMGNNPENLLVVDSRTGIITLRNRVTM
                     EQYQRLNGEYKGTVLSIDDSLQRTCTGTIVIELSGTGWVTGSESGGSSSGSGDDRDRV
                     TNGYQGTSSTENPQRVTGSWGGSGIDGTRPNTNPFQGDPDETLETPLYGDNVHFGPAG
                     IGLLIMGFLVLGLVPFLLICCDCGGAPGGGAGFEPVPECSDGAIHTWAVEGPQPEPHE
                     GITTICVPQMPPGNANVIEYIDNSGVYTNEYCGREMQDLGGGERTTGFELMDGVKTSA
                     APEICQEYSGTLRRNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYD
                     IEGVGSPAGSVGCCSFIGEDLDESFLDTLGPKFKKLADISLGKEIDSYPDSDPSWPPQ
                     STEPMCPQHTEPLGSGHPPISPHFGTTTVISENAYHSGPGVQHPVPIPDPLGYGNVTV
                     RESYTTSGTLKPSVHFHDNQQASNVVVTERVVGPISGADLHGMLEIPDLRGGANVIVT
                     ERVIAPGSSLPTSLTIPNPQETSNVVVTERVIQPTSGMIGNLSMTPELSSAHNVIVTE
                     RVVSGAGMSEIAGTAGLGGVGGIGSSGLVSTTMGASGTGLNMGGTATIGHMRSSSDHH
                     FSQTVGSASPSMARSRITKYNTVQYSK"
     exon            194..229
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            230..361
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            362..517
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            518..662
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            663..829
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            830..964
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1150
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1410
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1550
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1880
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2017
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2090
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2299
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..5627
                     /gene="Dsg1a"
                     /gene_synonym="DG1; DGI; Dsg1; dsg1-alpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaaacac ctcaaagcct gcatgtaaga acatctactg agaaattatt ttaatcagac
       61 accagcagag tgggagaaag aaagcaagca gagaagagca aagaaactgc cttgatcgtg
      121 gatgtaacag aagccagctg cagcgatgga ctggcactcc ttcaggatag ctgccctgct
      181 gctcacttcc ctggtggtgc ttgaagttaa cagtgaattt caaatccagg taagagatca
      241 taacgccaaa aatggtacca tcaagtggca ttccatcaga aggcagaaac gagaatggat
      301 caagtttgct gcagcctgtc gcgaaggtga agacaactca aagagaaacc caattgccaa
      361 aattcattca gattgtgctg caaatcaacc agtgacatac cgcatctcgg gagtgggaat
      421 tgaccagcca ccttatggaa tcttcattat taatcaaaaa actggtgaaa tcaatataac
      481 atccattgtt gatcgtgaag tcaccccctt tttcattatc tactgccgag cactgaatgc
      541 acaaggtcaa gacttggaga atccactgga gcttagagtt agagtgatgg atataaatga
      601 caaccctcct gtgttttcaa tgactacatt tctaggacaa atagaagaaa attctaatgc
      661 aaacacactg gtaatgaaac tcaatgctac cgatgccgat gagccaaata acttgaactc
      721 aatgatagcc ttcaagatca taagacagga gccttctgac tcaccaatgt tcatcatcaa
      781 caggaaaact ggagaaatca gaacaatgaa taactttcta gacagagagc aatatagcca
      841 gtattccctt gtggtgagag gctcagaccg ggacggtgga gcagacggca tgtctgcaga
      901 gagcgagtgc agcatcacca tcctggatgt caatgacaac atcccatact tggagcagtc
      961 atcttatgac atcacaattg aagaaaatgc acttcactca cagctagtgc agatcagagt
     1021 cattgatttg gatgaagaat tctcagacaa ctggaaggca atcattttct ttatctctgg
     1081 aaatgaggga aattggtttg aaatagaaat gaatgaaaga acaaatgtag gaactctgaa
     1141 ggttgtcaag cccctagatt atgaagccat gaagaatcta cagcttagta ttggtgttcg
     1201 gaatgtagct gaattccacc agtcaattat ttctcaatac agactcacag caactatggt
     1261 cactgtgact gtgttaaatg tcatcgaggg ctctgtgttc cgtccaggtt caaagacatt
     1321 tgtagtagac agtagaatgg aagcaaatca cagagtggga gagtttgtag ctacagacct
     1381 ggacacaggt cgagcttcca caaatgttag atatgaaatg ggaaataacc cagagaacct
     1441 gctggttgtt gactcaagaa caggcataat aacgttaaga aacagagtta ctatggaaca
     1501 ataccaaagg cttaatgggg aatataaagg aacagtgcta tcaatagatg attcccttca
     1561 gaggacctgc acggggacaa tcgtcattga acttagtggc actggctggg taactggttc
     1621 agaaagtggt ggcagttcca gtggcagtgg cgatgatcgt gaccgagtga ctaatggata
     1681 tcaaggcact tcttccactg agaacccaca acgcgtcaca ggatcatggg gaggcagcgg
     1741 catcgatggc actcgcccta acactaaccc tttccaaggg gatcctgatg aaacccttga
     1801 gacccctctc tatggagaca acgttcactt cggtcctgca ggcatcgggc tgctcatcat
     1861 ggggttccta gtcttaggat tggttccatt cctgctgatc tgctgtgatt gtggaggggc
     1921 ccctggtggt ggagctggat ttgaacctgt tccagaatgt tctgatggag caattcacac
     1981 gtgggctgta gaagggccac agcctgaacc ccatgaaggg ataaccacca tctgtgtgcc
     2041 acaaatgcca cctggtaatg ccaatgttat agaatatatt gacaactcag gagtttatac
     2101 aaatgaatat tgtggcagag aaatgcaaga tctgggagga ggagaaagaa ccacaggatt
     2161 tgaactaatg gatggagtta aaacatcagc tgcacctgag atatgccaag aatattcagg
     2221 aacattaaga agaaattcaa tgagagaatg tagagatggg ggtctcaaca tgaatttcat
     2281 ggaaagttac ttctgccaga aagcctatgc ttatgcggat gaagatgaag gacgtccatc
     2341 caatgactgt ttgctcatct atgacatcga aggtgtgggt tcccctgcag gctccgtggg
     2401 ctgttgcagt ttcattggag aagatctaga tgagagcttc ctggatacct tggggcccaa
     2461 gtttaagaag ttggcagata tcagcctggg aaaagaaata gactcatacc cagattctga
     2521 tccttcttgg cctcctcaga gcactgaacc gatgtgtccc cagcatacag agcccctggg
     2581 tagtggacac ccacccatct ccccacattt tggcacgacc acagtaattt ctgaaaatgc
     2641 ctaccactct ggacctggag tacagcatcc tgtaccaatt cctgatcctc tgggctatgg
     2701 caatgtcact gtgagggagt cctataccac ctctggcact ctgaaaccct ctgtccactt
     2761 tcatgataat cagcaggctt caaatgtggt ggtgacagag agggtggtgg gccccatctc
     2821 tggtgctgat ttgcatggca tgttagagat acctgactta agaggtggag caaatgttat
     2881 agtgacagaa agggtaatag caccaggctc aagtctaccc acttctctaa ccattcctaa
     2941 ccctcaagag acctcaaatg tagttgtgac agaaagagtg atccaaccaa cctctggcat
     3001 gataggcaat ctgagcatga cccctgaatt atcaagtgcc cacaacgtga ttgtgacaga
     3061 gagagtggtt tctggtgctg gtatgagtga aattgcaggc actgccggat tagggggggt
     3121 tggaggcata ggcagcagtg gccttgttag caccaccatg ggtgcttctg gcactgggct
     3181 gaacatggga ggaacagcca ctattggcca catgaggagc tcctctgacc atcactttag
     3241 tcagacagtt ggatctgcct cccccagcat ggctcgaagt cgaatcacaa agtacaatac
     3301 ggtacagtat agcaagtagt catgattaca gagtattgtt caccaccatc tcagtgactt
     3361 acatccaact cctgcctcca aatctaacag tgcaatttat gatacagagc aggctatggg
     3421 agacctgtgg agtaagaaag agccacagtg atagtaaccc atggaaacat caccatgggg
     3481 aagagtgctc cctagcattg gtaaactttt ttcttatatt gacactgata aaataatgaa
     3541 ggtgaacttg aggtacaatc ttatctgtgg ctatgtggtc cacagggttg tttttggttt
     3601 taggttttta atgttgccct gtagggtatc agcagcatgt tgaatatata aaacgtggct
     3661 acataaaagc actggcttta aatggcaatg agaagaattc ttattgctgt tcagaaatta
     3721 acaaaaaggg tttgaatatg tagcttgagc tcacataggt gaggaaaatc tgacatttcc
     3781 ttcccatatg ccctgtctgt ttcacaggga atacaaatta aaaatcattc cacagattca
     3841 ggctaaggtt aataaaattc taactacaaa gttatgtatg taagatacca gttattatta
     3901 ctgtgacaac atccaatcta cattggatgg aataattttc aaattaagaa atatgtcctg
     3961 ttagaaaagt ccatagacag taacaatatt gcgagactca tttggcacaa actgacactg
     4021 aatctcaaga tgtggtttag ttaagtcccc tgtggagttg ggaactttcc tggctcccac
     4081 tgtgtttcat gggtgtgact ctgaagaata ttgcttactg ggtggatgaa gggcaccatg
     4141 ctcatttttg cctttaccac tgtagttgaa gggagagttg caaatgacac atgacatggc
     4201 tgccctccca agtgttaaat ctcctcccaa gtacagacag gacagtatta tctcttcagt
     4261 ctaagcagta agtcatactc gtttctgtgc agctctttag ggcataaatg catagttaag
     4321 ataatgtacc taagctgagc tgttgggaag aagctcacag tatggctaag cattggggta
     4381 atttttcatg ggtatctgaa gaaggggaac tgtttttaga acatgaaagc tgtcttaagt
     4441 gggaaatgtt agaaaataat tgttctgtaa agcatacgat atcaccatat gatgagatat
     4501 agttgagatt agtgtcatca tttgaatgac cctctgctgc catttggaag tgattaaaca
     4561 ggacctttta ctagaattga tattacttta gaaagaatga tgtagttact agacaaggcc
     4621 attccttatc taaaatgtgt tatgcacaca tctttgaggt ttctctttga tttgttaata
     4681 atgtcttggc ttctaagcat tctaccttaa agacagttta caagttatag tatggtatat
     4741 ttttctagct ttgaaatgtg ctatttatga tgtgttgttt ctgtattttt gtcaactggt
     4801 gttccctggt ttaaagcccc tcagaagaat caaagctttt gaggacacag gtgcacttac
     4861 tattgcaggg taaaggaatc ttttcttgct tttaaatcaa tgttaaaata agctcactaa
     4921 tataaaatga tatatacatg tttatttggc catatatata tgaacatgga aaatactgga
     4981 cctgagttgt gaactatata tagtttttaa agatgtgttc atcccctgac ttttcttttc
     5041 tcatggtatc acagaatcac agaatttatc aaagagtgat tgattactcc cgcaagagct
     5101 actttgttct atataatatt ggatatggca aatgttttaa aggccacact atgtctaatt
     5161 ttaacagtat agaaaatgta cagttttgct aacatgaagc aagcaaaaat gcagaggcat
     5221 aaataaagtc actcacagga gtctttcttt tattttgttc taatatgtag ggtaatatat
     5281 tgaggatatg gttttggttt tggtttttgt ttttctgggt ttttttttaa agagataagc
     5341 tcaaaaggta tttgttgaaa tattcttgaa gatgcctagg tttgaaagtt ttgaacagat
     5401 agaaataatt aatatagttt tccttccttc ctttgttcat tcattcatcc aaaggcaagt
     5461 gtacttgttg ccctaatgtg ctatactctg gctatatctt tgcttcgatg cctgatgaat
     5521 cccaaatatt ttttcattgc ctaacaagtg gcaatatggc aatctttaat aaatgtgaca
     5581 ttcatcagtt atataagacc tgggaaaata aaactttaaa tgaagaa
//
