LOCUS       NM_001081316            5759 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus dermatan sulfate epimerase-like (Dsel), mRNA.
ACCESSION   NM_001081316 XM_892762
VERSION     NM_001081316.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5759)
  AUTHORS   Stachtea,X.N., Tykesson,E., van Kuppevelt,T.H., Feinstein,R.,
            Malmstrom,A., Reijmers,R.M. and Maccarana,M.
  TITLE     Dermatan Sulfate-Free Mice Display Embryological Defects and Are
            Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid
            Organogenesis
  JOURNAL   PLoS One 10 (10), e0140279 (2015)
   PUBMED   26488883
  REMARK    GeneRIF: Data show that dermatan sulfate is completely absent in
            dermatan sulfate epimerase 1 and 2 double knockout (DKO) mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5759)
  AUTHORS   Bartolini,B., Thelin,M.A., Svensson,L., Ghiselli,G., van
            Kuppevelt,T.H., Malmstrom,A. and Maccarana,M.
  TITLE     Iduronic acid in chondroitin/dermatan sulfate affects directional
            migration of aortic smooth muscle cells
  JOURNAL   PLoS One 8 (7), e66704 (2013)
   PUBMED   23843960
  REMARK    GeneRIF: DS-epi1 deficiency results in a major reduction of
            iduronic acid both on cell surface and in secreted CS/DS
            proteoglycans and affects directional migration of aortic smooth
            muscle cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5759)
  AUTHORS   Thelin,M.A., Bartolini,B., Axelsson,J., Gustafsson,R., Tykesson,E.,
            Pera,E., Oldberg,A., Maccarana,M. and Malmstrom,A.
  TITLE     Biological functions of iduronic acid in chondroitin/dermatan
            sulfate
  JOURNAL   FEBS J 280 (10), 2431-2446 (2013)
   PUBMED   23441919
  REMARK    Review article
REFERENCE   4  (bases 1 to 5759)
  AUTHORS   Bartolini,B., Thelin,M.A., Rauch,U., Feinstein,R., Oldberg,A.,
            Malmstrom,A. and Maccarana,M.
  TITLE     Mouse development is not obviously affected by the absence of
            dermatan sulfate epimerase 2 in spite of a modified brain dermatan
            sulfate composition
  JOURNAL   Glycobiology 22 (7), 1007-1016 (2012)
   PUBMED   22496542
  REMARK    GeneRIF: DS-epi2-deficient mice showed no anatomical, histological
            or morphological abnormalities and DS-epi1 likely compensates in
            vivo for the loss of DS-epi2
REFERENCE   5  (bases 1 to 5759)
  AUTHORS   Akatsu,C., Mizumoto,S., Kaneiwa,T., Maccarana,M., Malmstrom,A.,
            Yamada,S. and Sugahara,K.
  TITLE     Dermatan sulfate epimerase 2 is the predominant isozyme in the
            formation of the chondroitin sulfate/dermatan sulfate hybrid
            structure in postnatal developing mouse brain
  JOURNAL   Glycobiology 21 (5), 565-574 (2011)
   PUBMED   21177331
  REMARK    GeneRIF: the iduronic acid-containing structures in the developing
            brain are mainly produced by the actions of dermatan sulfate
            epimerase 2 and play crucial roles in postnatal development
REFERENCE   6  (bases 1 to 5759)
  AUTHORS   Chao,R., Nevin,L., Agarwal,P., Riemer,J., Bai,X., Delaney,A.,
            Akana,M., JimenezLopez,N., Bardakjian,T., Schneider,A.,
            Chassaing,N., Schorderet,D.F., FitzPatrick,D., Kwok,P.Y.,
            Ellgaard,L., Gould,D.B., Zhang,Y., Malicki,J., Baier,H. and
            Slavotinek,A.
  TITLE     A male with unilateral microphthalmia reveals a role for TMX3 in
            eye development
  JOURNAL   PLoS One 5 (5), e10565 (2010)
   PUBMED   20485507
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5759)
  AUTHORS   Zayed,H., Chao,R., Moshrefi,A., Lopezjimenez,N., Delaney,A.,
            Chen,J., Shaw,G.M. and Slavotinek,A.M.
  TITLE     A maternally inherited chromosome 18q22.1 deletion in a male with
            late-presenting diaphragmatic hernia and microphthalmia-evaluation
            of DSEL as a candidate gene for the diaphragmatic defect
  JOURNAL   Am J Med Genet A 152A (4), 916-923 (2010)
   PUBMED   20358601
  REMARK    GeneRIF: DSEL was selected for study in 125 patients with
            diaphragmatic hernias, as it is involved in the synthesis of
            decorin, a protein that is required for normal collagen formation
            and that is upregulated during myogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125403.4.
            
            On Jan 12, 2023 this sequence version replaced NM_001081316.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033983.1, SRR13948564.5296982.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-824               AC125403.4         35143-35966         c
            825-5759            AC125403.4         29754-34688         c
FEATURES             Location/Qualifiers
     source          1..5759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.84 cM"
     gene            1..5759
                     /gene="Dsel"
                     /gene_synonym="9330132E09Rik; DS-epi2"
                     /note="dermatan sulfate epimerase-like"
                     /db_xref="GeneID:319901"
                     /db_xref="MGI:MGI:2442948"
     exon            1..824
                     /gene="Dsel"
                     /gene_synonym="9330132E09Rik; DS-epi2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..5759
                     /gene="Dsel"
                     /gene_synonym="9330132E09Rik; DS-epi2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1662..5285
                     /gene="Dsel"
                     /gene_synonym="9330132E09Rik; DS-epi2"
                     /EC_number="5.1.3.19"
                     /note="dermatan-sulfate epimerase-like protein"
                     /codon_start=1
                     /product="dermatan-sulfate epimerase-like protein
                     precursor"
                     /protein_id="NP_001074785.1"
                     /db_xref="CCDS:CCDS35688.1"
                     /db_xref="GeneID:319901"
                     /db_xref="MGI:MGI:2442948"
                     /translation="MAFMFTEHLLFLTLMMCSFSTCEESVSNYSEWAVFTDDIQWLKS
                     QKIQDFKLNRRLHPNLYFDAGDIQTLKQKSRTSHLHIFRAIKSAVTIMLSNPSYYLPP
                     PKHAEFAAKWNEIYGNNLPPLALYCLLCPEDKVAFEFVMEYMDRMVSYKDWLVENAPG
                     DEVPVGHSLTGFATAFDFLYNLLGNQRKQKYLEKIWIVTEEMYEYSKIRSWGKQLLHN
                     HQATNMIALLIGALVTGVDKGSKANIWKQVVVDVMEKTMFLLKHIVDGSLDEGVAYGS
                     YTSKSVTQYVFLAQRHFNINNFDNNWLKMHFWFYYATLLPGYQRTVGIADSNYNWFYG
                     PESQLVFLDKFILQNGAGNWLAQQIRKHRPKDGPMVPSTAQRWSTLHTEYIWYDPTLT
                     PQPPVDFGTAKMHTFPNWGVVTYGGGLPNTQTNTFVSFKSGKLGGRAVYDIVHFQPYS
                     WIDGWRSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKLSHLNNVLVFAPSPSSQCNQ
                     PWEGQLGECAQWLKWTGEEVGDAAGEVITAAQHGDRMFVSGEAVSAYSSAMRLKSVYR
                     ALLLLNSQTLLVVDHIERQETSPINSVSAFFHNLDIDFKYIPYKFMNRYNGAMMDVWD
                     AHYKMFWFDHHGNSPVANIQEAEQAAEFKKRWTQFVNVTFHMESTITRIAYVFYGPYV
                     NVSSCRFIDSSSSGLQISLHVNSTEHSVSVVTDYQNLKSRFSYLGFGGFASVANQGQI
                     TRFGLGTQEIVNPVRHDKVNFPFGFKFNIAVGFILCISLVILTFQWRFYLSFRKLMRC
                     VLILVIALWFIELLDVWSTCTQPICAKWTRTEAKANEKVMISEGHHVDLPNVIITSLP
                     GSGAEILKQLFFNSSDFLYIRIPTAYMDIPETEFEIDSFVDACEWKVSDIRSGHFHLL
                     RGWLQSLVQDTKLHLQNIHLHETSRSKLAQYFTTNKDKKRKLKRRESLQDQRSRIKGP
                     FDRDAEYIRALRRHLVYYPSARPVLSLSSGSWTLKLHFFQEVLGTSMRALYIVRDPRA
                     WIYSVLYGSKPSLYSLKNVPEHLAKLFKIEEGKSKCNSNSGYAFEYESLKKELEISQS
                     NAISLLSHLWVANTAAALRINTDLLPTNYHLVKFEDIVHFPQKTTERIFAFLGIPLSP
                     ASLNQMLFATSTNLFYLPYEGEISPSNTNIWKTNLPRDEIKLIENICWTLMDHLGYPK
                     FMD"
     polyA_site      5735
                     /gene="Dsel"
                     /gene_synonym="9330132E09Rik; DS-epi2"
                     /note="major polyA site"
     regulatory      5741..5746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dsel"
                     /gene_synonym="9330132E09Rik; DS-epi2"
                     /note="hexamer: AATAAA"
     polyA_site      5759
                     /gene="Dsel"
                     /gene_synonym="9330132E09Rik; DS-epi2"
                     /note="major polyA site"
ORIGIN      
        1 gccttttttc cgccctccgt gggctaggcg gctccagcta gctcggcgga gcgccggtct
       61 aggcagcatc aggccttagg tcaccgtcgc tgcgctgaag acagcgcctg gagatcaccc
      121 gccgcccgcg ggtggcctcc cgccaagaga gccgcgccgg ccagcgcctg gcgttcctcc
      181 agggcgggtg tgtctgagtc tccatccccg agatccggcc ctgaggagac tccgcaccca
      241 gaggagcagc ggagactgtg gcgctgagga aagcacgcgc tctagggaag ccccccaccc
      301 cgccaccccc caagagtcgg ggcgctgagg agacgacgcc cgagctgagg agacccagcc
      361 cggccgctgc ctgtgcagtc cctggcagca cacgggcgga ggcgtgcgga gctcttggct
      421 tccgtaggcc cgcctccaaa aaatcctcaa ttgcttgaac tggcagcctt cgcctgtgtt
      481 ggggcccagc tccgcttgaa gatcctgttg caggcggcct gaggtaagcc gacttggcca
      541 tttagaggtc tctctagtcc ccacgttgca gccacaggtc agacagtggg gactggagca
      601 gaaggacgat gcgttctgaa gaaaggaatt aaaatatgca acaggcgggt caagtcagga
      661 actactagaa gtgtttgttt cctacagagg aggagacttg tctaagatcg aaacttggtg
      721 agtttcttcc aaatccaaga tgggcaaagg ataggcctgc tccttaaacc tgggtgtgaa
      781 cgccctctgg cggctcgtgg ggaggatgtt gacgacagcc acagagagga gtgacacgaa
      841 aatgaacaaa aaacagactt cagtgttgtg aaagtggaat tttcttaccc acttggtgga
      901 tgtgggcatg attggaagaa gagcatctag acattgaaga aattacattc ttttacaggt
      961 acagataaac ttgataaaag gatatttgga aacgctttaa aaagacgttt gaaatgaagg
     1021 cagaaatttc agtgtccctt atcaaccatg taggactttg aacatttgtt cagaatattt
     1081 tcctccccaa aatggaagaa aaaacaattg agaaatcatt atgcttcaga ctctgagaaa
     1141 aaaataatga agtctgcaca ctctgagaat gacagtactt tatcatcttc ttttggggaa
     1201 catacagaaa cataccattt atgtgtggta agttaatcac tacagatggt ttcttgtgct
     1261 acgtggtcaa atggcttcat ttgaattttg gaattttaaa aaattttttc tttttcacat
     1321 gttaattaga tttacacaca gggagtaaat gttggatttg ttgtattttc tgactagacc
     1381 actgttttct gtgcattgga gacattggag gcattaatat tccttgaaat tttattttat
     1441 tggaagcaaa cctgtgccag ggacacagac atgctatata atttcctaac ttttcttgct
     1501 ttgaataagc tgaatgtcac ctggatttca cagcctatga ggtatagtct gttttttgtt
     1561 tttgtttttt tgctacatct ttaatatata atttacaata accagatagg aaacactgtg
     1621 cttaacacat atgcctaagg aaaagatctt ccccatggat catggcgttt atgtttacag
     1681 aacatttact atttttaaca ttgatgatgt gtagtttttc tacttgtgaa gaatctgtga
     1741 gcaattattc tgaatgggca gttttcacag acgatataca atggcttaag tcacagaaaa
     1801 tacaagattt caaactcaac cgaagacttc atccaaattt atattttgat gctggagata
     1861 tacaaacatt gaaacaaaag tctcgtacaa gccatttgca tatttttaga gctatcaaaa
     1921 gtgcagtgac aattatgctg tccaatccat catactacct acctccaccc aagcatgctg
     1981 agtttgctgc caagtggaat gaaatttatg gtaataatct tcctccttta gcattgtatt
     2041 gtttattatg cccagaagac aaggttgcct ttgaatttgt tatggaatac atggatcgga
     2101 tggttagcta caaagactgg ctagttgaga atgcaccagg ggatgaggtt ccagttggcc
     2161 attctttaac aggttttgcc actgcctttg actttttata taatctatta ggtaatcagc
     2221 gtaaacaaaa atacctagaa aaaatttgga ttgttactga ggaaatgtat gaatattcca
     2281 agattcgatc atggggcaaa caacttcttc ataaccatca agctacaaat atgatagctt
     2341 tactcatagg ggccttggtt actggagtag ataaaggatc taaagcaaac atatggaaac
     2401 aagttgttgt tgatgtgatg gaaaagacta tgtttctctt gaagcatatt gtagatggct
     2461 cattggatga aggtgtggcc tatggaagct atacctcaaa atcagttaca cagtatgttt
     2521 ttttggcaca acgccatttt aacatcaaca actttgataa taactggcta aaaatgcatt
     2581 tttggtttta ttatgctaca cttttgccag gctatcaaag aactgtaggc atagcagatt
     2641 ccaattataa ttggttttat ggtccagaga gccagctagt tttcttggat aagttcattt
     2701 tacagaatgg agctggaaat tggttagctc agcaaattag aaagcatcga cctaaggatg
     2761 gaccaatggt tccttccact gctcagcggt ggagtactct tcatactgaa tacatctggt
     2821 atgatccaac actcacccca cagcctcctg ttgattttgg cactgcaaaa atgcacacat
     2881 ttcctaactg gggtgtcgtg acttatgggg gtgggctgcc aaacacccag accaatacct
     2941 ttgtgtcttt taaatctggg aaactgggag gacgagctgt gtatgacata gttcactttc
     3001 agccatattc ctggattgat ggatggagaa gctttaaccc aggacatgaa catccagatc
     3061 aaaattcatt tactttcgct cctaatgggc aggtattcgt ttctgaggct ctttatggac
     3121 caaaattgag ccaccttaac aacgtattgg tgtttgcccc atcaccatca agtcaatgta
     3181 atcagccctg ggaaggtcaa ctgggagaat gtgcacagtg gctcaagtgg actggggaag
     3241 aggttggtga tgcagctggg gaagttatta ctgctgctca acatggtgat aggatgtttg
     3301 tgagtgggga agcagtgtct gcttattctt ctgccatgag actgaaaagt gtctatcgtg
     3361 ctttacttct tttaaattca caaactctgc ttgttgtcga tcatattgaa aggcaagaaa
     3421 cttccccaat aaattctgtc agtgccttct ttcataattt ggatattgat tttaaataca
     3481 tcccatacaa gtttatgaat agatataatg gtgccatgat ggatgtgtgg gatgcacact
     3541 ataaaatgtt ttggtttgat caccatggca acagtcctgt ggctaatata caggaagcag
     3601 aacaggctgc tgaatttaag aaacggtgga cacagtttgt taatgttaca tttcatatgg
     3661 aatccacaat cacaagaatt gcttatgtat tttatgggcc atatgtcaat gtttccagct
     3721 gcagatttat tgatagttcc agttctggac ttcagatttc tttacatgtc aacagtactg
     3781 aacatagtgt gtctgttgta actgactatc aaaaccttaa aagcagattc agttacctgg
     3841 gatttggtgg ttttgccagt gtggctaatc aaggacagat aaccagattt ggtttgggta
     3901 ctcaagaaat agtaaaccct gtaagacatg ataaagttaa tttccccttt gggtttaaat
     3961 ttaatatagc agttggattc attttgtgta ttagtttggt tattttaact tttcaatggc
     4021 ggttttacct ttcctttaga aagctaatgc gctgtgtatt aatacttgtt attgccttgt
     4081 ggtttattga gcttctggat gtatggagta catgcactca gcccatctgt gcaaaatgga
     4141 caaggactga agctaaggca aatgagaagg tcatgatttc tgaagggcat catgtggatc
     4201 ttcctaatgt tattattacc tcactccctg gttcaggagc tgaaattctc aaacagcttt
     4261 ttttcaacag cagtgatttt ctctacatca gaattcctac agcctacatg gatatccctg
     4321 aaactgaatt tgaaattgac tcatttgtag atgcttgtga gtggaaagta tcagatatcc
     4381 gcagtgggca ctttcatctt cttcgagggt ggctgcagtc tttggtccag gatacaaaac
     4441 ttcacttgca aaacatccat ctacatgaaa ccagtaggag taaactggcc caatatttta
     4501 caactaataa ggacaaaaag cgaaaattaa aaagaaggga gtctttgcaa gatcaaagaa
     4561 gtagaataaa aggaccattt gatagagatg ctgaatatat tagggcttta agaagacacc
     4621 ttgtttatta cccaagtgca cgtcctgtgc tcagcttaag tagtggtagc tggacattga
     4681 agcttcattt ttttcaggaa gttttaggaa cttcaatgcg ggcattgtac atagtaagag
     4741 accctcgagc ttggatctat tcagtgctat atggtagtaa accaagtctt tattctttga
     4801 agaatgtacc agagcactta gcaaaattgt ttaaaataga ggaaggtaaa agcaaatgta
     4861 attcgaattc tggctatgct tttgagtatg aatcactgaa gaaagaatta gaaatatccc
     4921 aatcaaatgc tatctcctta ttatctcatt tgtgggtagc aaacactgca gcagccttga
     4981 gaataaatac agatttgctg cctaccaatt accatctggt caagtttgaa gatattgttc
     5041 attttcctca gaagactact gaaaggattt ttgctttcct tggcattcct ttgtctcctg
     5101 ctagtttaaa ccaaatgcta tttgccactt ccacaaacct tttttatctt ccatatgagg
     5161 gggaaatatc accatctaat actaatattt ggaaaacaaa cttgcctaga gatgaaatta
     5221 aactaattga aaacatttgc tggacactga tggatcatct aggatatcca aagtttatgg
     5281 actaaatgct gcaggtcggc aaaatttgca ctaatgtgtc ccaacctact ttgtggatat
     5341 gaactagaaa actttgttta ttcttgtaca tgtatgtatg tgtgtagagt gagtgcgtgt
     5401 gtccagtatg ttatttgcac agagatattt tcaaaatagg caccatattt ggcctagcag
     5461 gatttatttt tatgttacca cttttcttgc ctttgtttct gaattttttt ctgctaaaat
     5521 gtttctgcta cagaggtata tattctgggg ttctgaaata tggggtttta atggacttta
     5581 actcaacttc tttggaaact atttatctat cttaggacct caaacactac aaacggcctt
     5641 gcaattgctg ctgtatctag tcatctctcg ctcttaatat ggactacaaa actttatgtt
     5701 ttgaaaacgt ctaacattta ccttgcacac aaaaacgaga aataaaaaaa caaaaatta
//
