LOCUS       NM_172508               3920 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dermatan sulfate epimerase (Dse), mRNA.
ACCESSION   NM_172508
VERSION     NM_172508.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3920)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3920)
  AUTHORS   Stachtea,X.N., Tykesson,E., van Kuppevelt,T.H., Feinstein,R.,
            Malmstrom,A., Reijmers,R.M. and Maccarana,M.
  TITLE     Dermatan Sulfate-Free Mice Display Embryological Defects and Are
            Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid
            Organogenesis
  JOURNAL   PLoS One 10 (10), e0140279 (2015)
   PUBMED   26488883
  REMARK    GeneRIF: Data show that dermatan sulfate is completely absent in
            dermatan sulfate epimerase 1 and 2 double knockout (DKO) mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3920)
  AUTHORS   Gustafsson,R., Stachtea,X., Maccarana,M., Grottling,E., Eklund,E.,
            Malmstrom,A. and Oldberg,A.
  TITLE     Dermatan sulfate epimerase 1 deficient mice as a model for human
            abdominal wall defects
  JOURNAL   Birth Defects Res A Clin Mol Teratol 100 (9), 712-720 (2014)
   PUBMED   25186462
  REMARK    GeneRIF: The combination of defective collagen structure in the
            dermis and imbalanced keratinocyte maturation could be responsible
            for the observed developmental defects in DS-epi1-deficient mice.
REFERENCE   4  (bases 1 to 3920)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3920)
  AUTHORS   Bartolini,B., Thelin,M.A., Svensson,L., Ghiselli,G., van
            Kuppevelt,T.H., Malmstrom,A. and Maccarana,M.
  TITLE     Iduronic acid in chondroitin/dermatan sulfate affects directional
            migration of aortic smooth muscle cells
  JOURNAL   PLoS One 8 (7), e66704 (2013)
   PUBMED   23843960
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3920)
  AUTHORS   Thelin,M.A., Bartolini,B., Axelsson,J., Gustafsson,R., Tykesson,E.,
            Pera,E., Oldberg,A., Maccarana,M. and Malmstrom,A.
  TITLE     Biological functions of iduronic acid in chondroitin/dermatan
            sulfate
  JOURNAL   FEBS J 280 (10), 2431-2446 (2013)
   PUBMED   23441919
  REMARK    Review article
REFERENCE   7  (bases 1 to 3920)
  AUTHORS   Maccarana,M., Kalamajski,S., Kongsgaard,M., Magnusson,S.P.,
            Oldberg,A. and Malmstrom,A.
  TITLE     Dermatan sulfate epimerase 1-deficient mice have reduced content
            and changed distribution of iduronic acids in dermatan sulfate and
            an altered collagen structure in skin
  JOURNAL   Mol Cell Biol 29 (20), 5517-5528 (2009)
   PUBMED   19687302
  REMARK    GeneRIF: DS-epi1-deficient mice show chondroitin sulfate /dermatan
            sulfate with a marked deficiency in iduronic acid-containing
            structures.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC053095.1 and CJ269977.1.
            
            On Jun 29, 2018 this sequence version replaced NM_172508.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053095.1, AK150737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3909              BC053095.1         317-4225
            3910-3920           CJ269977.1         431-441
FEATURES             Location/Qualifiers
     source          1..3920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 18.85 cM"
     gene            1..3920
                     /gene="Dse"
                     /gene_synonym="6030499O08; B130024B19Rik; DS-epi1; Sart2"
                     /note="dermatan sulfate epimerase"
                     /db_xref="GeneID:212898"
                     /db_xref="MGI:MGI:2443455"
     exon            1..156
                     /gene="Dse"
                     /gene_synonym="6030499O08; B130024B19Rik; DS-epi1; Sart2"
                     /inference="alignment:Splign:2.1.0"
     exon            157..625
                     /gene="Dse"
                     /gene_synonym="6030499O08; B130024B19Rik; DS-epi1; Sart2"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..3086
                     /gene="Dse"
                     /gene_synonym="6030499O08; B130024B19Rik; DS-epi1; Sart2"
                     /EC_number="5.1.3.19"
                     /note="squamous cell carcinoma antigen recognized by T
                     cells 2; DS epimerase; chondroitin-glucuronate
                     5-epimerase"
                     /codon_start=1
                     /product="dermatan-sulfate epimerase precursor"
                     /protein_id="NP_766096.1"
                     /db_xref="CCDS:CCDS23776.1"
                     /db_xref="GeneID:212898"
                     /db_xref="MGI:MGI:2443455"
                     /translation="MRTHTRGAPSVFFICLLCCVSAFITDENPEVMIPFTNANYDSHP
                     MLYFSRKDVAELQLRAASSHEHIAARLTEAVHTMLTNPLEYLPPWDPKEYSARWNEIY
                     GNNLGALAMFCVLYPENTEARDMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFAT
                     AYDFLYNYLSKTQQETFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSL
                     ILMNQGYLQEAYLWTKQVLSIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYMFLV
                     QRHFDINHFGHPWLKQHFAFMYRTILPGFQRTVAIADSNYNWFYGPESQLVFLDKFVM
                     RNGSGNWLADQIRRNRVVEGPGTPSKGQRWCTLHTEFLWYDASLKPVPPPDFGTPTLH
                     YFEDWGVVTYGSALPAEINRSFLSFKSGKLGGRAIYDIVHRNKYKDWIKGWRNFNAGH
                     EHPDQNSFTFAPNGVPFITEALYGPKYTYFNNVLMFSPAVSKSCFSPWEGQVTEDCSS
                     KWSKYKHDLAASCQGRVIAADEKDGVVFIRGEGVGAYNPMLNLKHIQRNLILLHPQLL
                     LLVDQIHLGEESPLETAASFFHNVDVPFEETVVDGVHGALIRQRDGLYKMYWMDDTGY
                     SEKANFASVMYPRGYPYNGTNYVNVTMHLRSPITRAAYLFIGPSVDVQSFSIHGDPQR
                     LDVFIATSEHAYATYLWTGENTGHSAFAQVIADHQKILFDQSSAIKSTAVPEVKDYAA
                     IVEQNLQHFKPVFQLLEKQILSRVQNTASFRKTAERLLRFSDKRQTEEAIDRIFAISQ
                     QQRQQRGKSKKSRKAGKHYKFVDAVPDIFAQIEVNEKKIRQKAQVLAQREQPIDEDEE
                     MKDLLDFADVTYEKHKNEGSVKGGFGQVRMVTSHNRAPSLSASYTRLFLILNIAIFFV
                     MLAMQLTYFQRAQSLHGQRCLYAVLLIDSCVLLWLYSSCSQSQC"
     exon            626..879
                     /gene="Dse"
                     /gene_synonym="6030499O08; B130024B19Rik; DS-epi1; Sart2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1119
                     /gene="Dse"
                     /gene_synonym="6030499O08; B130024B19Rik; DS-epi1; Sart2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1327
                     /gene="Dse"
                     /gene_synonym="6030499O08; B130024B19Rik; DS-epi1; Sart2"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..3913
                     /gene="Dse"
                     /gene_synonym="6030499O08; B130024B19Rik; DS-epi1; Sart2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3891..3896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dse"
                     /gene_synonym="6030499O08; B130024B19Rik; DS-epi1; Sart2"
                     /note="hexamer: AATAAA"
     polyA_site      3912
                     /gene="Dse"
                     /gene_synonym="6030499O08; B130024B19Rik; DS-epi1; Sart2"
                     /note="major polyA site"
ORIGIN      
        1 agtccgcacg gcggctagag gctgcagcgg cgcaccccgg gcgcagcgcc ctgagctcgg
       61 atggctcggc gcgcaagctg agggcccgac tccaggggtc cggagtcccg gcgccccacg
      121 gggacgcaga gagaggacgc ccgggaggac ggagcggatc attcgaagat gatttggctg
      181 ccttggagac ttggagatcc ggtgccacga tgaggactca tacacggggg gcacccagtg
      241 tgtttttcat atgtttgctc tgctgtgtgt cagccttcat cactgacgag aacccagaag
      301 tcatgattcc cttcactaat gccaactatg acagccaccc aatgttgtac ttctccagga
      361 aagatgtggc agagctccag ctgagggctg ccagctccca tgagcacatt gcagctcggc
      421 ttacagaggc tgtgcatacc atgttgacta accccttgga gtacctccct ccttgggatc
      481 ccaaggagta cagtgcccgc tggaatgaga tctatggaaa caacctgggt gccttggcaa
      541 tgttctgtgt gctgtatcct gagaacactg aagctcgaga catggccaaa gactacatgg
      601 agaggatggc agcgcagcct agttggttgg tgaaagatgc gccttgggat gaagttccac
      661 ttgcccactc cctggtgggt ttcgccactg catatgactt cttatacaac tacctgagca
      721 agacacagca ggagacattc ctggaagtga ttgccaatgc ctcgggctat atgtatgaaa
      781 cttcctatag aagaggatgg gggttccagt acttgcacaa ccaccagccc accaactgca
      841 tggccttact cactggaagt ctcattctga tgaaccaagg gtaccttcag gaggcctatt
      901 tatggaccaa gcaagttcta agcatcatgg agaagtctct ggtcttgctg cgagaggtga
      961 cagatggctc tctctatgaa ggagttgcat acggcagcta taccactaga tccctgttcc
     1021 agtacatgtt tcttgttcag aggcactttg acatcaacca ctttggccat ccatggctta
     1081 agcaacactt tgcctttatg tataggacca tcttgccagg gtttcagaga actgtagcca
     1141 ttgcagattc aaattacaac tggttttatg gcccagaaag tcaattagtg ttcctggata
     1201 aatttgtcat gcgtaacggg agtggaaact ggctggctga ccaaatcaga aggaaccgtg
     1261 tagtggaagg tccagggaca ccatcgaaag ggcagcgctg gtgcacgcta cacaccgaat
     1321 ttctctggta tgatgccagc ttgaaaccag ttccacctcc agattttggt accccaacat
     1381 tgcattattt tgaggactgg ggtgttgtga cttatggaag tgcactacct gcagaaatca
     1441 acaggtcatt cctttccttc aagtcaggaa aacttggagg gcgtgcaata tatgacattg
     1501 ttcatagaaa caaatataaa gactggatca aagggtggag aaattttaat gcaggacatg
     1561 agcaccctga ccaaaactct ttcactttcg cccccaatgg tgtgccgttc attactgagg
     1621 ccctgtatgg gccaaagtac acctacttta acaacgttct aatgttttct ccagctgtgt
     1681 ctaagagttg cttttctccc tgggagggtc aggtcacaga agactgttca tcaaaatggt
     1741 caaagtataa gcatgacctg gcagccagct gtcaggggag agtgattgca gcagatgaaa
     1801 aggatggggt tgtttttatc cgaggagaag gcgtaggagc atataacccc atgctcaacc
     1861 tgaagcacat tcaacggaat ctcatcctcc tccacccaca gcttctcctt cttgtagacc
     1921 agatccacct gggagaggag agcccgctgg agacagcagc aagtttcttc cacaatgtgg
     1981 atgtcccttt tgaggagaca gtagtagatg gggtccatgg ggctctcatc cggcagcgag
     2041 acggtctcta taaaatgtac tggatggatg ataccggtta tagtgaaaaa gcaaactttg
     2101 cctcagtgat gtatcctcgg ggttatccct acaacgggac aaattatgtg aatgtcacca
     2161 tgcatcttcg aagccctatc accagggcag cttacctctt catagggcca tctgtggatg
     2221 tccagagctt cagcatccat ggagaccctc agcggctgga tgtgttcata gctaccagtg
     2281 aacacgccta tgcaacttac ctgtggacag gtgagaacac agggcattct gctttcgcac
     2341 aggtcattgc agatcatcag aaaattctgt ttgaccagag ttcagccatc aaaagcaccg
     2401 ctgtccctga agtgaaagat tatgctgcta tcgtggagca gaatctgcag cattttaagc
     2461 ccgtgttcca gctgcttgag aagcagatcc tatctcgagt ccagaacaca gctagcttta
     2521 gaaagactgc cgagcgccta ctgaggtttt cagataagag acagacagag gaagccattg
     2581 acagaatttt tgctatatcc cagcaacagc ggcagcagcg aggcaagtcg aagaaaagcc
     2641 gaaaggcggg taagcattac aagtttgtgg atgcggttcc tgatattttc gcacagattg
     2701 aagttaatga gaagaagatt cgacagaaag ctcaggtttt agctcagaga gaacagccca
     2761 tagacgaaga tgaagaaatg aaagaccttt tggattttgc tgatgtcaca tatgagaagc
     2821 ataaaaacga gggttccgtg aaaggtggct ttggacaggt gcggatggtg acaagtcaca
     2881 acagagcacc ttcactgtca gcctcctaca ccagactctt cttgatcctc aacattgcca
     2941 tcttctttgt catgctggca atgcaactga cttatttcca gagggctcag agcctccatg
     3001 gccaaaggtg tctttatgcg gtcctcctaa tagatagctg tgtcttactg tggttgtatt
     3061 cctcctgttc ccagtctcag tgctaacgcc aaggccatga gcctctcagg atcacgagag
     3121 gtcaggaaat gtatgcatgt atttcctaat tggttataat gtctcgtcca gatttacttg
     3181 agcaaattta agagaagttg ttttcacaca caaaaagtgg gggtatggaa agccctgagc
     3241 tagacacaca aaggatgtac ctagggtgta agaatggctt tggctgcccc cttgtgtttc
     3301 tggaaatgtt tggctttgct ggctgaccag tatctattag aagagtcaaa aatacctggc
     3361 tttttctttc tttttttttt ttttttacat cagctttctg ttactataaa gaaaaaaaat
     3421 gaattggact ttattatcat taatttaatt ctgttagaag cttccagatt ctgtattatg
     3481 gaacatatgg aggcacataa ttccaagcaa tacaggctgt taaaatataa ataatgggaa
     3541 ctgtgattat aagacctgga aacttcatga aattacgtga taaaatgata gcagaagatc
     3601 ataaaggaac tgaaattttt taaaatggaa aacatgtaag aatgaacatc tgtttgatgc
     3661 tgtttgtcag tgcaggaatg gtatttgtgg cttttcgata aataatacaa taacaggtaa
     3721 tttcatattc tcttcctctt ttatgtaaaa tgtttataga cccaaagggt aaagtttttg
     3781 aaataaacta ttttatatct tgaaactcaa taccaaagaa catggaacta aagttttggt
     3841 gtgattctga tgtttttaat tagaaaagtt tcttcaagtt tattttgcta aataaaccaa
     3901 tcataattat gataaaaaaa
//
