LOCUS       NM_183089               1322 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus DNA replication and sister chromatid cohesion 1
            (Dscc1), transcript variant 2, mRNA.
ACCESSION   NM_183089
VERSION     NM_183089.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1322)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1322)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1322)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   4  (bases 1 to 1322)
  AUTHORS   Simonson,L., Vold,S., Mowers,C., Massey,R.J., Ong,I.M.,
            Longley,B.J. and Chang,H.
  TITLE     Keratin 13 deficiency causes white sponge nevus in mice
  JOURNAL   Dev Biol 468 (1-2), 146-153 (2020)
   PUBMED   32758484
REFERENCE   5  (bases 1 to 1322)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1322)
  AUTHORS   Morris,J.A., Kemp,J.P., Youlten,S.E., Laurent,L., Logan,J.G.,
            Chai,R.C., Vulpescu,N.A., Forgetta,V., Kleinman,A., Mohanty,S.T.,
            Sergio,C.M., Quinn,J., Nguyen-Yamamoto,L., Luco,A.L., Vijay,J.,
            Simon,M.M., Pramatarova,A., Medina-Gomez,C., Trajanoska,K.,
            Ghirardello,E.J., Butterfield,N.C., Curry,K.F., Leitch,V.D.,
            Sparkes,P.C., Adoum,A.T., Mannan,N.S., Komla-Ebri,D.S.K.,
            Pollard,A.S., Dewhurst,H.F., Hassall,T.A.D., Beltejar,M.G.,
            Adams,D.J., Vaillancourt,S.M., Kaptoge,S., Baldock,P., Cooper,C.,
            Reeve,J., Ntzani,E.E., Evangelou,E., Ohlsson,C., Karasik,D.,
            Rivadeneira,F., Kiel,D.P., Tobias,J.H., Gregson,C.L., Harvey,N.C.,
            Grundberg,E., Goltzman,D., Adams,D.J., Lelliott,C.J., Hinds,D.A.,
            Ackert-Bicknell,C.L., Hsu,Y.H., Maurano,M.T., Croucher,P.I.,
            Williams,G.R., Bassett,J.H.D., Evans,D.M. and Richards,J.B.
  CONSRTM   23andMe Research Team
  TITLE     An atlas of genetic influences on osteoporosis in humans and mice
  JOURNAL   Nat Genet 51 (2), 258-266 (2019)
   PUBMED   30598549
  REMARK    Erratum:[Nat Genet. 2019 May;51(5):920. doi:
            10.1038/s41588-019-0415-x.. PMID: 30988516]
REFERENCE   7  (bases 1 to 1322)
  AUTHORS   Geyer,S.H., Reissig,L., Rose,J., Wilson,R., Prin,F., Szumska,D.,
            Ramirez-Solis,R., Tudor,C., White,J., Mohun,T.J. and Weninger,W.J.
  TITLE     A staging system for correct phenotype interpretation of mouse
            embryos harvested on embryonic day 14 (E14.5)
  JOURNAL   J Anat 230 (5), 710-719 (2017)
   PUBMED   28185240
REFERENCE   8  (bases 1 to 1322)
  AUTHORS   Machold,R., Klein,C. and Fishell,G.
  TITLE     Genes expressed in Atoh1 neuronal lineages arising from the
            r1/isthmus rhombic lip
  JOURNAL   Gene Expr Patterns 11 (5-6), 349-359 (2011)
   PUBMED   21440680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137950.16.
            
            On Sep 21, 2017 this sequence version replaced NM_183089.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011162.1, BC116833.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AC137950.16        19125-19390
            267-435             AC137950.16        20493-20661
            436-570             AC137950.16        21880-22014
            571-661             AC137950.16        22773-22863
            662-800             AC137950.16        25429-25567
            801-853             AC137950.16        26518-26570
            854-1008            AC137950.16        27295-27449
            1009-1157           AC137950.16        29275-29423
            1158-1322           AC137950.16        33351-33515
FEATURES             Location/Qualifiers
     source          1..1322
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 21.96 cM"
     gene            1..1322
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /note="DNA replication and sister chromatid cohesion 1"
                     /db_xref="GeneID:72107"
                     /db_xref="MGI:MGI:1919357"
     exon            1..266
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1266
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sister chromatid cohesion protein DCC1; defective in
                     sister chromatid cohesion protein 1 homolog; defective in
                     sister chromatid cohesion 1 homolog"
                     /codon_start=1
                     /product="sister chromatid cohesion protein DCC1 isoform
                     2"
                     /protein_id="NP_898912.2"
                     /db_xref="CCDS:CCDS27473.1"
                     /db_xref="GeneID:72107"
                     /db_xref="MGI:MGI:1919357"
                     /translation="MSPPSASRRTREEVDATLQVAKLNATELLPTVHCLSFSSGTGGA
                     ATGDFCLLELEPALCQQLEAGDSFVIRGDKDEQAVLCSKDKTYDLKIADTSNMLLFIP
                     GCKTPDQLKEEETPSAIVHTEIFGFSNNYWELRRCRPKLKKLKRLLMENTYEGPDSQK
                     EEDASRSKYTTEDLLNHIQASEEEIMAQLQVLNACEIGGYWRILEFDYEIKLLNHVTQ
                     LVDSESWSLDRVPLTVCLQELGPLEPEEMIEHCLKCYGKRYVDKDDVYFELDADKICR
                     VTAEMLLQNAVKFNLAEFQEVWQQSVPEGMTTRLDQLKGLALVDRNSRPEIIFLLKVD
                     DLPEGTQDRFNSLFSLREKWTEEDITPYIQDLCGEKQTIGALLTKYSRSSMQNGIKVY
                     NSRRLIS"
     exon            267..435
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..570
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..661
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..800
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..853
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1008
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1157
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1322
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1303..1308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /note="hexamer: AATAAA"
     polyA_site      1322
                     /gene="Dscc1"
                     /gene_synonym="2010006I05Rik; 2600005O03Rik; Dcc1"
                     /note="major polyA site"
ORIGIN      
        1 ggatttggcg cgcttttgaa gtcccgggag tttaggtcga ggacacaccc ctctccgtgc
       61 tgcgagatgt ccccgccgag cgcttcccgg aggacccgcg aggaagtgga cgcgacgctg
      121 caggttgcca agctgaacgc caccgagctg ctgcccacgg tgcactgcct gagcttcagc
      181 tccgggaccg gcggcgcggc caccggcgac ttctgcctgc tggagctgga accagcactg
      241 tgccagcagc tggaggccgg ggacagcttt gtgattagag gagataagga tgaacaggct
      301 gtgttgtgca gtaaagacaa aacctacgac ctgaagatag cagacacatc caacatgctg
      361 cttttcatcc ctggatgcaa aactccagac cagctgaagg aggaggaaac accaagtgcc
      421 atcgttcaca cggagatctt tggcttctct aataattatt gggaattaag aagatgcaga
      481 cctaagttaa aaaagctaaa gagacttcta atggaaaata cctacgaagg ccctgacagt
      541 cagaaagaag aggatgcaag ccgctcaaaa tatacaactg aagatttgct taatcatatt
      601 caggcaagtg aggaggagat aatggctcag ttacaagtcc taaatgcctg tgagattgga
      661 ggctactgga ggattcttga gtttgattat gagatcaaac ttctgaacca tgtgactcag
      721 cttgtggatt ctgaatcctg gtctttggat agagtcccct tgactgtgtg cctgcaggag
      781 cttggacctt tggagccaga ggaaatgatt gaacactgtc ttaaatgcta cggaaagaga
      841 tacgtggaca aagatgatgt ctattttgaa ttggacgctg acaaaatatg cagagtgacc
      901 gcggagatgc tgctgcagaa tgccgtgaag tttaatcttg cagagtttca ggaagtgtgg
      961 cagcagagtg ttcccgaggg aatgacgact cggcttgatc agctcaaggg tttagcactg
     1021 gttgacagaa actcaagacc agaaatcata tttttgctca aagtagatga tttgcctgag
     1081 ggaacacagg atcgttttaa tagtctgttc tctctaagag aaaagtggac agaggaagac
     1141 atcactccat atatccaaga tttgtgcgga gagaagcaaa ctataggtgc gttgcttact
     1201 aaatattctc gctcctcaat gcaaaatggc attaaagttt ataattccag gagactcatt
     1261 tcttaaaaga atgatataca actttataaa gttgctggat acaataaaaa aattcttttg
     1321 ca
//
