LOCUS       NM_031174               7481 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus DS cell adhesion molecule (Dscam), mRNA.
ACCESSION   NM_031174
VERSION     NM_031174.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7481)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7481)
  AUTHORS   Touahri,Y., Hanna,J., Tachibana,N., Okawa,S., Liu,H., David,L.A.,
            Olender,T., Vasan,L., Pak,A., Mehta,D.N., Chinchalongporn,V.,
            Balakrishnan,A., Cantrup,R., Dixit,R., Mattar,P., Saleh,F.,
            Ilnytskyy,Y., Murshed,M., Mains,P.E., Kovalchuk,I., Lefebvre,J.L.,
            Leong,H.S., Cayouette,M., Wang,C., Del Sol,A., Brand,M., Reese,B.E.
            and Schuurmans,C.
  TITLE     Pten regulates endocytic trafficking of cell adhesion and Wnt
            signaling molecules to pattern the retina
  JOURNAL   Cell Rep 43 (4), 114005 (2024)
   PUBMED   38551961
REFERENCE   3  (bases 1 to 7481)
  AUTHORS   Dewa,K.I., Arimura,N., Kakegawa,W., Itoh,M., Adachi,T.,
            Miyashita,S., Inoue,Y.U., Hizawa,K., Hori,K., Honjoya,N.,
            Yagishita,H., Taya,S., Miyazaki,T., Usui,C., Tatsumoto,S.,
            Tsuzuki,A., Uetake,H., Sakai,K., Yamakawa,K., Sasaki,T., Nagai,J.,
            Kawaguchi,Y., Sone,M., Inoue,T., Go,Y., Ichinohe,N., Kaibuchi,K.,
            Watanabe,M., Koizumi,S., Yuzaki,M. and Hoshino,M.
  TITLE     Neuronal DSCAM regulates the peri-synaptic localization of GLAST in
            Bergmann glia for functional synapse formation
  JOURNAL   Nat Commun 15 (1), 458 (2024)
   PUBMED   38302444
  REMARK    GeneRIF: Neuronal DSCAM regulates the peri-synaptic localization of
            GLAST in Bergmann glia for functional synapse formation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7481)
  AUTHORS   Liu,H., Caballero-Floran,R.N., Hergenreder,T., Yang,T., Hull,J.M.,
            Pan,G., Li,R., Veling,M.W., Isom,L.L., Kwan,K.Y., Huang,Z.J.,
            Fuerst,P.G., Jenkins,P.M. and Ye,B.
  TITLE     DSCAM gene triplication causes excessive GABAergic synapses in the
            neocortex in Down syndrome mouse models
  JOURNAL   PLoS Biol 21 (4), e3002078 (2023)
   PUBMED   37079499
  REMARK    GeneRIF: DSCAM gene triplication causes excessive GABAergic
            synapses in the neocortex in Down syndrome mouse models.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7481)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7481)
  AUTHORS   Zhao,Z., Yaar,R., Ladd,D., Cataldo,L.M. and Ravid,K.
  TITLE     Overexpression of A3 adenosine receptors in smooth, cardiac, and
            skeletal muscle is lethal to embryos
  JOURNAL   Microvasc Res 63 (1), 61-69 (2002)
   PUBMED   11749073
REFERENCE   7  (bases 1 to 7481)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
REFERENCE   8  (bases 1 to 7481)
  AUTHORS   Agarwala,K.L., Ganesh,S., Amano,K., Suzuki,T. and Yamakawa,K.
  TITLE     DSCAM, a highly conserved gene in mammals, expressed in
            differentiating mouse brain
  JOURNAL   Biochem Biophys Res Commun 281 (3), 697-705 (2001)
   PUBMED   11237714
REFERENCE   9  (bases 1 to 7481)
  AUTHORS   Cabin,D.E., McKee-Johnson,J.W., Matesic,L.E., Wiltshire,T.,
            Rue,E.E., Mjaatvedt,A.E., Huo,Y.K., Korenberg,J.R. and Reeves,R.H.
  TITLE     Physical and comparative mapping of distal mouse chromosome 16. 5
            p5
  JOURNAL   Genome Res 8 (9), 940-950 (1998)
   PUBMED   9750193
REFERENCE   10 (bases 1 to 7481)
  AUTHORS   Yamakawa,K., Huot,Y.K., Haendelt,M.A., Hubert,R., Chen,X.N.,
            Lyons,G.E. and Korenberg,J.R.
  TITLE     DSCAM: a novel member of the immunoglobulin superfamily maps in a
            Down syndrome region and is involved in the development of the
            nervous system
  JOURNAL   Hum Mol Genet 7 (2), 227-237 (1998)
   PUBMED   9426258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154814.2, AF315558.1 and AC154387.2.
            
            On Aug 22, 2007 this sequence version replaced NM_031174.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY005483.1, AF315558.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               AC154814.2         97045-97399         c
            356-6622            AF315558.1         1-6267
            6623-7481           AC154387.2         45687-46545
FEATURES             Location/Qualifiers
     source          1..7481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 57.02 cM"
     gene            1..7481
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /note="DS cell adhesion molecule"
                     /db_xref="GeneID:13508"
                     /db_xref="MGI:MGI:1196281"
     exon            1..502
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..6501
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /note="Down syndrome cell adhesion molecule homolog; cell
                     adhesion molecule DSCAM"
                     /codon_start=1
                     /product="cell adhesion molecule DSCAM precursor"
                     /protein_id="NP_112451.1"
                     /db_xref="CCDS:CCDS37415.1"
                     /db_xref="GeneID:13508"
                     /db_xref="MGI:MGI:1196281"
                     /translation="MWILALSLFQSFANVFSEEPHSSLYFVNASLQEVVFASTSGTLV
                     PCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYC
                     TAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYVTVVSW
                     EKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVS
                     DPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVT
                     GLLIENSRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLS
                     CSVTGNEDQELSWYRNGEILNPGKNVRITGLNHANLIMDHMVKSDGGAYQCFVRKDKL
                     SAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLVCNVKGTPLPTVTWTLDDDPILKG
                     SGHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIR
                     PMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNANLLPFNHRQVAFENNGTLKLSDVQK
                     EVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDL
                     PITITWQKDGRPIPASLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQS
                     QLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALN
                     GRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTL
                     ATQGQRKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTV
                     REDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSP
                     ITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS
                     NEITITADEAAPDGPPQEVHLEPTSSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTG
                     GNFQFNIISIDTTGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVP
                     SYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLIDGELGEIKNVTTT
                     QPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASM
                     VFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVV
                     AVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM
                     KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCVANNNWGSDEIILNLQVQV
                     PPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSY
                     RLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRL
                     NLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCN
                     SAGCAEKQANFATLNYDGSTIPPLIKSVVQSEEGLTTNEGLKILVTISCILVGVLLLF
                     VLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLL
                     IEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARP
                     GTNPTTRRNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRATGSVDKESD
                     SYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDT
                     SSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVVNMAVPKAHRPGDLIH
                     LPPYLRMDFLLNRGAPGTSRDLSLGQACLEPQKSRTLKRPTVLEPTPMEASSSTSSTR
                     EGQQSWQQGAVATLPQREGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV"
     exon            503..820
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            821..967
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1114
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1393
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1669
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1966
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2242
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2521
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2641
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2815
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..3012
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3109
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3238
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3406
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3477
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3718
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3865
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..4021
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4022..4155
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4309
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4310..4427
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4428..4591
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4592..4690
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..4879
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4880..5170
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5171..5347
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5348..5378
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5379..5494
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5495..5644
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5645..5842
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5843..6145
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6146..7481
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6609..6614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /note="hexamer: AATATA"
     polyA_site      6629
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /note="major polyA site"
     regulatory      7106..7111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7134
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /note="major polyA site"
     regulatory      7454..7459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7481
                     /gene="Dscam"
                     /gene_synonym="4932410A21Rik"
                     /note="major polyA site"
ORIGIN      
        1 caggcaggga agggcagcac aggggacccg gcgcccgagg ccgccgcagc aggatgagcc
       61 tggccgcgcg cctgctgcct ggctgcggag ggtgaggccg gcgcccggga ggccgccgcc
      121 tggccgcgct gcgcatcggg gggcgcccgg catgagctcg cgcccgcggc tgcggctgtg
      181 cgcccgcgcc tggctgcccg cggcccgctg agccgagccg agcgcacggc gcacctgggc
      241 tgtgtccgcg gcgcggggcg cggcgcccgg gagcaggtgt gcgggggcgc agcaagcggg
      301 gagcgcggct gggcggctgg gcggcccccg ggcaggtggc gggcagcaag cggagccggg
      361 ccgggcgcgg cggagcgcag cgcagcgcgg ggggcgaggc cggcgcgtgg ctcgctcgct
      421 ggctcgctgg ctcgcgggag gccgggcagc agcaggggca tgtggatact ggctctctcc
      481 ttgttccaga gcttcgcgaa tgttttcagt gaagagcccc actccagcct ctactttgtc
      541 aatgcatcgc tgcaagaggt agtgtttgca agcacatcgg ggacgctggt gccctgcccg
      601 gctgcaggca tccctcctgt gactctcaga tggtacctag caacgggcga ggagatctac
      661 gatgtccccg ggatccgcca cgtccatccc aatggcactc tccaaatttt cccctttcct
      721 ccttcaagct tcagcacctt aatccatgat aatacttact attgcacagc tgaaaaccct
      781 tcagggaaaa ttagaagtca ggatgtccac atcaaggctg ttttacggga gccctataca
      841 gtccgtgtgg aggaccagaa aaccatgaga ggcaatgtcg cggtgttcaa gtgcattatc
      901 ccctcctcgg tggaggcgta cgtcactgtc gtctcatggg agaaagacac ggtttcactt
      961 gtctcaggat ctagatttct catcacatcc acgggagcct tgtatattaa agatgtacag
     1021 aacgaagatg ggctgtacaa ctaccgctgc atcacgcggc acagatacac aggggagacg
     1081 agacaaagca acagcgcgag actgttcgtg tcagacccag caaactcagc cccatccatc
     1141 ctggacgggt ttgaccaccg caaagccatg gcagggcagc gcgtggagct gccttgcaaa
     1201 gcacttgggc accccgagcc agactaccgc tggctgaagg acaacatgcc cctggaactt
     1261 tctggaaggt tccaaaagac agtgactggg ttgctcattg agaacagccg cccctcagac
     1321 tcaggcagct atgtgtgtga agtatccaac cgatatggca ctgccaaggt gataggccgc
     1381 ctgtacgtga aacagccact gaaagccacc atcagtccca gaaaggttaa aagcagcgtg
     1441 ggcagccagg tctccttatc ctgcagtgtg acaggaaatg aagaccagga actctcctgg
     1501 taccgaaatg gcgaaatcct caaccctgga aaaaacgtga ggatcacagg actcaaccac
     1561 gcaaacctta taatggatca catggtcaag agtgatgggg gtgcctacca gtgctttgtg
     1621 cgcaaggaca agctatctgc tcaagactat gtccaggtgg tccttgaaga cggaactccc
     1681 aaaatcattt ctgcctttag cgagaaagtg gtgagcccgg cagagccagt gtccctcgtg
     1741 tgcaatgtga agggtacacc cttgcccacg gtcacctgga ccctggacga tgaccccatc
     1801 ctcaagggca gcggtcaccg catcagccaa atgatcacgt ccgaggggaa cgtggtcagc
     1861 tacctgaata tctccagctc ccaggtccgg gatgggggtg tctaccgctg cactgccaac
     1921 aactcggctg gagtcgtcct gtaccaggct cgaataaacg taagagggcc tgcaagcatc
     1981 agaccaatga aaaacatcac tgcgatagcg gggcgtgaca cgtacatcca ctgccgcgta
     2041 attggctatc cgtattactc catcaagtgg tacaagaacg ctaacctgct tcctttcaac
     2101 caccgccagg tggcgtttga gaacaatggg actctgaaac tctctgatgt gcagaaagaa
     2161 gttgacgagg gagagtacac gtgtaatgtg ctggtacagc cacagctctc caccagccag
     2221 agtgtccacg tgacagtgaa agttccacct ttcatccaac cttttgagtt cccaagattc
     2281 tccatcgggc agcgggtttt catcccatgt gtggtggtct caggggactt acccatcacc
     2341 atcacctggc agaaggatgg ccggccaatt ccagcaagcc tcggagtaac cattgacaac
     2401 attgacttca ccagctccct gaggatctcc aacctctccc taatgcacaa tgggaattac
     2461 acctgcattg cgagaaacga ggcagcagcc gtggaacacc agagtcagct gattgtgaga
     2521 gttcccccta agttcgtggt acagccccgg gaccaggacg ggatctatgg caaagcagtg
     2581 attctcaatt gctctgcaga gggttatcct gtgcctacaa ttgtgtggaa attctcaaaa
     2641 ggtgctgggg tcccccagtt ccagccaatt gccttgaatg gccgaatcca ggtcctgagt
     2701 aatggctcac tcttgatcaa gcatgttgta gaagaagaca gtggctacta cctctgcaag
     2761 gtcagcaacg atgtgggcgc agacgtcagc aagtccatgt acctcacagt gaaaattcct
     2821 gccatgataa cctcttaccc caacaccacc ctggccactc agggtcaaag gaaggaaatg
     2881 agctgcacag cccatgggga gaagcccatc attgtccgct gggagaaaga ggacaggatc
     2941 attaaccctg aaatggcccg ctacctggta tccaccaagg aggtgggaga ggaagtgata
     3001 tctacgctgc agattttgcc aacagtgaga gaagattccg gtttcttctc ctgccatgct
     3061 atcaattcat acggggagga ccgtggaata attcaactca cagtgcaaga acccccagat
     3121 cctcccgaga ttgagatcaa agatgtcaaa gctcgcacca tcacgctcag gtggaccatg
     3181 gggtttgatg gcaacagccc catcacaggc tatgacattg aatgcaaaaa taaatcagac
     3241 tcctgggatt ctgctcaaag aaccaaagat gtttcccctc agctgaactc ggccaccatc
     3301 attgatatcc acccttcctc cacctacagc atccgcatgt acgccaagaa ccggattggc
     3361 aagagtgagc ccagcaacga gatcaccatc acggcggatg aggcagctcc tgatggtcca
     3421 cctcaggaag ttcacttgga acccacctca tctcagagta tcagggttac ctggaaggct
     3481 cccaagaaac acttacaaaa cgggatcatt cgcggctacc aaataggcta ccgggagtac
     3541 agcacggggg gtaacttcca gttcaacatc atcagtatcg acaccaccgg ggacagcgaa
     3601 gtgtacaccc tggacaacct gaataagttc acgcagtatg gcctggtagt acaggcttgc
     3661 aaccgggccg gcacaggacc ttcttctcag gagatcatta ccaccactct ggaggatgta
     3721 cccagctacc ctcctgaaaa tgtccaagcc atagcaacct caccagaaag catatcaatc
     3781 tcctggtcca cactgtccaa ggaggccttg aatgggattc tccaggggtt cagggtcatc
     3841 tactgggcca acctcataga cggagagctg ggcgagatta agaacgtcac caccacgcag
     3901 ccttccttgg agttggatgg actagagaaa tacaccaact acagtatcca ggtcctggcc
     3961 ttcacccgtg caggggatgg cgtccggagc gagcagatct ttacccgtac caaggaggac
     4021 gttccaggtc ctcctgccgg tgtcaaggcg gcggcagcct cggcctccat ggtcttcgtg
     4081 tcctggctgc ccccgctgaa gctgaacggc atcattcgga agtacacagt gttctgctcc
     4141 catccctacc ctaccgtcat cagtgagttt gaagcctccc ctgactcatt ttcctacaga
     4201 atccctaatc tgagtcggaa tcggcagtat agcgtctggg tggtggcggt gacttccgcc
     4261 ggaagaggca acagcagcga gatcatcact gtggagcccc tagctaaagc tcctgcacgg
     4321 atcctcacgt tcagcgggac agtgactact ccatggatga aggacattgt cttgccttgt
     4381 aaagctgttg gagacccgtc acctgccgta aaatggatga aggatagtaa cgggacaccc
     4441 agcctggtga cgattgatgg ccgcaggagc atcttcagca atgggagttt catcattcgg
     4501 acggtgaaag cagaggactc tggctattac agctgtgttg ccaataacaa ctggggatca
     4561 gatgagatca tattaaattt gcaagtacaa gttccaccag atcagcctcg gctcaccgta
     4621 tccaagacga catcctcctc catcaccctc tcctggctcc ctggagataa tgggggtagc
     4681 tccattagag gctacatcct gcaatactcc gaggataaca gtgagcagtg gggcagcttt
     4741 cccatcagcc ccagcgagcg ttcataccgc ttggaaaacc taaagtgtgg gacttggtat
     4801 aagttcaccc ttactgccca aaatggagta ggtcccgggc gcataagtga aatcatagaa
     4861 gccaaaaccc tggggaaaga accccagttc tccaaggagc aggagctctt cgccagcatc
     4921 aataccaccc gagtgaggct gaatctgatt ggctggaatg acggcggctg tccaatcacc
     4981 tcattcactc ttgaatacag accctttggg accacggtct ggaccacagc tcagcggacc
     5041 tccctttcca agtcctacat tctgtatgac ctgcaagaag ccacgtggta tgaactgcag
     5101 atgagagtgt gcaacagcgc cggctgtgcg gagaagcaag ccaacttcgc cacgctgaac
     5161 tacgatggca gtacaatccc tccactcatt aagtcagttg tccaaagcga agaagggctg
     5221 acaaccaacg aagggctcaa gatcctcgtg accatctcct gcatcctggt cggggttcta
     5281 ctgctctttg tgcttctgct ggttgtgcgg aggagacggc gagagcagag gctgaagagg
     5341 ctgagagatg caaagagttt agctgaaatg ctcatgagca aaaacacacg gacttcagat
     5401 accttaagca aacagcagca gactttgaga atgcacattg atatacccag ggctcagctt
     5461 ttgattgaag agagagacac aatggagacc atagatgacc gctccacagt cctgttgacg
     5521 gatgctgact tcggggaggc agccaaacag aagtcactga cagtgactca cacggtgcat
     5581 taccaatcgg tgtctcaggc caccgggccc ctcgtggatg tctccgatgc tcggccagga
     5641 acgaatccca ccaccaggag gaatgcaaag gctggaccca cagcgagaaa ccggtacgcc
     5701 agccagtgga cgctcaacag accccatcct accatctctg cacacaccct caccacagac
     5761 tggagactgc ctacacccag ggctacagga tccgtggaca aggagagcga cagctacagc
     5821 gtcagcccat cacaagacac agaccgagca agaagcagca tggtctccac agaaagtgcc
     5881 tcctctacct acgaagaact ggccagggcc tatgaacacg ccaagatgga agagcagctg
     5941 aggcatgcca agttcaccat cacagagtgc ttcatatccg atacgtcctc cgagcagttg
     6001 acggcaggga caaatgagta cacggacagt ctgacctcca gtaccccttc agaatcgggg
     6061 atctgcagat tcactgcatc tccccccaaa cctcaggatg gaggacgagt ggtgaacatg
     6121 gcggttccaa aggcccatcg gccaggcgac ctcatacacc tgcctccata cctacgaatg
     6181 gacttcttgt taaaccgggg cgcaccaggc accagcaggg acctgagttt aggacaagcg
     6241 tgcttggaac cccagaaaag tcggaccctg aaacgcccca cggtccttga gcccacccct
     6301 atggaggcct cctcctccac ctcttccacg cgagaaggac agcagtcgtg gcaacaaggg
     6361 gctgtggcca ccttacctca gcgagagggt gcagagctgg gacaggcagc taaaatgagc
     6421 agctcccaag agtcactgct ggactcccgg ggccatttga aaggaaacaa tccctacgca
     6481 aaatcttaca ccttggtata acacatggca cctgatggac agcggttgta aatacaattt
     6541 aaacgagcca atcaaagcta cctttttttt actgaattcc gatatttata attaaagaaa
     6601 attgccaaaa tatattaaaa aaaaaagaag aaagaaagaa agaaagaaag aaaatactga
     6661 aaccacagac agcgcaaaga ctactctgct ttttttccgt ctgagtgtgg gctccatctg
     6721 cctgggcatc tgagttttgg ggaaagaagt ccagttttat gattttcaca ggctatagca
     6781 tttttactga ttttctacaa agtgcatggg gactcattaa accttctgaa cagaagaagt
     6841 tctagcacac aagagtaaaa aaaggaaacg gggggaacta gcctatttgt gaatcgaaga
     6901 gggacgttga cgtgggggca ggggacagct tccgtcacct cgcacacctt tccttcccac
     6961 taggaaccag gccctcggtt tgattttctg ttgttaatca ggatgagtgc tgtcagtgag
     7021 ggggtggggt ggggggaatc cattcggttt tctttttgtt tattttttaa tttgatgaga
     7081 cactctttgc attttgtcta agcgaaataa aagagaaaag gtggtctgcc tttatttgca
     7141 tgtctactga tacctcccta tccattgctc gggcctcctt cctgttcata ttggtgtttg
     7201 tgaacaaaat ggctggaccc agtgcccaat ctaggaaaaa gatgctaagt tttgaacagc
     7261 tcaggtgttg ctgggaagag acaagaagat acaacatcaa ctccatggat ggaaaccaca
     7321 ccaaaggcag cctggtctcc gtccagtatc ctaagcccct cacaggactc aggtccttgc
     7381 cagttgcagg acctgctctc taactcagta gggtcagcag accatttcca aatccagcgc
     7441 actgctcttt gtcaataaag ttttattgga agaagtccaa a
//
