LOCUS       NM_007882               5305 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus desmocollin 3 (Dsc3), transcript variant 1, mRNA.
ACCESSION   NM_007882
VERSION     NM_007882.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5305)
  AUTHORS   Xu,T., Herkens,L., Jia,T., Klinkhammer,B.M., Kant,S., Krusche,C.A.,
            Buhl,E.M., Hayat,S., Floege,J., Strnad,P., Kramann,R., Djudjaj,S.
            and Boor,P.
  TITLE     The role of desmoglein-2 in kidney disease
  JOURNAL   Kidney Int 105 (5), 1035-1048 (2024)
   PUBMED   38395410
REFERENCE   2  (bases 1 to 5305)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5305)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   4  (bases 1 to 5305)
  AUTHORS   Godsel,L.M., Roth-Carter,Q.R., Koetsier,J.L., Tsoi,L.C.,
            Huffine,A.L., Broussard,J.A., Fitz,G.N., Lloyd,S.M., Kweon,J.,
            Burks,H.E., Hegazy,M., Amagai,S., Harms,P.W., Xing,X., Kirma,J.,
            Johnson,J.L., Urciuoli,G., Doglio,L.T., Swindell,W.R.,
            Awatramani,R., Sprecher,E., Bao,X., Cohen-Barak,E., Missero,C.,
            Gudjonsson,J.E. and Green,K.J.
  TITLE     Translational implications of Th17-skewed inflammation due to
            genetic deficiency of a cadherin stress sensor
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34905516
REFERENCE   5  (bases 1 to 5305)
  AUTHORS   Ostermann,A.L., Wunderlich,C.M., Schneiders,L., Vogt,M.C.,
            Woeste,M.A., Belgardt,B.F., Niessen,C.M., Martiny,B., Schauss,A.C.,
            Frommolt,P., Nikolaev,A., Hovelmeyer,N., Sears,R.C., Koch,P.J.,
            Gunzel,D., Bruning,J.C. and Wunderlich,F.T.
  TITLE     Intestinal insulin/IGF1 signalling through FoxO1 regulates
            epithelial integrity and susceptibility to colon cancer
  JOURNAL   Nat Metab 1 (3), 371-389 (2019)
   PUBMED   32694718
REFERENCE   6  (bases 1 to 5305)
  AUTHORS   Gadhavi,P.L., Greenwood,M.D., Strom,M., King,I.A. and Buxton,R.S.
  TITLE     The regulatory region of the human desmocollin 3 promoter forms a
            DNA four-way junction
  JOURNAL   Biochem Biophys Res Commun 281 (2), 520-528 (2001)
   PUBMED   11181078
REFERENCE   7  (bases 1 to 5305)
  AUTHORS   Bierkamp,C., Schwarz,H., Huber,O. and Kemler,R.
  TITLE     Desmosomal localization of beta-catenin in the skin of plakoglobin
            null-mutant mice
  JOURNAL   Development 126 (2), 371-381 (1999)
   PUBMED   9847250
REFERENCE   8  (bases 1 to 5305)
  AUTHORS   King,I.A., Angst,B.D., Hunt,D.M., Kruger,M., Arnemann,J. and
            Buxton,R.S.
  TITLE     Hierarchical expression of desmosomal cadherins during stratified
            epithelial morphogenesis in the mouse
  JOURNAL   Differentiation 62 (2), 83-96 (1997)
   PUBMED   9404003
REFERENCE   9  (bases 1 to 5305)
  AUTHORS   Chidgey,M.A., Yue,K.K., Gould,S., Byrne,C. and Garrod,D.R.
  TITLE     Changing pattern of desmocollin 3 expression accompanies epidermal
            organisation during skin development
  JOURNAL   Dev Dyn 210 (3), 315-327 (1997)
   PUBMED   9389456
REFERENCE   10 (bases 1 to 5305)
  AUTHORS   Buxton,R.S., Wheeler,G.N., Pidsley,S.C., Marsden,M.D., Adams,M.J.,
            Jenkins,N.A., Gilbert,D.J. and Copeland,N.G.
  TITLE     Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely
            linked in the proximal region of chromosome 18
  JOURNAL   Genomics 21 (3), 510-516 (1994)
   PUBMED   7959727
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105159.15, BY151533.1,
            BY745760.1, Y11169.1 and CD773111.1.
            
            On Mar 20, 2007 this sequence version replaced NM_007882.2.
            
            Summary: This gene encodes a member of the cadherin family of
            proteins that mediates adhesion in desmosomes. Together with
            desmogleins, the encoded protein forms the transmembrane core of
            desmosomes, a multiprotein complex involved in cell adhesion,
            organization of the cytoskeleton, cell sorting and cell signaling.
            Mice lacking the encoded protein exhibit a pre-implantation lethal
            phenotype. This gene is located in a cluster of desmosomal cadherin
            genes on chromosome 18. This gene encodes distinct isoforms, some
            or all of which may undergo similar processing to generate the
            mature protein. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC105159.15        16965-16993
            30-332              BY151533.1         2-304
            333-476             AC105159.15        29357-29500
            477-606             BY745760.1         523-652
            607-1475            Y11169.1           607-1475
            1476-1476           AC105159.15        44803-44803
            1477-1788           Y11169.1           1477-1788
            1789-1989           CD773111.1         442-642
            1990-2063           AC105159.15        47611-47684
            2064-2288           AC105159.15        50619-50843
            2289-2410           AC105159.15        52721-52842
            2411-2665           AC105159.15        53180-53434
            2666-5305           AC105159.15        55493-58132
FEATURES             Location/Qualifiers
     source          1..5305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.11 cM"
     gene            1..5305
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /note="desmocollin 3"
                     /db_xref="GeneID:13507"
                     /db_xref="MGI:MGI:1194993"
     exon            1..241
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..2863
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="desmocollin-3 isoform 1 preproprotein"
                     /protein_id="NP_031908.3"
                     /db_xref="CCDS:CCDS37744.1"
                     /db_xref="GeneID:13507"
                     /db_xref="MGI:MGI:1194993"
                     /translation="MVVPEFRSPQCRALCTKLLLTLWVFSFVGEACKKVTFHVPSTLE
                     ADKIIGRVSLKECLSSADGIMPSDPDFRVLDDGSVYPTRAVVLSDEKRSFTIQLSDSK
                     MQTQKEIPVILEHKKKVLKKRHTKETVLRRSKRRWAPIPCSMQENSLGPFPLFLQQVQ
                     SDAAQNYTVFYSISGRGADQEPLNWFFIERDTGNLYCTRPVDREEYDVFDLIAYASTA
                     DGYSADLPLPLPIKIEDENDNYPLFTEAIYAFEVPEGSRLGTVVGTVCATDKDEPDTM
                     HTRLKYSILEQTPPSPGLFSVHPDTGVITTVSHYMDREVVDKYKLIMKVQDMNGQFFG
                     LISTSTCIITVQDSNDNAPTFRQNTYETAVEENTYNVEILRIPVDDKDMINTANWKAN
                     FTILKGNENGWFKITTDPVTNEGVLCVVKPLDYEENRQVTLEIGVNNEAPFIKDVANR
                     IPTMNRAMVTVHVKDQNEGPECKPPEQYVRIKENSAVGSKINGYKAYDPETKNSNGLR
                     YKKLQDPKDWVSIEEVSGLLTISKTLDREIMAPRNDMYNITVMAIDQEGKSCTGTLAV
                     NIEDVNDNAPEIIQDYIVICKPKMGYTDISAVDPDEPIHGPPFQFNLANTSPEVNRIW
                     TLNQVNDTAARLSYQKTADVQIYNVPVTVKDRAGQSATKILRVNLCDCTHPSQCPLRS
                     RSAGITLGKWAILAILLGIALLFSVLLTLVCGVVTARKGKHFPEDLAQQNLIISNTEA
                     PGDDRVCSANGFTTHTANNSSQGFCGTMGSGMRNGGQETIEMMKGHQTLDSCRVAGHH
                     HTLDSGRGGHMDTDNCRYTYSEWHSFTQPRLGEKLHVCNQNEDHIPSQDYVLTYNYEG
                     RGSPAGSVGCCSEKQEEEGLDFLNNLEPKFLTLAETCTKR"
     exon            242..326
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            327..526
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            527..646
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            647..802
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            803..947
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1114
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1249
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1435
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1695
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1838
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2063
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2288
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2410
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2665
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..5305
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5278..5283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /note="hexamer: AATAAA"
     regulatory      5284..5289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /note="hexamer: AACAAA"
     polyA_site      5297
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /note="major polyA site"
     polyA_site      5304
                     /gene="Dsc3"
                     /gene_synonym="5430426I24Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccagcgtctc cttggtccaa tccagtttca ggcgagaaca ccgctcctgg gcgaagaagc
       61 ttgagagagg ccagaacgac ttctcggcaa actgctgcgg aaaccctcct gcgtccaggc
      121 ttagagtcct tgtttggcgc cggcctgcgt cctcctgagg ctgcactgtg cgatggtggt
      181 tcctgagttc cggagcccac agtgcagggc actatgcacg aagctgctgc tgaccctctg
      241 ggtcttcagt tttgttggtg aagcctgtaa aaaggtgaca tttcatgtac cttcaacact
      301 agaggcagac aagatcatcg gaagagttag tttgaaagag tgtctcagct cggcagatgg
      361 catcatgcca agtgatcctg atttcagagt tctagatgat gggtcagttt atccgaccag
      421 agctgttgta ttgtctgatg agaaaagatc ttttaccatt cagctttctg attcaaagat
      481 gcagacacag aaagagatcc ctgtaatcct ggagcacaag aagaaggtac tgaagaaaag
      541 acacactaag gaaactgtcc tcagaagatc taagagaaga tgggcaccca ttccatgttc
      601 aatgcaagaa aattccttgg gtcccttccc attgtttctt caacaggttc agtctgatgc
      661 agctcagaac tacacagtct tctattcaat aagtgggcgt ggagctgatc aagaaccact
      721 taactggttt ttcatcgaga gagacactgg gaatctatat tgtactcggc ctgtggatcg
      781 tgaggaatat gatgtttttg atttgattgc ctatgcatcc actgcagatg gctattcagc
      841 agatttacct ctcccactgc ccatcaaaat agaggatgaa aatgacaatt accctctttt
      901 tacagaagca atttatgctt ttgaagttcc agaaggcagt agacttggta ctgtagtggg
      961 aacagtttgt gccacggata aagatgagcc tgacactatg cacacacgcc tcaagtacag
     1021 catcttggag cagaccccac catcacctgg gcttttttct gtgcaccctg acacaggtgt
     1081 catcaccacc gtctctcact acatggacag agaggtcgtg gacaagtaca aactgataat
     1141 gaaagttcag gacatgaatg gccaattttt tggactaatc agtacatcaa cttgtatcat
     1201 aactgtgcaa gattccaatg acaatgcacc cacattcaga caaaatactt atgaaactgc
     1261 tgtggaggaa aatacatata atgttgaaat cttgcgcata cctgtagatg ataaggacat
     1321 gattaacact gccaactgga aggcaaattt caccatctta aaaggaaatg aaaatggatg
     1381 gttcaaaatc acaacagacc cagtgacaaa tgaaggtgtt ctgtgtgttg tgaagccact
     1441 ggattatgaa gaaaatcgtc aagtgaccct agagattggt gtgaacaacg aagctccatt
     1501 cattaaagat gttgcaaacc gaattcccac catgaaccgg gctatggtta cagtacatgt
     1561 gaaggatcag aatgaggggc cagaatgcaa gcccccagag caatatgtgc ggatcaaaga
     1621 gaactcagca gttgggtcta agatcaatgg ctacaaggcc tacgaccctg aaaccaagaa
     1681 tagcaatggc ttaaggtaca aaaaattgca ggatcctaaa gactgggtca gcattgaaga
     1741 agtttcgggg ttgcttacca tatcaaaaac cctagacaga gaaataatgg ctccaagaaa
     1801 tgacatgtac aatattacag tcatggcaat tgaccaagag ggtaaatcat gcacaggaac
     1861 acttgcagtg aacatcgagg atgtgaatga caacgcacca gagataattc aagattatat
     1921 tgttatctgt aagccaaaga tggggtacac ggacatttca gctgtggatc ctgatgaacc
     1981 tatccatggc cctccctttc agttcaactt ggcaaacact tctccagaag tcaacagaat
     2041 ctggaccctc aaccaagtta atgatacagc tgctcgcctg tcctatcaga aaactgcgga
     2101 tgttcaaata tacaacgttc ctgttactgt aaaagacaga gcaggccaat ctgcaaccaa
     2161 aatcttgaga gttaacctgt gtgattgtac tcatcccagc caatgtccgc tcagatcaag
     2221 gagtgcagga attaccctgg gaaagtgggc catccttgcc atcttgctgg gcattgctct
     2281 gctattttcg gtactgctaa ctttggtatg tggagttgtt actgcccgaa aaggaaaaca
     2341 cttccctgaa gatttagcgc agcaaaactt aattatatca aataccgaag cacctgggga
     2401 tgacagagtg tgctctgcca atggattcac cacccacact gccaacaact ccagccaagg
     2461 cttctgtggt acaatggggt caggaatgag gaatggtggg caggagacca tcgagatgat
     2521 gaaaggacac cagaccttgg actcctgccg tgtggccggg catcaccata ccctggactc
     2581 cggcagggga ggacacatgg atactgacaa ctgcagatac acatactcag agtggcacag
     2641 tttcactcaa ccccgacttg gtgaaaaatt gcatgtgtgt aatcagaatg aagaccacat
     2701 cccatcccaa gactatgtcc tcacctataa ctatgaaggc agagggtctc cggccggctc
     2761 tgtaggttgc tgcagtgaaa agcaggaaga agagggactt gactttttaa acaacttgga
     2821 acccaaattt cttacattgg cagaaacatg cacaaagaga taatgccagt gggttacaat
     2881 ttgagatagc cttatcagac attccagaaa tttgaaacaa tgatactgta aaacagactc
     2941 agtacttata caaaatggtc ttgagttatg ctggcttgac atgtgatatt ctgagtgtag
     3001 tctagtgtaa aattgacaca tattcggaag aaaccatttg tgaaattctg atcttttcca
     3061 ggagttttgt gctgtgtgta actctcctgc aaggtgaggc aggaactgtg ctccagttcc
     3121 tggtctgtta tagggtcacg agatcctggc tgtgtgcagg gcatgtatct tcaagtacag
     3181 ctaaggtata cctacattgt gtggctaaga gcttctgcac atattatttt ctccatttta
     3241 caatctcccc cctatcaatt tgcgttgtta atgcagtttg ttgctgacca cttttcaaag
     3301 agtacaagtg ttaaaacaga ggaccagaag cgctcaagct gtagtagtag agttaagtaa
     3361 ggtccacaga gaactcaccc tgtcaggagg atattttcca aacaaatgaa actattagtc
     3421 tgaaaacagt taagttgtac cactatcaca tccttctaag gatggtttaa gaaacaaaca
     3481 aaacaccaag gaaggatgtt ttaggacaga acaaacttat gatgcattgc attaaaactt
     3541 ttgcagaggt gaagatcgag ggcctgactc tttataattt ctatcaaata ctttattgga
     3601 cattggaaac aaacttttgt acgctggcct aatgtgtgcc aattttctgt ttcagcacct
     3661 tctgaagcca gtgtttattt gcaaccaaag tatgcactgg aatgacattt aaaatacaaa
     3721 ggaaacaaca aggaaaatga caatgattga aaataaggct ggggatggct tatcttgtaa
     3781 aaagaaatca ggatcttaaa ggagtagact tccttctgcc aggctacagt gggctgtgtg
     3841 acacctaaaa gtgtcagctt ctgcctgctt gagtaatttg tttaaattta gaaacatata
     3901 ttgtagtttt agtggggaag aaagagacag ccacatggaa gagtagattc attttgcagg
     3961 atatatatac atttgtgcat tcaaacatta gcagccaatt acgagattca gccctctaca
     4021 ctgctggagc ctacggcttc ctggcctgca gttcacagaa aggatgtggt tttcttggga
     4081 cctagtgttg acagatgctg aaatacatgc tctaccgctc ttttcttcta tgtcttctct
     4141 ccttttcttt tttttttcct ttcttttatt ctattctggg gtattggatt acctctgcgt
     4201 attgcctggc ctcaaaatct tagtcctcct gttgcagtct ctggatatta gaattatagg
     4261 cagatactac cattcttgtt attgaagtag agccaattgg tcttgtcctt taaagttgga
     4321 gccttcatgg tgctgggaga tagtgggaaa aatgttgtta ccttcatgtg gactcagaat
     4381 catagctttg tttccagaac ccactcagac tttatgtgaa agtagctctg gcagccgtcc
     4441 agagagtcag cccttctttt tcctgtctgc caaggctgct tgaaagccct gcagcagatt
     4501 cactgagctg gcaaatcttc cagaaactct ataatccttc agagtgactt tatttttatt
     4561 tttatcagtt tgctttgtta gaggggattt atcacttaca gaagaaccag gaattttgga
     4621 tctatgcagg aaagaccttt ttcagacctc ttctcatctg gaatatgaaa tcaggaaagt
     4681 gggctgcaat gggggatgta actcagcctg gcatggacaa aataaaggaa ttgagtccaa
     4741 gctttgcgta aaacaggcat gatgacaaca tgcctgtagc cacagcactt aggaggcagg
     4801 gagcaggaaa atcgagggag ttcaacattc tccataatta tgtagaagct tgaggccagt
     4861 ttaggttaca tgtggtgagt ctttggatgg gccagaattg ttatactggt caaactacat
     4921 gtgcatctaa gattttgatt agattttaat ttttttcctg tttttatttt accccaaggg
     4981 ttactttcat gatagacttt tgaaacaatc aatttgtttt ttgttcacag catcatataa
     5041 tattatactc ttctcacatg tataggtgaa aattgtgcta ttttagtgtg taagaaaaat
     5101 catctctcct tttgtaacac tttccttccc tcccctgggt ttttatgtaa atgtacagtc
     5161 catttttttc ttacatttat aaggaagaag ttaactgtct aaagaacaat tggagtttat
     5221 ttttcaatgt tataaacaac tttaatttga caattaaatt gcttttgaac cttgtcaaat
     5281 aaaaacaaac aagcgttgaa tgtgt
//
