LOCUS       NM_001317365            4594 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus desmocollin 2 (Dsc2), transcript variant Dsc2a, mRNA.
ACCESSION   NM_001317365 XM_006525592
VERSION     NM_001317365.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4594)
  AUTHORS   Xu,T., Herkens,L., Jia,T., Klinkhammer,B.M., Kant,S., Krusche,C.A.,
            Buhl,E.M., Hayat,S., Floege,J., Strnad,P., Kramann,R., Djudjaj,S.
            and Boor,P.
  TITLE     The role of desmoglein-2 in kidney disease
  JOURNAL   Kidney Int 105 (5), 1035-1048 (2024)
   PUBMED   38395410
REFERENCE   2  (bases 1 to 4594)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4594)
  AUTHORS   Raya-Sandino,A., Luissint,A.C., Kusters,D.H.M., Narayanan,V.,
            Flemming,S., Garcia-Hernandez,V., Godsel,L.M., Green,K.J.,
            Hagen,S.J., Conway,D.E., Parkos,C.A. and Nusrat,A.
  TITLE     Regulation of intestinal epithelial intercellular adhesion and
            barrier function by desmosomal cadherin desmocollin-2
  JOURNAL   Mol Biol Cell 32 (8), 753-768 (2021)
   PUBMED   33596089
  REMARK    GeneRIF: Regulation of intestinal epithelial intercellular adhesion
            and barrier function by desmosomal cadherin desmocollin-2.
REFERENCE   4  (bases 1 to 4594)
  AUTHORS   Lin,J.I., Feinstein,T.N., Jha,A., McCleary,J.T., Xu,J.,
            Arrigo,A.B., Rong,G., Maclay,L.M., Ridge,T., Xu,X. and Lo,C.W.
  TITLE     Mutation of LRP1 in cardiac neural crest cells causes congenital
            heart defects by perturbing outflow lengthening
  JOURNAL   Commun Biol 3 (1), 312 (2020)
   PUBMED   32546759
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4594)
  AUTHORS   Huber,O.
  TITLE     Structure and function of desmosomal proteins and their role in
            development and disease
  JOURNAL   Cell Mol Life Sci 60 (9), 1872-1890 (2003)
   PUBMED   14523549
  REMARK    Review article
REFERENCE   6  (bases 1 to 4594)
  AUTHORS   Collins,J.E., Lorimer,J.E., Garrod,D.R., Pidsley,S.C., Buxton,R.S.
            and Fleming,T.P.
  TITLE     Regulation of desmocollin transcription in mouse preimplantation
            embryos
  JOURNAL   Development 121 (3), 743-753 (1995)
   PUBMED   7536656
REFERENCE   7  (bases 1 to 4594)
  AUTHORS   Ishikawa,H., Silos,S.A., Tamai,K., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Uitto,J.
  TITLE     cDNA cloning and chromosomal assignment of the mouse gene for
            desmoglein 3 (Dsg3), the pemphigus vulgaris antigen
  JOURNAL   Mamm Genome 5 (12), 803-804 (1994)
   PUBMED   7894164
REFERENCE   8  (bases 1 to 4594)
  AUTHORS   Lorimer,J.E., Hall,L.S., Clarke,J.P., Collins,J.E., Fleming,T.P.
            and Garrod,D.R.
  TITLE     Cloning, sequence analysis and expression pattern of mouse
            desmocollin 2 (DSC2), a cadherin-like adhesion molecule
  JOURNAL   Mol Membr Biol 11 (4), 229-236 (1994)
   PUBMED   7711832
REFERENCE   9  (bases 1 to 4594)
  AUTHORS   Buxton,R.S., Wheeler,G.N., Pidsley,S.C., Marsden,M.D., Adams,M.J.,
            Jenkins,N.A., Gilbert,D.J. and Copeland,N.G.
  TITLE     Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely
            linked in the proximal region of chromosome 18
  JOURNAL   Genomics 21 (3), 510-516 (1994)
   PUBMED   7959727
REFERENCE   10 (bases 1 to 4594)
  AUTHORS   Buxton,R.S., Cowin,P., Franke,W.W., Garrod,D.R., Green,K.J.,
            King,I.A., Koch,P.J., Magee,A.I., Rees,D.A., Stanley,J.R. et al.
  TITLE     Nomenclature of the desmosomal cadherins
  JOURNAL   J Cell Biol 121 (3), 481-483 (1993)
   PUBMED   8486729
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY093917.1, AK048547.1,
            BY422831.1 and BY425109.1.
            
            On Dec 2, 2015 this sequence version replaced XM_006525592.1.
            
            Summary: This gene encodes a member of the desmocollin protein
            subfamily. Desmocollins are cadherin-like transmembrane
            glycoproteins that are major components of the desmosome.
            Desmosomes are cell-cell junctions that help resist shearing forces
            and are found in high concentrations in cells subject to mechanical
            stress. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (Dsc2a) encodes the longest
            isoform (Dsc2a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777535.907400.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BY093917.1         1-49
            50-2813             AK048547.1         2-2765
            2814-4419           AK048547.1         2812-4417
            4420-4583           BY422831.1         209-372
            4584-4594           BY425109.1         373-383
FEATURES             Location/Qualifiers
     source          1..4594
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.14 cM"
     gene            1..4594
                     /gene="Dsc2"
                     /note="desmocollin 2"
                     /db_xref="GeneID:13506"
                     /db_xref="MGI:MGI:103221"
     exon            1..371
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..3011
                     /gene="Dsc2"
                     /note="isoform Dsc2a preproprotein is encoded by
                     transcript variant Dsc2a; epithelial type 2 desmocollin"
                     /codon_start=1
                     /product="desmocollin-2 isoform Dsc2a preproprotein"
                     /protein_id="NP_001304294.1"
                     /db_xref="CCDS:CCDS84361.1"
                     /db_xref="GeneID:13506"
                     /db_xref="MGI:MGI:103221"
                     /translation="MAAVGSMRSGSPAFGLGHLLTLAILALASDACKEVVLQVPSELP
                     AEKFVGRVNLMDCLKSADIVHLSDPDFQVLEDGSVYTTSSVVLSSGQRSFTIWLFSTD
                     SQEEREISVHLEGPVEVLNKRPHTEKVLSRAKRRWAPIPCSMLENSLGPFPLFLQQIQ
                     SDTAQNYTIYYSIRGPGVDKEPLNLFYVERDTGNLYCTGRVDREQYESFELTAFATTP
                     DGYTPEYPLPLLIKIEDENDNYPIFTQKLYSFTVQENSRIGSIVGEVCATDLDEPDTM
                     HTRLRYSILEQSPSPPMLFTMHPSTGVITTTSAQLDRELIDKYQLLIKVQDMDGQYFG
                     LHTTAKCIITIEDVNDNLPTFTRTTYVTSVEENTVNVEILRLTVQDKDLVNSPNWRAN
                     YTILKGNENGNFKIVTDPKTNEGILCVIKPLDYEERQQVTLQIGVVNEAPYTREASSK
                     SPMSTATVTVTVTNQDEGPECIPPMQTVRIQENVPVGTRNDGYKAYDPETRSSSGIRY
                     RKLSDPRGWVTVNEDSGSITIFRALDREAETVRNGIYNITVLALDADGRSCTGTLGII
                     LEDVNDNGPFIPKQTVVICKATMSSAEIVAVDLDDPVNGPPFDFSLESSDSEVQRMWR
                     LTRINDTAARLSYQNDPSFGSYAVPIRVTDRLGLSSVTTLNVLVCDCITESDCTLRSG
                     ERTGYADVRLGPWAILAILLGIALLFCILFTLVCSVSRASKQQKILPDDLAQQNLIVS
                     NTEAPGDDKVYSTNGLTTQTMGASGQTAFTTMGTGVKSGGQETIEMVKGGQQTLDSRR
                     GAGYHHHTLDPCRGGHVEVDNYRHTYSEWYNFIQPRLGDKVQFCHTDDNQKLAQDYVL
                     TYNYEGKGSAAGSVGCCSDLQEEDGLEFLDHLEPKFRTLAEVCAKR"
     exon            372..456
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            457..656
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..776
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..932
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1077
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1244
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1379
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1565
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1822
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1965
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2190
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2427
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2552
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2813
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..4584
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4563..4568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dsc2"
                     /note="hexamer: AATAAA"
     polyA_site      4584
                     /gene="Dsc2"
                     /note="major polyA site"
ORIGIN      
        1 ggggggtgac aagggacata taggtggcct ctgctggtga gaaataccta gtacaggtga
       61 aagggtggcg gccagaggga gttcccaccg gttgaattct taaagtcatg aagactcaag
      121 aaaaataaca aggagtggcc gattcgagtc ttttggactt gcccagagct ccaccctcgg
      181 acagaggaaa agcccctggg gacccaggcg ggagcatcag acaagcgcga gaaaagcgcc
      241 tgtgtgcgcg ctccacctct gcgcagcggg tgcggggcgg tgacctgtcc cttgagctgg
      301 ccatggcggc tgtgggatct atgcgctccg ggagccctgc cttcggcctg ggacacctgt
      361 tgacccttgc gatccttgca cttgcctctg atgcctgtaa agaagtcgtc ctccaggtcc
      421 cctctgaact acctgccgag aaatttgttg gcagagtgaa cctgatggac tgccttaaat
      481 cagcagacat agttcatctg agtgatcctg acttccaagt cttagaagat ggttctgtgt
      541 acacaaccag ttctgttgtt ttgtcctcgg ggcaaagaag ctttactata tggcttttta
      601 gcacagacag ccaagaagaa agggagatat ctgtccattt agagggccca gtagaggtac
      661 taaataaaag accgcataca gagaaggttc tcagccgtgc caagagaaga tgggctccta
      721 tcccttgttc catgctagag aattcattgg gtcccttccc acttttcctt caacagatcc
      781 agtctgacac agctcaaaac tataccatat actattccat cagaggtcca ggagttgata
      841 aagaacctct aaacttattt tatgtggaaa gagatactgg aaacctgtat tgcactggtc
      901 gtgtagatcg tgagcagtat gagtcctttg agctgactgc atttgcaaca actccagatg
      961 ggtatacgcc agagtaccca ctgccgctcc tcattaaaat agaggacgag aacgataatt
     1021 acccgatctt tacacagaaa ctgtacagct tcacagttca ggaaaatagt cgcattggtt
     1081 ctattgtggg ggaggtctgt gcaaccgacc tggatgagcc agacacaatg cacactcgcc
     1141 tgaggtactc catcctggag cagtcgcctt ctccacccat gctatttact atgcatccca
     1201 gcactggtgt gatcactacc acgtcggctc agctggacag agagttaatt gacaagtacc
     1261 agttgctaat aaaagtccag gatatggatg gccagtattt tggtttgcac acaacagcaa
     1321 agtgcatcat tactattgaa gatgtgaatg acaacctgcc cacgttcact cgcactacgt
     1381 atgtgacatc agtggaagaa aatacagtta atgtggaaat cttgcgactt actgttcagg
     1441 ataaagattt agttaactca cctaattgga gagctaatta caccattttg aagggcaatg
     1501 aaaatggaaa ttttaaaatc gtaacagatc ctaaaaccaa tgaaggcatt ctgtgtgtga
     1561 ttaagcctct ggactatgaa gaacggcaac aggtgaccct gcaaattgga gtagttaatg
     1621 aagctccata cactagagag gctagctcaa agtcacccat gagcacagcc acagtgactg
     1681 tcaccgtgac aaatcaggat gagggccccg agtgtatccc tccaatgcaa actgtgagga
     1741 ttcaagaaaa tgtaccagtt gggactagaa atgatggata taaggcatat gacccagaga
     1801 ccagaagcag cagtggcata aggtacagaa agttaagtga cccaagaggg tgggtcactg
     1861 ttaatgaaga ttcaggatcg atcactattt tccgagcgtt ggatcgagag gctgagactg
     1921 tcagaaatgg catttacaat attacagtcc ttgcgttaga tgcagatggg agaagctgta
     1981 ctggaactct gggaatcata cttgaagatg tgaatgataa tggcccattc atacccaagc
     2041 agacagtggt gatatgcaag gctaccatgt cctctgctga aattgttgca gttgatctcg
     2101 atgatccagt gaatggccca ccatttgatt tcagtttgga gagctctgat tcggaagttc
     2161 agaggatgtg gaggctaaca agaatcaatg atacagcagc tcgtctttcc tatcagaacg
     2221 acccttcatt tggatcctat gcagttccca ttcgagttac agacagactt ggtctgtcct
     2281 cagtaaccac attgaatgtc cttgtatgtg actgcattac tgaaagtgac tgcacactcc
     2341 gctctggaga aaggactggc tatgctgatg tgagacttgg accatgggcc atccttgcta
     2401 tactgttggg catagccttg ctattttgta tcctgtttac attagtctgt agtgtttccc
     2461 gggcatcaaa acaacagaaa attcttcctg atgacttagc tcaacagaac ctaattgtat
     2521 caaacaccga ggctcctgga gatgacaaag tttattccac aaacggcttg acaactcaaa
     2581 ctatgggagc ttctgggcag acagctttca ccaccatggg aactggagtc aaaagtggag
     2641 ggcaagagac cattgagatg gtaaaaggag ggcagcagac tttggactca cgcagagggg
     2701 ctggctatca tcaccatacc ctggatcctt gcaggggagg acatgtggag gtggacaact
     2761 acagacacac ttactcagag tggtacaatt tcattcagcc ccgacttggt gataaggtac
     2821 agttttgcca tacggatgac aaccagaagc ttgctcaaga ctacgtcctc acatacaact
     2881 atgagggaaa aggctcggct gctggctctg tgggttgctg tagtgaccta caggaagaag
     2941 acgggcttga gtttttggac catctggagc ccaaatttag gacattggca gaagtatgtg
     3001 caaagaggtg aacgacttct aataggaaaa cgaaaactaa tggattcact gccttgccct
     3061 ccctgctttt cactgtaaac caggagtttt caaaaaacag aagatgttat atttggggct
     3121 ccctctccta tctcggtctg cagaatctcc atgcaaatgc acatttacag agaaactttg
     3181 caattagtac ttgaaaacca ttatgcatgg atttcaatta cttctttttt accagatgac
     3241 atcttaggtg gaaacttaag gaaatttgca ttactgttta cattgggtat aatgacagca
     3301 gccaacttat agtgcaataa agttgaatgg atttgagtct attatagact attgactata
     3361 acccaattgg agactgtaga caccattatc tccagttaat ggattaactg gttgttcata
     3421 cggtgcttgg aaacagttgt tttcctaaac attctaaact gtatatgctg tgccttgctt
     3481 tagttatatt cttgtaatat ggcctggctt catagtacaa aggtagattg ccaggcagcc
     3541 tttgagtgtg cttgaaattc caatccagtg ggtgttagct tctgttctgt gtaaaatcct
     3601 gccctgaatc acaatctctt ttgtaccaac tttgtcagtt aaatttagtt ttcaaaactt
     3661 ctttataatg tgttctgttt ttctaaaagt tttgtctgtg aacaccaaat gctctaaact
     3721 cccatcttct ctatttttaa tttttttttc attttctctc ctgtttgact ttgcaaggtc
     3781 tgcttccaag atattcctaa aacttatctt ttctcataaa atagttggtg tgtatgcata
     3841 tcattgttgg ttttcttaag ctcaatataa tagcaacatt attgttttgg attttttggt
     3901 aattattgct tcatttttgt ccttagtaaa gaacttttaa ttttcccagt gaaactatgg
     3961 gactctttca taatcttttt gaagcaatgt tcttcgtgac agaagcaata gtgtatttag
     4021 aagtaggttg tggcaatcta atatagaata gcatagttac aatttccatc tttaattcag
     4081 ggaccctgga agtgggaagt agtgatagag tttagactaa gcatctcagc ataataatct
     4141 caaacaatct ctaggataat gccttctcca gtgttttaga tgatatggct agttataatt
     4201 gcattgttgt aaaattagtt ttagaagcag tttgtaatta tagttatttt atgaaatata
     4261 ggaaatgggc caagcaattt aaaatttttt agaaatttac acacaagtaa acttcatacc
     4321 acaggacaca ctcccttcaa tcagtgagct cagcacttaa cctagatgga tggatattct
     4381 aggttggata attggtgcaa tatagatatg tgtgattgtt cactgtgtgt ctgtcttgaa
     4441 tttatcaagt tggcttacaa caattgtttt cagaacaaac attgggaaaa aatgtaaaca
     4501 tgaactatgt atgcagtgag gtcattatta cttagtgaaa aatatttctc agagttattt
     4561 ttaataaatt atatataaaa tggtaaaaaa aaaa
//
