LOCUS       NM_001291804            4961 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus desmocollin 1 (Dsc1), transcript variant 1, mRNA.
ACCESSION   NM_001291804 XM_006525591
VERSION     NM_001291804.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4961)
  AUTHORS   Xu,T., Herkens,L., Jia,T., Klinkhammer,B.M., Kant,S., Krusche,C.A.,
            Buhl,E.M., Hayat,S., Floege,J., Strnad,P., Kramann,R., Djudjaj,S.
            and Boor,P.
  TITLE     The role of desmoglein-2 in kidney disease
  JOURNAL   Kidney Int 105 (5), 1035-1048 (2024)
   PUBMED   38395410
REFERENCE   2  (bases 1 to 4961)
  AUTHORS   Godsel,L.M., Roth-Carter,Q.R., Koetsier,J.L., Tsoi,L.C.,
            Huffine,A.L., Broussard,J.A., Fitz,G.N., Lloyd,S.M., Kweon,J.,
            Burks,H.E., Hegazy,M., Amagai,S., Harms,P.W., Xing,X., Kirma,J.,
            Johnson,J.L., Urciuoli,G., Doglio,L.T., Swindell,W.R.,
            Awatramani,R., Sprecher,E., Bao,X., Cohen-Barak,E., Missero,C.,
            Gudjonsson,J.E. and Green,K.J.
  TITLE     Translational implications of Th17-skewed inflammation due to
            genetic deficiency of a cadherin stress sensor
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34905516
REFERENCE   3  (bases 1 to 4961)
  AUTHORS   Quispe Calla,N.E., Vicetti Miguel,R.D., Aceves,K.M., Torres,A. and
            Cherpes,T.L.
  TITLE     Depot-medroxyprogesterone acetate reduces genital cell-cell
            adhesion molecule expression and increases genital herpes simplex
            virus type 2 infection susceptibility in a dose-dependent fashion
  JOURNAL   Contraception 100 (5), 397-401 (2019)
   PUBMED   31302121
  REMARK    GeneRIF: Depot-medroxyprogesterone acetate reduces genital
            cell-cell adhesion molecule expression and increases genital herpes
            simplex virus type 2 infection susceptibility in a dose-dependent
            fashion.
REFERENCE   4  (bases 1 to 4961)
  AUTHORS   Choi,Y.J., Laclef,C., Yang,N., Andreu-Cervera,A., Lewis,J., Mao,X.,
            Li,L., Snedecor,E.R., Takemaru,K.I., Qin,C., Schneider-Maunoury,S.,
            Shroyer,K.R., Hannun,Y.A., Koch,P.J., Clark,R.A., Payne,A.S.,
            Kowalczyk,A.P. and Chen,J.
  TITLE     RPGRIP1L is required for stabilizing epidermal keratinocyte
            adhesion through regulating desmoglein endocytosis
  JOURNAL   PLoS Genet 15 (1), e1007914 (2019)
   PUBMED   30689641
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4961)
  AUTHORS   Cheng,X., Mihindukulasuriya,K., Den,Z., Kowalczyk,A.P.,
            Calkins,C.C., Ishiko,A., Shimizu,A. and Koch,P.J.
  TITLE     Assessment of splice variant-specific functions of desmocollin 1 in
            the skin
  JOURNAL   Mol Cell Biol 24 (1), 154-163 (2004)
   PUBMED   14673151
REFERENCE   6  (bases 1 to 4961)
  AUTHORS   Henkler,F., Strom,M., Mathers,K., Cordingley,H., Sullivan,K. and
            King,I.
  TITLE     Trangenic misexpression of the differentiation-specific desmocollin
            isoform 1 in basal keratinocytes
  JOURNAL   J Invest Dermatol 116 (1), 144-149 (2001)
   PUBMED   11168810
REFERENCE   7  (bases 1 to 4961)
  AUTHORS   Bierkamp,C., Schwarz,H., Huber,O. and Kemler,R.
  TITLE     Desmosomal localization of beta-catenin in the skin of plakoglobin
            null-mutant mice
  JOURNAL   Development 126 (2), 371-381 (1999)
   PUBMED   9847250
REFERENCE   8  (bases 1 to 4961)
  AUTHORS   King,I.A., Angst,B.D., Hunt,D.M., Kruger,M., Arnemann,J. and
            Buxton,R.S.
  TITLE     Hierarchical expression of desmosomal cadherins during stratified
            epithelial morphogenesis in the mouse
  JOURNAL   Differentiation 62 (2), 83-96 (1997)
   PUBMED   9404003
REFERENCE   9  (bases 1 to 4961)
  AUTHORS   Chidgey,M.A., Yue,K.K., Gould,S., Byrne,C. and Garrod,D.R.
  TITLE     Changing pattern of desmocollin 3 expression accompanies epidermal
            organisation during skin development
  JOURNAL   Dev Dyn 210 (3), 315-327 (1997)
   PUBMED   9389456
REFERENCE   10 (bases 1 to 4961)
  AUTHORS   King,I.A., O'Brien,T.J. and Buxton,R.S.
  TITLE     Expression of the 'skin-type' desmosomal cadherin DSC1 is closely
            linked to the keratinization of epithelial tissues during mouse
            development
  JOURNAL   J Invest Dermatol 107 (4), 531-538 (1996)
   PUBMED   8823356
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK079441.1, BC109162.1 and
            AC132314.3.
            
            On Apr 29, 2014 this sequence version replaced XM_006525591.1.
            
            Summary: This gene encodes a member of the cadherin family of
            proteins that mediates adhesion in desmosomes. The encoded
            preproprotein undergoes proteolytic processing to generate the
            mature, functional protein. Mice lacking the encoded protein
            exhibit epidermal fragility together with defects of epidermal
            barrier and differentiation. The neonatal mice lacking the encoded
            protein exhibit epidermal lesions and older mice develop chronic
            dermatitis. This gene is located in a cluster of desmosomal
            cadherin genes on chromosome 18. Alternate splicing of this gene
            results in multiple transcript variants encoding different isoforms
            that may undergo similar proteolytic processing. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1, also known as Dsc1a)
            represents the shorter transcript and encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC109162.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AK079441.1         2-164
            164-2806            BC109162.1         1-2643
            2807-4961           AC132314.3         73105-75259
FEATURES             Location/Qualifiers
     source          1..4961
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.17 cM"
     gene            1..4961
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /note="desmocollin 1"
                     /db_xref="GeneID:13505"
                     /db_xref="MGI:MGI:109173"
     exon            1..280
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..2878
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="desmocollin-1 isoform 1 preproprotein"
                     /protein_id="NP_001278733.1"
                     /db_xref="CCDS:CCDS89198.1"
                     /db_xref="GeneID:13505"
                     /db_xref="MGI:MGI:109173"
                     /translation="MAVACAAPGSTFSKQLLFFLLVLVLFCDACQKVSLHVPSHLKAE
                     TPVGKVNLEECLKSPSLILSSDPAFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQ
                     EQKKLEVVLSAREKKVFRKRHTKEPVHNRSKRRWAPIPCSLMENSLGPFPQHIQQIQS
                     DAAQNYTIFYSISGPGVDKEPYNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTAD
                     GYAPDYPLPLLFKVEDDNDNAPYFETKLTVFSVPENCRSGTSVGQVTAIDKDEPGTLH
                     TRLKYKILQQIPDQPKHFSIHPDTGVITTTTPLLDREKCDTYKLVMEVRDMGGQPFGL
                     FTTGTITISLEDENDNSPYFTQTSYTTEVEENRIDVEILRMVVHDQDLPNTPHSKAVY
                     TILKGNENGNFKITTDPNTNEGVLCVVKPLNYEVSRQVTLQIGVLNEAQFTNAANAQP
                     PTMCTTTVTVKIKDRDEGPECQPPVKVIQSKDGLPAGQELLGYKAVDPETSSGEGLRY
                     EMVGDEDNWFEINKITGDLRTVKVLDRESKFVKNNQYNISVVATDTAGRSCTGTLVVL
                     LEDFNDHPPQIDKEVTICQQEKDFAVLEPIDLDGPDNGPPFQFLLDNSSSKLWTLESQ
                     DGKRAILRQRHNLNYNYYSVPIQIQDRHGFSAKHVLSVRVCDCTTPTECRMAVKEERD
                     AKPNIILGKWAILAMVLGSALLLCILFTCFCVTTTKRTVKKCFPDDVAQQNLIVSNTE
                     GPGEEVTEANIRLPTQTANICDTSMSVGTLGGQGIKTQQSFEMVKGGHTLESHKGGVL
                     GAAEPGRYAYTDWQTFTQPRLGEKVYLCGQAEEHKHCEDYVRPYNYEGKGSMAGSVGC
                     CSDRQEEEGLEFLDQLEPKFRTLAKTCVKK"
     exon            281..365
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            366..568
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            569..688
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            689..844
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            845..989
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1156
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1291
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1477
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1737
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1880
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2093
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2333
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2458
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2680
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..4961
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2968..2973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2987
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /note="major polyA site"
     regulatory      4937..4942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4961
                     /gene="Dsc1"
                     /gene_synonym="1110020A10Rik"
                     /note="major polyA site"
ORIGIN      
        1 aactggaagg agacgactgg ccagggaaga aggccaacct gttgctcctc ctcctgttgc
       61 ttatcacttg catcctgact ctcttccaaa gccacctcaa ccttgccaac ctggctgcag
      121 agcatcttga caattgccag catctgctta gcctccctgt gcactccagg ccaccctatc
      181 agctgttcac cgtccctggc cattgggacc acttcagatg gctgtggcct gtgctgcccc
      241 agggagcacc ttctctaagc agctcctttt ctttctcctg gttctggtat tattttgtga
      301 tgcctgtcaa aaagtttccc ttcacgttcc ctctcatctt aaggctgaaa cacctgtagg
      361 caaagtgaat ctggaagagt gtctcaaatc acccagcctg atcctgtcca gtgacccagc
      421 cttcagaatt ctagaagacg gcacaattta cacaacacat gacctgcttt tgtcttctga
      481 aaagaggggg ttctccatct tgctctcaga tggtcaaggg caggaacaaa agaagctaga
      541 agttgtactg tcagcaagag aaaaaaaggt ttttaggaaa agacatacca aagagccagt
      601 acacaaccgc agtaagagaa gatgggctcc tattccatgt tcactgatgg agaactcttt
      661 gggtccattt ccacaacaca ttcagcagat ccaatctgat gctgcccaga attacaccat
      721 cttttactct atcagtggac caggagtaga caaagagcct tacaatttgt tctacataga
      781 gaaagacacc ggggacatct attgtacccg aagcattgac cgtgaacagt atgaccaatt
      841 tttggtatat ggatatgcaa caactgctga tggctatgcc ccagactacc ctctccccct
      901 gctgtttaag gttgaagatg acaatgacaa tgccccatat tttgaaacca aattaacagt
      961 ttttagtgtg cctgaaaatt gccgatctgg aacttcagtg ggacaagtga ctgccataga
     1021 caaggatgag ccaggaactc tacacactcg tctgaagtac aaaatcttac aacaaatccc
     1081 agaccagcca aagcacttct ccatccaccc agacacaggt gtgatcacta ccaccacacc
     1141 tttactggac agagagaaat gtgacactta caagctagtg atggaggtac gagacatggg
     1201 gggccagccc tttggtctgt tcaccacagg aacaatcacc atctcactgg aggatgagaa
     1261 tgacaactcg ccatacttca cccaaacttc ttatactaca gaagtagaag aaaacagaat
     1321 tgatgttgag attctgagaa tggtggtgca cgaccaagat ttgcccaaca ccccccactc
     1381 gaaggcggta tacacaatcc taaaggggaa cgaaaacggg aacttcaaaa tcacaacgga
     1441 tccaaataca aatgaagggg tcttgtgtgt tgtcaagcca ctgaactatg aagtcagccg
     1501 ccaagtcact ctgcaaattg gtgtccttaa tgaagcccag ttcactaacg ctgccaacgc
     1561 acaaccacca acaatgtgca ccacaactgt cactgtgaaa attaaagaca gagatgaggg
     1621 ccctgagtgc cagccaccag tcaaagtcat tcagagcaaa gatggactgc cagcgggcca
     1681 agagctcctg ggctacaaag cggtggaccc agagacaagc agtggtgaag gcttaaggta
     1741 tgagatggta ggagatgaag ataattggtt tgagattaac aaaatcaccg gagacttgag
     1801 aactgtgaaa gtactggaca gagagtcgaa gtttgtgaaa aacaaccagt acaatatttc
     1861 agtagtggcg acagatacag ctggccgatc ttgcacagga acactggtag ttcttctgga
     1921 agattttaat gaccacccac cacagattga caaggaagtg accatttgtc agcaggagaa
     1981 ggattttgct gttttggaac ctatagattt agatgggcca gataatggtc caccttttca
     2041 gttccttctg gataattctt ccagcaaact ttggactcta gaatcacagg atggtaaacg
     2101 tgccattctt cgtcaacgac acaatcttaa ttataactat tattctgtgc caatccaaat
     2161 acaagacagg catggttttt ccgcaaaaca tgtattatca gtgcgagtgt gtgactgtac
     2221 aactccaaca gaatgtagaa tggctgttaa ggaagagagg gatgctaaac caaatataat
     2281 ccttgggaaa tgggccattc ttgccatggt cctgggctct gcattgctac tgtgcatttt
     2341 gtttacatgc ttctgtgtga ccactaccaa gagaacagtc aagaaatgct tcccagatga
     2401 tgtagctcag caaaatttaa ttgtatcaaa tactgaagga ccaggagaag aagtgacgga
     2461 agccaatatt agactcccca cacagacagc caacatctgt gatacaagca tgtctgttgg
     2521 gactcttggt ggtcaaggaa tcaaaacaca gcaaagtttt gagatggtca aaggaggcca
     2581 caccttggag tcccacaagg gaggagtgct aggagcagca gagcctggcc gatatgctta
     2641 cacagactgg caaactttca ctcaacctcg gcttggtgaa aaggtgtatt tgtgtgggca
     2701 agctgaagaa cacaagcatt gtgaagacta cgttcgccca tataactatg aaggcaaagg
     2761 ctccatggct ggctctgtgg gctgctgcag tgatcggcag gaggaagaag ggctagagtt
     2821 tttagatcaa ttggaaccaa aatttaggac attagcaaag acatgtgtga agaaataagg
     2881 tgctggttaa tagagcaact tctgtaaatg aatacagagg tgacactgga tgtaagggga
     2941 tagcagcttg tagtagcaac tttgggtatt aaaaggaggt aaagtcattt gtggataagg
     3001 gtgctttacc aatcatagct ccccaaattc tccttgtctc cagaacttcc ctgttgtcta
     3061 gacaggacat tgccacggtt gcttttcttt ctgtgcatgt atgcattgcc ctttcaggac
     3121 tgaactgcat gtgccactaa agttctggtg atgtttgaaa cttaagctct tttgcatgct
     3181 atgcaagact ccataatgga gttgggtatt gtggaagctt aaaatatgag tttgcattgt
     3241 atatatataa attaaatatt tttcaaggac atgggaagaa ttttgcttct aaaatatttc
     3301 ctttagtgcc aagatattgt tttccctttt ccagagtagc ttcaaatgaa attttaagta
     3361 tttttaggta tagccttttg tgtacctaaa caagctccac tcttactgta catttccctc
     3421 attagaagag cactatcttc atttaggaac ctccatagct taatacttgg gtttctgccc
     3481 atatggctat gttatcatca ggatcctgga gcttctatct gaatgacata ggtcagaaca
     3541 tcatgctcac agcacctaga actataaaga tttgtcaaaa actactggca ttcttatctt
     3601 tatagattta cagaatatat atatatatat atatatatat atatatatat atcttgctgg
     3661 tcaatctaaa tgtgatatta tcttaccaca ttcatatgta ctaaaaatat taaaaattat
     3721 ataaatactt tgggactggt agctctttaa ctcgatactg atctactatt tcagtggctt
     3781 ttaactggtc tgtgtcttca agtctctctc caactagtca taaaaatatc aagctgtaac
     3841 tctgatataa ggcttagtcc ttatcatgtg tcaatactga gttaatgtcc atattgggac
     3901 acaatactca ttctaccttg gaaattactc aaagaagaaa tttctggagg gctagaaata
     3961 attttaagta gatactcatt aagattatta gtccattaca gcaacatcta ccaaatctta
     4021 ctgaattaat agatatttta acatgcatga ataaatgggg tataacattt taataagatt
     4081 gttttattgc tctataaaga aaaactatat atttaaatga tattctatta gtcctttgtg
     4141 agaaactaca gatatgtgtc aggttacatc tcatgaaaat cttacattta aactaaactt
     4201 acctttttaa tctatacatt tctatctatt ggaaaaaata gatttctgtt tcacttatgt
     4261 tttgtaacta gtcttattgg tctctattag gataggtgct ctttattgca aaattggata
     4321 tttgaataaa atgaaatata gcgttagtaa ggctgatatg atcttgtaaa ttccccacaa
     4381 tgtgtgactt tgacaatcac tatacaatga tttggggtga tacaattttt actttttgag
     4441 gtaagtgtca ctctgacaat gtgaattttg acattttaga atctaggagt accaatttgg
     4501 aaatgcatca aatgtcatag taagttatat ttttcaatgt agttatatga gcagttggaa
     4561 attattagct taactttcac ttgcatgttg tttgtatcat cttgctctta tacttactga
     4621 attgtagatg agaaaatttg catctaaatt aagcagtaaa atttatatcc atgggtggat
     4681 ttcttttgca tcaagagaag gctttctaaa gttttagaag tcattagaaa atgttgggat
     4741 ttggtttata ttagcagttt tagctattta aaatattttc aagacattat taaaactttt
     4801 ctcagaggaa ttatatttat tgttggattt atttaggcaa ctcccagtaa ttctcatttt
     4861 ccatcaaaaa ttaaatatta actatatgat gaactaaatg tatgaagccc taccaggctg
     4921 cacaatttag tttgctaata aagtactgta tttcatacaa a
//
