LOCUS       NP_001398797             981 aa            linear   ROD 01-MAY-2025
DEFINITION  dystrophin-related protein 2 isoform 2 [Mus musculus].
ACCESSION   NP_001398797 XP_006528559
VERSION     NP_001398797.1
DBSOURCE    REFSEQ: accession NM_001411868.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 981)
  AUTHORS   Gacem,N., Kavo,A., Zerad,L., Richard,L., Mathis,S., Kapur,R.P.,
            Parisot,M., Amiel,J., Dufour,S., de la Grange,P., Pingault,V.,
            Vallat,J.M. and Bondurand,N.
  TITLE     ADAR1 mediated regulation of neural crest derived melanocytes and
            Schwann cell development
  JOURNAL   Nat Commun 11 (1), 198 (2020)
   PUBMED   31924792
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 981)
  AUTHORS   Sherman,D.L., Wu,L.M., Grove,M., Gillespie,C.S. and Brophy,P.J.
  TITLE     Drp2 and periaxin form Cajal bands with dystroglycan but have
            distinct roles in Schwann cell growth
  JOURNAL   J Neurosci 32 (27), 9419-9428 (2012)
   PUBMED   22764250
  REMARK    GeneRIF: Cajal band appositions contain a dystroglycan complex that
            includes periaxin and dystrophin-related protein (Drp)2.
REFERENCE   3  (residues 1 to 981)
  AUTHORS   Maddala,R., Skiba,N.P., Lalane,R. 3rd, Sherman,D.L., Brophy,P.J.
            and Rao,P.V.
  TITLE     Periaxin is required for hexagonal geometry and membrane
            organization of mature lens fibers
  JOURNAL   Dev Biol 357 (1), 179-190 (2011)
   PUBMED   21745462
REFERENCE   4  (residues 1 to 981)
  AUTHORS   Kirchhof,P., Kahr,P.C., Kaese,S., Piccini,I., Vokshi,I.,
            Scheld,H.H., Rotering,H., Fortmueller,L., Laakmann,S., Verheule,S.,
            Schotten,U., Fabritz,L. and Brown,N.A.
  TITLE     PITX2c is expressed in the adult left atrium, and reducing Pitx2c
            expression promotes atrial fibrillation inducibility and complex
            changes in gene expression
  JOURNAL   Circ Cardiovasc Genet 4 (2), 123-133 (2011)
   PUBMED   21282332
REFERENCE   5  (residues 1 to 981)
  AUTHORS   Nodari,A., Previtali,S.C., Dati,G., Occhi,S., Court,F.A.,
            Colombelli,C., Zambroni,D., Dina,G., Del Carro,U., Campbell,K.P.,
            Quattrini,A., Wrabetz,L. and Feltri,M.L.
  TITLE     Alpha6beta4 integrin and dystroglycan cooperate to stabilize the
            myelin sheath
  JOURNAL   J Neurosci 28 (26), 6714-6719 (2008)
   PUBMED   18579745
REFERENCE   6  (residues 1 to 981)
  AUTHORS   Alessi,A., Bragg,A.D., Percival,J.M., Yoo,J., Albrecht,D.E.,
            Froehner,S.C. and Adams,M.E.
  TITLE     gamma-Syntrophin scaffolding is spatially and functionally distinct
            from that of the alpha/beta syntrophins
  JOURNAL   Exp Cell Res 312 (16), 3084-3095 (2006)
   PUBMED   16857187
REFERENCE   7  (residues 1 to 981)
  AUTHORS   Sherman,D.L., Fabrizi,C., Gillespie,C.S. and Brophy,P.J.
  TITLE     Specific disruption of a schwann cell dystrophin-related protein
            complex in a demyelinating neuropathy
  JOURNAL   Neuron 30 (3), 677-687 (2001)
   PUBMED   11430802
REFERENCE   8  (residues 1 to 981)
  AUTHORS   Dixon,A.K., Tait,T.M., Campbell,E.A., Bobrow,M., Roberts,R.G. and
            Freeman,T.C.
  TITLE     Expression of the dystrophin-related protein 2 (Drp2) transcript in
            the mouse
  JOURNAL   J Mol Biol 270 (4), 551-558 (1997)
   PUBMED   9245586
REFERENCE   9  (residues 1 to 981)
  AUTHORS   Roberts,R.G., Freeman,T.C., Kendall,E., Vetrie,D.L., Dixon,A.K.,
            Shaw-Smith,C., Bone,Q. and Bobrow,M.
  TITLE     Characterization of DRP2, a novel human dystrophin homologue
  JOURNAL   Nat Genet 13 (2), 223-226 (1996)
   PUBMED   8640231
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672064.17.
            
            On Sep 8, 2022 this sequence version replaced XP_006528559.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.15138456.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 56.18 cM"
     Protein         1..981
                     /product="dystrophin-related protein 2 isoform 2"
                     /calculated_mol_wt=110114
     Region          135..363
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            253..258
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          381..409
                     /region_name="WW"
                     /note="Two conserved tryptophans domain; also known as the
                     WWP or rsp5 domain; around 40 amino acids; functions as an
                     interaction module in a diverse set of signalling
                     proteins; binds specific proline-rich sequences but at low
                     affinities compared to other...; cd00201"
                     /db_xref="CDD:238122"
     Site            order(393,404)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          446..607
                     /region_name="EFh_DRP-2"
                     /note="EF-hand-like motif found in dystrophin-related
                     protein 2 (DRP-2); cd16248"
                     /db_xref="CDD:320006"
     Region          446..484
                     /region_name="EF-hand-like motif"
                     /note="EF-hand-like motif [structural motif]"
                     /db_xref="CDD:320006"
     Region          492..526
                     /region_name="EF-hand-like motif"
                     /note="EF-hand-like motif [structural motif]"
                     /db_xref="CDD:320006"
     Region          532..568
                     /region_name="EF-hand-like motif"
                     /note="EF-hand-like motif [structural motif]"
                     /db_xref="CDD:320006"
     Region          581..607
                     /region_name="EF-hand-like motif"
                     /note="EF-hand-like motif [structural motif]"
                     /db_xref="CDD:320006"
     Region          632..680
                     /region_name="ZZ_dystrophin"
                     /note="Zinc finger, ZZ type. Zinc finger present in
                     dystrophin and dystrobrevin. The ZZ motif coordinates two
                     zinc ions and most likely participates in ligand binding
                     or molecular scaffolding. Dystrophin attaches actin
                     filaments to an integral membrane...; cd02334"
                     /db_xref="CDD:239074"
     Site            order(634,637,649,652,658,661,671,675)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239074"
     Site            order(634,637,658,661)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239074"
     Site            order(635,646,648,654,656)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239074"
     Site            order(647,662,677,680)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239074"
     Site            order(649,652,671,675)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239074"
     CDS             1..981
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /coded_by="NM_001411868.1:234..3179"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:13497"
                     /db_xref="MGI:MGI:107432"
ORIGIN      
        1 msgmlltgfi taaasetpvp slrlaqsssr fclsaltrre vqipaegkpw talilpwtpq
       61 aaqvraavti pappwdgagd pclspkllng tvgatgplep samnlcwnei kkkshnlrar
      121 leafsdlsgk lqlplreiid wlsqkdeels aqlplqgdva lvqqeketha afmeevkskg
      181 pyissvlesa qaflsqhpfe eleesqsesk dtsprqriqn lsrfvwkqat vaselweklt
      241 arcvdqhrhi ehtlehllei qgameelsst ltqaegvrat wepigdlfid slpehiqaik
      301 lfkeefspvk dgvklvndla hqlaisdvhl smensraleq inirwkqlqv svaerlkqlq
      361 dahrdfgpgs qhflstsvqv pweraispnk vpyyinhqaq ttcwdhpkmt elyqtladln
      421 nikfsayrta mklrrvqkal rldlvtltta leifnehdlq asehvmdvve vihcltalye
      481 rleeergilv nvplcvdmsl nwllnvfdsg rsgkmralsf ktgiaclcgt evkeklqylf
      541 sqvansgsqc dqrhlgallh eaiqvprqlg evaafggsnv epsvrscfrf stgkpvieas
      601 qflewvnlep qsmvwlavlh rvtiaeqvkh qtkcsicrqc pikgfryrsl kqfnvdicqt
      661 cfltgraskg nklhypimey ytpttssenm rdfattlknk frskqyfskh pqrgylpvqs
      721 vlesdcsetp asspmlphad thsriehfas rlaemesqnc sffndslspd dsidedqyll
      781 rhsspitdre pafgqqapcs mateskgele kilahleden rilqgelrrl kwqheeaaea
      841 ptlvegsaea tpdhrneell aearilrqhk srletrmqil edhnkqlesq lqrlrelllq
      901 ppsesdgngs agsslasspr qsegshprek gqttpdteva ddvgsksqdv slcledimek
      961 lrhafpsvrs sdvtantlla s
//
