LOCUS       NM_026799               4580 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus drosha, ribonuclease type III (Drosha), transcript
            variant 2, mRNA.
ACCESSION   NM_026799 XM_484445
VERSION     NM_026799.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4580)
  AUTHORS   Hou,A., Xu,X., Zhang,Y., He,H., Feng,Y., Fan,W., Tan,R., Gong,L.
            and Chen,J.
  TITLE     Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to
            regulate miRNA biogenesis and lipid metabolism
  JOURNAL   Liver Int 44 (7), 1634-1650 (2024)
   PUBMED   38517158
  REMARK    GeneRIF: Excessive fatty acids activate PRMT5/MDM2/Drosha pathway
            to regulate miRNA biogenesis and lipid metabolism.
REFERENCE   2  (bases 1 to 4580)
  AUTHORS   Forcella,P., Ifflander,N., Rolando,C., Balta,E.A., Lampada,A.,
            Giachino,C., Mukhtar,T., Bock,T. and Taylor,V.
  TITLE     SAFB regulates hippocampal stem cell fate by targeting Drosha to
            destabilize Nfib mRNA
  JOURNAL   Elife 13, e74940 (2024)
   PUBMED   38722021
  REMARK    GeneRIF: SAFB regulates hippocampal stem cell fate by targeting
            Drosha to destabilize Nfib mRNA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4580)
  AUTHORS   Guo,M., Luo,C., Wang,Z., Chen,S., Morris,D., Ruan,F., Chen,Z.,
            Yang,L., Wei,X., Wu,C., Luo,B., Lv,Z., Huang,J., Zhang,D., Yu,C.,
            Gao,Q., Wang,H., Zhang,Y., Sun,F., Yan,W. and Tang,C.
  TITLE     Uncoupling transcription and translation through miRNA-dependent
            poly(A) length control in haploid male germ cells
  JOURNAL   Development 149 (12) (2022)
   PUBMED   35588208
REFERENCE   4  (bases 1 to 4580)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4580)
  AUTHORS   Cui,Y., Lyu,X., Ding,L., Ke,L., Yang,D., Pirouz,M., Qi,Y., Ong,J.,
            Gao,G., Du,P. and Gregory,R.I.
  TITLE     Global miRNA dosage control of embryonic germ layer specification
  JOURNAL   Nature 593 (7860), 602-606 (2021)
   PUBMED   33953397
  REMARK    GeneRIF: Global miRNA dosage control of embryonic germ layer
            specification.
REFERENCE   6  (bases 1 to 4580)
  AUTHORS   Cobb,B.S., Hertweck,A., Smith,J., O'Connor,E., Graf,D., Cook,T.,
            Smale,S.T., Sakaguchi,S., Livesey,F.J., Fisher,A.G. and
            Merkenschlager,M.
  TITLE     A role for Dicer in immune regulation
  JOURNAL   J Exp Med 203 (11), 2519-2527 (2006)
   PUBMED   17060477
  REMARK    GeneRIF: Dicer is required in a cell-autonomous fashion for the
            development of natural T reg cells in the thymus and for efficient
            induction of Foxp3 by transforming growth factor beta.
REFERENCE   7  (bases 1 to 4580)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4580)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4580)
  AUTHORS   Fortin,K.R., Nicholson,R.H. and Nicholson,A.W.
  TITLE     Mouse ribonuclease III. cDNA structure, expression analysis, and
            chromosomal location
  JOURNAL   BMC Genomics 3 (1), 26 (2002)
   PUBMED   12191433
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4580)
  AUTHORS   Rout,U.K., Krawetz,S.A. and Armant,D.R.
  TITLE     Ethanol-induced intracellular calcium mobilization rapidly alters
            gene expression in the mouse blastocyst
  JOURNAL   Cell Calcium 22 (6), 463-474 (1997)
   PUBMED   9502196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA328055.1, BC088999.1 and U94841.1.
            
            On Jul 18, 2008 this sequence version replaced NM_026799.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148640.1, BC088999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                CA328055.1         1-62
            63-4522             BC088999.1         1-4460
            4523-4580           U94841.1           118-175
FEATURES             Location/Qualifiers
     source          1..4580
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.99 cM"
     gene            1..4580
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /note="drosha, ribonuclease type III"
                     /db_xref="GeneID:14000"
                     /db_xref="MGI:MGI:1261425"
     exon            1..124
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            125..227
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            228..293
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..4398
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /EC_number="3.1.26.3"
                     /note="ethanol induced 2; ribonuclease III, nuclear; RNase
                     III; protein Drosha"
                     /codon_start=1
                     /product="ribonuclease 3"
                     /protein_id="NP_081075.3"
                     /db_xref="CCDS:CCDS49583.1"
                     /db_xref="GeneID:14000"
                     /db_xref="MGI:MGI:1261425"
                     /translation="MQGNTCHRMSYHPGRGCPRGRGGHGARPSAPAFRPQNLRLLHPQ
                     QPPAQYQYEPPSAPSSSYSNSQAPSFMPPRPDFVPYPPPAAPSAQGPLPPCPVRPPYP
                     NHQMRHPFPVPPCFPPMPPPMPCPNNPPASGAPPGQGTFPFMVPPPSMPHPPPPPVMP
                     QQVNYQYPPGYSHSFPPPGFNSYQNNSSSFPPSANSSSTPHFRHLPPYSLPKAQNERR
                     SPERLKHYDDHRHRDHSHGRGERHRSLERRERGRSPERRRPESRYRSDYDRGRTPPPR
                     HRSYERSRERDRERHRHREARRSPSLERSYKKEYKRSGRSYALPVAPEPAGCTPELPG
                     EMIKTTESWAPPPENVNHRSPSREKKRARWEEEKDRWSDSQGSGKEKNYTSIKEKEAE
                     EVPPEKTEEEEEELLKPVWIRCTHSESYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEE
                     LGNRQEKAKAARPPWEPPKTKLDEDLESSSESECETDDDSTCSSSSDSEVFDVIAEIK
                     RKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNN
                     AGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNI
                     DYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMP
                     RFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMI
                     VTNPGTKPSSVRIDQLDREQFNPEVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVK
                     LRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVC
                     QHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARN
                     SLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGD
                     AVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLC
                     RESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQ
                     EPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRME
                     FLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDK
                     TKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKS
                     QLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAE
                     MGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMRWEREHQEREPEEAEDIKK"
     exon            294..1127
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1220
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1331
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1563
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1705
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1860
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1941
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2028
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2115
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2187
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2269
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2344
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2514
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2639
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2739
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2847
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2955
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3094
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3155
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3215
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3315
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3418
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3489
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..3534
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3692
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3798
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..3940
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3941..4023
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            4024..4127
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            4128..4220
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            4221..4267
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            4268..4567
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4505..4510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /note="hexamer: AATAAA"
     polyA_site      4522
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /note="major polyA site"
     regulatory      4543..4548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
                     /note="hexamer: ATTAAA"
     polyA_site      4567
                     /gene="Drosha"
                     /gene_synonym="1110013A17Rik; Etohi2; Rn3; Rnasen"
ORIGIN      
        1 atttctccgg tttgcctttt aattcccggg gcttcctgtt ccggaggcgt gggtggcgcc
       61 tcagccgtgg agggtgttat agtaaccagg ctgggctttg atggcggcga ccccgggact
      121 ctctagactg tgaatcctgc aggaatgact gaatgaaccc ttgattcacg gacatgccgg
      181 aggagttcaa catgggcaca cacgactgtc acagacggca gattctgaac ctacatcgtg
      241 agcggaagat gtagcctttc tacaggacgc atcgagatgc aaggcaatac gtgtcataga
      301 atgtcgtacc acccaggacg agggtgtccc cggggccgag gaggacacgg agccagacct
      361 tcagcaccag ctttcagacc ccaaaacctg cgacttcttc atccccagca gccgcctgcg
      421 cagtatcaat atgagcctcc gagcgccccc tcttcctcct actcgaactc tcaggccccc
      481 agctttatgc ccccacggcc agactttgtc ccttaccctc ccccagcggc gccgtctgcc
      541 caagggcctc tccctccctg cccagtgagg ccgccttacc ccaaccacca gatgagacac
      601 cctttcccgg tgcctccctg ttttccaccc atgccccctc cgatgccttg tcccaataac
      661 ccgcctgcct ccggagcacc tcccggacaa ggcactttcc ccttcatggt gccccctcct
      721 tccatgcccc accctccgcc cccgcccgtc atgccgcagc aggttaatta ccagtacccc
      781 cctgggtact cgcacagctt cccaccgccc ggcttcaaca gttaccagaa caactccagc
      841 tctttcccac ccagtgctaa cagcagcagc actcctcatt ttcgacacct cccaccatac
      901 tcactcccaa aggctcagaa tgagaggcgg tccccagaaa ggctcaagca ctacgacgac
      961 cacaggcacc gagatcacag tcacgggcga ggcgagaggc atcggtccct ggagcgcagg
     1021 gagcgcggcc gcagccctga aaggagaaga cctgagagcc gctaccgctc agactatgat
     1081 cgggggagaa cgccaccgcc tcgccaccgc agctatgaaa ggagcagaga gcgggatcga
     1141 gagagacaca ggcaccggga ggcccgcaga tcaccgtctc tagaaaggtc ctacaagaaa
     1201 gagtataaga gatctggaag gagttacgct ttaccagttg ctcctgagcc cgctgggtgc
     1261 acaccagagt tgcctgggga gatgattaaa actacagagt cttgggcccc gcccccggag
     1321 aatgtgaatc atcgttctcc aagcagggag aagaagagag ctcgttggga ggaggaaaaa
     1381 gacagatgga gcgacagcca gggctctggc aaagagaaga actacacgtc catcaaagag
     1441 aaagaggcag aggaggtgcc tccagagaag acggaggagg aggaggaaga gctccttaag
     1501 cctgtgtgga ttcgctgtac acattcggaa agctattact ccagtgaccc aatggatcag
     1561 gtgggagact cgactgtcgt agggacaagc aggctccgtg atttgtatga caaatttgag
     1621 gaagaattgg ggaataggca agagaaggcc aaagctgccc ggcctccgtg ggagcctccg
     1681 aagacaaagc tggatgaaga tttagagagt tccagtgagt ctgaatgtga gactgacgac
     1741 gacagcacct gttcgagcag ctcggactcg gaggtgttcg atgtcattgc agagattaaa
     1801 cgcaaaaagg ctcaccctga ccggcttcat gatgaactct ggtacaacga cccaggccag
     1861 atgaacgatg gaccgctttg caaatgcagt gcaaaagcca gacgcacagg aatccgccac
     1921 agcatttatc ccggagaaga ggcaatcaag ccctgccgtc cgatgaccaa caacgctggc
     1981 cggcttttcc actatcggat caccgtctcc ccgcctacca acttcttaac tgacaggcca
     2041 acagtcatag aatatgatga ccacgagtat atttttgaag gattttctat gtttgcacat
     2101 gctcctctga ccaatattcc actgtgtaaa gtgattcgat tcaacataga ctacacgatt
     2161 cattttatcg aagagatgat gcctgagaat ttttgtgtga aaggacttga actgttttca
     2221 ttgttcctat tcagagatat tttggaatta tatgactgga atcttaaagg tcctttgttt
     2281 gaagacagcc ctccctgctg tccgagattt catttcatgc cacgttttgt aagatttctt
     2341 ccagatggag gcaaagaagt gttatccatg caccagatcc ttctctacct gctgcgctgc
     2401 agcaaggctc tggtgcccga ggaggagatt gccaacatgc tccagtggga ggagctcgag
     2461 tggcagaaat acgcagagga gtgcaaaggc atgatcgtta ccaaccctgg gacgaaaccg
     2521 agctctgtcc gcattgatca gctggatcgt gaacagttca accccgaagt gatcactttc
     2581 ccgattatcg ttcactttgg gatccgcccc gcacagttga gttatgcagg agacccacag
     2641 tatcagaaat tatggaaaag ctatgtgaaa cttcgccacc tcctagcaaa cagtcccaaa
     2701 gtcaaacaaa ctgacaagca gaagctggct cagagggagg aagcgctcca gaaaatacgg
     2761 cagaagaaca cgatgcggcg agaagtcacc gtggagctga gtagccaagg attctggaaa
     2821 actggcattc gttctgatgt ctgtcagcat gcaatgatgc tgcctgttct gacccatcac
     2881 atccggtacc atcaatgctt aatgcacctg gacaagttga taggatatac tttccaagac
     2941 cgttgtctgc tccagcttgc catgactcat ccgagtcacc atttaaattt tggaatgaat
     3001 cctgaccatg ccaggaattc tttgtctaac tgtggaattc gacaacccaa atatggagac
     3061 agaaaagttc atcacatgca catgcggaaa aaaggaatta ataccctaat aaatatcatg
     3121 tcacgccttg gccaagatga tccaactcct tcaaggatta atcacaacga aaggttggag
     3181 ttcctggggg atgctgttgt tgagtttctg accagtgtcc acctgtacta cctgtttcct
     3241 agcttggagg aagggggctt ggcgacctat cggaccgcca ttgttcagaa tcagcacctc
     3301 gccatgcttg caaagaaact tgaactggat cgatttatgc tatatgccca tgggcccgac
     3361 ctatgtagag aatcagatct ccgccatgcg atggccaatt gttttgaagc cttgatagga
     3421 gctgtttact tggaggggag cctagaggaa gccaaacagt tatttggacg cttactcttt
     3481 aatgatccgg accttcgaga agtctggctc aattatcctc tccacccact ccaactacaa
     3541 gagccaaata cggatcggca acttattgaa acttccccag ttctacagaa acttacggag
     3601 tttgaagaag caattggagt gatcttcact cacgtccggc ttctggcgag ggcgttcaca
     3661 ctgagaaccg tgggctttaa ccacctgacc ctaggccaca atcagaggat ggaatttctg
     3721 ggcgactcca taatgcagct ggtggccaca gagtacttgt tcattcattt cccggaccat
     3781 cacgaaggac acttgacgtt gttacgaagt tccttagtga acaacagaac gcaagccaag
     3841 gtagcagagg aactgggcat gcaggagtat gccatcacca acgacaaaac caagagaccc
     3901 gtggccctaa gaaccaagac tttggcagac cttttggaat catttatcgc agcgctgtac
     3961 atcgacaagg acctggaata tgtccacact ttcatgaacg tctgcttctt tccccggctg
     4021 aaggagttca ttctgaatca ggattggaac gaccccaagt cgcagctgca gcagtgttgt
     4081 ctgaccctga ggacagaagg gaaagagcct gacatcccct tatacaagac tctgcagaca
     4141 gtggggccat cccatgctag aacctacact gtggctgttt atttcaaggg agaaaggata
     4201 ggctgtggga aaggaccaag cattcagcag gcggagatgg gagcagcaat ggatgcactg
     4261 gagaaatata actttcccca gatggcccat cagaagcggt tcattgagcg gaaatacaga
     4321 caagagttaa aggaaatgag gtgggaaaga gagcatcagg agagagagcc ggaggaggct
     4381 gaagacatca agaagtaaac gagggcagga gtggcggagc attgcctttc taagaactgt
     4441 gactgtggcc catcgagacc tagcctggtt ttcccttaga caatgaatga agtgtgccca
     4501 ttgaaataaa actcaaacca cactgcggtt gttgtcttaa tgattaaatg ttccgtttct
     4561 agctggaaaa aaaaaaaaaa
//
