LOCUS       NM_021354               1772 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus developmentally regulated GTP binding protein 2
            (Drg2), transcript variant 2, mRNA.
ACCESSION   NM_021354 XM_003945908
VERSION     NM_021354.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1772)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1772)
  AUTHORS   Lee,U.H., Park,S.J., Ju,S.A., Lee,S.C., Kim,B.S., Ahn,B., Yi,J.,
            Park,J., Won,Y.W., Han,I.S., Lee,B.J., Cho,W.J. and Park,J.W.
  TITLE     DRG2 in macrophages is crucial for initial inflammatory response
            and protection against Listeria monocytogenes infection
  JOURNAL   Clin Immunol 257, 109819 (2023)
   PUBMED   37918467
  REMARK    GeneRIF: DRG2 in macrophages is crucial for initial inflammatory
            response and protection against Listeria monocytogenes infection.
REFERENCE   3  (bases 1 to 1772)
  AUTHORS   Lim,H.R., Vo,M.T., Kim,D.J., Lee,U.H., Yoon,J.H., Kim,H.J., Kim,J.,
            Kim,S.R., Lee,J.Y., Yang,C.H., Kim,H.Y., Choi,J.S., Kim,K.,
            Yang,E., Kim,H., Lee,S., Lee,B.J., Kim,K., Park,J.W. and Ha,C.M.
  TITLE     DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced
            Striatal Dopamine Release
  JOURNAL   Int J Mol Sci 21 (1), 60 (2019)
   PUBMED   31861806
  REMARK    GeneRIF: DRG2 knockout (KO) mice displayed defects in motor
            function in motor coordination and rotarod tests and increased
            anxiety.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1772)
  AUTHORS   Mani,M., Lee,U.H., Yoon,N.A., Yoon,E.H., Lee,B.J., Cho,W.J. and
            Park,J.W.
  TITLE     Developmentally regulated GTP-binding protein 2 is required for
            stabilization of Rac1-positive membrane tubules
  JOURNAL   Biochem Biophys Res Commun 493 (1), 758-764 (2017)
   PUBMED   28865956
  REMARK    GeneRIF: Our results reveal a novel mechanism for regulation of
            membrane tubule stability mediated by DRG2.
REFERENCE   5  (bases 1 to 1772)
  AUTHORS   Mani,M., Lee,U.H., Yoon,N.A., Kim,H.J., Ko,M.S., Seol,W., Joe,Y.,
            Chung,H.T., Lee,B.J., Moon,C.H., Cho,W.J. and Park,J.W.
  TITLE     Developmentally regulated GTP-binding protein 2 coordinates Rab5
            activity and transferrin recycling
  JOURNAL   Mol Biol Cell 27 (2), 334-348 (2016)
   PUBMED   26582392
REFERENCE   6  (bases 1 to 1772)
  AUTHORS   Yan,J., Bi,W. and Lupski,J.R.
  TITLE     Penetrance of craniofacial anomalies in mouse models of
            Smith-Magenis syndrome is modified by genomic sequence surrounding
            Rai1: not all null alleles are alike
  JOURNAL   Am J Hum Genet 80 (3), 518-525 (2007)
   PUBMED   17273973
REFERENCE   7  (bases 1 to 1772)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1772)
  AUTHORS   Li,B. and Trueb,B.
  TITLE     DRG represents a family of two closely related GTP-binding proteins
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 196-204 (2000)
   PUBMED   10760581
REFERENCE   9  (bases 1 to 1772)
  AUTHORS   Liang,Y., Wang,A., Belyantseva,I.A., Anderson,D.W., Probst,F.J.,
            Barber,T.D., Miller,W., Touchman,J.W., Jin,L., Sullivan,S.L.,
            Sellers,J.R., Camper,S.A., Lloyd,R.V., Kachar,B., Friedman,T.B. and
            Fridell,R.A.
  TITLE     Characterization of the human and mouse unconventional myosin XV
            genes responsible for hereditary deafness DFNB3 and shaker 2
  JOURNAL   Genomics 61 (3), 243-258 (1999)
   PUBMED   10552926
REFERENCE   10 (bases 1 to 1772)
  AUTHORS   Probst,F.J., Chen,K.S., Zhao,Q., Wang,A., Friedman,T.B.,
            Lupski,J.R. and Camper,S.A.
  TITLE     A physical map of the mouse shaker-2 region contains many of the
            genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2)
  JOURNAL   Genomics 55 (3), 348-352 (1999)
   PUBMED   10049592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596090.11.
            
            On Mar 4, 2023 this sequence version replaced NM_021354.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ243590.1, BC082564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AL596090.11        176125-176252
            129-289             AL596090.11        178060-178220
            290-379             AL596090.11        180951-181040
            380-440             AL596090.11        181537-181597
            441-531             AL596090.11        182296-182386
            532-604             AL596090.11        182831-182903
            605-695             AL596090.11        183023-183113
            696-793             AL596090.11        183683-183780
            794-870             AL596090.11        184067-184143
            871-959             AL596090.11        185643-185731
            960-1018            AL596090.11        186342-186400
            1019-1072           AL596090.11        189194-189247
            1073-1772           AL596090.11        189573-190272
FEATURES             Location/Qualifiers
     source          1..1772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.81 cM"
     gene            1..1772
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /note="developmentally regulated GTP binding protein 2"
                     /db_xref="GeneID:13495"
                     /db_xref="MGI:MGI:1342307"
     exon            1..128
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1159
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /note="TRAFAC GTPase DRG2; translation factor GTPase DRG2"
                     /codon_start=1
                     /product="developmentally-regulated GTP-binding protein 2"
                     /protein_id="NP_067329.1"
                     /db_xref="CCDS:CCDS24791.1"
                     /db_xref="GeneID:13495"
                     /db_xref="MGI:MGI:1342307"
                     /translation="MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRAQLLEP
                     SKSASSKGEGFDVMKSGDARVALIGFPSVGKSTFLSLMTSTASEAASYEFTTLTCIPG
                     VIEYKGANIQLLDLPGIIEGAAQGRGRGRQVIAVARTADVVVMMLDATKGDVQRSLLE
                     KELESVGIRLNKHKPNIYFKPKKGGGISFNSTVTLTQCSEKLVQLILHEYKIFNAEVL
                     FREDCSPDDFIDVIVGNRVYMPCLYVYNKIDQISMEEVDRLARKPNSVVISCGMKLNL
                     DYLLEMLWEYLALTCIYTKKRGQRPDFTDAIILRKGASVEHVCHRIHRSLASQFKYAL
                     VWGTSTKYSPQRVGLTHTMEHEDVIQIVKK"
     exon            129..289
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            290..379
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..440
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..531
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..604
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..695
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..793
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..870
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..959
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1018
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1072
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1772
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1233..1238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /note="hexamer: CATAAA"
     polyA_site      1251
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
                     /note="major polyA site"
     polyA_site      1772
                     /gene="Drg2"
                     /gene_synonym="DRG-2"
ORIGIN      
        1 attagacgtg agcgctcagc gctgtaagct ataggcagcg tgaatctccg ccgaagctgc
       61 aactatgggg atcttggaga aaatctcgga gatcgagaag gagatcgctc gaacgcagaa
      121 gaacaaggcc accgagtacc acctgggcct gctgaaagca aaactggcca agtatcgggc
      181 ccagctcctg gaaccatcca aatccgcctc atccaaagga gagggctttg atgtcatgaa
      241 gtcaggtgat gcccgtgtgg cactgattgg ctttccctct gtgggtaagt ccaccttctt
      301 gagtctgatg acctctacag ccagcgaagc tgcgtcctat gagtttacca ccctgacgtg
      361 catccctggg gtcattgaat acaaaggtgc caacatccag ctcttggacc ttcctggaat
      421 cattgaagga gcagcacaag gccgaggccg tggccggcag gtgattgccg tagcacgcac
      481 agctgatgtc gtcgtcatga tgctggatgc caccaaggga gatgtgcaga ggtccctgct
      541 ggagaaggag ctggagtctg tgggtattcg cctgaacaag cataagccca acatctattt
      601 caagcccaag aaaggtggtg gcatctcctt taactcaaca gtcacactga cacaatgctc
      661 tgagaagctg gtgcagctca tcctacatga atacaagatc ttcaacgccg aggtactctt
      721 ccgagaagac tgctctccag acgacttcat cgatgtgatt gtgggcaacc gggtgtatat
      781 gccctgcctc tatgtgtata acaaaatcga ccagatctcc atggaagaag tagaccgttt
      841 agctcgaaag cccaacagtg tagttatcag ttgcggtatg aagttgaacc tcgactacct
      901 gctggagatg ctgtgggagt acctggccct cacctgcatt tacaccaaga agagaggaca
      961 gagaccggac ttcacagacg ccatcattct ccggaaaggg gcctctgttg aacacgtgtg
     1021 ccaccgcatc catcggtcac tggccagcca gttcaagtac gccttggtgt ggggtaccag
     1081 caccaagtac agcccacagc gggtaggcct gacccacact atggagcatg aggacgtcat
     1141 ccagattgtg aagaagtagt cacgacacct tcctgcagct tggctcccgg gaactcggcc
     1201 tccctggaac acacaaacgg gaaaagtaca aacataaacc ccaggaagcg attcttgagt
     1261 ggctgattca tgagctcctt cagaaacagt gttgggctag gcaaagctgg ggaccagggc
     1321 tttgctgagg acattcccta taaagcctgt gcctgtggca ggcttactca gcagcctaca
     1381 gcctgtgtcc atgccctgtg ccccttccgg gcactcaagg agcttagtta cccacatcct
     1441 cccagccaga cctaagctga ccctggctca agtagggtcc ctgaggctcc tgagaacaac
     1501 tctagcacat agtggcctca ggatgaagcc tcccacaggt cctcccaaca cagggctgtc
     1561 cctcatggaa gccagggccc agccaaagtg tcctaaagtg cctccccctt ggagcccctc
     1621 ccagaacagc ctcctcctgc ctgggtggga cctctgagtc tggctccatt tccttctaag
     1681 ctcctatgtc tgccctcctt tctgaaataa aattaaaaaa aaaaaaaaag gggtgcgggg
     1741 aagcggttcc ttcccagacc agacttaggg aa
//
