LOCUS       NM_007879               1616 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus developmentally regulated GTP binding protein 1
            (Drg1), mRNA.
ACCESSION   NM_007879
VERSION     NM_007879.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1616)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1616)
  AUTHORS   Westrip,C.A.E., Paul,F., Al-Murshedi,F., Qaitoon,H., Cham,B.,
            Fletcher,S.C., Hendrix,E., Boora,U., Ng,A.Y.J., Bonnard,C.,
            Najafi,M., Alawbathani,S., Lambert,I., Fox,G., Venkatesh,B.,
            Bertoli-Avella,A., Tan,E.S., Al-Maawali,A., Reversade,B. and
            Coleman,M.L.
  TITLE     Inactivation of DRG1, encoding a translation factor GTPase, causes
            a recessive neurodevelopmental disorder
  JOURNAL   Genet Med 25 (9), 100893 (2023)
   PUBMED   37179472
  REMARK    GeneRIF: Inactivation of DRG1, encoding a translation factor
            GTPase, causes a recessive neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 1616)
  AUTHORS   Park,C.S., Rehrauer,H. and Mansuy,I.M.
  TITLE     Genome-wide analysis of H4K5 acetylation associated with fear
            memory in mice
  JOURNAL   BMC Genomics 14, 539 (2013)
   PUBMED   23927422
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1616)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 1616)
  AUTHORS   Eswaran,J., Bernad,A., Ligos,J.M., Guinea,B., Debreczeni,J.E.,
            Sobott,F., Parker,S.A., Najmanovich,R., Turk,B.E. and Knapp,S.
  TITLE     Structure of the human protein kinase MPSK1 reveals an atypical
            activation loop architecture
  JOURNAL   Structure 16 (1), 115-124 (2008)
   PUBMED   18184589
REFERENCE   6  (bases 1 to 1616)
  AUTHORS   Zhao,X.F. and Aplan,P.D.
  TITLE     SCL binds the human homologue of DRG in vivo
  JOURNAL   Biochim Biophys Acta 1448 (1), 109-114 (1998)
   PUBMED   9824680
REFERENCE   7  (bases 1 to 1616)
  AUTHORS   Noble,J.A., Innis,M.A., Koonin,E.V., Rudd,K.E., Banuett,F. and
            Herskowitz,I.
  TITLE     The Escherichia coli hflA locus encodes a putative GTP-binding
            protein and two membrane proteins, one of which contains a
            protease-like domain
  JOURNAL   Proc Natl Acad Sci U S A 90 (22), 10866-10870 (1993)
   PUBMED   8248183
REFERENCE   8  (bases 1 to 1616)
  AUTHORS   Sazuka,T., Tomooka,Y., Ikawa,Y., Noda,M. and Kumar,S.
  TITLE     DRG: a novel developmentally regulated GTP-binding protein
  JOURNAL   Biochem Biophys Res Commun 189 (1), 363-370 (1992)
   PUBMED   1449490
REFERENCE   9  (bases 1 to 1616)
  AUTHORS   Sazuka,T., Kinoshita,M., Tomooka,Y., Ikawa,Y., Noda,M. and Kumar,S.
  TITLE     Expression of DRG during murine embryonic development
  JOURNAL   Biochem Biophys Res Commun 189 (1), 371-377 (1992)
   PUBMED   1280421
REFERENCE   10 (bases 1 to 1616)
  AUTHORS   Kumar,S., Tomooka,Y. and Noda,M.
  TITLE     Identification of a set of genes with developmentally
            down-regulated expression in the mouse brain
  JOURNAL   Biochem Biophys Res Commun 185 (3), 1155-1161 (1992)
   PUBMED   1378265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671968.17.
            
            On Feb 14, 2018 this sequence version replaced NM_007879.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10715.1, BC039649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AL671968.17        132477-132671       c
            196-319             AL671968.17        130975-131098       c
            320-495             AL671968.17        128697-128872       c
            496-565             AL671968.17        125514-125583       c
            566-735             AL671968.17        122751-122920       c
            736-866             AL671968.17        120720-120850       c
            867-1034            AL671968.17        118852-119019       c
            1035-1157           AL671968.17        118368-118490       c
            1158-1616           AL671968.17        116115-116573       c
FEATURES             Location/Qualifiers
     source          1..1616
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.23 cM"
     gene            1..1616
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /note="developmentally regulated GTP binding protein 1"
                     /db_xref="GeneID:13494"
                     /db_xref="MGI:MGI:1343297"
     exon            1..195
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1257
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /note="neural precursor cell expressed developmentally
                     down-regulated protein 3; GTP-binding protein; TRAFAC
                     GTPase DRG1; translation factor GTPase DRG1"
                     /codon_start=1
                     /product="developmentally-regulated GTP-binding protein 1"
                     /protein_id="NP_031905.1"
                     /db_xref="CCDS:CCDS24355.1"
                     /db_xref="GeneID:13494"
                     /db_xref="MGI:MGI:1343297"
                     /translation="MSGTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELIT
                     PKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTV
                     PGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKI
                     IENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNAD
                     VTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRW
                     NFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFK
                     YALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK"
     exon            196..319
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /inference="alignment:Splign:2.1.0"
     exon            320..495
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..565
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /inference="alignment:Splign:2.1.0"
     exon            566..735
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /inference="alignment:Splign:2.1.0"
     exon            736..866
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1034
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1157
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1616
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1578..1583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /note="hexamer: TATAAA"
     polyA_site      1601
                     /gene="Drg1"
                     /gene_synonym="DRG-1; NEDD-3; Nedd3"
                     /note="major polyA site"
ORIGIN      
        1 cgagagcgtc ggcgcggact tctcgcggaa ccgtgtcgcg agcttagcag atcccgcgct
       61 tgcgcgctgc agtggtggcc agaggcgcgg cgggcgcgag aagggggacc taaccagtgt
      121 ggaggctggt gtggccttaa gccctccgcc accatgagcg ggaccttagc gaagatcgcg
      181 gagatcgaag ccgagatggc tcggactcag aagaacaaag ccacagctca tcaccttggc
      241 ctgcttaagg ctcgccttgc taaacttcga agagaactca tcactcctaa aggtggcggc
      301 ggcggggggc caggagaagg ttttgatgtg gccaagacag gtgatgctcg aattgggttt
      361 gtgggttttc catctgtggg gaaatcaact ctgctaagta acttagcagg agtgtattct
      421 gaagtggcag cctatgaatt cactacattg accacagtgc ctggtgtcat cagatataaa
      481 ggtgccaaga tccagctcct ggatctcccg ggtattattg aaggtgccaa ggatgggaaa
      541 ggtagaggtc gtcaagtcat tgcagtggcc cgaacgtgta atttgatttt gattgttctg
      601 gatgtcctaa aacccttggg acataagaag ataattgaaa atgagttgga aggctttggg
      661 attcgcttga acagcaaacc ccccaacatt ggctttaaga agaaagacaa gggaggcatt
      721 aacctcacag ccacttgtcc tcagagtgaa ctggatgctg aaacagtgaa gagcattctg
      781 gctgaatata agattcataa tgctgatgtg actttgcgta gtgatgccac agctgacgac
      841 ctcattgacg tggtcgaagg gaacagagtt tatattccct gtatctatgt attaaataag
      901 attgatcaga tctccattga ggagttggat attatctata aggtgcctca ctgtgtaccc
      961 atctctgctc atcaccgctg gaattttgat gaccttttgg agaaaatctg ggactatctg
     1021 aaactagtga gaatttacac caaaccgaaa ggccagttac cagattacac atctccagta
     1081 gtgctgcctt attctaggac cactgtggaa gatttctgca tgaagattca caaaaatctc
     1141 atcaaagaat ttaaatatgc tttggtctgg ggtctgtctg tgaaacataa tcctcagaaa
     1201 gtgggtaaag accacacatt ggaagatgaa gacgtcattc agattgtgaa gaagtgaagt
     1261 cctcttgcca tctgctggct ggccacagca gtgttcctta tgactaagta ccttcctcag
     1321 cccctctgtc tttggcagcc tctggattgg gatacaggga ttgatatgga gacttatcaa
     1381 actgaaacac cacaattttt ttctttccgg agatagggtg ttatgtattt caggctggct
     1441 ttgaactctt gcagctgagg ctggcctaga atccctttca tcagcctcca tctcctcagt
     1501 gctgggctta ccactgtgca cctttagctc ctcagcaaca ccactttccc tactttgctg
     1561 tcacttctat tgaactgtat aaagaagctg gtgggcccgc tggccatgtg tcgtta
//
