LOCUS       NM_013503               3127 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus dopamine receptor D5 (Drd5), mRNA.
ACCESSION   NM_013503
VERSION     NM_013503.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3127)
  AUTHORS   Campos,J., Osorio-Barrios,F., Villanelo,F.,
            Gutierrez-Maldonado,S.E., Vargas,P., Perez-Acle,T. and Pacheco,R.
  TITLE     Chemokinergic and Dopaminergic Signalling Collaborates through the
            Heteromer Formed by CCR9 and Dopamine Receptor D5 Increasing the
            Migratory Speed of Effector CD4+ T-Cells to Infiltrate the Colonic
            Mucosa
  JOURNAL   Int J Mol Sci 25 (18), 10022 (2024)
   PUBMED   39337509
  REMARK    GeneRIF: Chemokinergic and Dopaminergic Signalling Collaborates
            through the Heteromer Formed by CCR9 and Dopamine Receptor D5
            Increasing the Migratory Speed of Effector CD4[+] T-Cells to
            Infiltrate the Colonic Mucosa.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3127)
  AUTHORS   Amatya,B., Yang,S., Yu,P., Vaz de Castro,P.A.S., Armando,I.,
            Zeng,C., Felder,R.A., Asico,L.D., Jose,P.A. and Lee,H.
  TITLE     Peroxiredoxin-4 and Dopamine D5 Receptor Interact to Reduce
            Oxidative Stress and Inflammation in the Kidney
  JOURNAL   Antioxid Redox Signal 38 (16-18), 1150-1166 (2023)
   PUBMED   36401517
  REMARK    GeneRIF: Peroxiredoxin-4 and Dopamine D5 Receptor Interact to
            Reduce Oxidative Stress and Inflammation in the Kidney.
REFERENCE   3  (bases 1 to 3127)
  AUTHORS   Sasamori,H., Asakura,T., Sugiura,C., Bouchekioua,Y., Nishitani,N.,
            Sato,M., Yoshida,T., Yamasaki,M., Terao,A., Watanabe,M., Ohmura,Y.
            and Yoshioka,M.
  TITLE     Behavioral characteristics of dopamine D5 receptor knockout mice
  JOURNAL   Sci Rep 12 (1), 6014 (2022)
   PUBMED   35399112
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3127)
  AUTHORS   Li,J., Price,T.J. and Baccei,M.L.
  TITLE     D1/D5 Dopamine Receptors and mGluR5 Jointly Enable Non-Hebbian
            Long-Term Potentiation at Sensory Synapses onto Lamina I
            Spinoparabrachial Neurons
  JOURNAL   J Neurosci 42 (3), 350-361 (2022)
   PUBMED   34815314
REFERENCE   5  (bases 1 to 3127)
  AUTHORS   Tanner,M.A. and Grisanti,L.A.
  TITLE     A Dual Role for Death Receptor 5 in Regulating Cardiac Fibroblast
            Function
  JOURNAL   Front Cardiovasc Med 8, 699102 (2021)
   PUBMED   34527710
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3127)
  AUTHORS   Zamanillo,D., Casanova,E., Alonso-Llamazares,A., Ovalle,S.,
            Chinchetru,M.A. and Calvo,P.
  TITLE     Identification of a cyclic adenosine 3',5'-monophosphate-dependent
            protein kinase phosphorylation site in the carboxy terminal tail of
            human D1 dopamine receptor
  JOURNAL   Neurosci Lett 188 (3), 183-186 (1995)
   PUBMED   7609904
REFERENCE   7  (bases 1 to 3127)
  AUTHORS   Grosson,C.L., MacDonald,M.E., Duyao,M.P., Ambrose,C.M.,
            Roffler-Tarlov,S. and Gusella,J.F.
  TITLE     Synteny conservation of the Huntington's disease gene and
            surrounding loci on mouse Chromosome 5
  JOURNAL   Mamm Genome 5 (7), 424-428 (1994)
   PUBMED   7919654
REFERENCE   8  (bases 1 to 3127)
  AUTHORS   Crabbe,J.C., Belknap,J.K., Mitchell,S.R. and Crawshaw,L.I.
  TITLE     Quantitative trait loci mapping of genes that influence the
            sensitivity and tolerance to ethanol-induced hypothermia in BXD
            recombinant inbred mice
  JOURNAL   J Pharmacol Exp Ther 269 (1), 184-192 (1994)
   PUBMED   8169823
REFERENCE   9  (bases 1 to 3127)
  AUTHORS   Chang,N.C., Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Chang,Y.H.,
            Chen,W.M. and Chang,A.C.
  TITLE     Assignment of two alpha 2 adrenoceptor subtype genes to murine
            chromosomes
  JOURNAL   Neurosci Lett 167 (1-2), 105-108 (1994)
   PUBMED   8177505
REFERENCE   10 (bases 1 to 3127)
  AUTHORS   Tiberi,M., Jarvie,K.R., Silvia,C., Falardeau,P., Gingrich,J.A.,
            Godinot,N., Bertrand,L., Yang-Feng,T.L., Fremeau,R.T. Jr. and
            Caron,M.G.
  TITLE     Cloning, molecular characterization, and chromosomal assignment of
            a gene encoding a second D1 dopamine receptor subtype: differential
            expression pattern in rat brain compared with the D1A receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7491-7495 (1991)
   PUBMED   1831904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AEKQ02088507.1.
            
            On Sep 29, 2022 this sequence version replaced NM_013503.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK032054.1, AK045456.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3127              AEKQ02088507.1     26810-29936
FEATURES             Location/Qualifiers
     source          1..3127
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 20.4 cM"
     gene            1..3127
                     /gene="Drd5"
                     /gene_synonym="D5R; Drd-5; Drd1b; Gpcr1"
                     /note="dopamine receptor D5"
                     /db_xref="GeneID:13492"
                     /db_xref="MGI:MGI:94927"
     exon            1..3127
                     /gene="Drd5"
                     /gene_synonym="D5R; Drd-5; Drd1b; Gpcr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1704
                     /gene="Drd5"
                     /gene_synonym="D5R; Drd-5; Drd1b; Gpcr1"
                     /note="dopamine D5 receptor; d(5) dopamine receptor;
                     dopamine receptor 5"
                     /codon_start=1
                     /product="D(1B) dopamine receptor"
                     /protein_id="NP_038531.1"
                     /db_xref="CCDS:CCDS19255.1"
                     /db_xref="GeneID:13492"
                     /db_xref="MGI:MGI:94927"
                     /translation="MLPPGRNGTAHRARLGLQRQLAQVDAPGGSAAPLGPAQVVTAGL
                     LTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVA
                     GYWPFGAFCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVA
                     LAWTLSILISFIPVQLNWHRDKAGSQGREGLLSNETPWEEGWELDGRTENCDSSLNRT
                     YAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSRGACEPDP
                     SLRASIKKETKVFKTLSVIMGVFVCCWLPFFILNCMVPFCSSGDAQGPRTGFPCVSET
                     TFDIFVWFGWANSSLNPIIYAFNADFRKVFAQLLGCSHLCFRTPVQTVNISNELISYN
                     QDTVFHREIAAAYVHMIPNAVSSGDREVGEEEEAEEEGPFDHMSQISPTTPDGDLAAE
                     SVWELDCEEEVSLGKISPLTPNCFHKTA"
     regulatory      3107..3112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Drd5"
                     /gene_synonym="D5R; Drd-5; Drd1b; Gpcr1"
                     /note="hexamer: AATAAA"
     polyA_site      3127
                     /gene="Drd5"
                     /gene_synonym="D5R; Drd-5; Drd1b; Gpcr1"
                     /note="major polyA site"
ORIGIN      
        1 agacgcagcg gcagccgccg tccggcgcgc tgccgacagg atcggcccgc gagcaccggt
       61 cgcttcctgt cccatcctgg ggactagagg cgcgcaagac tgataccatt aaaggatccc
      121 aagcagtgca gggtgagcgc ccctcgggtc tggggacggt cagctgcagg gccgggagca
      181 ccctctgggg tgcccgatgg ggccttccgc ggggcgcagg ggcgaagttg ggatcgcacg
      241 cagtgagccc gagctaccca gcgcgacatg ctgcctcctg ggcgcaatgg caccgcacat
      301 cgggcgcggc tggggttgca gaggcaactg gcgcaggtgg acgcccccgg gggctcagca
      361 gccccactgg gacccgcgca ggtggtcacc gctggcctcc tgactctctt aatcgtctgg
      421 accttgctcg gcaacgtcct agtgtgtgct gctatcgtcc gcagccgcca cctgcgcgcc
      481 aaaatgacca acatcttcat cgtatctctg gccgtctcag acctcttcgt ggcattgctg
      541 gtcatgcctt ggaaggccgt ggctgaggtg gccgggtact ggccctttgg ggcattctgc
      601 gacatctggg tggcctttga catcatgtgc tccactgctt ccatcctgaa tctgtgtatc
      661 atcagcgtgg accggtactg ggctatttcc agacccttcc gctacgagcg caagatgacc
      721 cagcgtgtag ccctggtcat ggtggccctg gcctggacct tgtccatcct catctccttt
      781 atcccggtcc aactcaattg gcacagagac aaggcaggct cccagggccg agagggcctg
      841 ctgtccaatg agacaccctg ggaggaaggt tgggagctag acgggagaac agagaactgt
      901 gactccagcc tgaaccgaac ctacgccatc tcctcgtcgc tcatcagctt ctatatcccg
      961 gtagccatca tgatagtgac ctacacgcgc atctaccgca ttgcacaggt tcagatccgc
     1021 cgtatctcct ccctagaaag ggcagctgag catgctcaga gttgccggag ccgtggggcc
     1081 tgcgaacctg accccagcct gcgagcatcc atcaagaagg agaccaaggt cttcaaaacc
     1141 ctgtccgtga tcatgggggt cttcgtgtgc tgctggttgc ctttcttcat cctgaactgt
     1201 atggttccct tctgcagcag tggagatgcc cagggcccaa ggactggctt cccttgtgtc
     1261 agcgagacca ccttcgacat attcgtctgg tttggctggg ccaactcctc tctcaacccc
     1321 atcatctatg cctttaatgc agacttccgg aaggtgttcg cccagctgct ggggtgcagc
     1381 cacctctgct tccggacccc cgtgcagacg gtaaacatca gtaatgaact tatttcctac
     1441 aaccaagaca cggtcttcca cagggagatc gctgctgcct atgtccacat gatcccaaat
     1501 gcggtgtcct ccggagacag ggaggtggga gaggaggagg aggcggagga ggaggggcct
     1561 ttcgatcaca tgtctcaaat ctctccaacg accccagatg gtgacctggc tgctgagtct
     1621 gtctgggagc ttgactgtga ggaggaggtt tccttaggca aaatctcacc actcaccccc
     1681 aattgtttcc ataaaactgc ttagaaacac cctcatgggc atgtacagtt gtggccatat
     1741 ttacaagcat gcacaaatgc gcgcgcacac gcacacaaat atacacactc ctggtgtgct
     1801 tatgctttct gtagtcctgc tgcgtagaaa ccaaacgatt cttagctgag aaaatgaatg
     1861 agcagaggct gttggaataa actcagatat tctgggcaca gaagagagtt ccctttagag
     1921 acgagaaagt ggaacctggt cctttaagaa gtacacctca atttaccctt tctaacagag
     1981 gcttgttctg tgacttgcac ctgggttgct ttttaaatga caggtctgag tggcaattgc
     2041 tggtatggtc tgtgactttc tagactttgg gaccatagcc ccctgttctc gggctgctgc
     2101 tttagtgcag gttgaagggt ctttcctgtg gccgggattt ctccctgatt tgttgtggtt
     2161 tccataagcg cacagtacat tcatttgtgg ctgggaggag gggcagtcac ctttgctttg
     2221 ccagttggtg ctcagtgttt ctcctagaga aaccacaagt gccagtgctc ttggaagaca
     2281 gcaggatttt ggagtacaca tttgttttct gagcagcttt gcttagggaa ctcgcagaac
     2341 aaagggcctt gaggaaatgc tgacttcttg gatttctttt ttcttagtca gtcacacctt
     2401 caggacacac tgacggctca tttcacctac acagtattag atgcgggatt ctcaagcctg
     2461 agactcaatt acggttgttt tttttttttt ttatcttttg gaactgtctt ctagaagtat
     2521 aggagacaat ggtcctgctt gctagataga taccctcggc tcatgggaaa gaccccctaa
     2581 cataactcat cttctccatc tctcatctag ggtgtttcag agcgacatgg cttcagtaaa
     2641 ccacaatttc tagggtcttt tagatgtgat atgcttcaaa atgcttcaaa accgaaatcc
     2701 tgctttgaag cagacgattt tctttgcagg ccattgcaaa tggaatgaac ttcagcctat
     2761 atatgcagaa agccagaggc aacacatgcc tggatgaact tgcagggtta ggggctcacg
     2821 gaggagccca cctgtctttt tgctttccca ccctgcactg agtacggtga agtgtccttt
     2881 attctggtat gatttttatt agacacaaat gtaaaaaaaa aattaaaaag tattggaagc
     2941 aaatgaaatg tgcatatgtt agttcttaca cgcccctgct ccaaaaacgg tttctcaagg
     3001 acagttcaat caattttggt ttccttatgg ataattgtat tatgagtctt ctgaacagcc
     3061 gtgttttgtt ccctgtaaaa tgtatagtgc ctgtcacatc atgcttaata aatgtcagtt
     3121 aaatgaa
//
