LOCUS       NM_007878               1278 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus dopamine receptor D4 (Drd4), transcript variant 1,
            mRNA.
ACCESSION   NM_007878
VERSION     NM_007878.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1278)
  AUTHORS   D'Souza,S.P., Upton,B.A., Eldred,K.C., Glass,I., Nayak,G.,
            Grover,K., Ahmed,A., Nguyen,M.T., Hu,Y.C., Gamlin,P. and Lang,R.A.
  TITLE     Developmental control of rod number via a light-dependent
            retrograde pathway from intrinsically photosensitive retinal
            ganglion cells
  JOURNAL   Dev Cell 59 (21), 2897-2911 (2024)
   PUBMED   39142280
REFERENCE   2  (bases 1 to 1278)
  AUTHORS   Ko,B., Yoo,J.Y., Yoo,T., Choi,W., Dogan,R., Sung,K., Um,D.,
            Lee,S.B., Kim,H.J., Lee,S., Beak,S.T., Park,S.K., Paik,S.B.,
            Kim,T.K. and Kim,J.H.
  TITLE     Npas4-mediated dopaminergic regulation of safety memory
            consolidation
  JOURNAL   Cell Rep 42 (7), 112678 (2023)
   PUBMED   37379214
REFERENCE   3  (bases 1 to 1278)
  AUTHORS   Haddish,K. and Yun,J.W.
  TITLE     Dopamine receptor D4 (DRD4) negatively regulates UCP1- and
            ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle
            cells
  JOURNAL   Pflugers Arch 475 (6), 757-773 (2023)
   PUBMED   37103560
  REMARK    GeneRIF: Dopamine receptor D4 (DRD4) negatively regulates UCP1- and
            ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle
            cells.
            Erratum:[Pflugers Arch. 2023 Jun;475(6):775. doi:
            10.1007/s00424-023-02819-7. PMID: 37138189]
REFERENCE   4  (bases 1 to 1278)
  AUTHORS   Liu,X., Guo,Y., Yang,Y., Qi,C., Xiong,T., Chen,Y., Wu,G., Zeng,C.
            and Wang,D.
  TITLE     DRD4 (Dopamine D4 Receptor) Mitigate Abdominal Aortic Aneurysm via
            Decreasing P38 MAPK (mitogen-activated protein kinase)/NOX4 (NADPH
            Oxidase 4) Axis-Associated Oxidative Stress
  JOURNAL   Hypertension 78 (2), 294-307 (2021)
   PUBMED   34176291
  REMARK    GeneRIF: DRD4 (Dopamine D4 Receptor) Mitigate Abdominal Aortic
            Aneurysm via Decreasing P38 MAPK (mitogen-activated protein
            kinase)/NOX4 (NADPH Oxidase 4) Axis-Associated Oxidative Stress.
REFERENCE   5  (bases 1 to 1278)
  AUTHORS   Knop,J., van IJzendoorn,M.H., Bakermans-Kranenburg,M.J., Joels,M.
            and van der Veen,R.
  TITLE     Maternal care of heterozygous dopamine receptor D4 knockout mice:
            Differential susceptibility to early-life rearing conditions
  JOURNAL   Genes Brain Behav 19 (7), e12655 (2020)
   PUBMED   32306548
  REMARK    GeneRIF: Maternal care of heterozygous dopamine receptor D4
            knockout mice: Differential susceptibility to early-life rearing
            conditions.
REFERENCE   6  (bases 1 to 1278)
  AUTHORS   Suzuki,T., Kobayashi,K. and Nagatsu,T.
  TITLE     Genomic structure and tissue distribution of the mouse dopamine D4
            receptor
  JOURNAL   Neurosci Lett 199 (1), 69-72 (1995)
   PUBMED   8584230
REFERENCE   7  (bases 1 to 1278)
  AUTHORS   Scott,A.W., Griffin,S.A. and Luedtke,R.R.
  TITLE     Genetic polymorphisms at the rat and murine loci coding for
            dopamine D2-like receptors
  JOURNAL   Brain Res Mol Brain Res 29 (2), 347-357 (1995)
   PUBMED   7609622
REFERENCE   8  (bases 1 to 1278)
  AUTHORS   Fishburn,C.S., Carmon,S. and Fuchs,S.
  TITLE     Molecular cloning and characterisation of the gene encoding the
            murine D4 dopamine receptor
  JOURNAL   FEBS Lett 361 (2-3), 215-219 (1995)
   PUBMED   7698326
REFERENCE   9  (bases 1 to 1278)
  AUTHORS   Guillemot,F., Caspary,T., Tilghman,S.M., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Anderson,D.J., Joyner,A.L., Rossant,J.
            and Nagy,A.
  TITLE     Genomic imprinting of Mash2, a mouse gene required for trophoblast
            development
  JOURNAL   Nat Genet 9 (3), 235-242 (1995)
   PUBMED   7773285
REFERENCE   10 (bases 1 to 1278)
  AUTHORS   Rao,P.A., Pickar,D., Gejman,P.V., Ram,A., Gershon,E.S. and
            Gelernter,J.
  TITLE     Allelic variation in the D4 dopamine receptor (DRD4) gene does not
            predict response to clozapine
  JOURNAL   Arch Gen Psychiatry 51 (11), 912-917 (1994)
   PUBMED   7944879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163434.5.
            
            On Sep 28, 2022 this sequence version replaced NM_007878.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051421.1, AK044436.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               AC163434.5         88249-88544
            297-409             AC163434.5         89944-90056
            410-981             AC163434.5         90144-90715
            982-1278            AC163434.5         90890-91186
FEATURES             Location/Qualifiers
     source          1..1278
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.6 cM"
     gene            1..1278
                     /gene="Drd4"
                     /gene_synonym="D4R; Drd-4"
                     /note="dopamine receptor D4"
                     /db_xref="GeneID:13491"
                     /db_xref="MGI:MGI:94926"
     exon            1..296
                     /gene="Drd4"
                     /gene_synonym="D4R; Drd-4"
                     /inference="alignment:Splign:2.1.0"
     exon            297..409
                     /gene="Drd4"
                     /gene_synonym="D4R; Drd-4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..981
                     /gene="Drd4"
                     /gene_synonym="D4R; Drd-4"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1278
                     /gene="Drd4"
                     /gene_synonym="D4R; Drd-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1258..1263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Drd4"
                     /gene_synonym="D4R; Drd-4"
                     /note="hexamer: ATTAAA"
     polyA_site      1278
                     /gene="Drd4"
                     /gene_synonym="D4R; Drd-4"
                     /note="major polyA site"
ORIGIN      
        1 gcgggttcag cagtggcacc atggggaaca gcagcgctac tgaggacggt gggctgttgg
       61 ccgggcgtgg gccagaatcc ctggggactg gcgccgggct tgggggcgcg ggcgcggcgg
      121 cgctggtggg gggcgtgctg ctcatcggct tggtgttggc agggaactcg ctcgtgtgcg
      181 tgagcgtggc ctccgagcgc acgctgcaga cacccaccaa ctacttcatc gtgagcctgg
      241 ctgctgccga cctcctcctc gcggtgctgg tgctgcctct ctttgtctac tccgaggtcc
      301 agggtggcgt gtggctcctg agcccccgtc tctgtgacac gctcatggcc atggacgtca
      361 tgctgtgcac cgcctccatc ttcaacctgt gcgccatcag cgtggacagg ttcgtggccg
      421 tgaccgtgcc gctgcgctac aaccagcagg gtcagtgcca gctgctgctc atcgccgcca
      481 cgtggctgct gtccgccgcg gtggcttcgc cagtggtgtg tggcctcaat gatgtgcccg
      541 gccgcgatcc ggccgtgtgc tgcctggaga accgagacta tgtggtctac tcgtccgtct
      601 gctccttctt cctgccctgt ccgctcatgc tactgcttta ctgggccact ttccgcggcc
      661 tgcggcgctg ggaggcagcc cggcacacca aacttcacag ccgcgcgccg cgccgaccca
      721 gcggccccgg cccgccggtg tcggacccta ctcagggtcc cttcttccca gactgcccac
      781 ctcccttacc cagcctccgg acgagcccca gcgactccag caggccggag tcagagctct
      841 ctcagagacc ctgcagcccc gggtgtctgc tcgctgatgc agctctcccg caacctcctg
      901 agccgtcttc ccgcagaagg agaggcgcca agatcacggg aagggagcgc aaggcaatga
      961 gagtcctgcc ggtggtagtc ggggccttcc tggtgtgttg gacgcctttc ttcgtggtgc
     1021 acatcacgcg ggcgctgtgt ccggcttgct tcgtgtctcc gcgcctggtc agtgccgtca
     1081 cctggctagg ctatgtcaac agtgccctca accccatcat ctacaccatc ttcaacgcgg
     1141 agtttcgaag tgtcttccgc aagactctcc gtctccgctg ctgaaaggat gtcctgcaga
     1201 ggtcaaggag ttccaagact gtgtgcagag tgcgctggcg cgcattcttt cagtctgatt
     1261 aaacgaaatc ttttctaa
//
