LOCUS       NM_007877               1455 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus dopamine receptor D3 (Drd3), mRNA.
ACCESSION   NM_007877
VERSION     NM_007877.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1455)
  AUTHORS   Tropea,M.R., Melone,M., Li Puma,D.D., Vacanti,V., Aceto,G.,
            Bandiera,B., Trovato,R.C., Torrisi,S.A., Leggio,G.M., Palmeri,A.,
            D'Ascenzo,M., Conti,F., Grassi,C. and Puzzo,D.
  TITLE     Blockade of dopamine D3 receptors improves hippocampal synaptic
            function and rescues age-related cognitive phenotype
  JOURNAL   Aging Cell 23 (11), e14291 (2024)
   PUBMED   39236310
REFERENCE   2  (bases 1 to 1455)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1455)
  AUTHORS   Bono,F., Tomasoni,Z., Mutti,V., Sbrini,G., Kumar,R., Longhena,F.,
            Fiorentini,C. and Missale,C.
  TITLE     G Protein-Dependent Activation of the PKA-Erk1/2 Pathway by the
            Striatal Dopamine D1/D3 Receptor Heteromer Involves Beta-Arrestin
            and the Tyrosine Phosphatase Shp-2
  JOURNAL   Biomolecules 13 (3), 473 (2023)
   PUBMED   36979407
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1455)
  AUTHORS   Wang,S., Li,M., Su,L., Wang,Y., Ma,D., Wang,H., Zhu,J. and Chen,T.
  TITLE     Knockout of Dopamine D3 Receptor Gene Blocked
            Methamphetamine-Induced Distinct Changes of Dopaminergic and
            Glutamatergic Synapse in the Nucleus Accumbens Shell of Mice
  JOURNAL   Front Cell Neurosci 16, 893190 (2022)
   PUBMED   35711471
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1455)
  AUTHORS   Sun,H., Li,J., Yan,J., Sun,B., Wei,X., Song,L. and Yan,J.
  TITLE     Decreased taste sensitivity to sucrose in dopamine D3 receptor
            mutant mice
  JOURNAL   Chem Senses 47 (2022)
   PUBMED   35762652
  REMARK    GeneRIF: Decreased taste sensitivity to sucrose in dopamine D3
            receptor mutant mice.
REFERENCE   6  (bases 1 to 1455)
  AUTHORS   Baik,J.H., Picetti,R., Saiardi,A., Thiriet,G., Dierich,A.,
            Depaulis,A., Le Meur,M. and Borrelli,E.
  TITLE     Parkinsonian-like locomotor impairment in mice lacking dopamine D2
            receptors
  JOURNAL   Nature 377 (6548), 424-428 (1995)
   PUBMED   7566118
REFERENCE   7  (bases 1 to 1455)
  AUTHORS   Fu,D., Skryabin,B.V., Brosius,J. and Robakis,N.K.
  TITLE     Molecular cloning and characterization of the mouse dopamine D3
            receptor gene: an additional intron and an mRNA variant
  JOURNAL   DNA Cell Biol 14 (6), 485-492 (1995)
   PUBMED   7598803
REFERENCE   8  (bases 1 to 1455)
  AUTHORS   Scott,A.W., Griffin,S.A. and Luedtke,R.R.
  TITLE     Genetic polymorphisms at the rat and murine loci coding for
            dopamine D2-like receptors
  JOURNAL   Brain Res Mol Brain Res 29 (2), 347-357 (1995)
   PUBMED   7609622
REFERENCE   9  (bases 1 to 1455)
  AUTHORS   Park,B.H., Fishburn,C.S., Carmon,S., Accili,D. and Fuchs,S.
  TITLE     Structural organization of the murine D3 dopamine receptor gene
  JOURNAL   J Neurochem 64 (2), 482-486 (1995)
   PUBMED   7830039
REFERENCE   10 (bases 1 to 1455)
  AUTHORS   Crabbe,J.C., Belknap,J.K., Mitchell,S.R. and Crawshaw,L.I.
  TITLE     Quantitative trait loci mapping of genes that influence the
            sensitivity and tolerance to ethanol-induced hypothermia in BXD
            recombinant inbred mice
  JOURNAL   J Pharmacol Exp Ther 269 (1), 184-192 (1994)
   PUBMED   8169823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC137819.1.
            
            On Nov 21, 2015 this sequence version replaced NM_007877.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119286.1, X67274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1455              BC137819.1         1-1455
FEATURES             Location/Qualifiers
     source          1..1455
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 28.44 cM"
     gene            1..1455
                     /gene="Drd3"
                     /gene_synonym="D3R"
                     /note="dopamine receptor D3"
                     /db_xref="GeneID:13490"
                     /db_xref="MGI:MGI:94925"
     exon            1..291
                     /gene="Drd3"
                     /gene_synonym="D3R"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1362
                     /gene="Drd3"
                     /gene_synonym="D3R"
                     /note="dopamine D3 receptor; dopamine receptor 3"
                     /codon_start=1
                     /product="D(3) dopamine receptor"
                     /protein_id="NP_031903.1"
                     /db_xref="CCDS:CCDS28179.1"
                     /db_xref="GeneID:13490"
                     /db_xref="MGI:MGI:94925"
                     /translation="MAPLSQISSHINSTCGAENSTGVNRARPHAYYALSYCALILAII
                     FGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRIC
                     CDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVL
                     AFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYMVLRQR
                     RRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKPYP
                     QKCQDPLLSHLQPLSPGQTHGELKRYYSICQDTALRHPNFEGGGGMSQVERTRNSLSP
                     TMAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFF
                     LTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC"
     exon            292..404
                     /gene="Drd3"
                     /gene_synonym="D3R"
                     /inference="alignment:Splign:2.1.0"
     exon            405..547
                     /gene="Drd3"
                     /gene_synonym="D3R"
                     /inference="alignment:Splign:2.1.0"
     exon            548..744
                     /gene="Drd3"
                     /gene_synonym="D3R"
                     /inference="alignment:Splign:2.1.0"
     exon            745..822
                     /gene="Drd3"
                     /gene_synonym="D3R"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1165
                     /gene="Drd3"
                     /gene_synonym="D3R"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1455
                     /gene="Drd3"
                     /gene_synonym="D3R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgaattcct ctgtctgggc catggcacct ctgagccaga taagcagcca catcaactcc
       61 acctgtgggg cagaaaactc cactggtgtc aaccgggccc gtccacatgc ctactacgcc
      121 ctgtcctact gtgcactcat cctggccatc atctttggca acggtctggt atgtgcagct
      181 gtgctgaggg agcgagccct acagaccacc accaactacc tagtggtgag cctggctgtg
      241 gcagacctgc tggtggccac tttggtgatg ccgtgggtgg tgtacttgga ggtgacaggt
      301 ggagtctgga atttcagccg catttgctgt gatgtttttg tcaccctgga tgtcatgatg
      361 tgtacagcca gcatcctgaa cctctgtgcc atcagcatag acaggtacac agcagtggtc
      421 atgccagttc actatcagca tggcaccggg cagagctcct gtcgacgtgt ggcgctcatg
      481 attacggctg tgtgggtgct ggcctttgct gtgtcctgcc ctctcctctt tggtttcaac
      541 acaacagggg atcccagcat ctgctccatc tccaaccctg attttgtcat ttactcttcg
      601 gtggtgtcct tctatgttcc ctttggggtg actgtcctgg tctatgccag gatctacatg
      661 gtcctgaggc aaaggcgaag aaaacggatc ctcactcgac agaacagcca gtgtatcagc
      721 atcagacctg gcttccctca gcagtcttcc tgtctgcggc tgcatcccat tcggcagttt
      781 tcaataaggg ccaggtttct gtcagatgcc acgggacaaa tggagcacat agaagacaaa
      841 ccatatcccc agaaatgcca ggaccctctc ttgtcacatc tacagcccct ctctcctggc
      901 cagacacatg gagagctgaa acgctactac agcatctgcc aagacactgc cttgaggcat
      961 ccaaacttcg aaggaggggg agggatgagc caagtggaga ggactcggaa ctccttaagc
     1021 cccaccatgg cacccaagct cagcttagag gttcgaaaac tcagcaatgg caggttatcc
     1081 acatccctga agctggggcc cctacagcct cggggagtac cacttcgaga gaagaaggcc
     1141 acccagatgg tggtcattgt gctcggggcc ttcattgtct gttggctgcc cttcttcttg
     1201 actcacgttc ttaataccca ctgtcaggca tgccacgtgt ccccagagct ttacagagcc
     1261 acgacatggc ttggctacgt gaacagtgcc ctgaaccctg tgatctacac caccttcaac
     1321 atagagttcc gcaaagcctt cctcaagatt ctatcctgct gaaggaggag aagagacatt
     1381 ccctttaccc acttcaagat gccaggcagt ttggaccccc aggagggtct ggttggaatg
     1441 actgccctgg cctct
//
