LOCUS       NM_010077               2778 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus dopamine receptor D2 (Drd2), transcript variant 1,
            mRNA.
ACCESSION   NM_010077
VERSION     NM_010077.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2778)
  AUTHORS   Bocarsly,M.E., Shaw,M.J., Ventriglia,E., Anderson,L.G.,
            Goldbach,H.C., Teresi,C.E., Bravo,M., Bock,R., Hong,P., Kwon,H.B.,
            Khawaja,I.M., Raman,R., Murray,E.M., Bonaventura,J., Burke,D.A.,
            Michaelides,M. and Alvarez,V.A.
  TITLE     Preexisting risk-avoidance and enhanced alcohol relief are driven
            by imbalance of the striatal dopamine receptors in mice
  JOURNAL   Nat Commun 15 (1), 9093 (2024)
   PUBMED   39438478
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2778)
  AUTHORS   Mathis,T., Baudin,F., Mariet,A.S., Augustin,S., Bricout,M.,
            Przegralek,L., Roubeix,C., Benzenine,E., Blot,G., Nous,C.,
            Kodjikian,L., Mauget-Faysse,M., Sahel,J.A., Plevin,R., Zeitz,C.,
            Delarasse,C., Guillonneau,X., Creuzot-Garcher,C., Quantin,C.,
            Hunot,S. and Sennlaub,F.
  TITLE     DRD2 activation inhibits choroidal neovascularization in patients
            with Parkinson's disease and age-related macular degeneration
  JOURNAL   J Clin Invest 134 (17), e174199 (2024)
   PUBMED   39012703
  REMARK    GeneRIF: DRD2 activation inhibits choroidal neovascularization in
            patients with Parkinson's disease and age-related macular
            degeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2778)
  AUTHORS   Han,L., Lu,S.N., Nishimura,T. and Kobayashi,K.
  TITLE     Regulatory roles of dopamine D2 receptor in milk protein production
            and apoptosis in mammary epithelial cells
  JOURNAL   Exp Cell Res 439 (1), 114090 (2024)
   PUBMED   38740167
  REMARK    GeneRIF: Regulatory roles of dopamine D2 receptor in milk protein
            production and apoptosis in mammary epithelial cells.
REFERENCE   4  (bases 1 to 2778)
  AUTHORS   Li,Y.D., Luo,Y.J., Su,W.K., Ge,J., Crowther,A., Chen,Z.K., Wang,L.,
            Lazarus,M., Liu,Z.L., Qu,W.M. and Huang,Z.L.
  TITLE     Anterior cingulate cortex projections to the dorsal medial striatum
            underlie insomnia associated with chronic pain
  JOURNAL   Neuron 112 (8), 1328-1341 (2024)
   PUBMED   38354737
REFERENCE   5  (bases 1 to 2778)
  AUTHORS   Scott,S.A., Fu,J. and Chang,P.V.
  TITLE     Dopamine receptor D2 confers colonization resistance via microbial
            metabolites
  JOURNAL   Nature 628 (8006), 180-185 (2024)
   PUBMED   38480886
  REMARK    GeneRIF: Dopamine receptor D2 confers colonization resistance via
            microbial metabolites.
REFERENCE   6  (bases 1 to 2778)
  AUTHORS   Mack,K.J., Todd,R.D. and O'Malley,K.L.
  TITLE     The mouse dopamine D2A receptor gene: sequence homology with the
            rat and human genes and expression of alternative transcripts
  JOURNAL   J Neurochem 57 (3), 795-801 (1991)
   PUBMED   1861151
REFERENCE   7  (bases 1 to 2778)
  AUTHORS   Montmayeur,J.P., Bausero,P., Amlaiky,N., Maroteaux,L., Hen,R. and
            Borrelli,E.
  TITLE     Differential expression of the mouse D2 dopamine receptor isoforms
  JOURNAL   FEBS Lett 278 (2), 239-243 (1991)
   PUBMED   1991517
REFERENCE   8  (bases 1 to 2778)
  AUTHORS   Ratty,A.K., Fitzgerald,L.W., Titeler,M., Glick,S.D., Mullins,J.J.
            and Gross,K.W.
  TITLE     Circling behavior exhibited by a transgenic insertional mutant
  JOURNAL   Brain Res Mol Brain Res 8 (4), 355-358 (1990)
   PUBMED   1980140
REFERENCE   9  (bases 1 to 2778)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Tirpak,A., Jarvie,K.R., Israel,Y.,
            Seeman,P. and Niznik,H.B.
  TITLE     Cloning of two additional catecholamine receptors from rat brain
  JOURNAL   FEBS Lett 262 (1), 8-12 (1990)
   PUBMED   2138567
REFERENCE   10 (bases 1 to 2778)
  AUTHORS   Chio,C.L., Hess,G.F., Graham,R.S. and Huff,R.M.
  TITLE     A second molecular form of D2 dopamine receptor in rat and bovine
            caudate nucleus
  JOURNAL   Nature 343 (6255), 266-269 (1990)
   PUBMED   2137198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167980.3, DN174660.1, BC105666.1, X55674.1, BM932444.1 and
            AW121101.1.
            
            On Jun 16, 2018 this sequence version replaced NM_010077.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X55674.1, BC105663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC167980.3         98997-99016
            21-259              DN174660.1         1-239
            260-1808            BC105666.1         1-1549
            1809-2336           X55674.1           1585-2112
            2337-2610           BM932444.1         93-366
            2611-2778           AW121101.1         1-168               c
FEATURES             Location/Qualifiers
     source          1..2778
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 26.72 cM"
     gene            1..2778
                     /gene="Drd2"
                     /gene_synonym="D2R; Drd-2"
                     /note="dopamine receptor D2"
                     /db_xref="GeneID:13489"
                     /db_xref="MGI:MGI:94924"
     exon            1..322
                     /gene="Drd2"
                     /gene_synonym="D2R; Drd-2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..638
                     /gene="Drd2"
                     /gene_synonym="D2R; Drd-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1688
                     /gene="Drd2"
                     /gene_synonym="D2R; Drd-2"
                     /note="isoform 1 is encoded by transcript variant 1; d(2)
                     dopamine receptor; dopamine receptor 2"
                     /codon_start=1
                     /product="D(2) dopamine receptor isoform 1"
                     /protein_id="NP_034207.2"
                     /db_xref="CCDS:CCDS40615.1"
                     /db_xref="GeneID:13489"
                     /db_xref="MGI:MGI:94924"
                     /translation="MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLL
                     IFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKF
                     SRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVW
                     VLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRK
                     RRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRA
                     QELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIV
                     NPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFI
                     THILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC"
     exon            639..748
                     /gene="Drd2"
                     /gene_synonym="D2R; Drd-2"
                     /inference="alignment:Splign:2.1.0"
     exon            749..885
                     /gene="Drd2"
                     /gene_synonym="D2R; Drd-2"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1076
                     /gene="Drd2"
                     /gene_synonym="D2R; Drd-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1163
                     /gene="Drd2"
                     /gene_synonym="D2R; Drd-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1494
                     /gene="Drd2"
                     /gene_synonym="D2R; Drd-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..2762
                     /gene="Drd2"
                     /gene_synonym="D2R; Drd-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2741..2746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Drd2"
                     /gene_synonym="D2R; Drd-2"
                     /note="hexamer: AATAAA"
     polyA_site      2762
                     /gene="Drd2"
                     /gene_synonym="D2R; Drd-2"
                     /note="major polyA site"
ORIGIN      
        1 agtgccggag ctggtcgcct ctcgcgcgca gcgccgactg cccgcctccc cgcctggtcc
       61 ccgcgctgcg ctcccgccct cccgccccgc ctcgccctgc cccgccgcgg cccgtccact
      121 gctccccgcg ggcccgagcc ggccgagcgg ctgcccgccg gggatctgaa cggcgcggcg
      181 gggccgggag ccgagggacc cgcagagggg accggcggcc ccggacggct gccggagggg
      241 cggccgtgcg tggatgcggc gggagctgga agcctcgagc agccggcgcc ttctctggcc
      301 ccgggcgccc tatggcttga agagccgtgc cacccagtgg ccccactgcc ccaatggatc
      361 cactgaacct gtcctggtac gatgatgatc tggagaggca gaactggagc cggcccttca
      421 atgggtccga agggaagcca gacaggcccc actacaacta ctatgccatg ctgctcaccc
      481 tcctcatctt tatcatcgtc tttggcaatg tgctggtgtg catggctgta tccagagaga
      541 aggctttgca gaccaccacc aactacctga tagtcagcct cgctgtggcc gatcttctgg
      601 tggccacact ggttatgccc tgggtcgtct atctggaggt ggtgggtgag tggaaattca
      661 gcaggattca ctgtgacatc tttgtcactc tggatgtcat gatgtgcaca gcaagcatct
      721 tgaacctgtg tgccatcagc atcgacaggt acacagctgt ggccatgcct atgttgtata
      781 acacacgcta cagctccaag cgccgagtta ctgtcatgat cgccattgtc tgggtcctgt
      841 ccttcaccat ctcttgccca ctgctctttg gactcaacaa cacagaccag aatgagtgta
      901 tcattgccaa ccctgccttc gtggtctact cctccatcgt ctcgttctac gtgcccttca
      961 tcgtcaccct gctggtctat atcaaaatct acatcgttct ccgcaagcgt cggaagcggg
     1021 tcaacaccaa gcgtagcagc cgagctttca gagccaacct gaagacacca ctcaagggca
     1081 actgtaccca ccctgaggac atgaaactct gcaccgttat catgaagtct aatgggagtt
     1141 tcccagtgaa caggcggaga atggatgctg cccgccgagc tcaggagctg gaaatggaga
     1201 tgctgtcaag caccagcccc ccagagagga cccggtatag ccccatccct cccagtcacc
     1261 accagctcac tctccccgat ccatcccacc acggtctaca tagcaaccct gacagtcctg
     1321 ccaaaccaga aaagaatggg catgccaaga ttgtcaatcc caggattgcc aagttctttg
     1381 agatccagac catgcccaat ggcaaaaccc ggacctccct taagacgatg agccgcagga
     1441 agctctccca gcagaaggag aagaaagcca ctcagatgct tgccattgtt cttggtgtgt
     1501 tcatcatctg ctggctgccc ttcttcatca cgcacatcct gaatatacac tgtgactgca
     1561 acatcccacc agtcctctac agcgccttca catggctggg ctatgtcaac agtgccgtga
     1621 accccatcat ctataccacc ttcaacattg agttccgcaa ggccttcatg aagatcctgc
     1681 actgctgagt ctgccccttg cctgcacagc agctgcttgc cgcctccctg cctaggcagg
     1741 ccagacctca tccctgcaag ctgtgggcag aaaggcccag atggactcgg ccttctcttg
     1801 accctgcagg ctctgcagtg ttagcttggc tcggtgcccc tctctgccca cacaccctta
     1861 tcctgccagg gtagggccag ggagactggt atcttaccag ctctggggtt ggatccatgg
     1921 ctcagagcag ctcacagagt gcccctttca catgcagatc ctgtctcctt ggcaccaaag
     1981 aagcagcagc cttccttgac cttcctctca ggcacggaag ctagctcagt agcggagcac
     2041 accttgattg ttggcttggc ctggcccttg cttgcctatg ttggatcagg tggtagaaga
     2101 gaaggacagt tcttacttta cagggaccac ataggaaagc agggaacatg ccaaggcctc
     2161 caggtgacgt tagtgtcggg agacacacat aaacaccagg tagctccacg gaccccagag
     2221 aaactgaggc tgaaaatctg ttttccaccc caactctagt gtgaatccct actttccata
     2281 gcagtgggta ttgctatgtt ctccactgtt atagaatccc atggggtttc tgtacccttc
     2341 gggggaaaac aactctaatc ctcaagggcc ccaagagaga ctgtaaagag aaaaatagct
     2401 gatttccctc taccctccaa tccactccgc cacttcttga catacattgg acatagccat
     2461 tccccacagc agatgctgga cagcctggga agttgagcct tggaccagtg ttggagctga
     2521 agttggaggt ggtaacttgg ggctcttggg cggggggtgt tgatatcttc cctctcccca
     2581 agtctcttct ctgccagtgc ctctgcctta gaggaggctg tggatggggc tgctggggct
     2641 gctgatacca ttgggtctgg ccctgagtga gggtggggaa gctgcagctt ggaggggtct
     2701 gggctccaac tctgtaacat caccatacat gcaccaaacc aataaaacct tgacaagagt
     2761 caaaaaaaaa aaaaaaaa
//
