LOCUS       NM_010076               3543 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus dopamine receptor D1 (Drd1), transcript variant 1,
            mRNA.
ACCESSION   NM_010076
VERSION     NM_010076.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3543)
  AUTHORS   Bocarsly,M.E., Shaw,M.J., Ventriglia,E., Anderson,L.G.,
            Goldbach,H.C., Teresi,C.E., Bravo,M., Bock,R., Hong,P., Kwon,H.B.,
            Khawaja,I.M., Raman,R., Murray,E.M., Bonaventura,J., Burke,D.A.,
            Michaelides,M. and Alvarez,V.A.
  TITLE     Preexisting risk-avoidance and enhanced alcohol relief are driven
            by imbalance of the striatal dopamine receptors in mice
  JOURNAL   Nat Commun 15 (1), 9093 (2024)
   PUBMED   39438478
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3543)
  AUTHORS   Bonnavion,P., Varin,C., Fakhfouri,G., Martinez Olondo,P., De
            Groote,A., Cornil,A., Lorenzo Lopez,R., Pozuelo Fernandez,E.,
            Isingrini,E., Rainer,Q., Xu,K., Tzavara,E., Vigneault,E., Dumas,S.,
            de Kerchove d'Exaerde,A. and Giros,B.
  TITLE     Striatal projection neurons coexpressing dopamine D1 and D2
            receptors modulate the motor function of D1- and D2-SPNs
  JOURNAL   Nat Neurosci 27 (9), 1783-1793 (2024)
   PUBMED   38965445
REFERENCE   3  (bases 1 to 3543)
  AUTHORS   Sun,M., Zhang,Y., Zhang,X.Q., Zhang,Y., Wang,X.D., Li,J.T., Si,T.M.
            and Su,Y.A.
  TITLE     Dopamine D1 receptor in medial prefrontal cortex mediates the
            effects of TAAR1 activation on chronic stress-induced cognitive and
            social deficits
  JOURNAL   Neuropsychopharmacology 49 (8), 1341-1351 (2024)
   PUBMED   38658737
  REMARK    GeneRIF: Dopamine D1 receptor in medial prefrontal cortex mediates
            the effects of TAAR1 activation on chronic stress-induced cognitive
            and social deficits.
REFERENCE   4  (bases 1 to 3543)
  AUTHORS   Rajagopal,L., Huang,M., Mahjour,S., Ryan,C., Elzokaky,A.,
            Svensson,K.A. and Meltzer,H.Y.
  TITLE     The dopamine D1 receptor positive allosteric modulator, DETQ,
            improves cognition and social interaction in aged mice and enhances
            cortical and hippocampal acetylcholine efflux
  JOURNAL   Behav Brain Res 459, 114766 (2024)
   PUBMED   38048913
REFERENCE   5  (bases 1 to 3543)
  AUTHORS   Zhang,Y., Gao,J., Li,N., Xu,P., Qu,S., Cheng,J., Wang,M., Li,X.,
            Song,Y., Xiao,F., Yang,X., Liu,J., Hong,H., Mu,R., Li,X., Wang,Y.,
            Xu,H., Xie,Y., Gao,T., Wang,G. and Aa,J.
  TITLE     Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid
            antidepressant strategy
  JOURNAL   Acta Pharm Sin B 14 (2), 667-681 (2024)
   PUBMED   38322327
REFERENCE   6  (bases 1 to 3543)
  AUTHORS   Baik,J.H., Picetti,R., Saiardi,A., Thiriet,G., Dierich,A.,
            Depaulis,A., Le Meur,M. and Borrelli,E.
  TITLE     Parkinsonian-like locomotor impairment in mice lacking dopamine D2
            receptors
  JOURNAL   Nature 377 (6548), 424-428 (1995)
   PUBMED   7566118
REFERENCE   7  (bases 1 to 3543)
  AUTHORS   Severynse,D.M., Colapietro,A.M., Box,T.L. and Caron,M.G.
  TITLE     The human D1A dopamine receptor gene promoter directs expression of
            a reporter gene to the central nervous system in transgenic mice
  JOURNAL   Brain Res Mol Brain Res 30 (2), 336-346 (1995)
   PUBMED   7637583
REFERENCE   8  (bases 1 to 3543)
  AUTHORS   Verma,A. and Kulkarni,S.K.
  TITLE     Role of D1/D2 dopamine and N-methyl-D-aspartate (NMDA) receptors in
            morphine tolerance and dependence in mice
  JOURNAL   Eur Neuropsychopharmacol 5 (2), 81-87 (1995)
   PUBMED   7549459
REFERENCE   9  (bases 1 to 3543)
  AUTHORS   O'Brien,E.P., Novak,E.K., Zhen,L., Manly,K.F., Stephenson,D. and
            Swank,R.T.
  TITLE     Molecular markers near two mouse chromosome 13 genes, muted and
            pearl, which cause platelet storage pool deficiency (SPD)
  JOURNAL   Mamm Genome 6 (1), 19-24 (1995)
   PUBMED   7719021
REFERENCE   10 (bases 1 to 3543)
  AUTHORS   Johnson,K.R. and Davisson,M.T.
  TITLE     A multipoint genetic linkage map of mouse chromosome 18
  JOURNAL   Genomics 13 (4), 1143-1149 (1992)
   PUBMED   1354640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044723.1, BY287823.1, CT030176.18 and BE957273.1.
            
            On Jan 11, 2008 this sequence version replaced NM_010076.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.54451.1,
                                           SRR1660821.52959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AK044723.1         2-85
            85-238              BY287823.1         133-286
            239-2280            AK044723.1         240-2281
            2281-2563           CT030176.18        186747-187029       c
            2564-3057           AK044723.1         2554-3047
            3058-3543           BE957273.1         1-486               c
FEATURES             Location/Qualifiers
     source          1..3543
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 28.4 cM"
     gene            1..3543
                     /gene="Drd1"
                     /gene_synonym="C030036C15Rik; Drd-1; Drd1a; Gpcr15"
                     /note="dopamine receptor D1"
                     /db_xref="GeneID:13488"
                     /db_xref="MGI:MGI:99578"
     exon            1..98
                     /gene="Drd1"
                     /gene_synonym="C030036C15Rik; Drd-1; Drd1a; Gpcr15"
                     /inference="alignment:Splign:2.1.0"
     exon            99..3529
                     /gene="Drd1"
                     /gene_synonym="C030036C15Rik; Drd-1; Drd1a; Gpcr15"
                     /inference="alignment:Splign:2.1.0"
     CDS             519..1859
                     /gene="Drd1"
                     /gene_synonym="C030036C15Rik; Drd-1; Drd1a; Gpcr15"
                     /note="D1A dopamine receptor; G protein-coupled receptor
                     DRD1; dopamine D1 receptor; dopamine receptor D1A"
                     /codon_start=1
                     /product="D(1A) dopamine receptor"
                     /protein_id="NP_034206.1"
                     /db_xref="CCDS:CCDS26524.1"
                     /db_xref="GeneID:13488"
                     /db_xref="MGI:MGI:99578"
                     /translation="MAPNTSTMDETGLPVERDFSFRILTACFLSLLILSTLLGNTLVC
                     AAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFD
                     IMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQL
                     SWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIY
                     RIAQKQIRRISALERAAVHAKNCQTTTGNGNPVECSQSESSFKMSFKRETKVLKTLSV
                     IMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFN
                     ADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIP
                     HAVGSSEDLKREEAGGIPKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST"
     regulatory      3494..3499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Drd1"
                     /gene_synonym="C030036C15Rik; Drd-1; Drd1a; Gpcr15"
                     /note="hexamer: AATAAA"
     polyA_site      3522
                     /gene="Drd1"
                     /gene_synonym="C030036C15Rik; Drd-1; Drd1a; Gpcr15"
                     /note="major polyA site"
ORIGIN      
        1 gcagaagcgc cttggcgggc ggagcgcgga gagcagagcg agcggcacag gagagggcgc
       61 agggttggcg gagtcgggga gcgtggtctc ccagatcggg catttggaga gatgtggcac
      121 caggggcttg aaggagaaat gcatgtattt taggctgtgt ctcagaagaa gaggcagcat
      181 ccccgaaaag tgactgagat tgaccaggaa gaggccccag actcttagag tatgcttaaa
      241 agcctatgca ttccttgggg aatctaggga ccagcggatg ccagggaaca gcgacctgga
      301 gcactgaacc cagaagacag gtggaaagca agcggctctt cttcctggta tggcttggat
      361 tgctatggag atgctcctga tggaacacca ttgtgctttt gtccagacag caactggggc
      421 tggagaaggg gctgggtggt gagtgattgg gggaagtctg gctaagcctg gccaagaacg
      481 tgagggctaa gccaccggaa gtgctttcct tctggaagat ggctcctaac acttctacca
      541 tggatgagac tggcctgcca gtggagaggg acttctcctt tcgcatcctc acagcctgtt
      601 ttctgtccct gcttatcctg tccactctct tagggaatac ccttgtctgt gccgctgtca
      661 tcaggtttcg acacctgcgg tccaaggtga ccaacttctt tgtcatctct ttagctgtgt
      721 cagatctctt ggtggctgtc ttggtcatgc cctggaaagc tgtggctgag attgctggct
      781 tttggccctt tgggtccttt tgtaacattt gggtagcctt tgacatcatg tgctccacgg
      841 catccatcct taacctctgt gtgatcagcg tggacaggta ttgggctatc tccagccctt
      901 tccagtatga gaggaagatg actccgaagg cagccttcat cctgattagc gtagcatgga
      961 ctttgtctgt tctcatatcc ttcattccag tgcagctaag ctggcacaag gcaaaaccta
     1021 catggccctt ggatggcaat tttacttccc tggaagatgc cgaggatgac aactgtgaca
     1081 cgaggttgag caggacatac gccatttcat cctccctcat aagcttttac atccccgtag
     1141 ccattatgat cgtcacttac accagtatct acaggattgc ccagaagcaa atccggcgca
     1201 tctcagcttt ggagagggca gcagtccatg ccaagaactg ccagaccacc acaggtaatg
     1261 gaaaccctgt cgaatgctct caatcagaaa gttcctttaa gatgtccttt aagagggaga
     1321 ctaaagtcct gaagacactg tctgtgatca tgggggtatt cgtgtgctgc tggctccctt
     1381 tcttcatttc gaactgtatg gtgcccttct gtggctctga ggagacccag ccattctgca
     1441 ttgattccat caccttcgat gtatttgtgt ggtttggctg ggcgaattcc tccctgaacc
     1501 ccattattta tgcttttaat gccgattttc agaaggcatt ctcgaccctc ttaggatgct
     1561 atagactctg ccctacaacg aataatgcca tagagactgt aagcatcaac aacaacgggg
     1621 ctgtgatgtt ttccagccac catgagcccc gaggctccat ctccaaggac tgtaatctgg
     1681 tttacctgat ccctcatgct gtgggctcct ctgaggacct gaagagggag gaggccggtg
     1741 gcatacctaa gccactggag aagctgtccc cggccttatc ggtcatattg gactatgaca
     1801 ccgatgtctc tctagaaaag atccaacccg ttacccacag cggacagcat tcaacctgaa
     1861 tattgggttc tcatctctga agctatgagt tccctagggc ttgctgttaa gaaattaaca
     1921 cgagacccct ctgctgcttt tggacagtta cagaacttct ccaactcact gactccagtg
     1981 tattctctag ccacaaggga aatgacttag gctctgaaat cctttttgaa gcattatctt
     2041 aggacactct atatatatat atttaaaaaa ataatagggc caaaagtcaa ctgtaaacag
     2101 cttcacttaa aaatcaaact ttccaggaag gaagtgtgag agttgtttgc tgtatccaaa
     2161 caggtgctaa aactgtccaa gcagttttca gattgtaaag gtaggtgcat gcctttgtta
     2221 attaacttct ctgacaataa ttgagcctta cagcaagagt gggatttctt tttttttttt
     2281 ctttctcaga attgacagat gcattgttga taatggtttt atttatttat ttatttattt
     2341 atttatttat ttattgtatt atatggatat tttaaattta tcatagtgaa cctatattta
     2401 gcttatttaa tagaccgaac caatgttaaa tcagagactg aactgtccat tgtactagca
     2461 cttcatgagc caatgaaaca gtacacatag actctgagat tctgagctgg gaatgacttc
     2521 tgggaaggca gcaaaggctg atgtggtggt tccttaactc aacacagaca caaataaaca
     2581 caaggtaaga agtgactaac actaccaatg ctctgcccct aaaaatattt tggaaagata
     2641 tgttttttaa aaaagaagct actattgtgt tctgaatgtt ttaaatggca gaggctttcc
     2701 ccgaggcaaa tttgcacttc tgtaaatatc tctgtaaaag ccagctcaag aagaaatcca
     2761 actttagatt tctgtctgaa tgtcgaggaa gagcatatgc cactttgtat ttatgtaaaa
     2821 taattggccc tccctgtcat ttctcatttc atgcttgaaa tggctttctg aaacaaacaa
     2881 atgactgtcc aggattaaga tgtgcatcga ggtgaatgag ctgtaaagtc acaggtcaca
     2941 gcagcccctc cgatagttgg gctcatcgct ggttcttcat ctgcccaggt ctaaccaagc
     3001 cggctgctca aggggctact tttgtagtgc tttaatccga atttagtatc ctctcttaaa
     3061 aaaaaaaaaa aaagctcttt aatgttagtg gtaaactagc taatgagctg tgcctcatcg
     3121 tggaagtata cacttctgtt gttggtgggg ggaatagaag aaccccttcc cggtgtgtgt
     3181 tgagcatcac aaagccatca gcatcactag tcacaaatgc tacttttttt cctccctgtg
     3241 gttttgaatc tagtttccaa gtcatagcct ggactgcaaa aagtaccatc aagtcccctc
     3301 gggtgggggt attgcaacag tgtttctttt gttgtttgaa atgtttacaa ggtgttcttt
     3361 ggaagcagct gcaacatgtg gatagaactg aaggaagggc tgactggctt gctaacagta
     3421 tctcctgcag gggtctgtgt tacgtacttt gaatgttttc tcagctctac cgcttgtatg
     3481 ctttcttaca taaaataaaa ttattttgtg aattcaaatc aaccccaaaa aaaaaaaaaa
     3541 aaa
//
