LOCUS       NM_001042715            2832 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dynein regulatory complex subunit 7 (Drc7), mRNA.
ACCESSION   NM_001042715 XM_991986
VERSION     NM_001042715.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2832)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2832)
  AUTHORS   Bachvarova,V., Dierker,T., Esko,J., Hoffmann,D., Kjellen,L. and
            Vortkamp,A.
  TITLE     Chondrocytes respond to an altered heparan sulfate composition with
            distinct changes of heparan sulfate structure and increased levels
            of chondroitin sulfate
  JOURNAL   Matrix Biol 93, 43-59 (2020)
   PUBMED   32201365
REFERENCE   3  (bases 1 to 2832)
  AUTHORS   Morohoshi,A., Miyata,H., Shimada,K., Nozawa,K., Matsumura,T.,
            Yanase,R., Shiba,K., Inaba,K. and Ikawa,M.
  TITLE     Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is
            required for sperm flagellum formation and male fertility in mice
  JOURNAL   PLoS Genet 16 (1), e1008585 (2020)
   PUBMED   31961863
  REMARK    GeneRIF: Drc7 KO male mice were infertile due to their short
            immotile spermatozoa.  Drc7 is essential for the correct assembly
            of the N-DRC and flagella.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2832)
  AUTHORS   Castaneda,J.M., Hua,R., Miyata,H., Oji,A., Guo,Y., Cheng,Y.,
            Zhou,T., Guo,X., Cui,Y., Shen,B., Wang,Z., Hu,Z., Zhou,Z., Sha,J.,
            Prunskaite-Hyyrylainen,R., Yu,Z., Ramirez-Solis,R., Ikawa,M.,
            Matzuk,M.M. and Liu,M.
  TITLE     TCTE1 is a conserved component of the dynein regulatory complex and
            is required for motility and metabolism in mouse spermatozoa
  JOURNAL   Proc Natl Acad Sci U S A 114 (27), E5370-E5378 (2017)
   PUBMED   28630322
REFERENCE   5  (bases 1 to 2832)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Gm770 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   6  (bases 1 to 2832)
  AUTHORS   Ma,Q., Wang,H., Guo,R., Wang,H., Ge,Y., Ma,J., Xue,S. and Han,D.
  TITLE     Molecular cloning and characterization of SRG-L, a novel mouse gene
            developmentally expressed in spermatogenic cells
  JOURNAL   Mol Reprod Dev 73 (9), 1075-1083 (2006)
   PUBMED   16804880
  REMARK    GeneRIF: SRG-L (Spermatogenesis Related Gene expressed in late
            stages of spermatogenic cells) may play definite roles regulating
            differentiation of germ cells during spermatogenesis, particularly
            during meiosis and spermiogenesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103935.10.
            
            On Jul 27, 2007 this sequence version replaced NM_001042715.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY352586.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC103935.10        85505-85545
            42-255              AC103935.10        86403-86616
            256-430             AC103935.10        87003-87177
            431-556             AC103935.10        88797-88922
            557-751             AC103935.10        89427-89621
            752-910             AC103935.10        92115-92273
            911-1129            AC103935.10        92579-92797
            1130-1261           AC103935.10        98451-98582
            1262-1334           AC103935.10        100805-100877
            1335-1463           AC103935.10        101643-101771
            1464-1592           AC103935.10        101945-102073
            1593-1813           AC103935.10        103144-103364
            1814-2029           AC103935.10        104518-104733
            2030-2140           AC103935.10        105395-105505
            2141-2251           AC103935.10        105606-105716
            2252-2446           AC103935.10        106652-106846
            2447-2586           AC103935.10        108075-108214
            2587-2832           AC103935.10        108298-108543
FEATURES             Location/Qualifiers
     source          1..2832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..2832
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /note="dynein regulatory complex subunit 7"
                     /db_xref="GeneID:330830"
                     /db_xref="MGI:MGI:2685616"
     exon            1..41
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            42..255
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..2680
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /note="coiled-coil domain-containing protein 135;
                     spermatogenesis-related gene in late stages of
                     spermatogenesis cells protein; coiled-coil
                     domain-containing protein lobo homolog; coiled-coil domain
                     containing 135"
                     /codon_start=1
                     /product="dynein regulatory complex subunit 7"
                     /protein_id="NP_001036180.2"
                     /db_xref="CCDS:CCDS40444.1"
                     /db_xref="GeneID:330830"
                     /db_xref="MGI:MGI:2685616"
                     /translation="MEVLREKVEEEEEAEREEAAERAERTEKLERVTKSAEVSREGTI
                     LSQDELRDLEGKLMAIEIPTQADHSVISQAPVDVTKLPPSYTTNSLKEEHLLLVADNF
                     SRQYSHLCPDRVPLFLHPLNECNVPKFVSTTLRPTLMPYPELYNWDSCAQFVSDFLTM
                     VPLVDPLKPPTHLYSSTTVLKCQKGNCFDFSTLLCSMLIGSGYDAYCVNGYGSLDLCL
                     MDLTREVCPLTVKAKEIVKKKEKTVPKKYSIKPPRDLTSKFEQEQEEKRIQEIKDLEQ
                     RRLKEEEDRILEAEKAKPDPLHGLRVHSWVLVLAGKREVPESFFIDPLTARSYSTKDE
                     HFLGIESLWNHKNYWINMQDCWNCCKDLIFDLGDPVRWEYMLLGTDKPHLSLTEEDEE
                     GLDDDDDDVEDLGKEEEDKSFDMPSSWVSQIEITPEEFETRCPSGKKVIQYKKAQLEK
                     WSPYLNNNGLVCRLTTYEDQQCTKVLEIKEWYQNREDMLELKHINKTTGLHVDYFKPG
                     HPQALCVHSYKSMLPEMDRVMEFYKKIRVDGLVKREETPMTMTEYYEGRSDFLAYRHV
                     NFGPRVKKLSQSSVESNPRPMVKITERFSRNPEKPADEDVAERLFLIVEERIQLRYHC
                     RDDYITASKREFLRRMEVDSKGNKIIMTPEMCISYEVEPMEHTKKLLYQYETMNQLKN
                     EEKLSRHQAWESELEVLEILKLREEEEEAHTLTISIYDTKRNEKSKEYREAMERVLHE
                     EHLRQVEAQLDYLAPFLAQLPPGEKLTRWQAVRLKDECLSDFKQRLIDKANLIQARFE
                     KETQELQKKQQWYQENQVTLTPEDENLYLSYCSQAMFRIRILEQRLNRHKELAPLKYL
                     ALEEKLYKDPRLIDFVKVFV"
     exon            256..430
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            431..556
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            557..751
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            752..910
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1129
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1261
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1334
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1463
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1592
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1813
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2029
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2140
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2251
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2446
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2586
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2832
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2805..2810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /note="hexamer: AATAAA"
     polyA_site      2832
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /note="major polyA site"
ORIGIN      
        1 gttaccatag agacaagtaa cagtaaggct gttcttggag gctgtcagga tggaggtcct
       61 gagagagaaa gtggaggagg aggaggaggc tgagcgtgaa gaagcagccg agagggccga
      121 acggactgag aagctggaga gggtgacaaa gtccgccgaa gtgagcagag aggggaccat
      181 cctgagccag gatgagcttc gagacctgga ggggaagctg atggccatcg agatccctac
      241 ccaagctgat cactcggtca taagccaggc ccctgttgat gtcaccaagc tgcctccttc
      301 ctataccacc aactcattga aggaggagca cctgctgctg gtggcagaca acttctcccg
      361 ccagtacagc cacctgtgtc cagaccgcgt gcctctcttc ttgcacccgt taaatgagtg
      421 caatgtgcct aagttcgtga gcaccaccct gaggcccaca ctgatgccct accctgaact
      481 ctacaactgg gacagctgcg cccagtttgt atctgacttc ctcaccatgg tcccactggt
      541 tgatcccctc aagccgccca cgcacttata ttcctcgacc accgtgctca agtgccagaa
      601 gggaaactgc tttgacttca gcaccctgct ctgctccatg ttgattggct ccggctatga
      661 tgcctactgc gtcaatggct atggctcact ggacctgtgc ctcatggacc tgacaaggga
      721 agtgtgtccg ctcactgtga aggccaaaga gatagtcaag aagaaagaga agacggtgcc
      781 taagaaatac tccatcaagc cgccccggga cctgaccagc aagtttgagc aggagcaaga
      841 ggagaagaga atacaggaga tcaaggatct agaacaaagg cgacttaagg aagaggaaga
      901 tcgcatcctg gaggcagaga aagcgaagcc cgaccccctg catggcctgc gggtacactc
      961 ctgggtcctg gtgctggcag gaaagcgaga ggtgcctgag agcttcttca tcgaccctct
     1021 gactgcacgc agctacagta ccaaggatga gcacttcctg ggcattgaga gcctctggaa
     1081 ccacaagaac tactggatca acatgcagga ttgctggaac tgctgcaagg acttgatctt
     1141 cgacctggga gaccctgtaa gatgggagta catgctcttg gggaccgata agcctcacct
     1201 gtccttgact gaggaggatg aagaagggct ggatgatgat gatgatgatg tggaagacct
     1261 gggcaaagaa gaggaggata agagctttga catgccgtct tcgtgggtct cccagattga
     1321 gatcacccca gaagagtttg agacccgttg tcccagtggg aagaaagtga tacagtacaa
     1381 gaaggcacag ctggagaagt ggtccccata cctcaacaac aacggcctgg tgtgtcgcct
     1441 caccacctac gaggaccaac agtgcacaaa ggttctagag ataaaggagt ggtaccagaa
     1501 ccgggaggat atgctagagc tgaagcacat caacaagacc acaggcctgc acgtggacta
     1561 cttcaagcca ggccatcccc aagctctgtg tgtgcactca tacaagtcta tgctacctga
     1621 gatggaccgc gtcatggagt tctataaaaa aatccgtgtg gatggcctgg tgaagcggga
     1681 ggagacgccc atgacaatga ccgagtacta tgaagggcgc tccgacttcc ttgcctatcg
     1741 gcacgtcaat tttggaccca gagtcaagaa gctcagccag agcagcgtgg agtcgaaccc
     1801 aaggcccatg gtgaaaatca cagagcggtt ctcccgcaat ccagagaagc ccgcggatga
     1861 ggacgtggca gagcgtttgt ttctgatagt ggaagagcgc atccagcttc gctaccattg
     1921 ccgcgacgac tacatcaccg catccaagcg agagttcctg cggcgcatgg aggtcgacag
     1981 caagggaaac aagatcatca tgacaccaga aatgtgcatc agctacgagg tagagccgat
     2041 ggagcacact aagaaactcc tctaccagta cgagaccatg aatcagctga agaacgaaga
     2101 aaagctgtcc cgacatcagg cctgggagtc ggagctggag gtgctggaga ttttgaagct
     2161 ccgtgaagag gaggaggagg cacacacgct gaccatctcc atctacgaca ccaagcgcaa
     2221 cgagaagagc aaagagtatc gggaggccat ggagcgcgtc ttgcatgagg agcacctgcg
     2281 gcaggtggag gcccagctgg actacctggc cccattcctg gcccagctcc ctccaggcga
     2341 gaagctaacc cgttggcagg cggtgcgtct caaggacgag tgtctcagcg acttcaagca
     2401 gcggctcatc gacaaggcta acctcatcca ggctcgcttt gagaaggaga cccaggagct
     2461 gcagaagaag cagcaatggt accaggagaa ccaggtaacc ctgacgccgg aggatgaaaa
     2521 cctgtacctg agctactgtt ctcaggccat gttccgcatc cgaatcttgg aacagcggct
     2581 caatcggcac aaagagctgg ctccactgaa gtacctggcg ctggaggaaa agctctacaa
     2641 agacccacgc ttaatagact tcgtaaaagt ctttgtttga tggcccctcc tggaactacg
     2701 gcagaccctg ccagagaatg gagtctctcc cttctcccca accactatga tcctatacta
     2761 gcctcgctgc cacactacct ccctatccct catagcctcc ctcaaataaa tgcatttcct
     2821 gtttgccatt ta
//
