LOCUS       NP_001036180             876 aa            linear   ROD 30-APR-2024
DEFINITION  dynein regulatory complex subunit 7 [Mus musculus].
ACCESSION   NP_001036180 XP_997080
VERSION     NP_001036180.2
DBSOURCE    REFSEQ: accession NM_001042715.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 876)
  AUTHORS   Bachvarova,V., Dierker,T., Esko,J., Hoffmann,D., Kjellen,L. and
            Vortkamp,A.
  TITLE     Chondrocytes respond to an altered heparan sulfate composition with
            distinct changes of heparan sulfate structure and increased levels
            of chondroitin sulfate
  JOURNAL   Matrix Biol 93, 43-59 (2020)
   PUBMED   32201365
REFERENCE   3  (residues 1 to 876)
  AUTHORS   Morohoshi,A., Miyata,H., Shimada,K., Nozawa,K., Matsumura,T.,
            Yanase,R., Shiba,K., Inaba,K. and Ikawa,M.
  TITLE     Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is
            required for sperm flagellum formation and male fertility in mice
  JOURNAL   PLoS Genet 16 (1), e1008585 (2020)
   PUBMED   31961863
  REMARK    GeneRIF: Drc7 KO male mice were infertile due to their short
            immotile spermatozoa.  Drc7 is essential for the correct assembly
            of the N-DRC and flagella.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 876)
  AUTHORS   Castaneda,J.M., Hua,R., Miyata,H., Oji,A., Guo,Y., Cheng,Y.,
            Zhou,T., Guo,X., Cui,Y., Shen,B., Wang,Z., Hu,Z., Zhou,Z., Sha,J.,
            Prunskaite-Hyyrylainen,R., Yu,Z., Ramirez-Solis,R., Ikawa,M.,
            Matzuk,M.M. and Liu,M.
  TITLE     TCTE1 is a conserved component of the dynein regulatory complex and
            is required for motility and metabolism in mouse spermatozoa
  JOURNAL   Proc Natl Acad Sci U S A 114 (27), E5370-E5378 (2017)
   PUBMED   28630322
REFERENCE   5  (residues 1 to 876)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Gm770 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   6  (residues 1 to 876)
  AUTHORS   Ma,Q., Wang,H., Guo,R., Wang,H., Ge,Y., Ma,J., Xue,S. and Han,D.
  TITLE     Molecular cloning and characterization of SRG-L, a novel mouse gene
            developmentally expressed in spermatogenic cells
  JOURNAL   Mol Reprod Dev 73 (9), 1075-1083 (2006)
   PUBMED   16804880
  REMARK    GeneRIF: SRG-L (Spermatogenesis Related Gene expressed in late
            stages of spermatogenic cells) may play definite roles regulating
            differentiation of germ cells during spermatogenesis, particularly
            during meiosis and spermiogenesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103935.10.
            
            On Jul 27, 2007 this sequence version replaced NP_001036180.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY352586.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     Protein         1..876
                     /product="dynein regulatory complex subunit 7"
                     /note="coiled-coil domain-containing protein 135;
                     spermatogenesis-related gene in late stages of
                     spermatogenesis cells protein; coiled-coil
                     domain-containing protein lobo homolog; coiled-coil domain
                     containing 135"
                     /calculated_mol_wt=103138
     Region          1..40
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6V3W6.4)"
     Region          <174..>215
                     /region_name="Transglut_core"
                     /note="Transglutaminase-like superfamily; cl17362"
                     /db_xref="CDD:450180"
     Region          385..412
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6V3W6.4)"
     Region          <688..>851
                     /region_name="PRK10246"
                     /note="exonuclease subunit SbcC; Provisional"
                     /db_xref="CDD:182330"
     CDS             1..876
                     /gene="Drc7"
                     /gene_synonym="Ccdc135; Gm770; SRG-L; SRG-S"
                     /coded_by="NM_001042715.3:50..2680"
                     /db_xref="CCDS:CCDS40444.1"
                     /db_xref="GeneID:330830"
                     /db_xref="MGI:MGI:2685616"
ORIGIN      
        1 mevlrekvee eeeaereeaa eraertekle rvtksaevsr egtilsqdel rdlegklmai
       61 eiptqadhsv isqapvdvtk lppsyttnsl keehlllvad nfsrqyshlc pdrvplflhp
      121 lnecnvpkfv sttlrptlmp ypelynwdsc aqfvsdfltm vplvdplkpp thlyssttvl
      181 kcqkgncfdf stllcsmlig sgydaycvng ygsldlclmd ltrevcpltv kakeivkkke
      241 ktvpkkysik pprdltskfe qeqeekriqe ikdleqrrlk eeedrileae kakpdplhgl
      301 rvhswvlvla gkrevpesff idpltarsys tkdehflgie slwnhknywi nmqdcwncck
      361 dlifdlgdpv rweymllgtd kphlslteed eegldddddd vedlgkeeed ksfdmpsswv
      421 sqieitpeef etrcpsgkkv iqykkaqlek wspylnnngl vcrlttyedq qctkvleike
      481 wyqnredmle lkhinkttgl hvdyfkpghp qalcvhsyks mlpemdrvme fykkirvdgl
      541 vkreetpmtm teyyegrsdf layrhvnfgp rvkklsqssv esnprpmvki terfsrnpek
      601 padedvaerl fliveeriql ryhcrddyit askreflrrm evdskgnkii mtpemcisye
      661 vepmehtkkl lyqyetmnql kneeklsrhq aweselevle ilklreeeee ahtltisiyd
      721 tkrnekskey reamervlhe ehlrqveaql dylapflaql ppgekltrwq avrlkdecls
      781 dfkqrlidka nliqarfeke tqelqkkqqw yqenqvtltp edenlylsyc sqamfriril
      841 eqrlnrhkel aplkylalee klykdprlid fvkvfv
//
