LOCUS       NP_083320                523 aa            linear   ROD 06-MAY-2025
DEFINITION  dynein regulatory complex subunit 3 [Mus musculus].
ACCESSION   NP_083320 XP_919689
VERSION     NP_083320.1
DBSOURCE    REFSEQ: accession NM_029044.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 523)
  AUTHORS   Zhou,S., Yuan,S., Zhang,J., Meng,L., Zhang,X., Liu,S., Lu,G.,
            Lin,G., Liu,M. and Tan,Y.Q.
  TITLE     DRC3 is an assembly adapter of the nexin-dynein regulatory complex
            functional components during spermatogenesis in humans and mice
  JOURNAL   Signal Transduct Target Ther 8 (1), 26 (2023)
   PUBMED   36627292
  REMARK    GeneRIF: DRC3 is an assembly adapter of the nexin-dynein regulatory
            complex functional components during spermatogenesis in humans and
            mice.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 523)
  AUTHORS   Morohoshi,A., Miyata,H., Shimada,K., Nozawa,K., Matsumura,T.,
            Yanase,R., Shiba,K., Inaba,K. and Ikawa,M.
  TITLE     Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is
            required for sperm flagellum formation and male fertility in mice
  JOURNAL   PLoS Genet 16 (1), e1008585 (2020)
   PUBMED   31961863
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 523)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   4  (residues 1 to 523)
  AUTHORS   Castaneda,J.M., Hua,R., Miyata,H., Oji,A., Guo,Y., Cheng,Y.,
            Zhou,T., Guo,X., Cui,Y., Shen,B., Wang,Z., Hu,Z., Zhou,Z., Sha,J.,
            Prunskaite-Hyyrylainen,R., Yu,Z., Ramirez-Solis,R., Ikawa,M.,
            Matzuk,M.M. and Liu,M.
  TITLE     TCTE1 is a conserved component of the dynein regulatory complex and
            is required for motility and metabolism in mouse spermatozoa
  JOURNAL   Proc Natl Acad Sci U S A 114 (27), E5370-E5378 (2017)
   PUBMED   28630322
REFERENCE   5  (residues 1 to 523)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   6  (residues 1 to 523)
  AUTHORS   Ha,S., Lindsay,A.M., Timms,A.E. and Beier,D.R.
  TITLE     Mutations in Dnaaf1 and Lrrc48 Cause Hydrocephalus, Laterality
            Defects, and Sinusitis in Mice
  JOURNAL   G3 (Bethesda) 6 (8), 2479-2487 (2016)
   PUBMED   27261005
  REMARK    GeneRIF: Mutations in Lrrc48 cause hydrocephalus, laterality
            defects, and sinusitis.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 523)
  AUTHORS   Ha,S., Stottmann,R.W., Furley,A.J. and Beier,D.R.
  TITLE     A forward genetic screen in mice identifies mutants with abnormal
            cortical patterning
  JOURNAL   Cereb Cortex 25 (1), 167-179 (2015)
   PUBMED   23968836
REFERENCE   8  (residues 1 to 523)
  AUTHORS   Yan,J., Bi,W. and Lupski,J.R.
  TITLE     Penetrance of craniofacial anomalies in mouse models of
            Smith-Magenis syndrome is modified by genomic sequence surrounding
            Rai1: not all null alleles are alike
  JOURNAL   Am J Hum Genet 80 (3), 518-525 (2007)
   PUBMED   17273973
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596090.11.
            
            On Dec 7, 2005 this sequence version replaced XP_919689.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018412.1, AK015430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.81 cM"
     Protein         1..523
                     /product="dynein regulatory complex subunit 3"
                     /note="leucine-rich repeat-containing protein 48; novel
                     Leucine Rich Repeat domain-containing protein; leucine
                     rich repeat containing 48"
                     /calculated_mol_wt=60697
     Region          44..65
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D5E4.1)"
     Region          47..66
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          53..200
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          66..87
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D5E4.1)"
     Region          67..88
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          88..109
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D5E4.1)"
     Region          89..110
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          110..131
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D5E4.1)"
     Region          111..132
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          132..153
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D5E4.1)"
     Region          133..157
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          158..169
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     CDS             1..523
                     /gene="Drc3"
                     /gene_synonym="4930449E07Rik; Lrrc48; m6Bei"
                     /coded_by="NM_029044.3:209..1780"
                     /db_xref="CCDS:CCDS36172.1"
                     /db_xref="GeneID:74665"
                     /db_xref="MGI:MGI:1921915"
ORIGIN      
        1 msrpydsmep kvmdddmlka avgeqgpqee agqlakqegi lfkdvlslql dfqnilridn
       61 lwqfenlkkl qlnnniieri egltnlihlv wldlsfnnie aiegldtlvn ledlslsnnr
      121 iskvdsldal vklqvlslgn nqisnmmnii ylrrfpclrt lslagnpvse aeeykmfiya
      181 ylsdlvyldf rrvdeqmrem akmkhqysid elkhreaqlq mkleeeqakq ekleehkmaf
      241 vehlngpflf dsmysedveg nklsylpgvr elleaykdkf viiclnifey glnqqekrkv
      301 eldtfneciq eailenqdqg klkvakfeek hllnlnaire etdlsniekk ltectesige
      361 lfntlmilem qlveqleeti nifernitdl vglfienvqs liaqcrdlen hhheklleia
      421 intlekilkg emdedlpddv ralfvdkdti vnavgashdi hllkidnred elvtginswc
      481 ahlvdkihkd eimrnrkrvk einqfvdhmq seldnlecgd iid
//
