LOCUS       NM_001033460            2466 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dynein regulatory complex subunit 1 (Drc1), mRNA.
ACCESSION   NM_001033460 XM_355721 XM_908351
VERSION     NM_001033460.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2466)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2466)
  AUTHORS   Zhang,J., He,X., Wu,H., Zhang,X., Yang,S., Liu,C., Liu,S., Hua,R.,
            Zhou,S., Zhao,S., Hu,F., Zhang,J., Liu,W., Cheng,H., Gao,Y.,
            Zhang,F., Cao,Y. and Liu,M.
  TITLE     Loss of DRC1 function leads to multiple morphological abnormalities
            of the sperm flagella and male infertility in human and mouse
  JOURNAL   Hum Mol Genet 30 (21), 1996-2011 (2021)
   PUBMED   34169321
  REMARK    GeneRIF: Loss of DRC1 function leads to multiple morphological
            abnormalities of the sperm flagella and male infertility in human
            and mouse.
REFERENCE   3  (bases 1 to 2466)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   4  (bases 1 to 2466)
  AUTHORS   Burnicka-Turek,O., Steimle,J.D., Huang,W., Felker,L., Kamp,A.,
            Kweon,J., Peterson,M., Reeves,R.H., Maslen,C.L., Gruber,P.J.,
            Yang,X.H., Shendure,J. and Moskowitz,I.P.
  TITLE     Cilia gene mutations cause atrioventricular septal defects by
            multiple mechanisms
  JOURNAL   Hum Mol Genet 25 (14), 3011-3028 (2016)
   PUBMED   27340223
REFERENCE   5  (bases 1 to 2466)
  AUTHORS   Navarro,N. and Maga,A.M.
  TITLE     Does 3D Phenotyping Yield Substantial Insights in the Genetics of
            the Mouse Mandible Shape?
  JOURNAL   G3 (Bethesda) 6 (5), 1153-1163 (2016)
   PUBMED   26921296
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2466)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   7  (bases 1 to 2466)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Gm1060 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC241618.4 and AC242405.4.
            
            On Feb 13, 2019 this sequence version replaced NM_001033460.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140154.1, BC150863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC241618.4         7355-7568           c
            215-302             AC242405.4         1428-1515
            303-415             AC242405.4         2432-2544
            416-599             AC242405.4         5255-5438
            600-737             AC242405.4         6820-6957
            738-824             AC242405.4         8427-8513
            825-947             AC242405.4         10165-10287
            948-1087            AC242405.4         14903-15042
            1088-1222           AC242405.4         15376-15510
            1223-1455           AC242405.4         16029-16261
            1456-1568           AC242405.4         18227-18339
            1569-1658           AC242405.4         19332-19421
            1659-1745           AC242405.4         19765-19851
            1746-2017           AC242405.4         22767-23038
            2018-2161           AC242405.4         23719-23862
            2162-2264           AC242405.4         24152-24254
            2265-2466           AC242405.4         26258-26459
FEATURES             Location/Qualifiers
     source          1..2466
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.42 cM"
     gene            1..2466
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /note="dynein regulatory complex subunit 1"
                     /db_xref="GeneID:381738"
                     /db_xref="MGI:MGI:2685906"
     exon            1..214
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2321
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /note="coiled-coil domain-containing protein 164;
                     coiled-coil domain containing 164"
                     /codon_start=1
                     /product="dynein regulatory complex protein 1"
                     /protein_id="NP_001028632.1"
                     /db_xref="CCDS:CCDS84857.1"
                     /db_xref="GeneID:381738"
                     /db_xref="MGI:MGI:2685906"
                     /translation="MNPSGTIGVLEQNGEEHLATPILGPSVHSDNPQERIQARRLRIA
                     ARQEARRREALGEYLDGKKESEEEQSKSYKQKEESRLKLTKLLLCGTELVTNIQVAAD
                     VREIHRRVEEEETKRQRLEKLENEVKTSQDKFDEITAKWEEGRRKRIPQELWEMLNSQ
                     QVHCAELIEDKNKLANELQQELKIKDDQYVKDLKKQSEDITLILERMEEQVKNVMKNF
                     RQELIHIEKAFESERQELLSSNKKKWERALQAHNAKELEYLTNRMKKVEDYEKQLNKQ
                     RVWDCEEYNTIKIKLEQDVQILEQQLQQMKATYQLNQEKLEYNFQVLKKRDEESTVIK
                     SQQKRKLNRLHDVVNNLRTKYTKQIRQFQDDNQSLTSDYKRLVTQFKDLQKALRHFII
                     IDEEKFREIWLMNEAEAKELAQRAFDVDRIIHSQHLGLPWNMPDLWFLNNVGPISLQQ
                     QKSVTQILEELLLQTEDEATEAAMSEDEDYMDLPNQISAKTTTKVLMLLCDESGFLIE
                     SKLLSLLHPLEKSECYLLRLDAIFSALAIEDEDDLYKLVNFFLRYRAHRLSSAQASSS
                     IHSNVERTSLMSALERLSLMSQTDKGSMVSKSDQEPTEQEDEQEGDNASLSSRELEEQ
                     EDLSSPRFIHPNDVLKILEAFVTGLKKPKDAQPVLKLKKETRDNSKDTEYWESLAAVI
                     PFFKQNLWDALYKALEKYYLVLTERAKLLMENESLEQQNAEMQSLLQQYLQAKVNTEL
                     QIPPTQGFRMPSK"
     exon            215..302
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            303..415
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            416..599
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            600..737
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            738..824
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            825..947
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1087
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1222
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1455
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1568
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1658
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1745
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..2017
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2161
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2264
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2466
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2446..2451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /note="hexamer: AATAAA"
     polyA_site      2466
                     /gene="Drc1"
                     /gene_synonym="b2b1654Clo; Ccdc164; Gm1060"
                     /note="major polyA site"
ORIGIN      
        1 gttcctagca acccggctgc tggtccaggc ggagctgcca gtgggtggga gacgccgcca
       61 tgaatccctc aggaaccatt ggggtcctag agcagaatgg ggaagaacac ttagccaccc
      121 cgattctcgg accctcggtg cattcggata acccgcagga gcggatccag gcccggcgcc
      181 tgcgcatcgc tgctcgtcag gaagcccgaa ggcgggaagc cctgggagag tatttggacg
      241 ggaagaagga gagtgaggag gagcagagca agagctacaa acagaaagaa gagagccgcc
      301 tgaaactgac taaactcctg ctctgcggga ccgagttggt gacaaatatt caggtggctg
      361 cagacgtcag agagatccac aggagggttg aagaggagga gacaaagcgg cagagactgg
      421 agaagctgga gaatgaagtt aagaccagcc aggataaatt tgatgaaatc acggcgaagt
      481 gggaggaggg cagacggaag cggattcccc aggaactgtg ggagatgctc aacagccagc
      541 aggtgcactg tgctgagctc atagaagaca agaacaagct ggccaacgag ctgcagcagg
      601 agttaaaaat aaaggatgac cagtatgtga aggacttgaa gaaacagtcg gaagacatca
      661 ccctgattct ggagagaatg gaggagcagg tgaagaatgt gatgaagaac ttccgccagg
      721 agctgattca catcgagaaa gcctttgagt cagaacggca agaactgcta tccagcaata
      781 agaagaaatg ggagcgagcc ctgcaggctc acaatgccaa ggagctggag tacctcacca
      841 accgcatgaa gaaggtggag gactacgaga agcagctcaa caagcagcgg gtctgggact
      901 gtgaggagta caacacaatc aagatcaagc tagagcagga tgtgcagatt cttgagcaac
      961 agcttcagca gatgaaagca acttaccagc taaaccaaga gaagctggag tacaactttc
     1021 aggtcctgaa gaagagagat gaagagagca cagtgatcaa gtcccagcag aagaggaaac
     1081 tgaaccgcct gcacgatgtc gtcaacaatc tgagaacaaa atacaccaag cagatacggc
     1141 agtttcagga tgacaaccag tccctgacct ccgactacaa acggcttgtg acgcaattca
     1201 aggacctaca gaaagccttg agacacttca tcatcatcga tgaggagaag tttcgggaga
     1261 tttggctgat gaatgaagca gaggcgaagg aactggcaca aagagccttt gatgtggaca
     1321 ggatcatcca ttcccagcac ctgggcttac cctggaatat gcctgacttg tggttcctga
     1381 ataacgtggg gccgatttcc ctgcagcagc agaagtcagt cacacaaata ctggaggaac
     1441 tgctgttgca gacagaggat gaggccacag aggcagccat gtcggaagac gaggattaca
     1501 tggacctgcc caatcaaatt tcagccaaaa ccaccacaaa ggtcctgatg ctcctgtgtg
     1561 atgagtcggg tttcctcata gagagcaaac tactgagtct gctccacccc ctggagaaga
     1621 gtgaatgcta tctgctgagg ttggacgcca tcttctccgc cctggcaatc gaagacgagg
     1681 atgacttata caagctggta aacttcttcc ttcgataccg agcccaccgt ctatcctctg
     1741 cccaggccag ttcctccatt catagcaatg tggagcgtac aagcctgatg tcagcactag
     1801 agcgtttgag tctgatgtcc cagacagaca agggaagcat ggtgtccaaa tcagatcagg
     1861 agcccacaga gcaggaggac gagcaggaag gtgacaacgc aagcctctcg agcagggagt
     1921 tggaagagca ggaggacctg tcatcaccca ggttcatcca ccccaatgat gttctcaaga
     1981 ttctggaggc ctttgtcacg gggctgaaga agcctaagga cgctcagcca gtactgaaat
     2041 tgaagaaaga gactcgagat aactcgaagg acacggagta ctgggaatcc ctggctgcgg
     2101 ttattccttt cttcaagcag aacctctggg atgcgctgta caaggccttg gagaaatact
     2161 atctcgtgct gaccgagagg gccaagctgc tgatggagaa tgagtctctg gagcagcaga
     2221 atgcagagat gcagtccctg ctgcagcagt atctccaggc caaggtaaac acagaactgc
     2281 agatcccacc aactcagggc ttccggatgc cctcaaaatg aagaaggatc ttcaaagcct
     2341 ggtgtcatgg agtctacacc catctcttga gagccagacc caccctgggt ttttctgagc
     2401 tggatctttc tgccaaaata aggcatcact gttccctgaa gttctaataa agtcttttaa
     2461 agctta
//
