LOCUS       NM_027426               5217 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus dorsal inhibitory axon guidance protein (Draxin),
            mRNA.
ACCESSION   NM_027426 XM_131857
VERSION     NM_027426.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5217)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5217)
  AUTHORS   Morcom,L., Edwards,T.J., Rider,E., Jones-Davis,D., Lim,J.W.,
            Chen,K.S., Dean,R.J., Bunt,J., Ye,Y., Gobius,I., Suarez,R.,
            Mandelstam,S., Sherr,E.H. and Richards,L.J.
  TITLE     DRAXIN regulates interhemispheric fissure remodelling to influence
            the extent of corpus callosum formation
  JOURNAL   Elife 10, e61618 (2021)
   PUBMED   33945466
  REMARK    GeneRIF: DRAXIN regulates interhemispheric fissure remodelling to
            influence the extent of corpus callosum formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5217)
  AUTHORS   Tawarayama,H., Yamada,H., Amin,R., Morita-Fujimura,Y., Cooper,H.M.,
            Shinmyo,Y., Tanaka,H. and Ikawa,S.
  TITLE     Draxin-mediated Regulation of Granule Cell Progenitor
            Differentiation in the Postnatal Hippocampal Dentate Gyrus
  JOURNAL   Neuroscience 431, 184-192 (2020)
   PUBMED   32081722
REFERENCE   4  (bases 1 to 5217)
  AUTHORS   Tenney,A.P., Livet,J., Belton,T., Prochazkova,M., Pearson,E.M.,
            Whitman,M.C., Kulkarni,A.B., Engle,E.C. and Henderson,C.E.
  TITLE     Etv1 Controls the Establishment of Non-overlapping Motor
            Innervation of Neighboring Facial Muscles during Development
  JOURNAL   Cell Rep 29 (2), 437-452 (2019)
   PUBMED   31597102
REFERENCE   5  (bases 1 to 5217)
  AUTHORS   Soldatov,R., Kaucka,M., Kastriti,M.E., Petersen,J.,
            Chontorotzea,T., Englmaier,L., Akkuratova,N., Yang,Y., Haring,M.,
            Dyachuk,V., Bock,C., Farlik,M., Piacentino,M.L., Boismoreau,F.,
            Hilscher,M.M., Yokota,C., Qian,X., Nilsson,M., Bronner,M.E.,
            Croci,L., Hsiao,W.Y., Guertin,D.A., Brunet,J.F., Consalez,G.G.,
            Ernfors,P., Fried,K., Kharchenko,P.V. and Adameyko,I.
  TITLE     Spatiotemporal structure of cell fate decisions in murine neural
            crest
  JOURNAL   Science 364 (6444) (2019)
   PUBMED   31171666
REFERENCE   6  (bases 1 to 5217)
  AUTHORS   Ahmed,G., Shinmyo,Y., Naser,I.B., Hossain,M., Song,X. and Tanaka,H.
  TITLE     Olfactory bulb axonal outgrowth is inhibited by draxin
  JOURNAL   Biochem Biophys Res Commun 398 (4), 730-734 (2010)
   PUBMED   20621059
  REMARK    GeneRIF: These results suggest that draxin functions as an
            inhibitory guidance cue for olfactory bulb axons and indicate its
            contribution to the formation of the lateral olfactory tract.
REFERENCE   7  (bases 1 to 5217)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 5217)
  AUTHORS   Zhang,S., Su,Y., Shinmyo,Y., Islam,S.M., Naser,I.B., Ahmed,G.,
            Tamamaki,N. and Tanaka,H.
  TITLE     Draxin, a repulsive axon guidance protein, is involved in
            hippocampal development
  JOURNAL   Neurosci Res 66 (1), 53-61 (2010)
   PUBMED   19808066
  REMARK    GeneRIF: This study found that draxin, a repulsive axon guidance
            cue, was widely expressed in the developing hippocampus and draxin
            deficient mice possessed a smaller hippocampus.
REFERENCE   9  (bases 1 to 5217)
  AUTHORS   Miyake,A., Takahashi,Y., Miwa,H., Shimada,A., Konishi,M. and
            Itoh,N.
  TITLE     Neucrin is a novel neural-specific secreted antagonist to canonical
            Wnt signaling
  JOURNAL   Biochem Biophys Res Commun 390 (3), 1051-1055 (2009)
   PUBMED   19857465
  REMARK    GeneRIF: Neucrin is a unique secreted Wnt antagonist that is
            predominantly expressed in developing neural tissues.
REFERENCE   10 (bases 1 to 5217)
  AUTHORS   Islam,S.M., Shinmyo,Y., Okafuji,T., Su,Y., Naser,I.B., Ahmed,G.,
            Zhang,S., Chen,S., Ohta,K., Kiyonari,H., Abe,T., Tanaka,S.,
            Nishinakamura,R., Terashima,T., Kitamura,T. and Tanaka,H.
  TITLE     Draxin, a repulsive guidance protein for spinal cord and forebrain
            commissures
  JOURNAL   Science 323 (5912), 388-393 (2009)
   PUBMED   19150847
  REMARK    GeneRIF: draxin knockout mice showed defasciculation of spinal cord
            commissural axons & absence of all forebrain commissures; draxin is
            a previously unknown chemorepulsive axon guidance molecule required
            for the development of spinal cord & forebrain commissures
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY728334.1, BC060239.1 and BC058734.1.
            
            On Apr 22, 2009 this sequence version replaced NM_027426.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060239.1, AK086198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY728334.1         1-19
            20-3263             BC060239.1         1-3244
            3264-5217           BC058734.1         2380-4333
FEATURES             Location/Qualifiers
     source          1..5217
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.67 cM"
     gene            1..5217
                     /gene="Draxin"
                     /gene_synonym="2610109H07Rik; neucrin"
                     /note="dorsal inhibitory axon guidance protein"
                     /db_xref="GeneID:70433"
                     /db_xref="MGI:MGI:1917683"
     exon            1..126
                     /gene="Draxin"
                     /gene_synonym="2610109H07Rik; neucrin"
                     /inference="alignment:Splign:2.1.0"
     exon            127..568
                     /gene="Draxin"
                     /gene_synonym="2610109H07Rik; neucrin"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1167
                     /gene="Draxin"
                     /gene_synonym="2610109H07Rik; neucrin"
                     /note="dorsal repulsive axon guidance protein"
                     /codon_start=1
                     /product="draxin precursor"
                     /protein_id="NP_081702.2"
                     /db_xref="CCDS:CCDS18931.1"
                     /db_xref="GeneID:70433"
                     /db_xref="MGI:MGI:1917683"
                     /translation="MAGCPVLRVPTLFLILLLFPELHTAGTLASGSSARNLPETHSHL
                     PSSALWVSQASHHGRRGLGKKDRGPGRPSRAQEGAVVTATKQASQMTLGQPPAGLLQN
                     KELLLGLTLPYPEKEARSPAWERVKKRGREHKRRRDRLRLHRGRAAIRGPSSLMKKVE
                     PSEDRMLEGTMEESSTSLAPTMFFLTMTDGATPTTEESRILPVTSLRPQTQPRSDGEV
                     MPTLDMALFDWTDYEDLKPEVWPSAKKKEKHWSHFTSDGNETSPAEGDPCDHHQDCLP
                     GTCCDLREHLCTPHNRGLNNKCFDDCMCMEGLRCYAKFHRNRRVTRRKGRCVEPETAN
                     GDQGSFINI"
     exon            569..762
                     /gene="Draxin"
                     /gene_synonym="2610109H07Rik; neucrin"
                     /inference="alignment:Splign:2.1.0"
     exon            763..874
                     /gene="Draxin"
                     /gene_synonym="2610109H07Rik; neucrin"
                     /inference="alignment:Splign:2.1.0"
     exon            875..964
                     /gene="Draxin"
                     /gene_synonym="2610109H07Rik; neucrin"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1054
                     /gene="Draxin"
                     /gene_synonym="2610109H07Rik; neucrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..5200
                     /gene="Draxin"
                     /gene_synonym="2610109H07Rik; neucrin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5174..5179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Draxin"
                     /gene_synonym="2610109H07Rik; neucrin"
                     /note="hexamer: AATAAA"
     polyA_site      5200
                     /gene="Draxin"
                     /gene_synonym="2610109H07Rik; neucrin"
                     /note="major polyA site"
ORIGIN      
        1 actccctcct tcgcagcccg agcagcctcc tgccacccgt gcacctctcc ctccgccctc
       61 cgctgcgctc cactcccgca ggcgctcggc cctgagccct cggtcccctc cccgtccgcc
      121 cgacagggag agccaatggc agggtgcccc gtcctcaggg tccccacgct gttcctgatc
      181 ctcctgctgt ttccagagct ccacacggca ggcacccttg catctggatc ctctgcccgg
      241 aacctgccgg agacccactc ccacctcccc agctctgcac tgtgggtgtc ccaggcaagc
      301 catcatggcc gtcggggcct ggggaagaaa gacaggggcc caggaaggcc tagccgggcc
      361 caggaggggg ctgtggtcac tgctaccaag caggcttccc agatgacact cggacagccc
      421 cctgctggcc ttctgcagaa taaggagctg cttctggggc tgactttgcc ctaccccgag
      481 aaggaggccc ggtctcccgc ttgggagagg gtgaagaaac gtggcagaga acacaagaga
      541 cgcagggacc gtctgcgact gcaccgaggc cgagctgcca tccgtggccc cagctccctc
      601 atgaagaagg tggaaccctc tgaagaccgg atgctggagg gtaccatgga ggagtcttcc
      661 actagcctgg cccccaccat gttcttcctg accatgacag acggtgccac gcctactaca
      721 gaagagtccc ggatcctgcc tgtcacgtcc ttgcggcccc agacacagcc caggtctgac
      781 ggggaggtga tgcccacact ggacatggcc ttatttgact ggacggatta tgaagactta
      841 aagccagagg tctggccttc tgcaaagaag aaagagaaac actggagtca ttttaccagt
      901 gatggtaacg agacctcgcc agctgagggg gatccgtgtg accatcacca ggattgcttg
      961 ccaggaactt gctgtgacct ccgggaacat ctctgcacac cccacaaccg cggcctcaac
     1021 aacaaatgtt tcgacgactg catgtgcatg gaagggctgc gttgctatgc caaattccac
     1081 cggaaccgca gggtcactcg gaggaagggg cgctgcgtgg aaccggagac agccaacggg
     1141 gaccagggat ctttcatcaa catctagtgc cctagtggtg cctccccacc ggcccggggt
     1201 ctgagccagg gaggtttagg acaaacagga ccgtgttagt aactagctca gcttgggctg
     1261 agtagggaac caatggctga ggcagcaggt gtacgcccag tacactcaac cacaagctgg
     1321 agagcggttt agcagagagc agtgcgccag agcccgcccg cccgcagtcc ggggtgggac
     1381 ccccacctgc tccctgattc tgctcgactc ggcggtggct ttgtgtagcg caccctcttc
     1441 tgctcgacac cagcattgca gcagtttcaa ttggcgaaaa caagaggctt ccttgactga
     1501 aaagggttgg aaagagaggg gacaactgac agtcctggat ctggaatgct atgtcgcagg
     1561 caaacgccaa gcgccacatg tatttttact gaatttccac agagaccgtg gtaagagacc
     1621 actgacccgc acctgaggtg cgcgatccca cgttcagagt cccacgtcat ccatgatcct
     1681 ccagttttgg ccacagagac tagacttgac ctgttctcag gcttttccca agagagactt
     1741 atgtcttttt tgatggactg agtctcactc tttggccaag ctggcaactc agacaatcct
     1801 cctgcctcag tcttccaaat gctggaatta taggcatggg tcagcatatt tggcaggtgt
     1861 atcttcctta aaaacaagac attagggctg gggatgtggc tacgtttgta acatgcttgc
     1921 ctggaatgca tgaatcctgc ccaggctgga cttcttctga ttagtgagtg tgaggccaga
     1981 ccacagcaga ctgcatctca agcaaaacaa agtaagctgt ttgcctcacc tgcgcgaggc
     2041 cctgggcttg ctcccattcc gtttccccct cctcccactt ctttccctca gctcctacac
     2101 agggcacctg ttttcaagtg aagaataatc cccatggctg ggtccttgca tgtgacaggt
     2161 gctaatcatc atcatgaata ggagaaacag taacgttgct ctgctcctat gcttatccat
     2221 agcccagatc atccagtcct gagacgccac gtcactccct cctcagtggt cctcagtctc
     2281 tgctctgctg caaaggcatg cacacacgtc cccacatgct cgccagacat actgtgtaat
     2341 gactctcacc ctccatccct gacactccat ccttcacatc agcagcgatg cccccttgga
     2401 aagtggggcc acctctgagt ctggggtaca gcgtgaagca cccctacagg ctagaaccgt
     2461 gacgacaagc ccacgcttac cggcactact caggacatgt ctcagcggat ctgagatccc
     2521 tgcgcctggc atctccgtcc tgatcaactt ttgcgaagga caaaagcctt cccaggacaa
     2581 gccctcccca gcctggacct cacccgtggg atgccagggc tgtttactgc tttgggataa
     2641 ccagtctggt ccagggtcag gctccaagga aagctggcag atcgagaaga aatcaaatat
     2701 gcttgttctt ctttccaagc tgggtctgat aggcctgggg agtgggcggg gtgggggcgg
     2761 ggccaggagt cggaaggatc aaggccaagg tgggaaagca agtcctaata cagatttctt
     2821 ttcctttttt gtagtaccag agccttgcac ggtccaggca agtgctcgac tactgagtta
     2881 cgtgctaact tggtctgggc ttcaaagtct ccaaagctcc cccagggagc tgccttggtc
     2941 ccctgtcttc tcacctgctg cagtaaagag cctgttcttc caactcactt tgctgacctt
     3001 agggaagtta cttaaggtct ctgtcccttg acttttcatg tctggttctt accaggtgtt
     3061 tagtacagtg tctggcccat aacacacaca cacacacaca cacacacaca cacacacacg
     3121 cacgcacgca cacacgcaca cacgcgcaca tgcacacaca cctagagtgc cagctaacaa
     3181 acgtcaacgg gccttttctt ccacagtgat ccatcatata gctagtgatt tttctaaaaa
     3241 ttgatgtctc actacacagt cctagctgat ctgaaattca taacgtagac cagcttggct
     3301 tggcctggga ctcacaggga tctgcctgcc tctgcctctg cctttcctgt cctgggatta
     3361 aaggtgtgca tctccaggca cagttcagga tgctttctct ttctctggtt tctccaaagt
     3421 gcattaatcc cagcactcgg gtggcagagg taggtgaatc tctgtgagtt caaagcacgg
     3481 ctggtctaca tagagagttc cgggacagcc agggctatgt agagagatcc tgcctcaaaa
     3541 aacaaaacaa caaaacaaaa accaaactaa caacaacaaa aaccaaagtg tacggcacag
     3601 agcaaagcca ctttgctggg gacacatttg gattcccggc tgaggcaggg ctggaagagc
     3661 ttgtggctat gcaggatcag gtttgtgtgt gtgtaaaagg gggtcctggt ggaggactga
     3721 gcaggatgag gagaggttaa tagctgccta gacaggccac ctgagctgat gcctcaagaa
     3781 cactctgaca gatctccatt gtccccagac agggactatt tgtctgggtt ttgtctgatg
     3841 atgcaaaggg gttgttctca cagttggtgg aaaagggctg agggtcctgt gacctgagac
     3901 tcaaacttca aaggaaaatg acagctttgc ctgccctttg aggaggtcga gttccaagac
     3961 ctcacccctt ctcctgctaa ggagcttcat tgagtccttc tccaagcctc ctcgggtcct
     4021 ctccaggctc ctcctaccac tgcctacagt gaacctatgg agcctacaag gaccatgttt
     4081 agaaactaag gaaccaggag tcctgggtgc cagaaaagtg gagtctggag aggccaacag
     4141 ccgaggctcc cttttgaggg gtcttgggtc tggactccat taattctggc cctccatgac
     4201 agccttcatg ctcacaggcc acagggagta tgtgattact gtaggccacg gcagttgtga
     4261 agacacagaa aatgggaggc caggttaagc cggctgcgta cagaacaagg tgtttatact
     4321 gcagggaatg aggtttccaa atctcaagga agagcagaca tgggacagat ccatggccaa
     4381 gcctcctctt gttgccaagt catctggtag aatcacagag cctcccttca actttcccta
     4441 gtctacatct gcaggtacca ataagaccat ctacataacc tgcaagaaac atgtttaaaa
     4501 agcaaaagat caggagccct ggctgccagg aatgcgggtt ctacccctta cctactgaag
     4561 cacagtcaca agggtgtccc cttccccact cccagcatct ggcttctaat acaatctcca
     4621 ggttgctctt gggtgtgatg ggttgggtgt cacaggtcca ggatacagat ggaggacaga
     4681 tgctgggggc cggggacagt cgtttggaca gttcagcact attgcattcg ctgtggcttg
     4741 gcaactctga ggtctgcttc ctggcaacta tcagcaaggg caaacttaac acccagagcc
     4801 tgccttctgg gctgttggct ctgcttagag gacacaagtg gggcccagtg gttaggaaca
     4861 ctgaatgctc tcccagggga cccatgttca atcccaggta gtctcacagc tacctataac
     4921 ttcaagatct gacaccctca cccagacata atgcaggcaa aacatcaatg tacaggaaat
     4981 aaaaaaataa actaacattt tagaggacgc caggtgggct cctaggccca gagcctctat
     5041 ggttggactt ttggagtctt gaataattcc ttggagggct gtagctcttc caccttggaa
     5101 cgtgggagca tcaggggaag gggtgtcatg ccttgattta taatgcctcc ttgcatggat
     5161 tctccaagct gtaaataaag aggtgacagt tgctaagcca aaaaaaaaaa aaaaaaa
//
