LOCUS       NM_026013               2722 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Mus musculus DNA-damage regulated autophagy modulator 2 (Dram2),
            transcript variant 2, mRNA.
ACCESSION   NM_026013
VERSION     NM_026013.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2722)
  AUTHORS   Jones,M.K., Orozco,L.D., Qin,H., Truong,T., Caplazi,P.,
            Elstrott,J., Modrusan,Z., Chaney,S.Y. and Jeanne,M.
  TITLE     Integration of human stem cell-derived in vitro systems and mouse
            preclinical models identifies complex pathophysiologic mechanisms
            in retinal dystrophy
  JOURNAL   Front Cell Dev Biol 11, 1252547 (2023)
   PUBMED   37691820
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2722)
  AUTHORS   Olthof,A.M., White,A.K., Mieruszynski,S., Doggett,K., Lee,M.F.,
            Chakroun,A., Abdel Aleem,A.K., Rousseau,J., Magnani,C.,
            Roifman,C.M., Campeau,P.M., Heath,J.K. and Kanadia,R.N.
  TITLE     Disruption of exon-bridging interactions between the minor and
            major spliceosomes results in alternative splicing around minor
            introns
  JOURNAL   Nucleic Acids Res 49 (6), 3524-3545 (2021)
   PUBMED   33660780
REFERENCE   3  (bases 1 to 2722)
  AUTHORS   El-Asrag,M.E., Sergouniotis,P.I., McKibbin,M., Plagnol,V.,
            Sheridan,E., Waseem,N., Abdelhamed,Z., McKeefry,D., Van Schil,K.,
            Poulter,J.A., Johnson,C.A., Carr,I.M., Leroy,B.P., De Baere,E.,
            Inglehearn,C.F., Webster,A.R., Toomes,C. and Ali,M.
  CONSRTM   UK Inherited Retinal Disease Consortium
  TITLE     Biallelic mutations in the autophagy regulator DRAM2 cause retinal
            dystrophy with early macular involvement
  JOURNAL   Am J Hum Genet 96 (6), 948-954 (2015)
   PUBMED   25983245
REFERENCE   4  (bases 1 to 2722)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2722)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI875295.1, AK009940.1 and AC117200.3.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_026013.4.
            
            On Nov 27, 2013 this sequence version replaced NM_026013.2.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longer isoform (2). Variants 2, 3 and 4
            encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172455.1, AK012044.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AI875295.1         1-64
            65-1308             AK009940.1         2-1245
            1309-2722           AC117200.3         108001-109414
FEATURES             Location/Qualifiers
     source          1..2722
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.5 cM"
     gene            1..2722
                     /gene="Dram2"
                     /gene_synonym="2010305N14Rik; 2610318G18Rik; Tmem77"
                     /note="DNA-damage regulated autophagy modulator 2"
                     /db_xref="GeneID:67171"
                     /db_xref="MGI:MGI:1914421"
     exon            1..123
                     /gene="Dram2"
                     /gene_synonym="2010305N14Rik; 2610318G18Rik; Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            124..248
                     /gene="Dram2"
                     /gene_synonym="2010305N14Rik; 2610318G18Rik; Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            249..393
                     /gene="Dram2"
                     /gene_synonym="2010305N14Rik; 2610318G18Rik; Tmem77"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1066
                     /gene="Dram2"
                     /gene_synonym="2010305N14Rik; 2610318G18Rik; Tmem77"
                     /note="isoform 2 is encoded by transcript variant 2; DNA
                     damage-regulated autophagy modulator protein 2;
                     transmembrane protein 77; VDNA-damage regulated autophagy
                     modulator 2"
                     /codon_start=1
                     /product="DNA damage-regulated autophagy modulator protein
                     2 isoform 2"
                     /protein_id="NP_080289.1"
                     /db_xref="CCDS:CCDS17725.1"
                     /db_xref="GeneID:67171"
                     /db_xref="MGI:MGI:1914421"
                     /translation="MWWFQQGLSFLPSALVIWTFATFIFSYITAITLHHVDPALPYIS
                     DTGTIPPERCLFGVMLNIAAVLGIATMYVRYKQVHALNPEENLIIKLNKAGLVLGILS
                     CLGLSLVANFQKSTLFIVHVCGAVLAFSMGSFYMFVQTILSYQMQPKIHSKQVFWVRL
                     LLVIWCGVSALSMMTCSSILYSSDFGPDVVQKLHWNPEDKGYVLHLVTTAAEWSMSFS
                     FFGFFLTYIRDFQKITLRVEANLHGLTLYDTVPCPVNNERTPLLSRDFQ"
     exon            394..461
                     /gene="Dram2"
                     /gene_synonym="2010305N14Rik; 2610318G18Rik; Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            462..601
                     /gene="Dram2"
                     /gene_synonym="2010305N14Rik; 2610318G18Rik; Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            602..779
                     /gene="Dram2"
                     /gene_synonym="2010305N14Rik; 2610318G18Rik; Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            780..862
                     /gene="Dram2"
                     /gene_synonym="2010305N14Rik; 2610318G18Rik; Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            863..955
                     /gene="Dram2"
                     /gene_synonym="2010305N14Rik; 2610318G18Rik; Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            956..2722
                     /gene="Dram2"
                     /gene_synonym="2010305N14Rik; 2610318G18Rik; Tmem77"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaaggttg aggcgcgcct ccgagctact cgggagcgcg ccccggggct ccgcccaggc
       61 tcctacagtg ggcctgttct gcactttgag gctggagctg gctggtcggg gacaggaaag
      121 aaggtggtgg aagataccat cagaaactgg aatctgtatg aagtcttcca taactgattc
      181 aaggttcaca ctcacagtct acatgctctg agaaactaga aacccgaatt aaccagaagt
      241 tcgcccagaa gacctgtctg aaatgtggtg gtttcagcaa ggcctcagtt ttcttccgtc
      301 ggcccttgta atttggacat ttgctacctt catattctca tatatcactg caataacact
      361 ccaccatgtt gaccctgcat tgccttatat cagcgacaca gggacaatac ctcctgaaag
      421 atgcctcttt ggagtaatgc taaatatcgc tgcagtttta ggcattgcta ccatgtatgt
      481 tcgttacaag caagttcatg cactgaaccc tgaagagaac cttatcatca aattaaacaa
      541 ggctggcctt gtacttggga tactgagttg tttaggactt tcccttgtgg caaatttcca
      601 gaaatcaaca ctatttattg tacatgtgtg tggagctgtc cttgccttta gtatgggctc
      661 attttacatg tttgttcaga caatcctttc ctaccaaatg cagcccaaaa ttcacagcaa
      721 acaagtcttc tgggtccgac tactgttggt tatctggtgt ggagtaagtg cacttagcat
      781 gatgacttgc tcatcaattt tgtacagtag tgattttggt cctgatgtag tacagaaact
      841 acactggaac ccggaggaca aaggctatgt gcttcacctg gttactacgg cagcagaatg
      901 gtccatgtca ttttcctttt ttggattttt ccttacttat attcgtgatt ttcagaaaat
      961 tactttgcgg gtggaagcca atttacatgg attaaccctc tatgacactg ttccttgccc
     1021 tgttaacaat gaaagaacac cactgctttc cagagatttt cagtaactgg atataagtct
     1081 tctgtgatga ttgtgattct cagggactgg gaaaagatgc acaaaagttg cttattatac
     1141 tgtgaaaatt tgaatcaatt aatcaaggct gacagtgaca ctaatgaaac atgatatcag
     1201 gaaaaatgta ataagccatc tggtaagttt tcttaaagga tgttgttaag aagtccatct
     1261 aaaaacatgt ctagactttt ttatatccag aaaataaaac caaaggataa tatcattgta
     1321 gtgtttgcta ctttatcaat gaaagcctga agtacaccga gtagtctcta tacttggcct
     1381 taaacatatt attttaaaag tatcttttgt taggagtact tttatgagag acattttcca
     1441 tggcacaccg taatcagcat tggtaaccaa atcatttgga atcacggctt aaaactgaag
     1501 ttttattata ttaatacatt tcttacagta cttaaaaatg tgttgctgtt gttgttgttg
     1561 ttattgttgt tgttgaatct tttctgtaaa taggagcctg cctgaaataa tctgagttct
     1621 ttgatggctt aaattttgcc tctctgcacc cccaaacaaa cacaaaatca atgggtattt
     1681 attctggcca catgaatatt aacagatcta tcatatatgc ttataataat ttcatcaagt
     1741 ctggtctctg agattagaat ttttaattac cagtaaaaga gagagattat ttgcaaattt
     1801 gctaccattt tgttctttat aaaataaagg ttacagctga tgacattgtt cagtagtgta
     1861 aattacttgc tgctaaccct gactatctga gttcaatatg taggatccac atagtcaaaa
     1921 gaaagaaaag ttatcctttg gccttgacct ccatatgcaa atacacatac acaataacta
     1981 aatgtgataa tagaaataaa cattaatgtt cctaaataag gttgcaaagt ctgtaaacaa
     2041 aaggatatga ttattaacat aaaaattaca ttatagttat aatctttgat ttttcattta
     2101 gagaaattta tacttagtag taagattagt tttgatcata tatttagtct ttttattgga
     2161 atgtgatcct tttgaaacct aaatctgaag aagagactga aatccaaaat aaaattctga
     2221 atctttttct cttgtcatga aaatgattgt aaagtttcaa tttagatctc tgtgtagata
     2281 aaggatggtt atacaggatg gtttctaaat gcctactagg attaaaaaga aggaactgtc
     2341 cgggcgttgg tagtgcacgc ctttaatccc agcacttggg aggcagaggc aagcggattt
     2401 ctgagttcga ggccaacctg gtctacagaa tgagttccag gacagccagg gctatacaga
     2461 gaaaccctgt ctcaaaaaac aaacaaaaaa aaaaaaaaag aagaagaaga agaaggaagt
     2521 gttgacctaa ataatatcca gggtcaaatt agtttgtaaa gtaatccttg atgaatacta
     2581 acataattta tatttttaga agaaataggg ctgaaaccag aagaaaagat ggtaaggaaa
     2641 agtttaaaat atatcaagaa ggaatttaag gaaaactgtt taaatgatgg agatgtagac
     2701 ttcagttata agttgttgaa tc
//
