LOCUS       NM_026106               3080 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus down-regulator of transcription 1 (Dr1), mRNA.
ACCESSION   NM_026106
VERSION     NM_026106.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3080)
  AUTHORS   de Oliveira-Higa,M.A., da Silva Rodrigues,P., Sampaio,A.C.S., de
            Camargo Coque,A., Kirsten,T.B., Massironi,S.M.G.,
            Alexandre-Ribeiro,S.R., Mori,C.M.C., da Silva,R.A. and
            Bernardi,M.M.
  TITLE     The dopaminergic D1 receptor modulates the hyperactivity of Bapa
            mutant mice
  JOURNAL   Behav Brain Res 452, 114562 (2023)
   PUBMED   37394124
  REMARK    GeneRIF: The dopaminergic D1 receptor modulates the hyperactivity
            of Bapa mutant mice.
REFERENCE   2  (bases 1 to 3080)
  AUTHORS   Goncalves,E.C.D., Lieberknecht,V., Horewicz,V.V., Rabelo,B.D.,
            Felipetti,F.A., Rodrigues,A.L.S., Martins,D.F. and Dutra,R.C.
  TITLE     Dopaminergic Receptors as Neuroimmune Mediators in Experimental
            Autoimmune Encephalomyelitis
  JOURNAL   Mol Neurobiol 58 (11), 5971-5985 (2021)
   PUBMED   34432265
  REMARK    GeneRIF: Dopaminergic Receptors as Neuroimmune Mediators in
            Experimental Autoimmune Encephalomyelitis.
REFERENCE   3  (bases 1 to 3080)
  AUTHORS   Xue,Y., Pradhan,S.K., Sun,F., Chronis,C., Tran,N., Su,T., Van,C.,
            Vashisht,A., Wohlschlegel,J., Peterson,C.L., Timmers,H.T.M.,
            Kurdistani,S.K. and Carey,M.F.
  TITLE     Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive
            Transcription in Yeast and Mammals
  JOURNAL   Mol Cell 67 (4), 594-607 (2017)
   PUBMED   28735899
  REMARK    GeneRIF: Mot1, Ino80 chromatin remodeling complex (Ino80C), and NC2
            co-localize on chromatin and coordinately suppress pervasive
            transcription in murine embryonic stem cells.
REFERENCE   4  (bases 1 to 3080)
  AUTHORS   Chang,A.C., Garside,V.C., Fournier,M., Smrz,J., Vrljicak,P.,
            Umlandt,P., Fuller,M., Robertson,G., Zhao,Y., Tam,A., Jones,S.J.,
            Marra,M.A., Hoodless,P.A. and Karsan,A.
  TITLE     A Notch-dependent transcriptional hierarchy promotes mesenchymal
            transdifferentiation in the cardiac cushion
  JOURNAL   Dev Dyn 243 (7), 894-905 (2014)
   PUBMED   24633789
REFERENCE   5  (bases 1 to 3080)
  AUTHORS   Taher,L., Collette,N.M., Murugesh,D., Maxwell,E., Ovcharenko,I. and
            Loots,G.G.
  TITLE     Global gene expression analysis of murine limb development
  JOURNAL   PLoS One 6 (12), e28358 (2011)
   PUBMED   22174793
REFERENCE   6  (bases 1 to 3080)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   7  (bases 1 to 3080)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 3080)
  AUTHORS   Iratni,R., Yan,Y.T., Chen,C., Ding,J., Zhang,Y., Price,S.M.,
            Reinberg,D. and Shen,M.M.
  TITLE     Inhibition of excess nodal signaling during mouse gastrulation by
            the transcriptional corepressor DRAP1
  JOURNAL   Science 298 (5600), 1996-1999 (2002)
   PUBMED   12471260
REFERENCE   9  (bases 1 to 3080)
  AUTHORS   Chelsea,D.M., Roberts,T. and Cowell,J.K.
  TITLE     A new region of synteny between human chromosome 1p22 and mouse
            chromosome 5
  JOURNAL   Int J Mol Med 5 (5), 553-556 (2000)
   PUBMED   10762661
REFERENCE   10 (bases 1 to 3080)
  AUTHORS   Purrello,M., Di Pietro,C., Rapisarda,A., Viola,A., Corsaro,C.,
            Motta,S., Grzeschik,K.H. and Sichel,G.
  TITLE     Genomic localization of the human gene encoding Dr1, a negative
            modulator of transcription of class II and class III genes
  JOURNAL   Cytogenet Cell Genet 75 (2-3), 186-189 (1996)
   PUBMED   9040789
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124107.8.
            
            On Nov 17, 2006 this sequence version replaced NM_026106.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075713.1, AK146573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-913               AC124107.8         152488-153400       c
            914-1077            AC124107.8         146565-146728       c
            1078-3080           AC124107.8         141776-143778       c
FEATURES             Location/Qualifiers
     source          1..3080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 52.82 cM"
     gene            1..3080
                     /gene="Dr1"
                     /gene_synonym="1700121L09Rik; Dr1l; NC2; NC2beta"
                     /note="down-regulator of transcription 1"
                     /db_xref="GeneID:13486"
                     /db_xref="MGI:MGI:1100515"
     exon            1..913
                     /gene="Dr1"
                     /gene_synonym="1700121L09Rik; Dr1l; NC2; NC2beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             694..1224
                     /gene="Dr1"
                     /gene_synonym="1700121L09Rik; Dr1l; NC2; NC2beta"
                     /note="NC2-beta; negative cofactor 2-beta; TATA-binding
                     protein-associated phosphoprotein"
                     /codon_start=1
                     /product="protein Dr1"
                     /protein_id="NP_080382.2"
                     /db_xref="CCDS:CCDS19509.1"
                     /db_xref="GeneID:13486"
                     /db_xref="MGI:MGI:1100515"
                     /translation="MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCT
                     EFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRR
                     KASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASA
                     STQAGSSQDEEDDDDI"
     exon            914..1077
                     /gene="Dr1"
                     /gene_synonym="1700121L09Rik; Dr1l; NC2; NC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..3080
                     /gene="Dr1"
                     /gene_synonym="1700121L09Rik; Dr1l; NC2; NC2beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagttcgac ttccggtggc gcaaagcgtg ccgggatcag cttgcggcaa acctccttcc
       61 ccggcccgta gagagaccac cgttagcgcc gctcctgctc gcacagcctg ctctcggcca
      121 cacgcttggc cgctgcggct cccgcagtgt tcggcccggt ccacttggtt tcccaggcag
      181 ccggcgtgcg ctcagctgcg gcttcggcag acatgttgtg aggcggcggc gcgggtgcct
      241 gaaggatggt ttggccgagg cggctgcaac cgctgctggt ggcggcgtcc tcgggggctc
      301 cggctctgta gagctgaccc tgctcagtgt ccgcccggga ccgcggccgg gcgggtattc
      361 ctctgtcttg cgtgcgctcc cgtgccgttt aggttcggtt agacgacagc gccagtccgt
      421 ttgaggcgac acgcagggtg gttctccagc cctgggagtg gtgtccctag aaccctcagc
      481 cccctgacct ttccttcata ttcccactaa aatctctcac acagtgggtg ttccctgccc
      541 tccagccctc cttcctggtt tctgcactct cttctctgag cttcccggac cccaacatcc
      601 ctctccaggg acagcctgtt gagaaatctt cgtggagtgg tggaccagag gcgaggagtt
      661 taaaagttgg ggcttgaaag acaggaagat acgatggctt cctcgtctgg caacgacgat
      721 gatctcacta tccccagagc tgctataaat aagatgatca aagagactct tcctaatgtc
      781 cgggtggcca acgatgcccg agagctggta gtgaactgct gcacggaatt cattcacctt
      841 atatcttctg aagccaacga gatttgtaac aagtcagaaa agaagacaat ttcaccagag
      901 catgttatac aagcactgga aagtttgggc tttggctctt acatcagtga agtaaaagaa
      961 gtcttacaag aatgcaagac agtagcatta aaaagaagaa aggccagttc tcgtttggaa
     1021 aacctcggca ttcctgaaga ggaattattg agacagcaac aggaattatt tgcaaaagct
     1081 agacagcaac aagcagaatt ggcccaacag gaatggcttc aaatgcagca agcagctcaa
     1141 caagcccagc tggctgcagc ctcagccagc gcgtccactc aagcaggatc ttcacaagac
     1201 gaagaagatg atgatgacat ctgacattca ccacctgggc tttcaagaaa acagtgaaag
     1261 atatgcctat ctgtaattct gtatgcatct tggtggactt accattggta ttctagagac
     1321 gtctgttgtc tggtttcaac tactgtgcta tacatgtaaa actgtctctt tgaactattg
     1381 aaaatttaag gttaagtata atatcacctt tggatttgta atggtgtttc tggaatctta
     1441 gaccagtgtg aaccctttat ttggtcaata aacagtgtta cagaaaactt caggtttata
     1501 aaatacagtg aaatttatag agatctctta atctgtattt gtattttgtc tgccctttga
     1561 actgaactaa aattgagaat ttatatagcg atggggcatg atgtgatgca gaatacattg
     1621 aatcaggttg gtgaaaaagt tcagttctat atagtatcta aattttttgt cttttaaggt
     1681 gagtatatat gcaggcaaca attatatatg ctcagataaa tatacttgtt tagaggaaat
     1741 ctcaaataag acattcaata actaggaaag aaatgtactc actagtagtt gtataaattt
     1801 ggtgagttat atttttgatt ttgttactgt tttgtgtaac agtgaagact ggttttatta
     1861 tagtataatt tatcttgaac tacactatgc catttcagag actggctaat cttgaagatt
     1921 gtcacaattc ttactgtttc actccagttc agtaattgtt catagtctta gttgtttcgt
     1981 ccattttttg agtgtatagg tgggacttgt gagacagttg cttgggttct gttagtttaa
     2041 ctgaggttgc tggatattca aacctttgct aggggaaata aacgaaagct aatgaacatg
     2101 tttgctatga aaaagggctt taaattttta tttaacatgt agtgtactta ttgtttggtt
     2161 ttagtgtagc atttacattt tctcgactag gtggcctaaa gaatccaatg ctaacttttg
     2221 ataataacat cattgtcccc gtcatcataa tttagtagta gctttaaaag ttttgtgttt
     2281 gcttaaaaag tgtcataact gcagccctat atgaagtgtt aacttgcttg ttaaaaggaa
     2341 gcagctttaa tttggttcca gtgcataaag tgtggtagtg tttgtgagag ggatccagtg
     2401 tatttggtga aatggcatat tacttatatt ttggaaacaa aaaaatgcca cctaagataa
     2461 taatataagt cattaagttc ctatgtcagt tgccaagcca tttaaatttc tgtattcacc
     2521 aagccccaga agagattcta gctgctagga tttgaatttt gaaagctaag aaatgtttat
     2581 aagtattaga tttcttaata ttcatatttt tgagttttag aagggaaatt tatatgcata
     2641 ttgttatgca tttatcagat attcttcccc catataacaa aaagggtagt aattttgctg
     2701 aatgttttat gttgaagtta tttcaaggta tttcatggat atgcccatga catatttgga
     2761 aaaaatagaa ggaattgatt ttttcaaaaa ggttaagtac caaaggtagg tagtttagtc
     2821 tacagaaata agttagtcac ttttggcttt tctaatttgt actgtaacat tcttttattt
     2881 tgttttaaat atatgtttct caagtaaaca atttaggtaa ttttccatac ctttttcttt
     2941 ctgatgcaga cttcaggtta attaatattt tactgcatct gatgatgtat tatatgtttg
     3001 aagcctagtg acttttaatt ttgatgttct tgtgatttca tatgttgtat tcttcaagca
     3061 ataaaattct gatgtgtttt
//
