LOCUS       NM_001356948            5185 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus dihydropyrimidinase-like 5 (Dpysl5), transcript
            variant 2, mRNA.
ACCESSION   NM_001356948 XM_006504045
VERSION     NM_001356948.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5185)
  AUTHORS   Jin,Z., Zhang,Z.C., Xiao,C.Y., Li,M.Q., Li,Q.R. and Gao,L.L.
  TITLE     CRMP5 participates in oocyte meiosis by regulating spastin to
            correct microtubule-kinetochore misconnection
  JOURNAL   Zygote 32 (1), 21-27 (2024)
   PUBMED   38047349
  REMARK    GeneRIF: CRMP5 participates in oocyte meiosis by regulating spastin
            to correct microtubule-kinetochore misconnection.
REFERENCE   2  (bases 1 to 5185)
  AUTHORS   Jin,Z., Shou,H.F., Liu,J.W., Jiang,S.S., Shen,Y., Cheng,W.Y. and
            Gao,L.L.
  TITLE     Spastin interacts with CRMP5 to promote spindle organization in
            mouse oocytes by severing microtubules
  JOURNAL   Zygote 30 (1), 80-91 (2022)
   PUBMED   34034836
  REMARK    GeneRIF: Spastin interacts with CRMP5 to promote spindle
            organization in mouse oocytes by severing microtubules.
REFERENCE   3  (bases 1 to 5185)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5185)
  AUTHORS   Lin,Y.F., Chen,K.C., Yang,Y.K. and Hsiao,Y.H.
  TITLE     Collapsin response mediator protein 5 (CRMP5) modulates
            susceptibility to chronic social defeat stress in mice
  JOURNAL   Mol Neurobiol 58 (7), 3175-3186 (2021)
   PUBMED   33638112
  REMARK    GeneRIF: Collapsin response mediator protein 5 (CRMP5) modulates
            susceptibility to chronic social defeat stress in mice.
REFERENCE   5  (bases 1 to 5185)
  AUTHORS   Lin,Y.S., Lin,Y.F., Chen,K.C., Yang,Y.K. and Hsiao,Y.H.
  TITLE     Collapsin response mediator protein 5 (CRMP5) causes social
            deficits and accelerates memory loss in an animal model of
            Alzheimer's disease
  JOURNAL   Neuropharmacology 157, 107673 (2019)
   PUBMED   31233825
  REMARK    GeneRIF: results suggest that CRMP5 regulates social behavior via
            modulation of surface GluA2 trafficking and affects memory
            performance in Alzheimer Disease mice.
REFERENCE   6  (bases 1 to 5185)
  AUTHORS   Bretin,S., Reibel,S., Charrier,E., Maus-Moatti,M., Auvergnon,N.,
            Thevenoux,A., Glowinski,J., Rogemond,V., Premont,J., Honnorat,J.
            and Gauchy,C.
  TITLE     Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in
            axons or dendrites of distinct neurons in the mouse brain
  JOURNAL   J Comp Neurol 486 (1), 1-17 (2005)
   PUBMED   15834957
  REMARK    GeneRIF: beyond their signalling function in axon outgrowth and
            guidance, CRMPs also play a role in mature neurons both in axons
            and in dendrites
REFERENCE   7  (bases 1 to 5185)
  AUTHORS   Veyrac,A., Giannetti,N., Charrier,E., Reymond-Marron,I., Aguera,M.,
            Rogemond,V., Honnorat,J. and Jourdan,F.
  TITLE     Expression of collapsin response mediator proteins 1, 2 and 5 is
            differentially regulated in newly generated and mature neurons of
            the adult olfactory system
  JOURNAL   Eur J Neurosci 21 (10), 2635-2648 (2005)
   PUBMED   15926912
  REMARK    GeneRIF: In the olfactory bulb, CRMP1, CRMP2 and CRMP5 are abundant
            in neuronal progenitors of the subependymal layer and in
            differentiating interneurons.
REFERENCE   8  (bases 1 to 5185)
  AUTHORS   Hotta,A., Inatome,R., Yuasa-Kawada,J., Qin,Q., Yamamura,H. and
            Yanagi,S.
  TITLE     Critical role of collapsin response mediator protein-associated
            molecule CRAM for filopodia and growth cone development in neurons
  JOURNAL   Mol Biol Cell 16 (1), 32-39 (2005)
   PUBMED   15509652
  REMARK    GeneRIF: CRAM regulates filopodial dynamics and growth cone
            development, thereby restricting the response of growth cone to
            repulsive guidance cues
REFERENCE   9  (bases 1 to 5185)
  AUTHORS   Fukada,M., Watakabe,I., Yuasa-Kawada,J., Kawachi,H., Kuroiwa,A.,
            Matsuda,Y. and Noda,M.
  TITLE     Molecular characterization of CRMP5, a novel member of the
            collapsin response mediator protein family
  JOURNAL   J Biol Chem 275 (48), 37957-37965 (2000)
   PUBMED   10956643
REFERENCE   10 (bases 1 to 5185)
  AUTHORS   Diamond,I., Owolabi,T., Marco,M., Lam,C. and Glick,A.
  TITLE     Conditional gene expression in the epidermis of transgenic mice
            using the tetracycline-regulated transactivators tTA and rTA linked
            to the keratin 5 promoter
  JOURNAL   J Invest Dermatol 115 (5), 788-794 (2000)
   PUBMED   11069615
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105298.21 and AC109611.24.
            
            On Oct 12, 2017 this sequence version replaced XM_006504045.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF249295.1, AK044866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               AC105298.21        21058-21496         c
            440-704             AC109611.24        94737-95001         c
            705-863             AC109611.24        62745-62903         c
            864-1043            AC109611.24        62069-62248         c
            1044-1112           AC109611.24        61287-61355         c
            1113-1157           AC109611.24        58700-58744         c
            1158-1233           AC109611.24        56953-57028         c
            1234-1390           AC109611.24        55756-55912         c
            1391-1532           AC109611.24        51383-51524         c
            1533-1675           AC109611.24        48589-48731         c
            1676-1883           AC109611.24        47896-48103         c
            1884-2052           AC109611.24        46121-46289         c
            2053-5185           AC109611.24        40854-43986         c
FEATURES             Location/Qualifiers
     source          1..5185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.8 cM"
     gene            1..5185
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /note="dihydropyrimidinase-like 5"
                     /db_xref="GeneID:65254"
                     /db_xref="MGI:MGI:1929772"
     exon            1..439
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            440..704
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             444..2138
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /note="isoform a is encoded by transcript variant 2;
                     dihydropyrimidinase-related protein 5; DRP-5; collapsin
                     response mediator protein 5"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 5 isoform a"
                     /protein_id="NP_001343877.1"
                     /db_xref="CCDS:CCDS39047.1"
                     /db_xref="GeneID:65254"
                     /db_xref="MGI:MGI:1929772"
                     /translation="MLANSASVRILIKGGKVVNDDCTHEADVYIESGIIQQVGRELMI
                     PGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVL
                     PDKETSLVEAYEKCRALADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMF
                     MTYKDLYMLRDSELYQVFHACRDIGAIPRVHAENGELVAEGAKEALDLGITGPEGIEI
                     SHPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTNAHA
                     TLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQK
                     AMGKEDFTKIPHGVSGVQDRMSVVWERGVVGGKMDENRFVAVTSSNAAKILNLYPRKG
                     RIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENG
                     VFMCAEGTGKFCPLRSFPDIVYKKLVQREKTLKVRGVDRTPYLGDVAIVVHPGKKEMG
                     TPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW"
     exon            705..863
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1043
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1112
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1157
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1233
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1390
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1532
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1675
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1883
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2052
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..5185
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4761..4766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /note="hexamer: AATAAA"
     polyA_site      4785
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /note="major polyA site"
     regulatory      5164..5169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /note="hexamer: ATTAAA"
     polyA_site      5185
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /note="major polyA site"
ORIGIN      
        1 ctagttacca tgggaccaga aaggaacgct gagaatggcg cttagatggc tgggggttgt
       61 cgaggtcctg gggccatgcc ctctgtccct tctcggaccc ggggcctgca aaagggactg
      121 tcgggatttg tagtcccaaa ggcggcggca acgcggagga cgcggggcgc tactggtccc
      181 gcctccgcct aacctgctag ctcgaggtgg cgagcacttg gggcggagcc ctcggatccg
      241 tgattggccc aggcggctcc ccgcccccac cctcgtcccc acccccgctc gccactcggg
      301 actccgctcc aggcgcgcaa ggcagccacc gagagagcgc gctagcagcc gctcccgccc
      361 cgtgcaaccg cagctaccgc gccgcggcga gacccagaga ccgaccgacg gacccgcaca
      421 atcgcatcat cctggagcag aacatgcttg ccaattcagc cagcgtgcgg attctcatca
      481 agggaggcaa ggtggtgaac gatgactgta cccacgaggc agacgtctac atcgagagcg
      541 gcatcatcca gcaggtgggc cgtgagctca tgatccccgg tggggccaag gtgattgacg
      601 ccaccgggaa actggtgatc ccgggaggga ttgacaccag cacccacttc caccagacct
      661 tcatgaacgc cacctgtgtg gacgacttct accatgggac caaggcggcc ctcgttggag
      721 gcaccaccat gatcatcggt cacgtcctgc cagacaagga gacctccctc gtggaagcct
      781 atgagaagtg cagggctcta gctgacccca aggtctgctg tgactatgcc ctccatgtgg
      841 ggatcacctg gtgggcaccc aaggtgaaag cagaaatgga gacactggtg cgggagaagg
      901 gggtcaactc cttccagatg ttcatgacct acaaggactt gtacatgctt cgagacagtg
      961 agctgtacca agtgtttcat gcctgcaggg acatcggggc gatcccccgg gtccacgctg
     1021 aaaatggaga gctcgtggct gagggtgcta aggaggctct agacttgggt atcacaggcc
     1081 cagaaggaat cgagatcagc catccagagg agctggaagc agaagccact caccgtgtca
     1141 tcaccattgc aaaccggact cactgtccca tctacctggt caatgtgtct agtatctcag
     1201 ctggtgatgt cattgcagct gctaagatgc aagggaaggt ggtgctagcc gagaccacca
     1261 acgcacacgc cacgctcacg ggcttgcact actaccatca ggactggtcg catgcagccg
     1321 cctatgtcac ggtgcctcct ctgagactgg acaccaacac ttccacctac ctcatgagcc
     1381 tgctggccaa tgacactctg aacattgtgg catccgatca ccggccattc accacaaagc
     1441 agaaagccat gggcaaggaa gacttcacta agatccccca cggtgtgagc ggtgtacagg
     1501 atcgaatgag cgtcgtctgg gagaggggcg tggttggagg aaagatggat gagaaccgtt
     1561 tcgtggccgt caccagttct aacgcagcca agatcctcaa cctgtatcct cgcaagggcc
     1621 gtatcatccc cggagccgac gctgatgtcg tggtgtggga cccggaagcc acaaagacca
     1681 tctcagccag cacccaggtg cagggtggag acttcaatct gtatgagaac atgcgctgcc
     1741 acggtgtacc gctggtcacc atcagccggg gacgagtcgt gtatgagaac ggcgtcttca
     1801 tgtgtgcaga gggcactggc aagttctgtc ccctgcggtc tttcccagac attgtctata
     1861 agaagctggt acagagagag aagaccttaa aagtgagggg agtggaccgc actccctacc
     1921 taggggatgt cgccattgtt gtccaccctg ggaaaaaaga gatgggaaca ccattggcag
     1981 acacgcccac acggccagtc acccggcacg ggggcatgcg ggaccttcat gaatccagtt
     2041 tcagcctctc tggttctcag atcgatgacc acgttccaaa gcgggcctca gctcggatcc
     2101 ttgcgccccc tggaggcagg tcgagcggta tttggtaaag gctctgacca gccccaccct
     2161 caacaagtga ggatgctaaa ccaccacctg cctgcaaatg ttccagccag agctgcagtg
     2221 ggtgggagag gttgggcagg gcagtgctcc accggtgggg gctctaggaa ccagggagcc
     2281 ctccccttgt ctgaacgtga ttcacggggc tttgatccac ccctaacaag gcactttgag
     2341 ctgtccctcc tgccctgctc cttccttcct tggccctggg gtttctctgg gccccagaag
     2401 cccacactat gcacagcacc caatgcatag cacctggccc taaaccctcc tctcaccatg
     2461 acctcctgtg ctggctctgg gaaggcccag actttagtgc tctgccctgc tgcccaccca
     2521 cacaggtgtc cagagcactt tagcaaatgt gttttataag taagggcctt cccccttcat
     2581 cccttaggcc ccatggtgac attttcccaa gtcagacagg tgtcaactcc acagccatgc
     2641 ccaaggtgtc ccatctctcc tgactcatcc cagctgtacc cttgtgggta cagtcaggac
     2701 accccgggtg tggctgtgct tgggacaccc tgtgctttct gctagcctct ttcattccct
     2761 acccacgccc tctgggagtc ccaggccccg gaagggtagc tgggtgggca tgtggctggt
     2821 gccaggcgcg tgtaaatggt tttgttttgc acgtttggtt tgcgcagtgg tttggtttga
     2881 cttgtttgtg caccctgtgg aaaataacgg tgctttgtgt cactagcata gcatagaatc
     2941 tggaatagat ttggtttgta ggagatgctg cactcaccac caaccagaca gtacagggca
     3001 gaggcggggg caggctggac ccctggcccc ttcctcccaa cccagggtcc ttttgcttcc
     3061 tgtaccgtgc ctcccctatc ccacacctcc tgccaccccc tcctacttcc ctacattcaa
     3121 acaatgctgg atgctgaccc tggaaacctt caggccgcat ctctgctccg ggttacccca
     3181 gcgctaaccc cacatccaca ccctcatagc ccaacacagc ttcctataac ttgcccctgc
     3241 tgggcaaggc ctagctactc ctcctgggtg actagtaaga ggcctcatac tggctgagaa
     3301 agagggactg gggggtgggg aggttgccta ggcaaccgcc agggaagggg cttcaaccca
     3361 caaggcctag ctgtagcatc cacccccact gcacaggtgc tatggaatcc tcggcactaa
     3421 gctctccttg aggactggtc ggacccgccc tgttttagaa gctccttaga ggttctcgta
     3481 ggtggctaca cagtctgcag agtggctcag ctgtctgcct ttgataagcc tcatccccgc
     3541 ccctctttgg caagtgatct cacttttgtt ggagctccac aaacctgtca gaggctccac
     3601 agagcttgtc agtcacccct gcacgctttt gtcctgcttt gggtccatca aagagctcag
     3661 ctctcactga gtgacaggta aactccaagg ggcttctgag atggggtggg gcttaccact
     3721 gtcccccatc ttgcagataa aaactgaggc ccccaagagt ttaggcacca gaaatgtctg
     3781 tccatgactg ctctcatggc ctcggcagtc taacctagct gtgggaaaca gttgtggatt
     3841 gatgtcaggc ccaccaggag tttaaccaga cagagtgctt tcttcctggg ggcgtgttct
     3901 gctttgcttt gcacaagccg attttatctt tgtcatgaac tgactcatgt tcgagcctgg
     3961 actagaaaag tgttaggaac ctgcgtgcgg ttttagttgc acccaatgtc ctcacttagg
     4021 agctgaagag acagataacc cagaggactg agatagccct gggaacagta ggtaatgacc
     4081 ctagaggtca caggtatcat aaacagtgac gctgacggtg tctatctctc tttctctcct
     4141 actctccttc tcctaccttc tcctcctctt ctcttttctc ctccccctcc tcctctttcc
     4201 cctttttctt cttcttgaga caaaatcttg cttaggtagc ctggccttga acttacagaa
     4261 atcctgcctt cgtttcccca agtactggaa ttatacacac aagctaccac acctagctat
     4321 acatcatctt tgtctatttc tgcccttgct gggtcatggg ccttgggcag atgccaaaga
     4381 tccaaggggt ggtagggcca gctaggcagg ccacctggag tgggccagga gcgctttacc
     4441 ctctctaatc gcctccacct gagaagtgca tcacctgaag tggtaggaga gtgcgcgtac
     4501 aaggggccac tgtgggcctt ctacttcatc caccccgccc ttccacagac ccaagcccac
     4561 cctttcatag cctgtgtgct cacccaggag cttctagatg ggaggcttag agccaaccaa
     4621 acccgtcact cccctgtgtc cactccctgc cccatgcaga gctcccacca ccccatccca
     4681 ggtccggtgg ctgccagctg gagcgaaagg ggtctctggt tgccccgaat gcagctctca
     4741 aactggtctt gtacttgctg aataaacact gttgttcttg ccttagctgc tttctaggtt
     4801 tgtggggtta acttgccaga aaattgtgct acagtgtgtg tgtgcgtgtg tgtatgtgta
     4861 gtgctaggag tccacagtag gttgcttgtc aagccattgc cgtgacaatg gcatctctta
     4921 tattgaccca aaaaccacag aaccacacgg aagccaaacc cccaccagct gttgaggtgg
     4981 caggcacagc ctggggtcag aaaggagctg tcagcacccc agcacccaag tgacttcctc
     5041 actctgtaaa tgtcatggtg ctaaggttgt attgatccca agacgacaca tggccctatg
     5101 ctttggccac cgtctgaggc aaaacaaaac agcccaacac gttgtgttct ggtgcaggtt
     5161 tgaattaaac tgtagctact tctca
//
