LOCUS       NP_001343877             564 aa            linear   ROD 05-JUN-2024
DEFINITION  dihydropyrimidinase-related protein 5 isoform a [Mus musculus].
ACCESSION   NP_001343877 XP_006504108
VERSION     NP_001343877.1
DBSOURCE    REFSEQ: accession NM_001356948.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 564)
  AUTHORS   Jin,Z., Zhang,Z.C., Xiao,C.Y., Li,M.Q., Li,Q.R. and Gao,L.L.
  TITLE     CRMP5 participates in oocyte meiosis by regulating spastin to
            correct microtubule-kinetochore misconnection
  JOURNAL   Zygote 32 (1), 21-27 (2024)
   PUBMED   38047349
  REMARK    GeneRIF: CRMP5 participates in oocyte meiosis by regulating spastin
            to correct microtubule-kinetochore misconnection.
REFERENCE   2  (residues 1 to 564)
  AUTHORS   Jin,Z., Shou,H.F., Liu,J.W., Jiang,S.S., Shen,Y., Cheng,W.Y. and
            Gao,L.L.
  TITLE     Spastin interacts with CRMP5 to promote spindle organization in
            mouse oocytes by severing microtubules
  JOURNAL   Zygote 30 (1), 80-91 (2022)
   PUBMED   34034836
  REMARK    GeneRIF: Spastin interacts with CRMP5 to promote spindle
            organization in mouse oocytes by severing microtubules.
REFERENCE   3  (residues 1 to 564)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 564)
  AUTHORS   Lin,Y.F., Chen,K.C., Yang,Y.K. and Hsiao,Y.H.
  TITLE     Collapsin response mediator protein 5 (CRMP5) modulates
            susceptibility to chronic social defeat stress in mice
  JOURNAL   Mol Neurobiol 58 (7), 3175-3186 (2021)
   PUBMED   33638112
  REMARK    GeneRIF: Collapsin response mediator protein 5 (CRMP5) modulates
            susceptibility to chronic social defeat stress in mice.
REFERENCE   5  (residues 1 to 564)
  AUTHORS   Lin,Y.S., Lin,Y.F., Chen,K.C., Yang,Y.K. and Hsiao,Y.H.
  TITLE     Collapsin response mediator protein 5 (CRMP5) causes social
            deficits and accelerates memory loss in an animal model of
            Alzheimer's disease
  JOURNAL   Neuropharmacology 157, 107673 (2019)
   PUBMED   31233825
  REMARK    GeneRIF: results suggest that CRMP5 regulates social behavior via
            modulation of surface GluA2 trafficking and affects memory
            performance in Alzheimer Disease mice.
REFERENCE   6  (residues 1 to 564)
  AUTHORS   Bretin,S., Reibel,S., Charrier,E., Maus-Moatti,M., Auvergnon,N.,
            Thevenoux,A., Glowinski,J., Rogemond,V., Premont,J., Honnorat,J.
            and Gauchy,C.
  TITLE     Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in
            axons or dendrites of distinct neurons in the mouse brain
  JOURNAL   J Comp Neurol 486 (1), 1-17 (2005)
   PUBMED   15834957
  REMARK    GeneRIF: beyond their signalling function in axon outgrowth and
            guidance, CRMPs also play a role in mature neurons both in axons
            and in dendrites
REFERENCE   7  (residues 1 to 564)
  AUTHORS   Veyrac,A., Giannetti,N., Charrier,E., Reymond-Marron,I., Aguera,M.,
            Rogemond,V., Honnorat,J. and Jourdan,F.
  TITLE     Expression of collapsin response mediator proteins 1, 2 and 5 is
            differentially regulated in newly generated and mature neurons of
            the adult olfactory system
  JOURNAL   Eur J Neurosci 21 (10), 2635-2648 (2005)
   PUBMED   15926912
  REMARK    GeneRIF: In the olfactory bulb, CRMP1, CRMP2 and CRMP5 are abundant
            in neuronal progenitors of the subependymal layer and in
            differentiating interneurons.
REFERENCE   8  (residues 1 to 564)
  AUTHORS   Hotta,A., Inatome,R., Yuasa-Kawada,J., Qin,Q., Yamamura,H. and
            Yanagi,S.
  TITLE     Critical role of collapsin response mediator protein-associated
            molecule CRAM for filopodia and growth cone development in neurons
  JOURNAL   Mol Biol Cell 16 (1), 32-39 (2005)
   PUBMED   15509652
  REMARK    GeneRIF: CRAM regulates filopodial dynamics and growth cone
            development, thereby restricting the response of growth cone to
            repulsive guidance cues
REFERENCE   9  (residues 1 to 564)
  AUTHORS   Fukada,M., Watakabe,I., Yuasa-Kawada,J., Kawachi,H., Kuroiwa,A.,
            Matsuda,Y. and Noda,M.
  TITLE     Molecular characterization of CRMP5, a novel member of the
            collapsin response mediator protein family
  JOURNAL   J Biol Chem 275 (48), 37957-37965 (2000)
   PUBMED   10956643
REFERENCE   10 (residues 1 to 564)
  AUTHORS   Diamond,I., Owolabi,T., Marco,M., Lam,C. and Glick,A.
  TITLE     Conditional gene expression in the epidermis of transgenic mice
            using the tetracycline-regulated transactivators tTA and rTA linked
            to the keratin 5 promoter
  JOURNAL   J Invest Dermatol 115 (5), 788-794 (2000)
   PUBMED   11069615
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105298.21 and AC109611.24.
            
            On Oct 12, 2017 this sequence version replaced XP_006504108.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF249295.1, AK044866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.8 cM"
     Protein         1..564
                     /product="dihydropyrimidinase-related protein 5 isoform a"
                     /note="dihydropyrimidinase-related protein 5; DRP-5;
                     collapsin response mediator protein 5"
                     /calculated_mol_wt=61386
     Region          10..459
                     /region_name="D-HYD"
                     /note="D-hydantoinases (D-HYD) also called
                     dihydropyrimidases (DHPase) and related proteins; DHPases
                     are a family of enzymes that catalyze the reversible
                     hydrolytic ring opening of the amide bond in five- or
                     six-membered cyclic diamides, like dihydropyrimidine...;
                     cd01314"
                     /db_xref="CDD:238639"
     Site            order(21..22,24,37..38,173,194,197,200,223,227,231,234,
                     261..262,264..265,383,388,393)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:238639"
     Site            order(66,68,158,191,247,325)
                     /site_type="active"
                     /db_xref="CDD:238639"
     Site            509
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9EQF6.1)"
     Site            514
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9EQF6.1)"
     Site            532
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9EQF6.1)"
     Site            538
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9EQF6.1)"
     Site            559
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9EQF6.1)"
     CDS             1..564
                     /gene="Dpysl5"
                     /gene_synonym="CRAM; CRMP-5; Crmp5"
                     /coded_by="NM_001356948.1:444..2138"
                     /note="isoform a is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS39047.1"
                     /db_xref="GeneID:65254"
                     /db_xref="MGI:MGI:1929772"
ORIGIN      
        1 mlansasvri likggkvvnd dctheadvyi esgiiqqvgr elmipggakv idatgklvip
       61 ggidtsthfh qtfmnatcvd dfyhgtkaal vggttmiigh vlpdketslv eayekcrala
      121 dpkvccdyal hvgitwwapk vkaemetlvr ekgvnsfqmf mtykdlymlr dselyqvfha
      181 crdigaiprv haengelvae gakealdlgi tgpegieish peeleaeath rvitianrth
      241 cpiylvnvss isagdviaaa kmqgkvvlae ttnahatltg lhyyhqdwsh aaayvtvppl
      301 rldtntstyl msllandtln ivasdhrpft tkqkamgked ftkiphgvsg vqdrmsvvwe
      361 rgvvggkmde nrfvavtssn aakilnlypr kgriipgada dvvvwdpeat ktisastqvq
      421 ggdfnlyenm rchgvplvti srgrvvyeng vfmcaegtgk fcplrsfpdi vykklvqrek
      481 tlkvrgvdrt pylgdvaivv hpgkkemgtp ladtptrpvt rhggmrdlhe ssfslsgsqi
      541 ddhvpkrasa rilappggrs sgiw
//
