LOCUS       NM_011993               2646 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus dihydropyrimidinase-like 4 (Dpysl4), mRNA.
ACCESSION   NM_011993
VERSION     NM_011993.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2646)
  AUTHORS   Rao,X., Zhou,D., Deng,H., Chen,Y., Wang,J., Zhou,X., Jie,X., Xu,Y.,
            Wu,Z., Wang,G., Dong,X., Zhang,S., Meng,R., Wu,C., Xing,S., Fan,K.,
            Wu,G. and Zhou,R.
  TITLE     Activation of NLRP3 inflammasome in lung epithelial cells triggers
            radiation-induced lung injury
  JOURNAL   Respir Res 24 (1), 25 (2023)
   PUBMED   36694200
  REMARK    GeneRIF: Activation of NLRP3 inflammasome in lung epithelial cells
            triggers radiation-induced lung injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2646)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2646)
  AUTHORS   Tsutiya,A., Nishihara,M., Goshima,Y. and Ohtani-Kaneko,R.
  TITLE     Mouse pups lacking collapsin response mediator protein 4 manifest
            impaired olfactory function and hyperactivity in the olfactory bulb
  JOURNAL   Eur J Neurosci 42 (6), 2335-2345 (2015)
   PUBMED   26118640
  REMARK    GeneRIF: Study provides evidence for an animal model for
            elucidating the roles of collapsin response mediator protein 4 in
            the development of higher brain functions and developmental
            regulatory mechanisms controlling the activity of the neural
            circuitry.
REFERENCE   4  (bases 1 to 2646)
  AUTHORS   Quach,T.T., Wilson,S.M., Rogemond,V., Chounlamountri,N.,
            Kolattukudy,P.E., Martinez,S., Khanna,M., Belin,M.F., Khanna,R.,
            Honnorat,J. and Duchemin,A.M.
  TITLE     Mapping CRMP3 domains involved in dendrite morphogenesis and
            voltage-gated calcium channel regulation
  JOURNAL   J Cell Sci 126 (Pt 18), 4262-4273 (2013)
   PUBMED   23868973
REFERENCE   5  (bases 1 to 2646)
  AUTHORS   Yasukawa,M., Ishida,K., Yuge,Y., Hanaoka,M., Minami,Y., Ogawa,M.,
            Sasaki,T., Saito,M. and Tsuji,T.
  TITLE     Dpysl4 is involved in tooth germ morphogenesis through growth
            regulation, polarization and differentiation of dental epithelial
            cells
  JOURNAL   Int J Biol Sci 9 (4), 382-390 (2013)
   PUBMED   23630450
  REMARK    GeneRIF: Findings suggest that Dpysl4 plays essential roles in
            tooth germ morphogenesis through the regulation of dental
            epithelial cell proliferation, cell polarization and
            differentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2646)
  AUTHORS   Fukada,M., Watakabe,I., Yuasa-Kawada,J., Kawachi,H., Kuroiwa,A.,
            Matsuda,Y. and Noda,M.
  TITLE     Molecular characterization of CRMP5, a novel member of the
            collapsin response mediator protein family
  JOURNAL   J Biol Chem 275 (48), 37957-37965 (2000)
   PUBMED   10956643
REFERENCE   7  (bases 1 to 2646)
  AUTHORS   Quach,T.T., Mosinger,B. Jr., Ricard,D., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Stankoff,B., Honnorat,J., Belin,M.F.
            and Kolattukudy,P.
  TITLE     Collapsin response mediator protein-3/unc-33-like protein-4 gene:
            organization, chromosomal mapping and expression in the developing
            mouse brain
  JOURNAL   Gene 242 (1-2), 175-182 (2000)
   PUBMED   10721710
REFERENCE   8  (bases 1 to 2646)
  AUTHORS   Inagaki,H., Kato,Y., Hamajima,N., Nonaka,M., Sasaki,M. and
            Eimoto,T.
  TITLE     Differential expression of dihydropyrimidinase-related protein
            genes in developing and adult enteric nervous system
  JOURNAL   Histochem Cell Biol 113 (1), 37-41 (2000)
   PUBMED   10664068
REFERENCE   9  (bases 1 to 2646)
  AUTHORS   Byk,T., Ozon,S. and Sobel,A.
  TITLE     The Ulip family phosphoproteins--common and specific properties
  JOURNAL   Eur J Biochem 254 (1), 14-24 (1998)
   PUBMED   9652388
REFERENCE   10 (bases 1 to 2646)
  AUTHORS   Hamajima,N., Matsuda,K., Sakata,S., Tamaki,N., Sasaki,M. and
            Nonaka,M.
  TITLE     A novel gene family defined by human dihydropyrimidinase and three
            related proteins with differential tissue distribution
  JOURNAL   Gene 180 (1-2), 157-163 (1996)
   PUBMED   8973361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165694.1 and AI173505.1.
            
            On May 15, 2008 this sequence version replaced NM_011993.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165694.1, BC090674.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2625              AK165694.1         2-2626
            2626-2646           AI173505.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2646
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 83.92 cM"
     gene            1..2646
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /note="dihydropyrimidinase-like 4"
                     /db_xref="GeneID:26757"
                     /db_xref="MGI:MGI:1349764"
     exon            1..161
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1841
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /note="ULIP-4; UNC33-like phosphoprotein 4; collapsin
                     response mediator protein 3; unc-33-like phosphoprotein 4"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 4"
                     /protein_id="NP_036123.3"
                     /db_xref="CCDS:CCDS21951.1"
                     /db_xref="GeneID:26757"
                     /db_xref="MGI:MGI:1349764"
                     /translation="MSFQGKKSIPRITSDRLLIKGGKIVNDDQSFHADLYVEDGLIKQ
                     IGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVMGMTPADDFCQGTKAALAGGTT
                     MILDHVFPDAGVSLLAAYEQWRERADSAACCDYSLHVDIPRWHESTKEELEALVRDKG
                     VNSFLVFMAYKDRCQCTDGQIYEIFSLIRDLGAVAQVHAENGDIVEEEQKRLLEQGIT
                     GPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADMVAQAKRRGVVVFG
                     EPITASLGTDGSHYWSKNWAKAAAFVTSPPINPDPTTADHLTSLLSSGDLQVTGSAHC
                     TFTTAQKAVGKDNFTLIPEGVNGIEERMSVVWEKCVASGKMDENEFVAVTSTNAAKIF
                     NFYPRKGRVAVGSDADLVIWNPRATKVISAKSHNLNVEYNIFEGVECRGVPTVVISQG
                     RVVLEDGNLLVTPGAGRFIPRKTFPDFVYKRIKARNRLAEIHGVPRGLYDGPVHEVML
                     PAKPGSGTQARASCSGKISVPPVRNLHQSGFSLSGSQADDHIARRTAQKIMAPPGGRS
                     NITSLS"
     exon            162..250
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     exon            251..435
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     exon            436..600
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     exon            601..662
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     exon            663..743
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     exon            744..812
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     exon            813..933
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1090
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1232
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1403
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1583
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1749
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..2643
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2623..2628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /note="hexamer: AACAAA"
     polyA_site      2643
                     /gene="Dpysl4"
                     /gene_synonym="CRMP-3; Crmp3; DPY4; Drp-4; Ulip4"
                     /note="major polyA site"
ORIGIN      
        1 aatcggagcc cagagccggg ctagctcaca ctcggacttc ctaagctccg cgcgtgtcct
       61 cgtcggtacg tccacgcccg cgcagcccct accgaggaca ctcagcccgc ccgtgtatca
      121 ggatgtcctt ccaaggcaag aagagcattc cccggataac gagcgaccgc cttctcatca
      181 aaggtgggaa gattgtgaac gatgaccagt cctttcatgc tgatctgtat gtggaagacg
      241 gtctgattaa acaaattgga gaaaatctca tcgtccctgg gggcatcaaa accatcgatg
      301 ctcatggcct gatggtgctg cctgggggag ttgacgttca cacccggctg cagatgcctg
      361 tgatgggcat gaccccagct gatgatttct gtcagggcac caaggcggct ctagcaggcg
      421 ggaccaccat gatattggac catgtgtttc ctgacgctgg tgtgagcctg ctggcagcct
      481 atgagcagtg gcgggagcga gcagacagcg cggcctgctg tgactactcc ttacatgtgg
      541 acattcctcg ctggcacgag agcaccaaag aagagctgga ggccctagtc agggacaaag
      601 gtgtgaactc cttcctggtc ttcatggcat acaaggacag gtgccagtgt actgacggtc
      661 agatatatga aatcttcagc ctcatccggg acctgggagc tgtggcccag gtgcacgcag
      721 aaaatgggga catcgtggag gaggaacaga agcgcctgct ggagcaaggc atcactggtc
      781 ctgagggcca tgtgctcagc cacccagaag aggtagaggc cgaggctgtg tacagagcag
      841 tcaccattgc caagcaggcc aactgcccac tatacgtcac caaggtgatg agcaagggtg
      901 cagctgacat ggttgcccaa gccaagcgca ggggggtggt cgtctttggg gaacctatca
      961 ctgccagcct gggcactgat ggctcacact actggagcaa gaactgggcc aaggctgcag
     1021 cctttgtcac ttcaccccct atcaacccgg accctactac tgcagaccac ctcacctctc
     1081 tgctgtccag tggggacctc caggtgacag gcagtgccca ctgcaccttc actactgccc
     1141 agaaggctgt tggcaaagac aacttcacac tgatccccga gggagtcaac ggtatagaag
     1201 agcgcatgtc tgtggtctgg gagaaatgtg tggcttcagg gaaaatggac gagaatgagt
     1261 tcgttgccgt gaccagcaca aatgctgcca aaatcttcaa tttttacccc aggaaggggc
     1321 gtgtggccgt gggctctgat gctgacctgg tcatctggaa ccccagggcc acgaaagtca
     1381 tctctgccaa gagccataac ctgaatgtag agtacaacat ctttgaagga gtggagtgcc
     1441 gaggagtgcc cacggtggtc ataagtcagg gcagagtggt gctggaggac ggaaacctgc
     1501 ttgtcactcc aggggctggc cgcttcattc cccggaagac gttcccggac tttgtctata
     1561 agaggataaa ggctcgcaac aggctagcag agatccacgg tgtgcctcga ggcctgtacg
     1621 acgggcctgt gcatgaagtg atgttacctg ccaagccagg aagtggcaca caggcccgtg
     1681 catcctgttc aggcaagatc tcagtgccac ccgtgcgcaa cctgcaccag tcggggttca
     1741 gcctatctgg ctctcaggct gacgatcaca ttgccagacg tacggctcag aagatcatgg
     1801 caccccccgg aggacgctcc aacatcacgt ctctttccta gacttggggt cttggcaagc
     1861 tggtgctgtc cccactggca gggtgtgggg acgactcacg tcagttagct ccttcctttg
     1921 tagattgtta ttgtgaaagg tgctcagcct taccctcccc ctccccataa gctctctctt
     1981 gggtgaccca gcccccactc tgaggtaccc gccccagagg gctgaaccca gggagagttc
     2041 actgccagag tgagaggatt aggcatggca gtgagcaggt gcctcttgcc ccccctgacc
     2101 ttaccacgaa ggccttccat gagagctctc ggcctccagc tcctgagctt tctgggggtc
     2161 ttggtgtagg cagggtgggc gtttgctgct gccaccccct aagaaatcac tgccccgtgg
     2221 gagcccccaa gcttccacca gttccatgtt gctaaggtgc agctacccct tgggggcctg
     2281 tccccctggc tgccctggtg tagggaggag agcaggtgag cagggcctcc gccttgcgga
     2341 gctgccgtga cttcagggat ccaccagtta ctcggtgcag gggagctccc tcccacacag
     2401 acacttccaa ggaccaaacc tgagctccta tagcagcccc cctctagggc gttggatgat
     2461 cccttagcta aggcttgcct tttcctacaa agtgtgtttc tataggatta ctagagtagc
     2521 ggttttgtac tgtgaggaaa ctgtagccag ggatctgcat gctgctgtac cagatgccgg
     2581 ccaccaccgg ccaagcctga tgtgagtcag gtcaataaaa aaaacaaaaa caaaaacaaa
     2641 aaaaaa
//
