LOCUS       NM_001291455            5477 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus dihydropyrimidinase-like 3 (Dpysl3), transcript
            variant 3, mRNA.
ACCESSION   NM_001291455 XM_006525780
VERSION     NM_001291455.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5477)
  AUTHORS   Asahina,R., Takahashi,M., Takano,H., Yao,R., Abe,M., Goshima,Y. and
            Ohshima,T.
  TITLE     The role of CRMP4 in LPS-induced neuroinflammation
  JOURNAL   Brain Res 1841, 149094 (2024)
   PUBMED   38914219
  REMARK    GeneRIF: The role of CRMP4 in LPS-induced neuroinflammation.
REFERENCE   2  (bases 1 to 5477)
  AUTHORS   Minegishi,Y., Hiroshima,Y., Yazawa,K., Sato,S., Yabushita,Y.,
            Homma,Y., Matsuyama,R., Kato,I., Goshima,Y. and Endo,I.
  TITLE     CRMP4 Up-regulates M2 Macrophages and Myeloid-derived Suppressor
            Cells to Promote Pancreatic Cancer in Mice
  JOURNAL   Anticancer Res 42 (2), 791-799 (2022)
   PUBMED   35093877
  REMARK    GeneRIF: CRMP4 Up-regulates M2 Macrophages and Myeloid-derived
            Suppressor Cells to Promote Pancreatic Cancer in Mice.
REFERENCE   3  (bases 1 to 5477)
  AUTHORS   Boulan,B., Ravanello,C., Peyrel,A., Bosc,C., Delphin,C., Appaix,F.,
            Denarier,E., Kraut,A., Jacquier-Sarlin,M., Fournier,A.,
            Andrieux,A., Gory-Faure,S. and Deloulme,J.C.
  TITLE     CRMP4-mediated fornix development involves Semaphorin-3E signaling
            pathway
  JOURNAL   Elife 10, e70361 (2021)
   PUBMED   34860155
  REMARK    GeneRIF: CRMP4-mediated fornix development involves Semaphorin-3E
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5477)
  AUTHORS   Maimon,R., Ankol,L., Gradus Pery,T., Altman,T., Ionescu,A.,
            Weissova,R., Ostrovsky,M., Tank,E., Alexandra,G., Shelestovich,N.,
            Opatowsky,Y., Dori,A., Barmada,S., Balastik,M. and Perlson,E.
  TITLE     A CRMP4-dependent retrograde axon-to-soma death signal in
            amyotrophic lateral sclerosis
  JOURNAL   EMBO J 40 (17), e107586 (2021)
   PUBMED   34190355
  REMARK    GeneRIF: A CRMP4-dependent retrograde axon-to-soma death signal in
            amyotrophic lateral sclerosis.
REFERENCE   5  (bases 1 to 5477)
  AUTHORS   Blasco,H., Bernard-Marissal,N., Vourc'h,P., Guettard,Y.O.,
            Sunyach,C., Augereau,O., Khederchah,J., Mouzat,K., Antar,C.,
            Gordon,P.H., Veyrat-Durebex,C., Besson,G., Andersen,P.M.,
            Salachas,F., Meininger,V., Camu,W., Pettmann,B., Andres,C.R. and
            Corcia,P.
  CONSRTM   French ALS Study Group
  TITLE     A rare motor neuron deleterious missense mutation in the DPYSL3
            (CRMP4) gene is associated with ALS
  JOURNAL   Hum Mutat 34 (7), 953-960 (2013)
   PUBMED   23568759
  REMARK    GeneRIF: In the human ortholog of Dpysl3, the association between
            the rs147541241 variant and amyotrophic lateral sclerosis was
            limited to the French population.
REFERENCE   6  (bases 1 to 5477)
  AUTHORS   Duplan,L., Bernard,N., Casseron,W., Dudley,K., Thouvenot,E.,
            Honnorat,J., Rogemond,V., De Bovis,B., Aebischer,P., Marin,P.,
            Raoul,C., Henderson,C.E. and Pettmann,B.
  TITLE     Collapsin response mediator protein 4a (CRMP4a) is upregulated in
            motoneurons of mutant SOD1 mice and can trigger motoneuron axonal
            degeneration and cell death
  JOURNAL   J Neurosci 30 (2), 785-796 (2010)
   PUBMED   20071543
REFERENCE   7  (bases 1 to 5477)
  AUTHORS   Gaetano,C., Matsuo,T. and Thiele,C.J.
  TITLE     Identification and characterization of a retinoic acid-regulated
            human homologue of the unc-33-like phosphoprotein gene (hUlip) from
            neuroblastoma cells
  JOURNAL   J Biol Chem 272 (18), 12195-12201 (1997)
   PUBMED   9115293
REFERENCE   8  (bases 1 to 5477)
  AUTHORS   Hamajima,N., Matsuda,K., Sakata,S., Tamaki,N., Sasaki,M. and
            Nonaka,M.
  TITLE     A novel gene family defined by human dihydropyrimidinase and three
            related proteins with differential tissue distribution
  JOURNAL   Gene 180 (1-2), 157-163 (1996)
   PUBMED   8973361
REFERENCE   9  (bases 1 to 5477)
  AUTHORS   Wang,L.H. and Strittmatter,S.M.
  TITLE     A family of rat CRMP genes is differentially expressed in the
            nervous system
  JOURNAL   J Neurosci 16 (19), 6197-6207 (1996)
   PUBMED   8815901
REFERENCE   10 (bases 1 to 5477)
  AUTHORS   Byk,T., Dobransky,T., Cifuentes-Diaz,C. and Sobel,A.
  TITLE     Identification and molecular characterization of Unc-33-like
            phosphoprotein (Ulip), a putative mammalian homolog of the axonal
            guidance-associated unc-33 gene product
  JOURNAL   J Neurosci 16 (2), 688-701 (1996)
   PUBMED   8551352
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC101718.6.
            
            On Dec 20, 2021 this sequence version replaced NM_001291455.1.
            
            Summary: This gene encodes a protein that belongs to the TUC
            (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are
            phosphoproteins that function in axonal guidance and neuronal
            differentiation during development and regeneration of the nervous
            system. A mutation in the human gene is associated with amyotrophic
            lateral sclerosis. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Apr 2014].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (CRMP4b, also known as
            isoform 3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.323620.1,
                                           SRR11927934.5854561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               AC101718.6         6846-7305
            461-549             AC101718.6         81544-81632
            550-734             AC101718.6         83989-84173
            735-899             AC101718.6         86737-86901
            900-961             AC101718.6         90331-90392
            962-1042            AC101718.6         91174-91254
            1043-1111           AC101718.6         99961-100029
            1112-1232           AC101718.6         102773-102893
            1233-1389           AC101718.6         111098-111254
            1390-1531           AC101718.6         112122-112263
            1532-1702           AC101718.6         115274-115444
            1703-1882           AC101718.6         116631-116810
            1883-2045           AC101718.6         119248-119410
            2046-5477           AC101718.6         120715-124146
FEATURES             Location/Qualifiers
     source          1..5477
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18"
     gene            1..5477
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /note="dihydropyrimidinase-like 3"
                     /db_xref="GeneID:22240"
                     /db_xref="MGI:MGI:1349762"
     exon            1..460
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2134
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /note="isoform CRMP4b is encoded by transcript variant 3;
                     dihydropyrimidinase-related protein 3; collapsin response
                     mediator protein 4; unc-33-like phosphoprotein 1"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 3 isoform
                     CRMP4b"
                     /protein_id="NP_001278384.1"
                     /db_xref="CCDS:CCDS79639.1"
                     /db_xref="GeneID:22240"
                     /db_xref="MGI:MGI:1349762"
                     /translation="MASGRRGWDSSHEDDLPVYLARPGTTDQVPRQKYGGMFCNVEGA
                     FESKTLDFDALSVGQRGAKTPRSSQGSGRGAGNRPGMEVDARRGPGREESREPAPESP
                     KPAGVEIRSATGKEVLQNLGPKDKSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGD
                     NLIVPGGVKTIEANGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMII
                     DHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQSLSKEKGVNS
                     FMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQARMLEMGITGPE
                     GHVLSRPEELEAEAVFRAITVASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPI
                     TASLGIDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFS
                     TAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLY
                     PRKGRIAVGSDSDLVIWDPDALKIVSAKNHQSVAEYNIFEGMELRGAPLVVICQGKIM
                     LEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYDGPVFDLTTTPK
                     GGTPAGSTRGSPTRPNPPVRNLHQSGFSLSGTQVDEGVRSASKRIVAPPGGRSNITSL
                     S"
     exon            461..549
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..734
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..899
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..961
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1042
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1111
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1232
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1389
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1531
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1702
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1882
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2045
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..5477
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5456..5461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /note="hexamer: ATTAAA"
     polyA_site      5477
                     /gene="Dpysl3"
                     /gene_synonym="CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1"
                     /note="major polyA site"
ORIGIN      
        1 actgtggctc tgtgcgcgct gccggccgct gctctctcca gcctctgaag aagaaagccc
       61 ctgagccgct gtcgcttgaa ccatggcttc gggccgaagg ggttgggaca gctcccacga
      121 ggacgacctg cctgtgtact tggcccgtcc gggcaccaca gatcaggtcc cacggcagaa
      181 gtacggtggc atgttctgca acgtggaggg tgccttcgag agcaagacgt tggattttga
      241 tgccctgagt gtgggacagc gcggcgccaa gactccccgg agcagccagg gcagcggccg
      301 tggcgcaggg aaccggcccg ggatggaagt ggacgcgcgc aggggcccgg gccgggagga
      361 gagcagggaa cccgcgccgg agtcccccaa gcccgctggg gtggagatcc ggagcgccac
      421 cggcaaggag gtcttgcaga accttggtcc caaggacaag agtgaccgtc ttctaatcaa
      481 gggagggaga atcgtcaatg atgatcagtc cttttatgct gatatttaca tggaggatgg
      541 cttaataaag caaattggag acaatctgat tgtccccgga ggtgtgaaga ccatcgaggc
      601 caacgggaag atggtgatcc ctggaggcat tgacgtccat acccacttcc agatgcctta
      661 caagggaatg accacagtgg acgatttctt ccaagggaca aaggctgcct tagcgggagg
      721 caccaccatg atcattgacc acgtggtacc tgaacctgag tctagcctga cagaggccta
      781 tgaaaagtgg cgtgagtggg ccgatgggaa gagctgctgt gactatgctt tgcatgtgga
      841 catcacccac tggaatgaca gcgtcaagca ggaggtacag agcctcagca aggaaaaagg
      901 cgttaactcc ttcatggttt acatggccta caaggattta tatcaagtgt ccaacacaga
      961 gctctatgag atcttcacct gcctgggaga gctgggggcc attgctcaag ttcatgccga
     1021 gaatggagat atcattgccc aggagcaggc acggatgctg gaaatgggga taaccggccc
     1081 agaaggccac gttctgagca gaccggaaga gctggaagct gaggctgtgt tccgtgccat
     1141 caccgtcgcc agccagacca actgccccct ctatgtcacc aaggtcatga gcaagagcgc
     1201 ggctgatctc atctcacaag ccaggaagaa aggaaatgtg gtctttggcg agcccatcac
     1261 tgccagcctg ggaatagatg gaactcatta ctggagtaag aactgggcca aagcagctgc
     1321 gtttgtgaca tccccacctc tgagccctga ccctaccaca cctgactaca tcaactcctt
     1381 gctggccagc ggggatctgc agctctctgg aagtgcccac tgtaccttta gcactgccca
     1441 gaaagccatt gggaaggaca acttcacagc catccctgaa ggcaccaatg gcgtggagga
     1501 gcgtatgtct gtcatctggg acaaggctgt ggccacgggg aagatggatg aaaaccagtt
     1561 tgtggccgtg acaagcacca atgctgccaa gatattcaac ctgtaccctc gaaaggggag
     1621 aatagctgtg ggctctgaca gcgaccttgt catctgggat ccagatgcct tgaagattgt
     1681 ctctgccaag aaccaccagt cggttgccga atacaacatc tttgaaggga tggagctgcg
     1741 tggtgcacct ctggtggtta tctgccaggg caagatcatg ctggaagatg gcaacctgca
     1801 cgtgacccag ggggctggcc gcttcattcc ctgcagccca ttctctgact atgtctataa
     1861 gcgcattaaa gcaaggagga agatggcaga cctgcatgca gtcccaagag gcatgtatga
     1921 tggaccagtg tttgacttga ccaccacccc caaggggggc accccagctg gctctactcg
     1981 gggctctccc actcggccaa acccgccagt gaggaacctc catcagtcag gatttagcct
     2041 gtcaggcacc caagtggatg agggtgtccg ctcagctagc aaacgcattg tggcaccccc
     2101 tggaggccgt tctaacatca catccctgag ttaagccctc ccaaagaggg aggcagaagc
     2161 aagaagaaaa aaaaaaaatt gaagccaaaa tggtacaccg atatttaaga aggaacgtga
     2221 atccatgcag ttgagatcta aagaatcact aagcctcaag ccttatgttt cccaatgtta
     2281 tgctcgcttg cctagcttta tgaattgctt tggtttctgt ttttgcatac tctcaatttc
     2341 tttgaacccc acccccaccc cacccccact tacatgcatg cgatcagaca ggccactaag
     2401 gtagattctg catattatag tgttgagagc gtatgtagca ctgcatctta caacaagggg
     2461 acagacaaag ctgggatgtc gagaaaaaaa cgaatgaagg cacgaagggc ctttggatga
     2521 ttgggtggtg ggagcccagg gcaagatgga gggcacaaag gggctggggt gggacgtgta
     2581 ctagggaggt gggtgggtgg ggtgagcaga agggcattgt gtgttgtatt atgatgtgtg
     2641 ttaatttcca tggaggatgg tcacatatgg cagtggtgct ccatcacagt cccctgggat
     2701 ctgcagagat ggcaggaggt ctttgggttc tggactttgt catgtccttt cctagtagat
     2761 cttgtttcct taccatgtat tgaatgacag aatccagcca tttcttccac ctgtgatgcc
     2821 agttgcttgc tcaggcctct ttctcctgtg gctttctagt cttctattcc cagctgtgaa
     2881 gaccacacac agatgaacaa atggacaggt ctcttcttct ttagcttctt tggggctctt
     2941 ccaaggctgc catggagaat gcagccccag ctctatttag gggaggacag gtaagcttag
     3001 acagccttcc tttcagccct ggggaggtac tccccaccct cctctctagt gtctgcaaac
     3061 tgagttagga ccatggcaga gctagagcca aaggcttcct ttgctcatgg cgaatggcta
     3121 acctcctcat cccacacctg agcgcatttc ccgatgttat ttcttttggg agagctgact
     3181 ttctctattg ttcctaaact ttgctcccaa cagtaatctc tgcttccgag ggagagtaca
     3241 gcagagatgt agggaaccca gctttgagta gcaggagtgc actgtataac cacattttca
     3301 atgctaagcc aagtgtttcc tcgtctgcta gcagatccca ggggctggga tatcactttt
     3361 taattggtac taaatctcta gggtgatatg gataaagcga catgatgcag ttttcttggt
     3421 gtgcaacaca taagggcagt gggcagcagt ggtagcctcc ctctttgtct gtcagagttg
     3481 gaagcccgtg ttcctatcac accatttcca aaatcaaccg tgagccagat tctgtgagca
     3541 aggcaggggg gctgtagaag ccaagatact cttcctgcag gaaacgtggt agtgaccttg
     3601 gctcagactt ctgtgctcta gggacccact cggtgagaaa tatcacactg cgcattaagt
     3661 actctgaaga gcagagcagg cctcgtacac cttcgaagta cttagagaaa actccatctc
     3721 tgcctgcagg tgttgtttgg ttttgctggg ttttgttttt tgttttttgt tgttgttgtt
     3781 gttgtttttt ttttttgagg tggggaattt ctgtttattt cattttgtag agctggacaa
     3841 ttgagtccag ggcctctcaa atgctaggca aaactctgtc acggtgcttc atctttgctc
     3901 cccttacagc cctggctgta ggctgtcata aaatttagaa ctagagaaat atgaacagtt
     3961 tggatacata aggatttgga aattgccgag gaagggattt tcctgagaaa gctattctgt
     4021 tctaatcttg aaaaaaggct ttcacctcag aagaggaatc ttgcttcttt aaagctctca
     4081 tggtgctttc attttaaagg agactttaga agaaaaagaa tggaatgaag ttttgagtta
     4141 caattcaaat ttggggatca atccaggaac acagaaggac ttttatacgc aaagggagtt
     4201 tgccagatct gaagcttgta tactaaatac ctcaaaagct aggctcggca gcagcatagg
     4261 ttgtagtacc atctgtggcc accagatggg ggaagagaca tgtaaatgaa ctgtaattct
     4321 gcgcctcctc aactgtgtgg ttccccatgc ctgagccctt ccagggtctc tctgatcatg
     4381 aaaaataaac tcctttgggt catttgcact gcacttggca tttccaaagt gtaccactgt
     4441 gccgaaacct tatgttccac tcaagtgttc ctttcctgtg caaggaacag cttcttgaag
     4501 tcctcaaggt gggcaggcgc catctcagga tgcgtctctt tcttcattca ctatgagtag
     4561 tgcccaagcc tcgtaaatcc tgagaatccc ttggcaactc cccaactgtt ttcttaacat
     4621 gagaattttt ctaagcaaca tgttacttga gctacaaatc aaaatgcaaa ttgcttctgc
     4681 ttcacaggca gacagccgca ttccagggtg ggagagcgtg ctggtaccat cttctctcaa
     4741 gtagctctgt catcggggct ttccaccaag tcccctctaa gaatactctg cagtctccaa
     4801 acgccaagtt attgctgagc ccccaatggc aacctattga cattctttct gaaagggcca
     4861 caggcgtgag tggttgaaac ggtctttctg gagcaattaa atcaacctcc tcagtggaga
     4921 aatttgttac ttctaagttt tttgggtttt gttttgtttt ttaatctagt aggattatag
     4981 tcatcctcta aaatggcctt tctctaactt caaagtccac tggttctatg ggtcatttct
     5041 ttatcaagat atgcagaggt ctatctccca aggcctgaat cctaactctg gactccattc
     5101 taatcattct gctcagtccc ttccaagagg cgagtgcttg ccaacgttgc ttcttgccac
     5161 aagcctccca gatctcctcc ccttagaccg tcccagcttg agtcctgatg cagtcatgca
     5221 ttcctcgtaa ttcccctttg agacatggtg tgtgggtgtt cagttctgtg tctggtggct
     5281 atggacagac agtgcgtctc cctgtgacct gtgctagctg tgaggcagct cggatatgga
     5341 agagctgttt ggtttgaacc gtgaagaaaa ctgtgtattg agttagctga gattaaagaa
     5401 acaaacgaac aaacaaacaa aagctcatca cgtgactgtt aatgtaaacc tggttattaa
     5461 aataattata aaattac
//
