LOCUS       NM_001378767            4761 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus dihydropyrimidinase-like 2 (Dpysl2), transcript
            variant 1, mRNA.
ACCESSION   NM_001378767 XM_006518508
VERSION     NM_001378767.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4761)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4761)
  AUTHORS   Madugalle,S.U., Liau,W.S., Zhao,Q., Li,X., Gong,H., Marshall,P.R.,
            Periyakaruppiah,A., Zajaczkowski,E.L., Leighton,L.J., Ren,H.,
            Musgrove,M.R.B., Davies,J.W.A., Kim,G., Rauch,S., He,C.,
            Dickinson,B.C., Fulopova,B., Fletcher,L.N., Williams,S.R.,
            Spitale,R.C. and Bredy,T.W.
  TITLE     Synapse-Enriched m6A-Modified Malat1 Interacts with the Novel m6A
            Reader, DPYSL2, and Is Required for Fear-Extinction Memory
  JOURNAL   J Neurosci 43 (43), 7084-7100 (2023)
   PUBMED   37669863
  REMARK    GeneRIF: Synapse-Enriched m[6]A-Modified Malat1 Interacts with the
            Novel m[6]A Reader, DPYSL2, and Is Required for Fear-Extinction
            Memory.
REFERENCE   3  (bases 1 to 4761)
  AUTHORS   Laddach,A., Chng,S.H., Lasrado,R., Progatzky,F., Shapiro,M.,
            Erickson,A., Sampedro Castaneda,M., Artemov,A.V.,
            Bon-Frauches,A.C., Amaniti,E.M., Kleinjung,J., Boeing,S.,
            Ultanir,S., Adameyko,I. and Pachnis,V.
  TITLE     A branching model of lineage differentiation underpinning the
            neurogenic potential of enteric glia
  JOURNAL   Nat Commun 14 (1), 5904 (2023)
   PUBMED   37737269
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4761)
  AUTHORS   Grycel,K., Larsen,N.Y., Feng,Y., Qvortrup,K., Jensen,P.H.,
            Fayyaz,M., Madsen,M.G., Midtgaard,J., Xu,Z., Hasselholt,S. and
            Nyengaard,J.R.
  TITLE     CRMP2 conditional knockout changes axonal function and
            ultrastructure of axons in mice corpus callosum
  JOURNAL   Mol Cell Neurosci 126, 103882 (2023)
   PUBMED   37479154
  REMARK    GeneRIF: CRMP2 conditional knockout changes axonal function and
            ultrastructure of axons in mice corpus callosum.
REFERENCE   5  (bases 1 to 4761)
  AUTHORS   Brustovetsky,T., Khanna,R. and Brustovetsky,N.
  TITLE     CRMP2 Participates in Regulating Mitochondrial Morphology and
            Motility in Alzheimer's Disease
  JOURNAL   Cells 12 (9), 1287 (2023)
   PUBMED   37174687
  REMARK    GeneRIF: CRMP2 Participates in Regulating Mitochondrial Morphology
            and Motility in Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4761)
  AUTHORS   Fukada,M., Watakabe,I., Yuasa-Kawada,J., Kawachi,H., Kuroiwa,A.,
            Matsuda,Y. and Noda,M.
  TITLE     Molecular characterization of CRMP5, a novel member of the
            collapsin response mediator protein family
  JOURNAL   J Biol Chem 275 (48), 37957-37965 (2000)
   PUBMED   10956643
REFERENCE   7  (bases 1 to 4761)
  AUTHORS   Inagaki,H., Kato,Y., Hamajima,N., Nonaka,M., Sasaki,M. and
            Eimoto,T.
  TITLE     Differential expression of dihydropyrimidinase-related protein
            genes in developing and adult enteric nervous system
  JOURNAL   Histochem Cell Biol 113 (1), 37-41 (2000)
   PUBMED   10664068
REFERENCE   8  (bases 1 to 4761)
  AUTHORS   Byk,T., Ozon,S. and Sobel,A.
  TITLE     The Ulip family phosphoproteins--common and specific properties
  JOURNAL   Eur J Biochem 254 (1), 14-24 (1998)
   PUBMED   9652388
REFERENCE   9  (bases 1 to 4761)
  AUTHORS   Kamata,T., Subleski,M., Hara,Y., Yuhki,N., Kung,H., Copeland,N.G.,
            Jenkins,N.A., Yoshimura,T., Modi,W. and Copeland,T.D.
  TITLE     Isolation and characterization of a bovine neural specific protein
            (CRMP-2) cDNA homologous to unc-33, a C. elegans gene implicated in
            axonal outgrowth and guidance
  JOURNAL   Brain Res Mol Brain Res 54 (2), 219-236 (1998)
   PUBMED   9555025
REFERENCE   10 (bases 1 to 4761)
  AUTHORS   Hamajima,N., Matsuda,K., Sakata,S., Tamaki,N., Sasaki,M. and
            Nonaka,M.
  TITLE     A novel gene family defined by human dihydropyrimidinase and three
            related proteins with differential tissue distribution
  JOURNAL   Gene 180 (1-2), 157-163 (1996)
   PUBMED   8973361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165148.2 and AC154693.2.
            
            On Mar 9, 2020 this sequence version replaced XM_006518508.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.805664.1,
                                           ERR3363660.1259392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-600               AC165148.2         58500-59099         c
            601-689             AC154693.2         19033-19121
            690-874             AC154693.2         21546-21730
            875-1039            AC154693.2         49827-49991
            1040-1101           AC154693.2         54221-54282
            1102-1182           AC154693.2         54761-54841
            1183-1251           AC154693.2         55364-55432
            1252-1372           AC154693.2         59738-59858
            1373-1529           AC154693.2         68616-68772
            1530-1671           AC154693.2         69107-69248
            1672-1842           AC154693.2         70907-71077
            1843-2022           AC154693.2         76162-76341
            2023-2188           AC154693.2         77123-77288
            2189-4761           AC154693.2         78767-81339
FEATURES             Location/Qualifiers
     source          1..4761
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.6 cM"
     gene            1..4761
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /note="dihydropyrimidinase-like 2"
                     /db_xref="GeneID:12934"
                     /db_xref="MGI:MGI:1349763"
     exon            1..600
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..2280
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dihydropyrimidinase-related protein 2; DRP-2; ULIP-2;
                     unc-33-like phosphoprotein 2; collapsin response mediator
                     protein 2"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 2 isoform 1"
                     /protein_id="NP_001365696.1"
                     /db_xref="GeneID:12934"
                     /db_xref="MGI:MGI:1349763"
                     /translation="MAERKQSGKAAEDEEVPAFFKNLGSGSPKPRQKFCGMFCPVEGS
                     SENKTIDFDSLSVGRGSGQVVAQQRDVAHLGPDPHRQSRRASGEPSVESSRKVEIRRA
                     SGKEALQNIYDQSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIE
                     AHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLL
                     AAFDQWREWADSKSCCDYSLHVDITEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQ
                     LTDSQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEA
                     EAVNRSITIANQTNCPLYVTKVMSKSAAEVIAQARKKGTVVYGEPITASLGTDGSHYW
                     SKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFT
                     LIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRISVGSDA
                     DLVIWDPDSVKTISAKTHNSALEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGS
                     GRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSP
                     AKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRANITSLG"
     exon            601..689
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     exon            690..874
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1039
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1101
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1182
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1251
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1372
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1529
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1671
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1842
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2022
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2188
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..4761
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4737..4742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /note="hexamer: AATAAA"
     polyA_site      4761
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; DRP2; Musunc33; TOAD-64; Ulip2"
                     /note="major polyA site"
ORIGIN      
        1 agatccaact ttgctcggag gtggcgtggc ggcgccgggg ggcgtgggca gggagggaga
       61 aagcggggtc aggaggaggg accgcgaggg gtgggtcgcc ggttcgccag ctctccatcc
      121 tttctgtgca ccttgcggta ggcagggaga ggcagccgcg gcggcagcaa gaggctagtg
      181 cacacccagc tagggagact taggaaacca cggacggacg gacgaacaga caggaccttc
      241 cccagcgccc cctgagccat ggccgagaga aagcaatctg gaaaggcagc agaggacgaa
      301 gaggtccctg ccttttttaa aaacctgggc tccggcagtc ccaagccgcg gcagaaattc
      361 tgcggcatgt tctgccctgt ggaagggtcc tcggagaaca agaccatcga cttcgactcg
      421 ctttcagtgg gccggggctc ggggcaagtg gtggctcagc agcgcgatgt cgcccacttg
      481 ggccccgacc cgcaccggca gagccggcgt gccagtgggg agccatctgt tgaatcgagc
      541 cggaaggtgg agatccggcg ggcctcgggc aaggaagccc tgcagaacat ctatgatcag
      601 agcgatcgtc ttctgatcaa aggtggcaag attgtgaatg atgaccagtc cttctatgca
      661 gacatataca tggaagatgg gttgatcaag caaataggag aaaacctgat tgtaccagga
      721 ggggtgaaga ccatcgaagc ccactccaga atggtgattc ccggagggat tgacgtgcat
      781 actcgcttcc agatgcctga ccagggaatg acatccgctg atgacttctt ccagggaacc
      841 aaggcggccc tggccggggg aaccaccatg atcattgacc atgttgttcc tgagcccggg
      901 acgagcctat tggctgcctt tgatcagtgg agggagtggg ctgacagcaa gtcctgctgt
      961 gactattcgc tgcacgtgga catcactgag tggcacaagg gcatccagga ggagatggaa
     1021 gctctggtga aggaccacgg ggtaaactcc ttcctcgtgt acatggcttt caaagatcga
     1081 ttccagctga cggattccca gatctatgaa gtgctgagcg tgatccggga tatcggtgcc
     1141 atagctcaag tccacgcaga gaatggtgac atcattgctg aggaacagca gaggatcctg
     1201 gatctgggca tcacgggccc cgagggacac gtgttgagcc ggccagagga ggtcgaggct
     1261 gaagctgtga accggtccat cactattgcc aaccagacca actgccctct gtatgtcacc
     1321 aaagtgatga gcaagagtgc ggctgaagtc atcgctcagg cacggaagaa gggaactgtg
     1381 gtgtatggtg agcccatcac ggccagcctg gggactgatg gctctcatta ctggagcaag
     1441 aactgggcca aggctgcggc ctttgtcacc tccccaccct tgagccccga cccaaccact
     1501 ccagactttc tcaactcgtt gctgtcctgt ggagacctcc aagtcactgg cagtgcccac
     1561 tgcaccttca acactgccca gaaggctgtg gggaaggaca acttcacctt gattcccgag
     1621 ggcaccaacg gcactgagga gcggatgtct gtcatttggg ataaagctgt ggtcactggg
     1681 aagatggatg agaatcagtt tgtggctgtg accagcacca acgcagccaa agtcttcaac
     1741 ctttaccccc ggaaaggtcg catctcggtg ggatctgatg ctgacttggt catctgggac
     1801 cctgacagtg tgaagaccat ctctgccaag acacacaaca gtgctcttga gtacaacatc
     1861 tttgaaggca tggagtgtcg cggctcccca ctggtggtca tcagccaggg caagattgtc
     1921 ctggaggacg gcacacttca tgtcactgaa ggctcaggac gctacattcc ccggaagccc
     1981 ttccctgact ttgtgtacaa acgcatcaaa gcaaggagca ggctggctga gctgagaggg
     2041 gtccctcgtg gcctgtatga cggaccggta tgcgaggtgt ctgtgacgcc caagacggtg
     2101 actccagcct catcagctaa gacatcccct gccaagcagc aggcaccacc tgttcggaac
     2161 ctgcaccagt ctggattcag cttgtctggt gctcagattg acgacaacat tccccgccgc
     2221 accacccagc gcatcgtggc accccctggt ggccgtgcca acatcaccag cctgggctaa
     2281 agcccctagg cctgcaggcc acttggggat gggggatggg acacctgagg acattctgag
     2341 acttcctttc ttccattttt ttttttttta aagagcctgt gatagttgct gtgggcagcc
     2401 agttcctggg gcttcctctt gggccccctg cactcggtct cccctggagt ttctgaattc
     2461 tctcacccaa gtccctacac agtcatgaac accacaccca agcctagcca tccaccccac
     2521 acggagctgc atccaacatg cagacatgcg ccaccaagca gatcccagca agggtgcccc
     2581 agtcacatcc ttggccatgc agttagcacc ttcctgtcat ggggaagata tagtgaattg
     2641 ccctgagctg ccttcttttc tttttaaaaa tttttaaata aggttttctt tgtgggactg
     2701 gggaggggtg gggagggtgg gagagatttt tttttttttt aatactaaat tgaaagcctg
     2761 attcaatatt aatcctcggg tcttgaactg gacatcctaa tgatgcaatt atgtaaccat
     2821 taagctgatt ccgaggctgg caggctaggg ccgcccctct ggaaaggttc catgtgtctc
     2881 catccccatc ccttactctt cgggtcagct gttgagaaga ggcgggtttt cttcattggc
     2941 ctagattttg cggcagatta gaccttttga aggttctcca ccattttcgt acgtctcctg
     3001 tcctggtttt ttcttctgca ctcttggaga gatttagatg ttggtctcct ggtttgtgtt
     3061 tctccgagac aatgctcttt tttttttttt tttttttttt tttttttttt cctcttaact
     3121 ctgtctgctc ttaaagccag gcaacccagt ttggtctcag gcatagcctg agcagatctt
     3181 agttttgccc ccaccaccat agttttgtgc tatcctagtt tctgttaaga ttggtgctat
     3241 ccaattccca tcactaggag gtggctgagc ttgaggcttg ccagacacag gaatggcccc
     3301 gattatgtca ccaatattgt cacatgtggg ccaagaatag agtcacatgt ggtggaaaga
     3361 tgaggagtta ggctgtagaa gtgacagttt ccagtcaaat ctgtaaaccc agcccccaag
     3421 ctgagaccag tctccctgtg gcggagccag ccaagatggg gccattctct ctgtggagga
     3481 gccccttcca gcctttgtca ggaagtgtct ttggggattc tagaatgttg ggacttctca
     3541 gtgtgtgtgt tgtggtgggg gaactttttt tttttttctg tacagttttt tttttttttt
     3601 tttttctcaa aaggtctaac atggtggtgg aaggtagaaa tctttgggat acttagactt
     3661 caagtctttt acaagaggga caaccctatt ttgggaaaca atatctcatg ggaagaaaac
     3721 tgtacacact gaacgcatag cccgcttaga gatcacatcg cctcttagag accatgtcac
     3781 ctcctatctg tcacccttcc tcttcctgtc acagtgacag gtcttcacta gctggcttct
     3841 ttctgtactt gctgacttct gtcatatttc tttccagatg tgtttacagg tccctgtaag
     3901 cagtgttagg tccataggct tttatgactc cagtctgcaa gcagtgttag gttgacctca
     3961 taggctttta tgattccagt ctgctggtat gaagcagagc atcaaaaaaa attcgtgatt
     4021 ccttgagtgt ccacacgttt tgtctttggg ggttaagggt tgggattttg ggtttgttgt
     4081 taattttgtt gttttaaagg taaattgcac ttttaaaaat tggttgactt aatatatttg
     4141 ctcttttttt ttttttacct gcacttagag aggaaatttg aacaccagaa accacttttt
     4201 ttttctccct gtttatttgt ttggattctg agaaacttgc agctcttcac catttactcc
     4261 tgatgtttct tgtatggggc cgtggccctt ttggttgttt ttggtcattt tcttaaaaac
     4321 acaacacaac acaatacaac acaacagttt taaacctgaa gatttccgca gtccgtgtaa
     4381 gcatgtttac ccgttggctc gctttctgtg tctgttaaat gaatgtcata tgtaaatgct
     4441 aaactaagtc aacagtgtct cagaactgaa taactgcagt gacttgatgc tctaaatcat
     4501 tgtaggattt accgctagat ggttttgaac ccttgaacct gtgattgtga cccatgaggg
     4561 gggacctttc agtgctaaag ctgatcatgt gtgtagccag aaaggtactt tttttctttt
     4621 aatttttgtt ttattttttg taaccactgt cttaatggca aaataattat ggtaaaatac
     4681 aagtctcgtg tttattattc cttaagaagt ctgtgttata ttaccacgga acacccaata
     4741 aagcaaaatg tggttgtttc a
//
