LOCUS       NM_001164466            2110 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus dihydropyrimidinase (Dpys), transcript variant 2,
            mRNA.
ACCESSION   NM_001164466
VERSION     NM_001164466.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2110)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   2  (bases 1 to 2110)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   3  (bases 1 to 2110)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 2110)
  AUTHORS   Fukada,M., Watakabe,I., Yuasa-Kawada,J., Kawachi,H., Kuroiwa,A.,
            Matsuda,Y. and Noda,M.
  TITLE     Molecular characterization of CRMP5, a novel member of the
            collapsin response mediator protein family
  JOURNAL   J Biol Chem 275 (48), 37957-37965 (2000)
   PUBMED   10956643
REFERENCE   5  (bases 1 to 2110)
  AUTHORS   Tamaki,N., Fujimoto-Sakata,S., Kikugawa,M., Kaneko,M., Onosaka,S.
            and Takagi,T.
  TITLE     Analysis of cyclic feed intake in rats fed on a zinc-deficient diet
            and the level of dihydropyrimidinase (EC 3.5.2.2)
  JOURNAL   Br J Nutr 73 (5), 711-722 (1995)
   PUBMED   7626590
REFERENCE   6  (bases 1 to 2110)
  AUTHORS   Kikugawa,M., Kaneko,M., Fujimoto-Sakata,S., Maeda,M., Kawasaki,K.,
            Takagi,T. and Tamaki,N.
  TITLE     Purification, characterization and inhibition of
            dihydropyrimidinase from rat liver
  JOURNAL   Eur J Biochem 219 (1-2), 393-399 (1994)
   PUBMED   8307005
REFERENCE   7  (bases 1 to 2110)
  AUTHORS   Sanno,Y., Holzer,M. and Schimke,R.T.
  TITLE     Studies of a mutation affecting pyrimidine degradation in inbred
            mice
  JOURNAL   J Biol Chem 245 (21), 5668-5676 (1970)
   PUBMED   5472365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004822.1 and AC158776.5.
            
            Transcript Variant: This variant (2) differs in the 3' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004822.1, BC037086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2109              AK004822.1         1-2109
            2110-2110           AC158776.5         121540-121540       c
FEATURES             Location/Qualifiers
     source          1..2110
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 15.53 cM"
     gene            1..2110
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /note="dihydropyrimidinase"
                     /db_xref="GeneID:64705"
                     /db_xref="MGI:MGI:1928679"
     exon            1..372
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1668
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /EC_number="3.5.2.2"
                     /note="hydantoinase; dihydropyrimidine amidohydrolase"
                     /codon_start=1
                     /product="dihydropyrimidinase"
                     /protein_id="NP_001157938.1"
                     /db_xref="CCDS:CCDS27445.1"
                     /db_xref="GeneID:64705"
                     /db_xref="MGI:MGI:1928679"
                     /translation="MAPQGRLLIRGGRIVNDDFSQVADVLVEDGVVRALGRDLLPPED
                     ASRGLRILDAAGKLVLPGGIDTHTHMQFPFMGSQSVDDFYQGTKAALAGGTTMIIDFA
                     IPQKGSSLIEAFETWRNWADPKVCCDYSLHVAVTWWSDKVKEEMKTLARDKGVNSFKM
                     FMAYKGLYMVQDEQLYAAFSQCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHE
                     LCRPEAVEAEATLRAITIASAVNCPLYVVHVMSKSAAKVVADARRAGNVVYGEPIAAG
                     LGTDGRQYWSEEWSHAAHHVMGPPLRPDPLTPGFLMDLLANGDLTTTGSDNCTFNTCQ
                     KALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPKK
                     GRIAVGSDADIVIWDPEATRRISAKTHHQAVNFNIFEGMVCHGVPLVTISRGRVVYEA
                     GVFNVTAGHGKFIPRQPFAEYIYKRIKQRDQTCTPVPVKRAPYKGEVTTLKARETKED
                     DTAGTRMQGHS"
     exon            373..531
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /inference="alignment:Splign:2.1.0"
     exon            532..711
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /inference="alignment:Splign:2.1.0"
     exon            712..901
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1058
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1200
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1343
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1551
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1697
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..2110
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2084..2089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /note="hexamer: AATAAA"
     polyA_site      2110
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /note="major polyA site"
ORIGIN      
        1 accagagatc tgcccgcctt cagcccagcg ggagagggag ttctggcaca gttcgtggag
       61 agcttaaagg aaagccaact ttgttcgcag tccccagcgc cctggaccat ggcaccacag
      121 ggacgacttc tcatccgcgg gggtcgcatt gtcaatgacg acttctcaca ggtggccgat
      181 gtgctagtgg aggacggcgt ggtgcgggcg ctgggacggg acctgctgcc tcctgaggac
      241 gcatctcggg ggctgcgaat cctagatgca gcgggcaagc tcgtcctgcc cgggggcatc
      301 gacacgcaca cgcacatgca attcccgttc atgggctcgc agtcagtgga cgacttctac
      361 cagggcacca aggctgcttt ggcaggaggc accaccatga tcattgattt tgccattcct
      421 cagaaaggca gctccctcat cgaggccttt gagacttggc gcaactgggc agacccgaaa
      481 gtctgctgtg actatagcct gcatgtggca gtgacgtggt ggagcgacaa ggtaaaagaa
      541 gaaatgaaaa cccttgcccg agataaaggc gttaactctt tcaagatgtt tatggcctac
      601 aaaggtctgt acatggtgca agacgagcag ctgtatgcgg ccttctctca gtgcaaggag
      661 ataggagcga ttgctcaggt gcacgccgag aatggagatt tgattgcaga gggagcaaag
      721 aagatgctgg cactggggat aacaggccct gaggggcacg agctgtgccg tccagaagca
      781 gtggaggcag aggccaccct gagagccatc accatagcca gcgctgtgaa ctgcccttta
      841 tacgtcgtgc atgtgatgag caaatctgca gcgaaggtgg tagccgatgc gaggagagca
      901 ggaaatgtgg tctatggaga accaattgca gcgggtctcg gcactgatgg cagacagtac
      961 tggagtgaag aatggagcca tgcagcccac catgtcatgg gtcccccact gagacccgat
     1021 cctttaacac ctggctttct tatggatctg ttggctaatg gcgatttgac cacaacaggg
     1081 agtgacaact gcacttttaa cacctgccaa aaagctctag ggaaggatga cttcactaag
     1141 attcccaatg gggtgaatgg tgtcgaggac aggatgtcgg tgatatggga aaagggcgtg
     1201 cacagtggta aaatggatga aaacaggttt gtggcagtta ccagcacaaa cgcagccaaa
     1261 atctttaatc tttatccgaa aaaaggaaga atagctgtag gctcagatgc tgacattgtg
     1321 atctgggacc cagaagcaac aaggaggatc tcagccaaaa ctcatcatca ggccgttaac
     1381 ttcaacatct tcgagggcat ggtttgtcac ggggtgcccc tggtgactat ttcaagaggc
     1441 agagtggtgt atgaagcagg tgttttcaac gtcacagcag gacatgggaa gtttattccc
     1501 cgccaaccct ttgccgaata catttacaaa cgaatcaagc agcgagacca gacctgcaca
     1561 cctgtgcccg tgaagcgcgc cccctacaag ggagaagtca ccacactgaa agccagagag
     1621 acaaaagaag atgacactgc tggaaccagg atgcagggcc actcctgatc tggatgctgg
     1681 agttaagcaa gtgcaaggca aaggcagagc aaaggctctg aggcgcctct tcccgccatg
     1741 ccgccaaccc ctggagaaac acctgctatt tcaactcccc aagatccttt aggaaaaatc
     1801 attgctctag gcctctttga tttttctctc aaaagcaata gctgtctgcc tcactgtgcc
     1861 tttgttgctg tggaagactg aagatataaa tgagcattac tgggacggga cgtctgcgtg
     1921 aagactcact ggagattcct ttcaaatgcc atctttctgt acactagatt tctttctttg
     1981 gatccttaaa gatttctttc cagtgtaaag gttttatttg ttttgtttta atgtctatat
     2041 ttgtttgaaa aaaatcactg tgattttaca tttcaccaca attaataaac attgggagct
     2101 tcattctgta
//
