LOCUS       NP_001157938             519 aa            linear   ROD 03-JUN-2024
DEFINITION  dihydropyrimidinase [Mus musculus].
ACCESSION   NP_001157938
VERSION     NP_001157938.1
DBSOURCE    REFSEQ: accession NM_001164466.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 519)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   2  (residues 1 to 519)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   3  (residues 1 to 519)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (residues 1 to 519)
  AUTHORS   Fukada,M., Watakabe,I., Yuasa-Kawada,J., Kawachi,H., Kuroiwa,A.,
            Matsuda,Y. and Noda,M.
  TITLE     Molecular characterization of CRMP5, a novel member of the
            collapsin response mediator protein family
  JOURNAL   J Biol Chem 275 (48), 37957-37965 (2000)
   PUBMED   10956643
REFERENCE   5  (residues 1 to 519)
  AUTHORS   Tamaki,N., Fujimoto-Sakata,S., Kikugawa,M., Kaneko,M., Onosaka,S.
            and Takagi,T.
  TITLE     Analysis of cyclic feed intake in rats fed on a zinc-deficient diet
            and the level of dihydropyrimidinase (EC 3.5.2.2)
  JOURNAL   Br J Nutr 73 (5), 711-722 (1995)
   PUBMED   7626590
REFERENCE   6  (residues 1 to 519)
  AUTHORS   Kikugawa,M., Kaneko,M., Fujimoto-Sakata,S., Maeda,M., Kawasaki,K.,
            Takagi,T. and Tamaki,N.
  TITLE     Purification, characterization and inhibition of
            dihydropyrimidinase from rat liver
  JOURNAL   Eur J Biochem 219 (1-2), 393-399 (1994)
   PUBMED   8307005
REFERENCE   7  (residues 1 to 519)
  AUTHORS   Sanno,Y., Holzer,M. and Schimke,R.T.
  TITLE     Studies of a mutation affecting pyrimidine degradation in inbred
            mice
  JOURNAL   J Biol Chem 245 (21), 5668-5676 (1970)
   PUBMED   5472365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004822.1 and AC158776.5.
            
            Transcript Variant: This variant (2) differs in the 3' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004822.1, BC037086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 15.53 cM"
     Protein         1..519
                     /product="dihydropyrimidinase"
                     /EC_number="3.5.2.2"
                     /note="hydantoinase; dihydropyrimidine amidohydrolase"
                     /calculated_mol_wt=56594
     Region          7..460
                     /region_name="D-HYD"
                     /note="D-hydantoinases (D-HYD) also called
                     dihydropyrimidases (DHPase) and related proteins; DHPases
                     are a family of enzymes that catalyze the reversible
                     hydrolytic ring opening of the amide bond in five- or
                     six-membered cyclic diamides, like dihydropyrimidine...;
                     cd01314"
                     /db_xref="CDD:238639"
     Site            order(18..19,21,34..35,174,195,198,201,224,228,232,235,
                     262..263,265..266,384,389,394)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:238639"
     Site            order(67,69,159,192,248,326)
                     /site_type="active"
                     /db_xref="CDD:238639"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14117; propagated from
                     UniProtKB/Swiss-Prot (Q9EQF5.2)"
     Site            510
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9EQF6; propagated from
                     UniProtKB/Swiss-Prot (Q9EQF5.2)"
     CDS             1..519
                     /gene="Dpys"
                     /gene_synonym="1200017I10Rik; 1300004I01Rik; DHP; DHPase"
                     /coded_by="NM_001164466.1:109..1668"
                     /db_xref="CCDS:CCDS27445.1"
                     /db_xref="GeneID:64705"
                     /db_xref="MGI:MGI:1928679"
ORIGIN      
        1 mapqgrllir ggrivnddfs qvadvlvedg vvralgrdll ppedasrglr ildaagklvl
       61 pggidththm qfpfmgsqsv ddfyqgtkaa laggttmiid faipqkgssl ieafetwrnw
      121 adpkvccdys lhvavtwwsd kvkeemktla rdkgvnsfkm fmaykglymv qdeqlyaafs
      181 qckeigaiaq vhaengdlia egakkmlalg itgpeghelc rpeaveaeat lraitiasav
      241 ncplyvvhvm sksaakvvad arragnvvyg epiaaglgtd grqywseews haahhvmgpp
      301 lrpdpltpgf lmdllangdl tttgsdnctf ntcqkalgkd dftkipngvn gvedrmsviw
      361 ekgvhsgkmd enrfvavtst naakifnlyp kkgriavgsd adiviwdpea trrisakthh
      421 qavnfnifeg mvchgvplvt isrgrvvyea gvfnvtaghg kfiprqpfae yiykrikqrd
      481 qtctpvpvkr apykgevttl karetkeddt agtrmqghs
//
