LOCUS       NM_170778               4441 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dihydropyrimidine dehydrogenase (Dpyd), mRNA.
ACCESSION   NM_170778
VERSION     NM_170778.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4441)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4441)
  AUTHORS   Keenan,B.T., Galante,R.J., Lian,J., Zhang,L., Guo,X., Veatch,O.J.,
            Chesler,E.J., O'Brien,W.T., Svenson,K.L., Churchill,G.A. and
            Pack,A.I.
  TITLE     The dihydropyrimidine dehydrogenase gene contributes to heritable
            differences in sleep in mice
  JOURNAL   Curr Biol 31 (23), 5238-5248 (2021)
   PUBMED   34653361
  REMARK    GeneRIF: The dihydropyrimidine dehydrogenase gene contributes to
            heritable differences in sleep in mice.
REFERENCE   3  (bases 1 to 4441)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4441)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   5  (bases 1 to 4441)
  AUTHORS   Maddala,R., Nagendran,T., Lang,R.A., Morozov,A. and Rao,P.V.
  TITLE     Rap1 GTPase is required for mouse lens epithelial maintenance and
            morphogenesis
  JOURNAL   Dev Biol 406 (1), 74-91 (2015)
   PUBMED   26212757
REFERENCE   6  (bases 1 to 4441)
  AUTHORS   Porsin,B., Formento,J.L., Filipski,E., Etienne,M.C., Francoual,M.,
            Renee,N., Magne,N., Levi,F. and Milano,G.
  TITLE     Dihydropyrimidine dehydrogenase circadian rhythm in mouse liver:
            comparison between enzyme activity and gene expression
  JOURNAL   Eur J Cancer 39 (6), 822-828 (2003)
   PUBMED   12651209
REFERENCE   7  (bases 1 to 4441)
  AUTHORS   Yamada,H., Fukushima,M., Koizumi,K., Katakura,H., Nakanishi,H.,
            Teshima,S., Kamiyama,Y. and Ikenaka,K.
  TITLE     Regulation of dihydropyrimidine dehydrogenase gene expression in
            regenerating mouse liver
  JOURNAL   Int J Oncol 22 (2), 359-364 (2003)
   PUBMED   12527935
  REMARK    GeneRIF: DPD gene expression is regulated first at the mRNA level
            when the hepatocytes enter the cell cycle. There is little
            regulation at the translational level. Cell proliferation rate is
            influences the enzyme activity modification.
REFERENCE   8  (bases 1 to 4441)
  AUTHORS   Yokota,H., Fernandez-Salguero,P., Furuya,H., Lin,K., McBride,O.W.,
            Podschun,B., Schnackerz,K.D. and Gonzalez,F.J.
  TITLE     cDNA cloning and chromosome mapping of human dihydropyrimidine
            dehydrogenase, an enzyme associated with 5-fluorouracil toxicity
            and congenital thymine uraciluria
  JOURNAL   J Biol Chem 269 (37), 23192-23196 (1994)
   PUBMED   8083224
REFERENCE   9  (bases 1 to 4441)
  AUTHORS   Sanno,Y., Holzer,M. and Schimke,R.T.
  TITLE     Studies of a mutation affecting pyrimidine degradation in inbred
            mice
  JOURNAL   J Biol Chem 245 (21), 5668-5676 (1970)
   PUBMED   5472365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122183.4, AC152401.6, AC121544.9, AC161223.4, AC115935.9,
            AC116409.9, AC115017.11, AC115012.9 and AC110513.6.
            
            On Apr 12, 2018 this sequence version replaced NM_170778.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039699.1, SRR7345562.2051965.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC122183.4         10831-10965         c
            136-246             AC152401.6         130246-130356       c
            247-329             AC152401.6         66230-66312         c
            330-417             AC121544.9         27574-27661         c
            418-579             AC121544.9         5320-5481           c
            580-776             AC161223.4         55939-56135
            777-858             AC161223.4         62642-62723
            859-946             AC161223.4         69771-69858
            947-1054            AC161223.4         155685-155792
            1055-1224           AC115935.9         115128-115297       c
            1225-1435           AC115935.9         97181-97391         c
            1436-1620           AC115935.9         70129-70313         c
            1621-1836           AC115935.9         15079-15294         c
            1837-2001           AC116409.9         78112-78276         c
            2002-2070           AC116409.9         7365-7433           c
            2071-2154           AC116409.9         1170-1253           c
            2155-2275           AC115017.11        82636-82756         c
            2276-2395           AC115017.11        81810-81929         c
            2396-2538           AC115017.11        10901-11043         c
            2539-2718           AC115012.9         74692-74871
            2719-2862           AC110513.6         32277-32420
            2863-3003           AC110513.6         47291-47431
            3004-4441           AC110513.6         51630-53067
FEATURES             Location/Qualifiers
     source          1..4441
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 51.96 cM"
     gene            1..4441
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /note="dihydropyrimidine dehydrogenase"
                     /db_xref="GeneID:99586"
                     /db_xref="MGI:MGI:2139667"
     exon            1..135
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            136..246
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            247..329
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            330..417
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            418..579
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            580..776
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            777..858
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            859..946
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1054
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1224
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1435
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1620
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1836
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2001
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2070
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2154
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2275
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2395
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2538
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2718
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2862
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..3003
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..4441
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4417..4422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4435
                     /gene="Dpyd"
                     /gene_synonym="DHPDHase; DPD; E330028L06Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtgctgggg caagctgagg ctttggtgcg gggctggagg ctgctgcagc agagggaggg
       61 tctgtgtgcg ggagtctgag gccagaaagc gctgccatgg cgggtgtgct gagcagggac
      121 gcgccggaca tcgagagtat cctggcttta aaccctcgag tacaagctca tgcaactctg
      181 cgttccaccg cagccaagaa actagacaag aaacactgga aaaggaacac ggacaagaac
      241 tgctttacct gtgagaagct ggagagtaat tttgatgaca tcaagcacac gactcttggt
      301 gagcgaggag ctctccgaga agcagtgaga tgcctgaagt gcgcagatgc tccctgccag
      361 aagagctgtc ccacatctct tgacattaaa tcatttatca caagtatcgc caacaagaac
      421 tactatggtg cagctaagct gattttttct gataaccctc ttggtcttac ttgtggaatg
      481 gtttgtccaa catctgacct ctgtgttgga ggatgcaact tacatgctgc tgaagaggga
      541 ccaattaata ttggtgggct gcagcagttt gctactgagg tgttcaaagc aatgaacatc
      601 ccacagatca gaaacccatc gctgcctcct ccggaacata tgccggaagc ctactcagca
      661 aaaattgcac tttttggtgc agggcctgcg agtataagct gtgcctcctt tttggctcgg
      721 ttgggctatt ccaacattac tatattcgaa aaacaagaat atgttggtgg tttaagcact
      781 tctgaaatcc ctcagtttcg actcccatat gacgtcgtga attttgagat tgagctcatg
      841 aaggaccttg gtgtaaagat aatttgtggt aaaagccttt ccaccgatga aatgactctt
      901 agctctttga aagaaaatgg ctacagagct gcatttattg gaataggctt gccagaaccc
      961 aaaaaggacc atattttcca aggcttgaca caagtccagg gattttacac atctaaagac
     1021 tttctgccac ttgtcgccaa aagcagtaaa acaggaatgt gcgcctgtca ctctccattg
     1081 ccatccataa ggggagccgt gattgtactc ggagctggag atactgcgtt tgactgtgca
     1141 acatccgctc tgcgctgtgg agcccttcgc gtgttcatcg tcttcagaaa gggctttgtt
     1201 aatattcgag ctgttccaga ggagatggag ctcgctaagg aagagaaatg tgaatttttg
     1261 cctttcctct cgccacggaa ggttatagtc aaagatggaa agattgtggc aatgcaattt
     1321 gttcgaactg agcaagatga aaccggaaac tgggtggaag atgaagagca gacggtgcgg
     1381 ctaaaggctg atgtggttat tagtgccttt ggatctgtcc tggaggatcc caaagtgaaa
     1441 gaagcattga gtcccatcaa gtttaacaga tggggtctcc cagaagtaaa tccagaaacc
     1501 atgcaaacca gtgaaccatg ggtgtttgca ggtggtgatg ttgtgggtat ggctaacacc
     1561 acagtggaat ctgtcaacga tggaaagcaa gcttcatggt acattcacaa gcacatacag
     1621 gcacaatatg gaacctcagt gccttctcag cctacaatgc ccctatttta cactccggtt
     1681 gacttagtgg acatcagcgt ggaaatggca gggttgaggt ttcccaatcc ctttggcctt
     1741 gccagtgcga caccagccac tagcacacca atgattcgaa gggcctttga agctggctgg
     1801 ggttttgctc tgaccaaaac tttctctctt gataaggaca tcgtgacaaa cgtctcacca
     1861 agaatcatcc gggggacaac ttctggcccc ttgtatggcc ctggacaaag ctcctttctt
     1921 aacattgagc tcatcagtga gaaaacagct gcatattggt gtcacagtgt caccgaacta
     1981 aaggctgact tcccggacaa tatcctgatc gccagcatca tgtgcagtta caacaagagt
     2041 gactggatgg aactctccaa aatggctgag gcttctggag cagatgccct ggagttaaat
     2101 ttatcgtgtc cacatggcat gggggagaga ggaatgggcc tggcttgtgg gcaggatcca
     2161 gagctggtga ggaacatctg tcgctgggtt aggcaagctg ttcgggttcc attttttgcc
     2221 aagttgaccc caaatgtcac tgatattgta agcatcgcaa gagcagcaaa ggaaggtgga
     2281 gcagatggtg taacagccac caacaccgtc tcgggtctga tgggactgaa agctgatggc
     2341 acaccctggc ctgctgtggg cattggaagg aggactacat atggaggagt gtcaggaact
     2401 gctatcaggc ccattgcttt gagagctgtg accgccattg cccgtgcttt gcctgggttt
     2461 cctattttgg ccacaggtgg aattgactca gctgaaagtg gacttcagtt tcttcatagt
     2521 ggtgcttcag ttcttcaggt atgcagcgct attcagaatc aggacttcac tgtgattgaa
     2581 gattactgca ctggactcaa agccctgctt tatctgaaga gcattgaaga gttagcagac
     2641 tgggatggtc agagtccacc cattataagt catcagaaag ggaaaccagt tccacgcgtt
     2701 gctgagctca tgggacagaa actgcccagc tttggacctt accttgaaca gcgcaagaaa
     2761 atcatagcag caagcaaaat cagacagaaa gatcaaaaca cagcttgctc acctctccag
     2821 agaaagcact ttaactcgca aaagcctatt cctgccatca aggatgtaat tggaaaatca
     2881 ctgcaatacc tgggaacatt tggtgagatg agcatcatgg aacaagttgt ggccctgatc
     2941 gatgaggaaa tgtgcatcaa ttgcggcaaa tgttacatga cctgtaatga ctctggctac
     3001 caggctatcc agttcgatcc agaaactcac ctgcctaccg ttagcgacac atgtacaggc
     3061 tgtactctct gcctcagcgt ctgccctatt atggactgta tcaggatggt ttccagggca
     3121 acaccttatc aaccaaagag aggcctacca ttagccgtga agccggtgtg ttaaggtgat
     3181 ttgtaagaca gctgctgtga actttgatat tacccatgta ggctgatctt taagaacaat
     3241 aacaattgta atcattatga tcagttcttt ccaaatttta tagctgaaca ataacaattg
     3301 taatcattat gatcagttct ttccaaattt tatagctatg catatataat ttctaaataa
     3361 gtgtctaaat tggaaaacaa tgtctaatgc cagtgacaaa ttaatggtca taaaatggaa
     3421 taactcttct ctgaggtagc tggtgagtaa ctgcagacca gttaattgga tgtgctctgt
     3481 ccgttgtgtg ctgtgaaaaa ttaacttttt catggcaatt agcgtgacaa tttctaaatt
     3541 gccctatgcc gtactcactc tttgatttct aattgtaaac gaaatgaact attttggaac
     3601 ggagtgcact ttcatataca ggaaaccgtt tccaaggaaa cgctttgtaa ttaaaaatta
     3661 cctgtaattt taacactgtt tctaaggaca tgtaattagt tccattaaga acaattgaag
     3721 aaagtcaagg cattatttac tatgacaagg gggaagaaaa cctggaagag ggtttctaga
     3781 gttttctaaa gtcccccttt gctgaagtaa ctcactcttc ggtgctggac acggaaaggg
     3841 agattatttc ctgactaaaa tgctgttgac cacctgaaac aggtgtcaga ctgaccaggg
     3901 atggagtcct ggccattttt atttgaatac caaagcggtg ttcctaatga aataagatat
     3961 cgaggtgaat gtctggtgaa tggcccactt tcactgagca cagacagcta gatctgcttc
     4021 ttttagtcac cttcattatg agagcaatta atgttcaaac aagggctaga ttacacagcg
     4081 ctgagccata ggcttcaaga ttcaacaaca aagtgtgtca tatctgaacc tgctacataa
     4141 taaacctaac taactttact ttgatactca tgtgaattca aaattaatga aagagaaatg
     4201 tgtatctttg gatattgatc agtgtttttc cccatatctt tatttttata atcagtaaat
     4261 agcatcacat aaattcattt attccttctt tatggcacat tttaaaatga atctatagaa
     4321 agtaagtgag aaatgacaac ctgtggaata tttctatgat aaatgcaaga tatctacaag
     4381 tgcattttaa aaaatgtgta tgatttaaaa atcacaaata aaattttatg atctattttc
     4441 a
//
