LOCUS       NM_001146223             704 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dpy-30, histone methyltransferase complex regulatory
            subunit (Dpy30), transcript variant 3, mRNA.
ACCESSION   NM_001146223
VERSION     NM_001146223.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 704)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 704)
  AUTHORS   Zhao,Y., Hao,X., Li,Z., Feng,X., Katz,J., Michalek,S.M., Jiang,H.
            and Zhang,P.
  TITLE     Role of chromatin modulator Dpy30 in osteoclast differentiation and
            function
  JOURNAL   Bone 159, 116379 (2022)
   PUBMED   35307321
  REMARK    GeneRIF: Role of chromatin modulator Dpy30 in osteoclast
            differentiation and function.
REFERENCE   3  (bases 1 to 704)
  AUTHORS   Ma,M., Zhou,J., Ma,Z., Chen,H., Li,L., Hou,L., Yin,B., Qiang,B.,
            Shu,P. and Peng,X.
  TITLE     The Ash2l SDI Domain Is Required to Maintain the Stability and
            Binding of DPY30
  JOURNAL   Cells 11 (9), 1450 (2022)
   PUBMED   35563756
  REMARK    GeneRIF: The Ash2l SDI Domain Is Required to Maintain the Stability
            and Binding of DPY30.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 704)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 704)
  AUTHORS   Zhao,Z.H., Ma,J.Y., Meng,T.G., Wang,Z.B., Yue,W., Zhou,Q., Li,S.,
            Feng,X., Hou,Y., Schatten,H., Ou,X.H. and Sun,Q.Y.
  TITLE     Single-cell RNA sequencing reveals the landscape of early female
            germ cell development
  JOURNAL   FASEB J 34 (9), 12634-12645 (2020)
   PUBMED   32716582
REFERENCE   6  (bases 1 to 704)
  AUTHORS   Bertero,A., Madrigal,P., Galli,A., Hubner,N.C., Moreno,I.,
            Burks,D., Brown,S., Pedersen,R.A., Gaffney,D., Mendjan,S.,
            Pauklin,S. and Vallier,L.
  TITLE     Activin/nodal signaling and NANOG orchestrate human embryonic stem
            cell fate decisions by controlling the H3K4me3 chromatin mark
  JOURNAL   Genes Dev 29 (7), 702-717 (2015)
   PUBMED   25805847
REFERENCE   7  (bases 1 to 704)
  AUTHORS   Jiang,H., Shukla,A., Wang,X., Chen,W.Y., Bernstein,B.E. and
            Roeder,R.G.
  TITLE     Role for Dpy-30 in ES cell-fate specification by regulation of H3K4
            methylation within bivalent domains
  JOURNAL   Cell 144 (4), 513-525 (2011)
   PUBMED   21335234
  REMARK    GeneRIF: Results indicate an essential functional role for Dpy-30
            and SET1/MLL complex-mediated H3K4 methylation, as a component of
            the bivalent mark, at developmental genes during the embryonic stem
            cells fate transitions.
            Erratum:[Cell. 2011 Mar 4;144(5):825]
REFERENCE   8  (bases 1 to 704)
  AUTHORS   Cho,Y.W., Hong,T., Hong,S., Guo,H., Yu,H., Kim,D., Guszczynski,T.,
            Dressler,G.R., Copeland,T.D., Kalkum,M. and Ge,K.
  TITLE     PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4
            methyltransferase complex
  JOURNAL   J Biol Chem 282 (28), 20395-20406 (2007)
   PUBMED   17500065
REFERENCE   9  (bases 1 to 704)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   10 (bases 1 to 704)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV460563.1, AK077902.1 and AK013073.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013073.1, AK077902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AV460563.1         1-12
            13-697              AK077902.1         1-685
            698-704             AK013073.1         687-693
FEATURES             Location/Qualifiers
     source          1..704
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 45.64 cM"
     gene            1..704
                     /gene="Dpy30"
                     /gene_synonym="2810410M20Rik"
                     /note="dpy-30, histone methyltransferase complex
                     regulatory subunit"
                     /db_xref="GeneID:66310"
                     /db_xref="MGI:MGI:1913560"
     exon            1..89
                     /gene="Dpy30"
                     /gene_synonym="2810410M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            90..162
                     /gene="Dpy30"
                     /gene_synonym="2810410M20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..426
                     /gene="Dpy30"
                     /gene_synonym="2810410M20Rik"
                     /note="dosage compensation-related protein DPY30; dpy-30L;
                     dpy-30-like protein; dpy-30 homolog"
                     /codon_start=1
                     /product="protein dpy-30 homolog"
                     /protein_id="NP_001139695.1"
                     /db_xref="CCDS:CCDS28970.1"
                     /db_xref="GeneID:66310"
                     /db_xref="MGI:MGI:1913560"
                     /translation="MESEQMLEGQTQVAENPHSEYGLTDSVERIVENEKINAEKSSKQ
                     KVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN"
     exon            163..210
                     /gene="Dpy30"
                     /gene_synonym="2810410M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            211..353
                     /gene="Dpy30"
                     /gene_synonym="2810410M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            354..704
                     /gene="Dpy30"
                     /gene_synonym="2810410M20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      676..681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpy30"
                     /gene_synonym="2810410M20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      698
                     /gene="Dpy30"
                     /gene_synonym="2810410M20Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgacgtccc tcacttacgg ccgaagcggt tcgcgctgtg agtcggtggc gccgtgcagg
       61 gcacttagga accgacagcc ttggcgcgga ctggtatccg gttgattgcg gtttgcaggg
      121 tccgccatgg agtcggagca gatgctggag ggacagacac aggttgcaga aaaccctcac
      181 tctgagtacg ggctcacaga cagcgttgag agaatagtcg aaaatgagaa gattaatgca
      241 gaaaagtcat cgaaacagaa ggtggatcta cagtccttgc ccacccgtgc ctacctggac
      301 cagacagttg tgcctatctt attacaggga cttgctgtgc ttgccaagga aagaccacca
      361 aatcccatcg agttcctagc atcttatctt ttaaaaaaca aggcgcagtt tgaagatcga
      421 aattgatttc ttgggaagag aagaaacatt tggttgctac tgtagattta catgattacg
      481 aggcagcttt aattgccatg attcccctcc ccactctgga cggctaagaa ccttcaggac
      541 cacagacctc acttctggag ttgcagaaga gagcatatcc ctgtctgatt taatcaccat
      601 acttatttaa tgagtatcat ctgtgcaatt tttttctcag attgtctttt actttgtttt
      661 taaaaagacc ttcaaaataa actgttaaaa cacctttatt ttat
//
