LOCUS       NM_001166207            3441 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus dpy-19 like 2 (Dpy19l2), mRNA.
ACCESSION   NM_001166207
VERSION     NM_001166207.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3441)
  AUTHORS   Castaneda,J.M., Shimada,K., Satouh,Y., Yu,Z., Devlin,D.J., Ikawa,M.
            and Matzuk,M.M.
  TITLE     FAM209 associates with DPY19L2, and is required for sperm acrosome
            biogenesis and fertility in mice
  JOURNAL   J Cell Sci 134 (21) (2021)
   PUBMED   34471926
REFERENCE   2  (bases 1 to 3441)
  AUTHORS   Yassine,S., Escoffier,J., Abi Nahed,R., Pierre,V., Karaouzene,T.,
            Ray,P.F. and Arnoult,C.
  TITLE     Dynamics of Sun5 localization during spermatogenesis in wild type
            and Dpy19l2 knock-out mice indicates that Sun5 is not involved in
            acrosome attachment to the nuclear envelope
  JOURNAL   PLoS One 10 (3), e0118698 (2015)
   PUBMED   25775128
  REMARK    GeneRIF: In Dpy19l2 knock-out round spermatids, the detachment of
            the acrosome leads to Sun5 and lamin B1 relocalization, confirming
            that Sun5 protein is excluded from the nuclear envelope facing the
            acrosome.
            Erratum:[PLoS One. 2015 Apr 10;10(4):e0125452. doi:
            10.1371/journal.pone.0125452.. Nahed, Roland Abi [corrected to Abi
            Nahed, Roland]. PMID: 25860994]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3441)
  AUTHORS   Escoffier,J., Yassine,S., Lee,H.C., Martinez,G., Delaroche,J.,
            Coutton,C., Karaouzene,T., Zouari,R., Metzler-Guillemain,C.,
            Pernet-Gallay,K., Hennebicq,S., Ray,P.F., Fissore,R. and Arnoult,C.
  TITLE     Subcellular localization of phospholipase Czeta in human sperm and
            its absence in DPY19L2-deficient sperm are consistent with its role
            in oocyte activation
  JOURNAL   Mol Hum Reprod 21 (2), 157-168 (2015)
   PUBMED   25354701
REFERENCE   4  (bases 1 to 3441)
  AUTHORS   Yassine,S., Escoffier,J., Martinez,G., Coutton,C., Karaouzene,T.,
            Zouari,R., Ravanat,J.L., Metzler-Guillemain,C., Lee,H.C.,
            Fissore,R., Hennebicq,S., Ray,P.F. and Arnoult,C.
  TITLE     Dpy19l2-deficient globozoospermic sperm display altered genome
            packaging and DNA damage that compromises the initiation of embryo
            development
  JOURNAL   Mol Hum Reprod 21 (2), 169-185 (2015)
   PUBMED   25354700
REFERENCE   5  (bases 1 to 3441)
  AUTHORS   Pierre,V., Martinez,G., Coutton,C., Delaroche,J., Yassine,S.,
            Novella,C., Pernet-Gallay,K., Hennebicq,S., Ray,P.F. and Arnoult,C.
  TITLE     Absence of Dpy19l2, a new inner nuclear membrane protein, causes
            globozoospermia in mice by preventing the anchoring of the acrosome
            to the nucleus
  JOURNAL   Development 139 (16), 2955-2965 (2012)
   PUBMED   22764053
  REMARK    GeneRIF: Absence of Dpy19l2 leads to the destabilization of both
            the nuclear dense lamina and the junction between the acroplaxome
            and the nuclear envelope in spermatids. Consequently, the acrosome
            and the manchette fail to be linked to the nucleus.
REFERENCE   6  (bases 1 to 3441)
  AUTHORS   Watanabe,K., Takebayashi,H., Bepari,A.K., Esumi,S., Yanagawa,Y. and
            Tamamaki,N.
  TITLE     Dpy19l1, a multi-transmembrane protein, regulates the radial
            migration of glutamatergic neurons in the developing cerebral
            cortex
  JOURNAL   Development 138 (22), 4979-4990 (2011)
   PUBMED   22028030
  REMARK    Erratum:[Development. 2012 Mar;139(6):1225]
REFERENCE   7  (bases 1 to 3441)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029497.1, AK030128.1 and AV254516.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029497.1, AK030128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AK029497.1         2-23
            23-312              AK030128.1         13-302
            313-313             AK029497.1         315-315
            314-597             AK030128.1         304-587
            598-894             AK029497.1         600-896
            895-1800            AK029497.1         898-1803
            1801-3436           AK029497.1         1805-3440
            3437-3441           AV254516.1         223-227
FEATURES             Location/Qualifiers
     source          1..3441
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 10.22 cM"
     gene            1..3441
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /note="dpy-19 like 2"
                     /db_xref="GeneID:320752"
                     /db_xref="MGI:MGI:2444662"
     exon            1..512
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2452
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /note="protein dpy-19 homolog 2; dpy-19-like protein 2"
                     /codon_start=1
                     /product="probable C-mannosyltransferase DPY19L2"
                     /protein_id="NP_001159679.1"
                     /db_xref="CCDS:CCDS52743.1"
                     /db_xref="GeneID:320752"
                     /db_xref="MGI:MGI:2444662"
                     /translation="MVGPTRSKLREGSSDRPQSSCTGQARRRWSAATMEPQQERSAPQ
                     ERTKWSLLQHFLLGGRKLPSGARNYAARRIQSLNAQNYFQLEEVAKLLLLNRFQFLFT
                     LLDHFREKVQALQMHRFSHRTLFGLAIFVGILHWLHLITLFENDHHFSHLSSLEREMT
                     FRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLVINTVKRFHLYPEVVIAYWY
                     RTIIGIMNLFGIETKTCWNVTRMEPLNEVQSCEGLGDPACFYIGVIFILNGLMMGLFF
                     IYSTYLSGSQLGGLITVACYFFNHGEATRVMWTPPLRESFSYPFLVLQMYILTIILRT
                     STVHKKHYMALCFSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPSKFQKIIYVNM
                     SSVALCFILMFGNSMYLSSYYSSCLLVTWAIMQKKSKIQKLGGTELQFWLIQGCFWWC
                     GTIILKFLTSKICGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDFMEQATPLRYI
                     KTLLLPLILVITYLIFKKIVRDIMCVLYTNTYVRKQLLDNAELIFHTLQLLAFTGLAI
                     LIMRLKLFLTPHMCIMASLICSQRLFGWLFCRIHFENVVFGILTMMSIQGCANLHNQW
                     SIMGEFTNLPQEELIHWIKHSTRPDAVFAGAMPTMASIKLSTLRPIVNHPHYEDADLR
                     ARTKIVYSVYSRKSAVEVRNNLLKLHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSN
                     AANPPLCSILLKDSRPYFTTVFQNSMYRVLKIN"
     exon            513..537
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            538..625
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            626..763
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            764..884
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            885..978
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1036
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1128
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1228
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1306
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1393
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1453
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1534
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1636
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1708
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1755
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1780
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1900
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2075
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2175
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2301
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..3441
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2526..2531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
                     /note="hexamer: AATAAA"
     polyA_site      2552
                     /gene="Dpy19l2"
                     /gene_synonym="4932443J21Rik; Gm18376"
ORIGIN      
        1 acggtcgcca tgacgacgag gctgcccgca acggtggctg gtcgttgagg ctgcctggtg
       61 gtgtgtccgc cccccggaca ttgcccagcg gtgatccagc tccatccacc tgatcacggg
      121 ctatgagaag atggtggggc cgacaaggag taagctcagg gaagggagct ccgacaggcc
      181 acaatcctcc tgcacggggc aggcgaggag gaggtggagc gcagcgacca tggagcccca
      241 gcaggagcga agcgcgcccc aggagagaac gaagtggtcg ttgctgcagc atttcctcct
      301 aggcggcagg aaactgccct cgggtgctcg caactacgcg gcgcggagga tccaaagtct
      361 gaacgcacaa aattactttc agctggaaga ggtcgccaag ctccttcttc ttaaccgctt
      421 ccaattcctc ttcactctcc tggaccactt tcgcgaaaag gtgcaggcac tgcagatgca
      481 tcggttctcc cacaggaccc tctttggcct agctatcttt gtggggattt tgcactggtt
      541 acacttaata acactttttg aaaatgatca tcatttttct cacctttcat ctttggaacg
      601 ggagatgact tttcgcacag aaatgggact ttattattcc tacttcaaga ccattatcga
      661 agcaccttcg tttctggaag gactgtggat gatcatgaat gacaggctca ctgagtatcc
      721 cctggtaatc aacacagtga aacgcttcca tctttaccca gaggtagtca tagcctactg
      781 gtatcgcaca atcataggaa taatgaattt atttgggata gaaactaaga catgttggaa
      841 cgtcaccaga atggagcctc ttaatgaagt tcagagctgt gaaggattgg gagacccagc
      901 ttgcttttac atcggagtaa tttttatttt aaatggacta atgatgggct tgttcttcat
      961 atacagtaca tacctgagtg ggagtcagtt aggaggtctg attacagtag cctgctactt
     1021 tttcaatcat ggagaggcca cccgtgtgat gtggacaccg cctctccggg aaagtttctc
     1081 ctacccattc cttgtacttc agatgtacat cttaactata atcctcagga cctccaccgt
     1141 tcacaaaaaa cactacatgg ctctctgctt ctccaacgtc gcttttatgc ttccgtggca
     1201 gtttgctcag tttatacttt ttacacagat agcctcatta tttcccatgt atgttgtggg
     1261 atacattgag ccaagcaaat ttcagaagat catttatgtc aatatgagtt cggttgccct
     1321 atgcttcatt ttgatgtttg ggaattcaat gtacttaagt tcatattatt cctcatgttt
     1381 gttagtgaca tgggcaataa tgcaaaagaa aagcaaaatc caaaaattgg gaggcactga
     1441 acttcagttt tggctaatcc aaggctgttt ttggtggtgt ggaacaatta ttttgaaatt
     1501 tctgacatct aaaatctgtg gtgtttcaga ccatattcgc ctgagtgacc ttatagcagc
     1561 cagaatacta aggtatacag attttgatac cttaatatac acctgtgctc ccgaatttga
     1621 cttcatggaa caagcgactc cgctgagata tataaaaaca ttattgcttc cacttatcct
     1681 agtgattact tatcttatct ttaaaaagat tgttcgtgat atcatgtgtg tcttatatac
     1741 aaacacttat gtaagaaaac agcttcttga caacgctgag ttgattttcc acaccttgca
     1801 gttgctggca ttcacaggtc ttgccatctt aatcatgcgg ttgaagctgt ttctgacccc
     1861 ccacatgtgc attatggctt ccttgatctg ctcacaacgg ctctttggct ggcttttttg
     1921 cagaattcat tttgagaatg ttgtcttcgg cattctgaca atgatgtcaa tacaaggttg
     1981 tgcaaatctc cataaccaat ggagcataat gggagaattt actaacttgc ctcaggaaga
     2041 gctcatacat tggatcaaac acagcaccag gccagatgcc gtctttgcag gtgccatgcc
     2101 tacaatggca agcatcaagc tgtctacact gcgtccaatt gtgaaccacc cacactatga
     2161 ggacgcagac ttgagggctc ggacaaaaat agtttattct gtgtatagtc gaaaatctgc
     2221 agtagaagtg agaaataatc tgttgaaatt acatgtgaat tattatgttc tagaagaggc
     2281 atggtgtgtc gtgagaacaa aacctggttg cagcatgctt gaaatatggg atgtggaaga
     2341 cccgtccaac gcagctaacc ctcccctctg cagtatcctg ctcaaggatt ctcggccgta
     2401 ctttaccaca gtgtttcaga atagtatgta cagagtactg aagattaact gagatcaagg
     2461 tgtcccaacc tgctgtagtg gaaagatgtg tatcaaaaat gaacacttcc agccttattt
     2521 acagcaataa aattcacaag ctttactaag aagacacttt taaagcaaga taaaaactat
     2581 ttaaattttt ctggttacta ctaatgataa attacttcat tatttgcatt gaatgtcagt
     2641 ctgtcaagct tacctcataa atgattaagt caccaacaga tgttcatttt agagttccaa
     2701 gggaacgtgt atggaaaata tcaatataat tttagaaacc aaagcgaagt aattcctttt
     2761 cagtccagct aggtgagttg tttcaggttt ccctagtacc catggatcag cccagacctt
     2821 ctcagccatg gaaacgagca caggctctga gaaatccgat gatggtggta gcctcattca
     2881 gttttagttt atgatgaaga cggtattgct ttataaattt tatctcccaa taaaagctat
     2941 ctatcaaaaa cgctttgaaa attggtaatt accttgaaga tagagtatgt ccatcaaaga
     3001 gtaaaattgt ctctttcttt tcatgataaa ctttaaacat gctagatgtt tgatatgcat
     3061 ctgctccaag ttaagcatct tggatttttt atacttgtat tttccttatg tttttggtca
     3121 accataaaag atgattcaat ttcatagatt agttacatat aattacttgc aataggtatg
     3181 caattacatc ccaactttta tagttggaaa acattttgat gctgaacaca aaatagctaa
     3241 gaaagaatgc tgaattgtgt tgattttaac attttcaagt agtttctttt ctgtgtggag
     3301 caaagagggg aacagatata acactcattt aaaagtaaca tgttttggac aatgtcacta
     3361 gagggatatt ttaaagtaat tattagaatt caacaaaaat ggtacgagct atgttaacca
     3421 ataaagtgtt ccttgtacat a
//
