LOCUS       NM_001359948            3502 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dpy-19 like C-mannosyltransferase 1 (Dpy19l1),
            transcript variant 2, mRNA.
ACCESSION   NM_001359948 XM_006510296
VERSION     NM_001359948.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3502)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3502)
  AUTHORS   Shcherbakova,A., Tiemann,B., Buettner,F.F. and Bakker,H.
  TITLE     Distinct C-mannosylation of netrin receptor thrombospondin type 1
            repeats by mammalian DPY19L1 and DPY19L3
  JOURNAL   Proc Natl Acad Sci U S A 114 (10), 2574-2579 (2017)
   PUBMED   28202721
  REMARK    GeneRIF: Mannosylation by DPY19L1 but not DPY19L3 is required for
            transport of UNC5A from the endoplasmic reticulum to the cell
            surface. In vertebrates, a new C-mannosyltransferase has apparently
            evolved to increase glycosylation of TSRs, potentially to increase
            the stability of the structurally essential tryptophan ladder or to
            provide additional adhesion functions.
REFERENCE   3  (bases 1 to 3502)
  AUTHORS   Watanabe,K., Bizen,N., Sato,N. and Takebayashi,H.
  TITLE     Endoplasmic Reticulum-Localized Transmembrane Protein Dpy19L1 Is
            Required for Neurite Outgrowth
  JOURNAL   PLoS One 11 (12), e0167985 (2016)
   PUBMED   27959946
  REMARK    GeneRIF: Dpy19L1 is localized to the ER membrane and regulates
            neurite extension during development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3502)
  AUTHORS   Watanabe,K., Takebayashi,H., Bepari,A.K., Esumi,S., Yanagawa,Y. and
            Tamamaki,N.
  TITLE     Dpy19l1, a multi-transmembrane protein, regulates the radial
            migration of glutamatergic neurons in the developing cerebral
            cortex
  JOURNAL   Development 138 (22), 4979-4990 (2011)
   PUBMED   22028030
  REMARK    GeneRIF: Dpy19l1 is required for the proper radial migration of
            glutamatergic neurons, an evolutionarily conserved role for the
            Dpy19 family in neuronal migration.
            Erratum:[Development. 2012 Mar;139(6):1225]
REFERENCE   5  (bases 1 to 3502)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102554.7, CT010514.9 and BU757480.1.
            
            On Jan 20, 2018 this sequence version replaced XM_006510296.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.19401.1,
                                           SRR1660813.215489.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AC102554.7         43705-44006
            303-327             AC102554.7         61116-61140
            328-415             AC102554.7         61744-61831
            416-553             AC102554.7         64779-64916
            554-674             CT010514.9         126-246
            675-768             CT010514.9         1712-1805
            769-826             CT010514.9         12945-13002
            827-918             CT010514.9         21682-21773
            919-1018            CT010514.9         24824-24923
            1019-1096           CT010514.9         27715-27792
            1097-1183           CT010514.9         34738-34824
            1184-1243           CT010514.9         36391-36450
            1244-1324           CT010514.9         36870-36950
            1325-1426           CT010514.9         41139-41240
            1427-1498           CT010514.9         43148-43219
            1499-1548           CT010514.9         45099-45148
            1549-1573           CT010514.9         49421-49445
            1574-1693           CT010514.9         50734-50853
            1694-1868           CT010514.9         52392-52566
            1869-1968           CT010514.9         53220-53319
            1969-2094           CT010514.9         54373-54498
            2095-2280           CT010514.9         61156-61341
            2281-3189           CT010514.9         62593-63501
            3190-3502           BU757480.1         1-313               c
FEATURES             Location/Qualifiers
     source          1..3502
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 10.15 cM"
     gene            1..3502
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /note="dpy-19 like C-mannosyltransferase 1"
                     /db_xref="GeneID:244745"
                     /db_xref="MGI:MGI:1915685"
     exon            1..302
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2251
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /note="protein dpy-19 homolog 1; dpy-19-like protein 1;
                     dpy-19-like 1; probable C-mannosyltransferase DPY19L1"
                     /codon_start=1
                     /product="protein C-mannosyl-transferase DPY19L1"
                     /protein_id="NP_001346877.1"
                     /db_xref="CCDS:CCDS22931.2"
                     /db_xref="GeneID:244745"
                     /db_xref="MGI:MGI:1915685"
                     /translation="MVLQARSKHRDAAPRPPRSARSSPPPLSGASEVDAGELGSERTP
                     PSPGRRGAAGRKGPRAGTAAPAPDGLAGRLAAGLHWALGLRRGRGRTWSTLLLASFAA
                     LLHWSHITHLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTIVEAPSFLNGVWMIMN
                     DKLTEYPLVINTLKRFNLYPEVILASWYRIYTKIMDLIGIQTKICWTVTRGEGLSPIE
                     SCEGLGDPACFYVAVIFMLNGLMMALFFIYGTYLSGSRLGGVVTVLCFFFNHGECTRV
                     MWTPPLRESFSYPFLVLQMLLVTHILRAPELCRGSLIALCISNVLFMLPWQFAQFVLL
                     TQIASLFAVYVVGYIDTHKLQKIIYMHMISLVLCFVLMFGNSMLLTSYYASSLVIIWG
                     MLAMKPQFLRMNVSELSLWVIQGCGWLFGTVILKSVTSRIFGIADDAHIGNLLTSKFF
                     SYKDFDTLLYTCAAEFDFMEKETPLRYTKTLLLPVVLVTVAAIVRKIFNDMRGVVAKQ
                     RTHTRKQQFEHGELVYHALQLLAYTALGVLIMRLKLFLTPHMCVMASLICSRQLFGWL
                     FGKVHPGAVVFAILAAMSIQGSANLQTQWNIVGEFSNLPQEELIEWIRYSTKPDAVFA
                     GAMPTMASVKLSALRPVVNHPHYEDAGLRARTKIVYSMYSRKAPEDVKKELMKLKVNY
                     YILEESWCIRRSKPGCSMPEIWDVEDPDNAGKTPLCNILVKDSKPHFTTVFQNSVYKV
                     LEVLRQ"
     exon            303..327
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            328..415
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            416..553
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            554..674
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            675..768
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            769..826
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            827..918
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1018
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1096
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1183
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1243
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1324
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1426
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1498
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1548
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1573
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1693
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1868
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1968
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2094
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2280
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..3489
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3466..3471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /note="hexamer: AATAAA"
     polyA_site      3489
                     /gene="Dpy19l1"
                     /gene_synonym="1100001I19Rik; 6030402K12"
                     /note="major polyA site"
ORIGIN      
        1 ctatgccaag atggtcctgc aggcgcggag caagcaccgg gacgcggctc ccaggccgcc
       61 ccggtcggcc cgctcgtcgc cgccgccact gagcggggca tccgaggtgg acgccgggga
      121 gctggggtcg gagcgcacgc cgccgtcgcc ggggcgcagg ggcgcggcgg gcaggaaggg
      181 accccgcgca gggaccgccg cgcccgcccc ggacggcctc gcgggccgcc tggcggccgg
      241 gctgcactgg gcgctgggcc tgcggcgcgg gcgcggccgg acctggagca cgctgctgct
      301 agcttccttt gcagctctat tgcactggag ccacataacg cacctctttg aaaacgatcg
      361 gcatttctct cacctctcaa cgctggaaag ggagatggct ttccgcactg aaatggggct
      421 gtattactct tacttcaaga ctattgtgga agcaccctca tttttgaatg gagtatggat
      481 gataatgaat gacaagctga ctgaataccc ccttgttatt aacacattaa aaaggttcaa
      541 tctttaccct gaggtgatct tagccagctg gtaccggatt tataccaaaa taatggattt
      601 gattggtatt caaaccaaga tctgctggac agttacccga ggagaaggac tcagtccgat
      661 tgagagctgt gagggattgg gcgatcctgc ttgcttttat gttgctgtaa tttttatgtt
      721 aaatggacta atgatggcat tattcttcat atatggcaca tatttaagtg gcagccgatt
      781 gggaggcgtg gtcacagtgc tgtgcttctt tttcaatcat ggagagtgta cgcgcgtaat
      841 gtggacgcca cctctccgag aaagcttctc atacccattc cttgtgctgc agatgttgct
      901 tgtgacccat attctcaggg ctccagagct ttgcagaggg agtctgattg cactctgcat
      961 ctccaacgtg ctcttcatgc tgccctggca gtttgcccag ttcgtgcttc ttactcagat
     1021 tgcatcatta tttgccgtgt atgttgtggg atacattgat acacacaaat tacagaagat
     1081 catttatatg cacatgattt ctcttgtgct ttgctttgtg ttgatgtttg ggaactcgat
     1141 gttactaaca tcttattatg catcgtcttt ggtaattatt tggggcatgc tggcaatgaa
     1201 gccccagttc ctaagaatga atgtatctga actcagctta tgggttatcc aagggtgtgg
     1261 ttggttgttt ggaactgtta tactcaagtc tgtgacttcc aggatctttg gcattgcaga
     1321 tgatgctcat attggcaact tattaacatc aaaattcttc agttacaagg attttgatac
     1381 tttactatat acttgtgcag ccgagtttga cttcatggag aaggagactc cgctgcgata
     1441 cacgaagaca ctgctgcttc ccgtggttct ggtcaccgtc gctgccattg ttagaaagat
     1501 ttttaatgat atgcggggtg tcgtagctaa acaacggaca catacaagaa aacaacaatt
     1561 tgaacatgga gagttggttt accacgctct gcagctgtta gcgtacacag cccttggtgt
     1621 tctgatcatg agactgaagc tcttcctgac accacacatg tgtgttatgg catccttgat
     1681 ctgttccaga cagctgtttg gatggctctt tggcaaagtg catcccggtg ctgttgtctt
     1741 tgctatatta gcagcaatgt ctattcaagg ttcagcaaac ctacaaaccc agtggaacat
     1801 tgtaggggag ttcagcaatt taccacaaga agaactcata gaatggatcc gatacagcac
     1861 aaaaccagat gcagtgtttg caggcgccat gcccaccatg gcaagtgtga agctctctgc
     1921 tctccgaccc gtggtgaacc acccacatta tgaagatgca ggtctaagag ccagaacaaa
     1981 aatagtatac tcaatgtata gccggaaagc gcccgaggac gtgaagaagg aattgatgaa
     2041 attaaaagtg aattactaca ttttggaaga gtcatggtgc ataagaagat ccaagcctgg
     2101 atgcagcatg cctgaaatct gggatgtaga ggatccagac aacgctggga aaactcccct
     2161 gtgcaacatc ttggtgaagg attccaagcc tcactttacc acagtgttcc agaacagtgt
     2221 ttacaaagtc ctagaagttc tcagacagtg actgcacgtg catctgccag agacgcacca
     2281 gcagattaac ctcagtgtgg attgtccttg agacctgaac cctcagggat ggcttccggt
     2341 gcccactcca gtcctgacag ccacggaagg aagagctgtt ctttctgcct tcttcccaga
     2401 gccgaaggac aagcttgtct gggggacatt ggtcacctgc aaagacagca cttgcaactg
     2461 aggagtgtgg cctcagtaag gagccagcct caccagccag ggcctccctc cctgaagctg
     2521 cccggggact gccattccca ctgttgcaga ctgtggccag gcttcctcat ctgatgctta
     2581 gttttagttc ccaagctttt acgaactccg aaaatagggg agcaactgga ggtcatggtt
     2641 taggggtgtt tgagtgatag tgtggcaatg cagggcaatg taaagaaagg ggcaggcatg
     2701 ggagtgaggg acacatgccc tgcctgctcc gcagctcttc tgcagcccaa tatggctgct
     2761 gtgtggatac agcagttagg gttttttttt tttatcaccc tttaaaagtt attttctgtc
     2821 cttaccctct aacaattccc ttcataataa gttcacatgt aatgattgga aattctgtac
     2881 agagaaacaa aacattaaaa tactgttaga gccagttcac atgctgggaa acattaaaag
     2941 tagtctaaat taggtttttt tgcagaaacc ttttgtaaca aacagtatgt cgtaatgtaa
     3001 ctccagcagc aagctttgct tgtatttagt caagtcagct tggaaatgcg gccttggggc
     3061 ccactgcatt ctcagtccag cacatctagt agcagtgtgg cggaaacact tttatggcaa
     3121 catggagcag tattagattt tatgtagctg acaatgcagt attaaagctc agtattttgc
     3181 atatttttag catttacaaa tatttttgct ttagtgtgag aaaaggaaag aaagacagaa
     3241 ggcagttgaa tagttattat tgtgacatta aacaaaaaat aagctgggta atatgtccat
     3301 taaaagctaa acctctaaaa tgcctgtcag agtgtgtgct gttctggtag gccagcagca
     3361 tggatgagaa gacaaaagga tgtgtctgag ctaaagcgat cctgcacagg agtgttgtat
     3421 ttttatgaat tttatgcccc ttgtttacat gtactatata tgttaaataa aaaaaaaaaa
     3481 catgaaaaaa aaaaaaaaaa aa
//
