LOCUS       NM_025274                647 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus developmental pluripotency associated 5A (Dppa5a),
            mRNA.
ACCESSION   NM_025274 XM_486238
VERSION     NM_025274.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 647)
  AUTHORS   Swenson,S.A., Dobish,K.K., Peters,H.C., Bea Winship,C., Willow
            Hynes-Smith,R., Caplan,M., Wittorf,K.J., Ghosal,G. and Buckley,S.M.
  TITLE     Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5
            for Ubiquitylation and Degradation
  JOURNAL   Stem Cells 42 (4), 317-328 (2024)
   PUBMED   38227647
  REMARK    GeneRIF: Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by
            Targeting DPPA5 for Ubiquitylation and Degradation.
REFERENCE   2  (bases 1 to 647)
  AUTHORS   Gomez-Redondo,I., Ramos-Ibeas,P., Pericuesta,E.,
            Fernandez-Gonzalez,R., Laguna-Barraza,R. and Gutierrez-Adan,A.
  TITLE     Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early
            Embryo Development and 2-Cell-Like Conversion
  JOURNAL   Int J Mol Sci 21 (11), 4115 (2020)
   PUBMED   32527007
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 647)
  AUTHORS   Brici,D., Zhang,Q., Reinhardt,S., Dahl,A., Hartmann,H., Schmidt,K.,
            Goveas,N., Huang,J., Gahurova,L., Kelsey,G., Anastassiadis,K.,
            Stewart,A.F. and Kranz,A.
  TITLE     Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a
            maternal effect gene required for the oogenic gene expression
            program
  JOURNAL   Development 144 (14), 2606-2617 (2017)
   PUBMED   28619824
REFERENCE   4  (bases 1 to 647)
  AUTHORS   Langer,D., Martianov,I., Alpern,D., Rhinn,M., Keime,C., Dolle,P.,
            Mengus,G. and Davidson,I.
  TITLE     Essential role of the TFIID subunit TAF4 in murine embryogenesis
            and embryonic stem cell differentiation
  JOURNAL   Nat Commun 7, 11063 (2016)
   PUBMED   27026076
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 647)
  AUTHORS   Suzuki,A., Niimi,Y. and Saga,Y.
  TITLE     Interaction of NANOS2 and NANOS3 with different components of the
            CNOT complex may contribute to the functional differences in mouse
            male germ cells
  JOURNAL   Biol Open 3 (12), 1207-1216 (2014)
   PUBMED   25416063
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 647)
  AUTHORS   Mitsui,K., Tokuzawa,Y., Itoh,H., Segawa,K., Murakami,M.,
            Takahashi,K., Maruyama,M., Maeda,M. and Yamanaka,S.
  TITLE     The homeoprotein Nanog is required for maintenance of pluripotency
            in mouse epiblast and ES cells
  JOURNAL   Cell 113 (5), 631-642 (2003)
   PUBMED   12787504
REFERENCE   7  (bases 1 to 647)
  AUTHORS   Bortvin,A., Eggan,K., Skaletsky,H., Akutsu,H., Berry,D.L.,
            Yanagimachi,R., Page,D.C. and Jaenisch,R.
  TITLE     Incomplete reactivation of Oct4-related genes in mouse embryos
            cloned from somatic nuclei
  JOURNAL   Development 130 (8), 1673-1680 (2003)
   PUBMED   12620990
REFERENCE   8  (bases 1 to 647)
  AUTHORS   Tanaka,T.S., Kunath,T., Kimber,W.L., Jaradat,S.A., Stagg,C.A.,
            Usuda,M., Yokota,T., Niwa,H., Rossant,J. and Ko,M.S.
  TITLE     Gene expression profiling of embryo-derived stem cells reveals
            candidate genes associated with pluripotency and lineage
            specificity
  JOURNAL   Genome Res 12 (12), 1921-1928 (2002)
   PUBMED   12466296
REFERENCE   9  (bases 1 to 647)
  AUTHORS   Bierbaum,P., MacLean-Hunter,S., Ehlert,F., Moroy,T. and Muller,R.
  TITLE     Cloning of embryonal stem cell-specific genes: characterization of
            the transcriptionally controlled gene esg-1
  JOURNAL   Cell Growth Differ 5 (1), 37-46 (1994)
   PUBMED   8123591
REFERENCE   10 (bases 1 to 647)
  AUTHORS   Astigiano,S., Barkai,U., Abarzua,P., Tan,S.C., Harper,M.I. and
            Sherman,M.I.
  TITLE     Changes in gene expression following exposure of nulli-SCCl murine
            embryonal carcinoma cells to inducers of differentiation:
            characterization of a down-regulated mRNA
  JOURNAL   Differentiation 46 (1), 61-67 (1991)
   PUBMED   2044862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV457404.1 and AV476247.1.
            
            On Jan 12, 2008 this sequence version replaced NM_025274.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092353.1, AK145761.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-473               AV457404.1         3-475
            474-647             AV476247.1         87-260
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.65 cM"
     gene            1..647
                     /gene="Dppa5a"
                     /gene_synonym="Dppa5; ecat2; Esg1"
                     /note="developmental pluripotency associated 5A"
                     /db_xref="GeneID:434423"
                     /db_xref="MGI:MGI:101800"
     exon            1..215
                     /gene="Dppa5a"
                     /gene_synonym="Dppa5; ecat2; Esg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..457
                     /gene="Dppa5a"
                     /gene_synonym="Dppa5; ecat2; Esg1"
                     /note="developmental pluripotency associated 5; embryonal
                     stem cell specific gene 1; ESG-1; mDppa5; protein pH 34;
                     ES cell-associated transcript 2 protein; embryonal stem
                     cell-specific gene 1 protein"
                     /codon_start=1
                     /product="developmental pluripotency-associated protein
                     5A"
                     /protein_id="NP_079550.2"
                     /db_xref="CCDS:CCDS23360.1"
                     /db_xref="GeneID:434423"
                     /db_xref="MGI:MGI:101800"
                     /translation="MMVTLVTRKDIPPWVKVPEDLKDPEVFQVQSLVLKYLFGPQGSR
                     MSHIEQVSQAMFELKNLESPEELIEVFIYGSQNNKIRAKWMLQSMAERYHLRQQKGVL
                     KLEESMKTLELGQCIE"
     exon            216..398
                     /gene="Dppa5a"
                     /gene_synonym="Dppa5; ecat2; Esg1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..641
                     /gene="Dppa5a"
                     /gene_synonym="Dppa5; ecat2; Esg1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      613..618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dppa5a"
                     /gene_synonym="Dppa5; ecat2; Esg1"
                     /note="hexamer: AATAAA"
     regulatory      620..625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dppa5a"
                     /gene_synonym="Dppa5; ecat2; Esg1"
                     /note="hexamer: AATAAA"
     polyA_site      635
                     /gene="Dppa5a"
                     /gene_synonym="Dppa5; ecat2; Esg1"
                     /note="major polyA site"
     polyA_site      641
                     /gene="Dppa5a"
                     /gene_synonym="Dppa5; ecat2; Esg1"
                     /note="major polyA site"
ORIGIN      
        1 cgcccacaca ggtactaaaa cttcctgaac ctggagctgt gggccgtgcg tggtggataa
       61 gcttgatctc gtcttccctg aagtctggtt ccttggcagg atgatggtga ccctcgtgac
      121 ccgtaaagat atccccccgt gggtgaaagt tcctgaagac ctgaaagatc cagaagtatt
      181 ccaggtccag tcgctggtgc tgaaatatct gtttggccca cagggatctc gaatgtctca
      241 catcgagcag gtgagccagg ccatgtttga gctgaagaac ctggaatctc ccgaagaact
      301 tatcgaggtc ttcatttacg gctctcaaaa caacaagatt cgggctaaat ggatgcttca
      361 gtccatggct gagaggtacc acctgcgcca gcaaaaagga gtgctgaagc tggaggaatc
      421 catgaagacc ctggagctag gccagtgtat cgagtgaagc cagtttccag tccttgtgtc
      481 tccgacctgg atgcaggtta agctgtggcc agtgtttggt tctggcggga tttttagctt
      541 tgttacatcc tagcaagata ttcctggatc cctgctgcgc attctgatgt gaatcccaag
      601 gttaccactc taaataaaaa ataaaattga agtgattaaa aaaaaaa
//
