LOCUS       NM_028610               1534 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus developmental pluripotency associated 4 (Dppa4),
            transcript variant 1, mRNA.
ACCESSION   NM_028610
VERSION     NM_028610.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1534)
  AUTHORS   Zhang,W., Zhang,R., Wu,L., Zhu,C., Zhang,C., Xu,C., Zhao,S.,
            Liu,X., Guo,T., Lu,Y., Gao,Z., Yu,X., Li,L., Chen,Z.J., Qin,Y. and
            Jiao,X.
  TITLE     NLRP14 deficiency causes female infertility with oocyte maturation
            defects and early embryonic arrest by impairing cytoplasmic UHRF1
            abundance
  JOURNAL   Cell Rep 42 (12), 113531 (2023)
   PUBMED   38060382
REFERENCE   2  (bases 1 to 1534)
  AUTHORS   Kubinyecz,O., Santos,F., Drage,D., Reik,W. and
            Eckersley-Maslin,M.A.
  TITLE     Maternal Dppa2 and Dppa4 are dispensable for zygotic genome
            activation but important for offspring survival
  JOURNAL   Development 148 (24) (2021)
   PUBMED   34931676
  REMARK    GeneRIF: Maternal Dppa2 and Dppa4 are dispensable for zygotic
            genome activation but important for offspring survival.
REFERENCE   3  (bases 1 to 1534)
  AUTHORS   Chen,Z., Xie,Z. and Zhang,Y.
  TITLE     DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation
            and pre-implantation development
  JOURNAL   Development 148 (24) (2021)
   PUBMED   34878123
  REMARK    GeneRIF: DPPA2 and DPPA4 are dispensable for mouse zygotic genome
            activation and pre-implantation development.
REFERENCE   4  (bases 1 to 1534)
  AUTHORS   Li,H., Long,C., Xiang,J., Liang,P., Li,X. and Zuo,Y.
  TITLE     Dppa2/4 as a trigger of signaling pathways to promote zygote genome
            activation by binding to CG-rich region
  JOURNAL   Brief Bioinform 22 (4) (2021)
   PUBMED   33316032
  REMARK    GeneRIF: Dppa2/4 as a trigger of signaling pathways to promote
            zygote genome activation by binding to CG-rich region.
REFERENCE   5  (bases 1 to 1534)
  AUTHORS   Wu,Y., Dong,J., Feng,S., Zhao,Q., Duan,P., Xiong,M., Wen,Y., Lv,C.,
            Wang,X. and Yuan,S.
  TITLE     Maternal UHRF1 Is Essential for Transcription Landscapes and
            Repression of Repetitive Elements During the Maternal-to-Zygotic
            Transition
  JOURNAL   Front Cell Dev Biol 8, 610773 (2021)
   PUBMED   33634103
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1534)
  AUTHORS   Chakravarthy,H., Boer,B., Desler,M., Mallanna,S.K., McKeithan,T.W.
            and Rizzino,A.
  TITLE     Identification of DPPA4 and other genes as putative Sox2:Oct-3/4
            target genes using a combination of in silico analysis and
            transcription-based assays
  JOURNAL   J Cell Physiol 216 (3), 651-662 (2008)
   PUBMED   18366076
  REMARK    GeneRIF: Thsi study identifies DPPA4 and other genes as putative
            Sox2:Oct-3/4 target genes using a combination of in silico analysis
            and transcription-based assays.
REFERENCE   7  (bases 1 to 1534)
  AUTHORS   Mitiku,N. and Baker,J.C.
  TITLE     Genomic analysis of gastrulation and organogenesis in the mouse
  JOURNAL   Dev Cell 13 (6), 897-907 (2007)
   PUBMED   18061570
REFERENCE   8  (bases 1 to 1534)
  AUTHORS   Masaki,H., Nishida,T., Kitajima,S., Asahina,K. and Teraoka,H.
  TITLE     Developmental pluripotency-associated 4 (DPPA4) localized in active
            chromatin inhibits mouse embryonic stem cell differentiation into a
            primitive ectoderm lineage
  JOURNAL   J Biol Chem 282 (45), 33034-33042 (2007)
   PUBMED   17855347
  REMARK    GeneRIF: DPPA4 is a nuclear factor associated with active chromatin
REFERENCE   9  (bases 1 to 1534)
  AUTHORS   Maldonado-Saldivia,J., van den Bergen,J., Krouskos,M.,
            Gilchrist,M., Lee,C., Li,R., Sinclair,A.H., Surani,M.A. and
            Western,P.S.
  TITLE     Dppa2 and Dppa4 are closely linked SAP motif genes restricted to
            pluripotent cells and the germ line
  JOURNAL   Stem Cells 25 (1), 19-28 (2007)
   PUBMED   16990585
  REMARK    GeneRIF: Study of expression and function of pluripotent markers
            such as Dppa2 and Dppa4 is likely to unveil new aspects of the
            regulation of pluripotency and germ line development in mammals.
REFERENCE   10 (bases 1 to 1534)
  AUTHORS   Bortvin,A., Eggan,K., Skaletsky,H., Akutsu,H., Berry,D.L.,
            Yanagimachi,R., Page,D.C. and Jaenisch,R.
  TITLE     Incomplete reactivation of Oct4-related genes in mouse embryos
            cloned from somatic nuclei
  JOURNAL   Development 130 (8), 1673-1680 (2003)
   PUBMED   12620990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033197.1, BC064754.1 and CAAA01133063.1.
            
            On May 6, 2005 this sequence version replaced NM_028610.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033197.1, AK010753.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AK033197.1         2-290
            290-1019            BC064754.1         229-958
            1020-1534           CAAA01133063.1     11041-11555         c
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 30.75 cM"
     gene            1..1534
                     /gene="Dppa4"
                     /gene_synonym="2410091M23Rik; ECAT15-1"
                     /note="developmental pluripotency associated 4"
                     /db_xref="GeneID:73693"
                     /db_xref="MGI:MGI:2157525"
     exon            1..107
                     /gene="Dppa4"
                     /gene_synonym="2410091M23Rik; ECAT15-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..974
                     /gene="Dppa4"
                     /gene_synonym="2410091M23Rik; ECAT15-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     developmental pluripotency-associated protein 4; embryonic
                     stem cell-associated transcript 15-1 protein"
                     /codon_start=1
                     /product="developmental pluripotency-associated protein 4
                     isoform 1"
                     /protein_id="NP_082886.2"
                     /db_xref="CCDS:CCDS28209.1"
                     /db_xref="GeneID:73693"
                     /db_xref="MGI:MGI:2157525"
                     /translation="METAGDKKWSAEEPKEEVELQMSSQPSTAPAKAKATGKKQKKSE
                     TDNGCKPKEGKPQDTETPGQTRRKVPIPPIPEYLPPVNLIHRDVLRAWCQKKRVSSKG
                     QKLDAYKRLLARAFPEQMLELRNVPDSAKDARLKTAHKKMKTEPGEESEVTVPLEMVP
                     VPEEQIPALIDPPMLYEEVSTTVVTTPATEAVLASWARIASNAKKYEAVPADASSSSE
                     VKGEMWCVVHGTSLPGNSRGWVRLQFHAGQAWVPDKKGKAIALFLLPACTFPPPHLED
                     NMLCPKCVHKNKILTKSLEG"
     exon            108..225
                     /gene="Dppa4"
                     /gene_synonym="2410091M23Rik; ECAT15-1"
                     /inference="alignment:Splign:2.1.0"
     exon            226..392
                     /gene="Dppa4"
                     /gene_synonym="2410091M23Rik; ECAT15-1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..443
                     /gene="Dppa4"
                     /gene_synonym="2410091M23Rik; ECAT15-1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..744
                     /gene="Dppa4"
                     /gene_synonym="2410091M23Rik; ECAT15-1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..940
                     /gene="Dppa4"
                     /gene_synonym="2410091M23Rik; ECAT15-1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1534
                     /gene="Dppa4"
                     /gene_synonym="2410091M23Rik; ECAT15-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1470..1475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dppa4"
                     /gene_synonym="2410091M23Rik; ECAT15-1"
                     /note="hexamer: ACTAAA"
     polyA_site      1475
                     /gene="Dppa4"
                     /gene_synonym="2410091M23Rik; ECAT15-1"
                     /note="major polyA site"
ORIGIN      
        1 ggagattttg aaaagccggc tgaggtcaga ggtcttttgg aagctgggag aactttcttt
       61 cggaggattc atctattctc aagatggaga ctgctggaga caagaagtgg agcgcagaag
      121 agccgaagga agaagtggaa ttgcagatgt ctagtcaacc aagcacggct cctgcaaagg
      181 ctaaagcaac ggggaaaaaa caaaagaagt cggagacaga taatggttgt aaaccaaagg
      241 agggaaaacc acaagacact gagacgccag gacagactcg taggaaggta ccaattcctc
      301 ctattccaga gtatctgccc ccagtgaacc tgattcaccg agatgttttg cgggcatggt
      361 gccagaagaa acgagtgagc agcaaaggcc agaaattaga tgcttataaa cgactccttg
      421 caagggcttt cccagaacaa atgctggagt tgaggaacgt ccctgactca gccaaagacg
      481 ccaggttgaa gacagctcac aaaaaaatga agactgaacc gggggaggag tctgaggtga
      541 cagttcctct ggaaatggtc cctgtgccag aggagcagat acctgccctc attgaccctc
      601 ctatgctcta tgaggaagtc agcaccaccg tagtgactac acctgccact gaggccgtgt
      661 tagcatcttg ggccagaatt gcatccaatg ctaagaagta cgaggcagtg ccagccgatg
      721 cttcgtcctc atcagaagtc aaaggggaaa tgtggtgtgt ggttcatggg accagccttc
      781 ctgggaactc gcgtggttgg gttcggctgc agttccacgc tggacaagcc tgggtacccg
      841 ataagaaagg aaaagccatt gccctcttcc tgcttccggc ctgcacattt ccacccccac
      901 acctggagga caacatgctg tgccccaagt gtgttcataa gaacaagatc ttgactaaga
      961 gcctcgaagg ataaaggaca gatctcttgt ttgagctagc tgctggcgtc actcactctt
     1021 gtggtgtgat cagcagagct gcggctgacg ctgagactga tagaaatcta catctctgcc
     1081 tttgaaggtg cctttctcat ccagaactta agggatagtg taagttagtt gatgcttaag
     1141 ttcacgcagt ttgaaaaaag ccagcgaggc cacctctgct cgctgtgatg actgatcact
     1201 gagagtgaac tcttactctt ttgtgaagat aaaaatacat cctatgtgtt ttgctgcaag
     1261 taggtcctgg ggcaggagga tgatatctcc agataacaat agttgctagt cctgtcacca
     1321 gcacaacggg cgtcataacc agttcagcag tcaactgtaa agacttggct tatacctgta
     1381 gcctccgcat gcatgtcctc ttccctgggt tgtagtgtgt tgttagtgtt taatacttgt
     1441 gtttgttttc tgctgttgta aaatattaca ctaaatctgg cttgtggctt ttgtttttgt
     1501 tatctgaatg gttaaatttc ccctgagttc cttc
//
