LOCUS       NM_001163358            2264 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus developmental pluripotency associated 1 (Dppa1),
            transcript variant 2, mRNA.
ACCESSION   NM_001163358
VERSION     NM_001163358.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2264)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2264)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2264)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 2264)
  AUTHORS   Boroviak,T., Loos,R., Bertone,P., Smith,A. and Nichols,J.
  TITLE     The ability of inner-cell-mass cells to self-renew as embryonic
            stem cells is acquired following epiblast specification
  JOURNAL   Nat Cell Biol 16 (6), 516-528 (2014)
   PUBMED   24859004
REFERENCE   5  (bases 1 to 2264)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2264)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   7  (bases 1 to 2264)
  AUTHORS   Bortvin,A., Eggan,K., Skaletsky,H., Akutsu,H., Berry,D.L.,
            Yanagimachi,R., Page,D.C. and Jaenisch,R.
  TITLE     Incomplete reactivation of Oct4-related genes in mouse embryos
            cloned from somatic nuclei
  JOURNAL   Development 130 (8), 1673-1680 (2003)
   PUBMED   12620990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669948.8.
            
            Transcript Variant: This variant (2) lacks an alternate segment in
            the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: C88843.1, CJ041856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AL669948.8         205115-205164       c
            51-108              AL669948.8         201458-201515       c
            109-161             AL669948.8         192040-192092       c
            162-273             AL669948.8         188811-188922       c
            274-307             AL669948.8         186337-186370       c
            308-2264            AL669948.8         182900-184856       c
FEATURES             Location/Qualifiers
     source          1..2264
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 28.02 cM"
     gene            1..2264
                     /gene="Dppa1"
                     /note="developmental pluripotency associated 1"
                     /db_xref="GeneID:347708"
                     /db_xref="MGI:MGI:2157522"
     exon            1..50
                     /gene="Dppa1"
                     /inference="alignment:Splign:2.1.0"
     exon            51..108
                     /gene="Dppa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..410
                     /gene="Dppa1"
                     /codon_start=1
                     /product="developmental pluripotency associated 1
                     precursor"
                     /protein_id="NP_001156830.1"
                     /db_xref="CCDS:CCDS24581.1"
                     /db_xref="GeneID:347708"
                     /db_xref="MGI:MGI:2157522"
                     /translation="MMSLQVLISGLLLLLPAVWSTTVTFSHDPWNNHTEVIPTQPSLK
                     ISTKDLYIGISVSAALLILLASALTIIKCRHRKKKTLESSVVFHGFQNEVFQSAEQPE
                     AVDTVDIIKVPVAI"
     exon            109..161
                     /gene="Dppa1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..273
                     /gene="Dppa1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..307
                     /gene="Dppa1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..2264
                     /gene="Dppa1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatgaccag aaggagagac tagcaagaag tcactttccc ctaagtacag gtcaccatca
       61 tgatgtccct tcaagtcctc atttcaggcc tcctactcct tctcccagca gtttggagca
      121 ccactgtgac attttcacat gacccttgga ataatcacac tgaagtgatc ccaacacaac
      181 cctccctgaa gatctccact aaggacctct atattggaat ctctgtgtct gctgcattgc
      241 tgatcctcct tgcaagtgcc ctgactatca taaagtgcag acacagaaaa aagaagactc
      301 tagaaagctc ggttgtcttc catggatttc agaatgaagt ttttcaaagt gcagagcaac
      361 ccgaagctgt agacactgtc gacattatca aagttccagt tgccatttga ggggccatca
      421 tcctaagact gcagaagaaa gaatgtcacc tgaccatgct gttatatttt ctctgtgtca
      481 gttcatagcg tgttccaatt tgccagcagc agtggagagg gcgtccctct cgctgttcat
      541 aggcctagtc attgttcata taggactcat tcctaccaca cactggggag cattctctca
      601 aacaggaaca gcttagaatc tcctgtgtgc tttagatgcc ccaagttgtg tctatgagac
      661 aaaatcattg gtaatgcaga aaagggactt caacttagtt atgaaaccca taaagaagag
      721 agggatacga tttaaaaatt aaaatatgta aataattaaa taaataaatg cacgggggag
      781 gaataaataa atgcaagtgg ggagggcaag acttaatttt gaagtacttc attatcatgc
      841 ttcctttctt ttattgtaac ttataacatt attttcatca ccttccccaa aggggcttaa
      901 gtcatgggaa ctacgggttt aatttgtctg gtagataaac agaaaggagt ctagaggcgt
      961 ctatgttttc taatggctcc tgaaatatga cacagtgtac tatggttgat cttaggataa
     1021 gaatgtgtgt tttctgtcag gagaggctac catggtgagt atggaccagg cagacacctg
     1081 ggaagaggat aatggggcac aggcttgagt tcattagagc tattttcact acacttctgc
     1141 cttgatgctc ggtgttccta gactcactcc ccgagctctg agttaggagc tagaaggaga
     1201 caaagcagaa atggaaggga agatgagcga gggggcctca gggtctcagc cttagagaag
     1261 tcctgttgca ggtgggacaa tgtttggggc taccactggt ttcatgtaga gttctaagtt
     1321 tctaattgtc tacaggccat gtttatattt aaatgtattt cagaaaacaa aatatttttt
     1381 tatagtgaat cagtttgaaa caatcagcaa actatctggt tttgctaaga attaacaaag
     1441 gctgctgtat tgatatccgc attgcctttt tgattgatta gaattcctgc ttttcaaagg
     1501 agtattaact tttacatgag atttcttcct cctgagtgct ggtgcccctg gttgtcctcc
     1561 tgtctccata tgtcctcaat ggcaaatgta cacacacaca cacacacaca gaggcatgca
     1621 tgcacataag tacacaaata tctaaactta atgagattta aacagtaaat actaaagtag
     1681 aagaaggtag aaatgaccga taagaagaca ctgatttatt aatgtatttt atgtatttag
     1741 ttatttactt aaagaatcag ttgtaatgtc catttgccaa acacagcttc acttgttacc
     1801 tgcaacagaa tagtctgaag gaatagctga agcaatgggc cgttgccctt gacaaccttg
     1861 acaaactgct gactggcata tgtttctgta aaattttgct tacttgcccc atatttctta
     1921 ttttgtaatt atactttaaa tgcctatttt ctaatgagaa agagaaaggg ggtagatttg
     1981 catgagaggt tctggggaga ttctgagagg agttggggac agagaaacag aaatagattg
     2041 tatggaaaag actattttca gtaaaagaaa agcagaaaca aaacatgaga ctaccaagtg
     2101 gagccatcct ggaagcctaa tgggagccat gctggctgtg ggtcaccagt gctagctcct
     2161 gtcttcccct ttcagtggtg ttgagttctt atctgagcaa gattcctaca acagtaagac
     2221 atggataact ggctatcttt ttaaaatgaa aagatggtca catg
//
