LOCUS       NM_172624               3509 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus dipeptidylpeptidase 9 (Dpp9), transcript variant 2,
            mRNA.
ACCESSION   NM_172624
VERSION     NM_172624.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3509)
  AUTHORS   Hess,L., Aliar,K., Grunwald,B.T., Griffin,R., Lozan,A., Knoller,M.,
            Khokha,R., Brummer,T. and Reinheckel,T.
  TITLE     Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and
            metastasis in breast cancer
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167133 (2024)
   PUBMED   38531482
  REMARK    GeneRIF: Dipeptidyl-peptidase 9 regulates the dynamics of
            tumorigenesis and metastasis in breast cancer.
REFERENCE   2  (bases 1 to 3509)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3509)
  AUTHORS   Harapas,C.R., Robinson,K.S., Lay,K., Wong,J., Moreno Traspas,R.,
            Nabavizadeh,N., Rass-Rothschild,A., Boisson,B., Drutman,S.B.,
            Laohamonthonkul,P., Bonner,D., Xiong,J.R., Gorrell,M.D.,
            Davidson,S., Yu,C.H., Fleming,M.D., Gudera,J., Stein,J.,
            Ben-Harosh,M., Groopman,E., Shimamura,A., Tamary,H., Kayserili,H.,
            Hatipoglu,N., Casanova,J.L., Bernstein,J.A., Zhong,F.L.,
            Masters,S.L. and Reversade,B.
  TITLE     DPP9 deficiency: An inflammasomopathy that can be rescued by
            lowering NLRP1/IL-1 signaling
  JOURNAL   Sci Immunol 7 (75), eabi4611 (2022)
   PUBMED   36112693
  REMARK    GeneRIF: DPP9 deficiency: An inflammasomopathy that can be rescued
            by lowering NLRP1/IL-1 signaling.
REFERENCE   4  (bases 1 to 3509)
  AUTHORS   Gall,M.G., Zhang,H.E., Lee,Q., Jolly,C.J., McCaughan,G.W., Cook,A.,
            Roediger,B. and Gorrell,M.D.
  TITLE     Immune regeneration in irradiated mice is not impaired by the
            absence of DPP9 enzymatic activity
  JOURNAL   Sci Rep 9 (1), 7292 (2019)
   PUBMED   31086209
  REMARK    GeneRIF: Immune regeneration in irradiated mice is not impaired by
            the absence of DPP9 enzymatic activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3509)
  AUTHORS   de Vasconcelos,N.M., Vliegen,G., Goncalves,A., De Hert,E.,
            Martin-Perez,R., Van Opdenbosch,N., Jallapally,A.,
            Geiss-Friedlander,R., Lambeir,A.M., Augustyns,K., Van Der Veken,P.,
            De Meester,I. and Lamkanfi,M.
  TITLE     DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome
            hallmarks in murine macrophages
  JOURNAL   Life Sci Alliance 2 (1), e201900313 (2019)
   PUBMED   30718379
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3509)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3509)
  AUTHORS   Chowdhury,S., Chen,Y., Yao,T.W., Ajami,K., Wang,X.M., Popov,Y.,
            Schuppan,D., Bertolino,P., McCaughan,G.W., Yu,D.M. and Gorrell,M.D.
  TITLE     Regulation of dipeptidyl peptidase 8 and 9 expression in activated
            lymphocytes and injured liver
  JOURNAL   World J Gastroenterol 19 (19), 2883-2893 (2013)
   PUBMED   23704821
  REMARK    GeneRIF: Suggest roles for DPP8 and DPP9 in lymphocyte activation
            and apoptosis and in hepatocytes during liver disease pathogenesis.
REFERENCE   8  (bases 1 to 3509)
  AUTHORS   Yu,D.M., Ajami,K., Gall,M.G., Park,J., Lee,C.S., Evans,K.A.,
            McLaughlin,E.A., Pitman,M.R., Abbott,C.A., McCaughan,G.W. and
            Gorrell,M.D.
  TITLE     The in vivo expression of dipeptidyl peptidases 8 and 9
  JOURNAL   J Histochem Cytochem 57 (11), 1025-1040 (2009)
   PUBMED   19581630
  REMARK    GeneRIF: DP8 and DP9 tissue and cellular expression
REFERENCE   9  (bases 1 to 3509)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   10 (bases 1 to 3509)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050023.1, AK050021.1 and AK078301.1.
            
            On Aug 1, 2009 this sequence version replaced NM_172624.2.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR, lacks a portion of the 5' coding region, and initiates
            translation at an alternate start codon, compared to variant 1. The
            encoded isoform (2) has a distinct N-terminus and is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078301.1, BC057631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AK050023.1         2-60
            60-3301             AK050021.1         2-3243
            3302-3383           AK050021.1         3245-3326
            3384-3509           AK078301.1         3332-3457
FEATURES             Location/Qualifiers
     source          1..3509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.2 cM"
     gene            1..3509
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /note="dipeptidylpeptidase 9"
                     /db_xref="GeneID:224897"
                     /db_xref="MGI:MGI:2443967"
     exon            1..149
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            150..202
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            203..456
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..2822
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /EC_number="3.4.14.5"
                     /note="isoform 2 is encoded by transcript variant 2; DP9;
                     DPLP9; dipeptidyl peptidase IX; dipeptidyl peptidase-like
                     protein 9"
                     /codon_start=1
                     /product="dipeptidyl peptidase 9 isoform 2"
                     /protein_id="NP_766212.2"
                     /db_xref="CCDS:CCDS37663.1"
                     /db_xref="GeneID:224897"
                     /db_xref="MGI:MGI:2443967"
                     /translation="MCSGVSPVEQVAAGDMDDTAARFCVQKHSWDGLRSIIHGSRKSS
                     GLIVSKAPHDFQFVQKPDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLL
                     SWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFH
                     CRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEE
                     RRLTFCHQGSAGVLDNPKSAGVATFVIQEEFDRFTGCWWCPTASWEGSEGLKTLRILY
                     EEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAELQTDHQGKIVSSCE
                     KELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQRLQLVLLPPALFIPAVESE
                     AQRQAAARAVPKNVQPFVIYEEVTNVWINVHDIFHPFPQAEGQQDFCFLRANECKTGF
                     CHLYRVTVELKTKDYDWTEPLSPTEDEFKCPIKEEVALTSGEWEVLSRHGSKIWVNEQ
                     TKLVYFQGTKDTPLEHHLYVVSYESAGEIVRLTTLGFSHSCSMSQSFDMFVSHYSSVS
                     TPPCVHVYKLSGPDDDPLHKQPRFWASMMEAANCPPDYVPPEIFHFHTRADVQLYGMI
                     YKPHTLQPGRKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSC
                     QRGLHFEGALKNQMGQVEIEDQVEGLQYVAEKYGFIDLSRVAIHGWSYGGFLSLMGLI
                     HKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQQGYEAGSVALHVEKLPNEPNR
                     LLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCRESGEHYEVTLLH
                     FLQEHL"
     exon            457..569
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            570..743
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            744..912
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1026
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1155
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1217
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1318
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1496
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1659
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1739
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1892
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2028
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2174
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2321
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2474
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2617
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2729
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..3509
                     /gene="Dpp9"
                     /gene_synonym="6430584G11Rik; A330078I11; DPP IX; DPRP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctggcggg tccccccggt gtccgccgcc ttcgctgtcc ccccgcgccc gccacttccg
       61 ggccctcgtc ttgggcatgg agcgtcgcgt gtgaggcgcc gccggccccg gggacgccct
      121 gctcagcttg tcctccgcgc cacgctcggg tccgtgcccc tcgcctgcag ctgccatgga
      181 agctccttgg accctttaga agcttctcgc cgccatcaca ggagccccag aggatgtgca
      241 gcggggtctc cccagttgag caggtggccg caggggacat ggatgacacg gcagcacgct
      301 tctgtgtgca gaagcactcg tgggatgggc tgcgtagcat tatccacggc agtcgcaagt
      361 cctcgggcct cattgtcagc aaggcccccc acgacttcca gtttgtgcag aagcctgacg
      421 agtctggccc ccactctcac cgtctctatt acctcggaat gccttacggc agccgtgaga
      481 actccctcct ctactccgag atccccaaga aagtgcggaa ggaggccctg ctgctgctgt
      541 cctggaagca gatgctggac cacttccagg ccacacccca ccatggtgtc tactcccgag
      601 aggaggagct actgcgggag cgcaagcgcc tgggcgtctt cggaatcacc tcttatgact
      661 tccacagtga gagcggcctc ttcctcttcc aggccagcaa tagcctgttc cactgcaggg
      721 atggtggcaa gaatggcttt atggtgtccc cgatgaagcc actggagatc aagactcagt
      781 gttctgggcc acgcatggac cccaaaatct gccccgcaga ccctgccttc ttttccttca
      841 tcaacaacag tgatctgtgg gtggcaaaca tcgagactgg ggaggaacgg cggctcacct
      901 tctgtcacca gggttcagct ggtgtcctgg acaatcccaa atcagcaggc gtggccacct
      961 ttgtcatcca ggaggagttc gaccgcttca ctgggtgctg gtggtgcccc acggcctctt
     1021 gggaaggctc cgaaggtctc aagacgctgc gcatcctata tgaggaagtg gacgagtctg
     1081 aagtggaggt cattcatgtg ccctcccccg ccctggagga gaggaagacg gactcctacc
     1141 gctaccccag gacaggcagc aagaacccca agattgccct gaagctggct gagctccaga
     1201 cggaccatca gggcaaaatc gtgtcaagct gcgagaagga actggtacag ccattcagct
     1261 cccttttccc caaagtggag tacatcgccc gggctggctg gacacgggac ggcaaatatg
     1321 cctgggccat gttcctggac cgtccccagc aacggcttca gcttgtcctc ctgccccctg
     1381 ctctcttcat cccggccgtt gagagtgagg cccagcggca ggcagctgcc agagccgtcc
     1441 ccaagaatgt gcagcccttt gtcatctatg aagaagtcac caatgtctgg atcaacgtcc
     1501 acgacatctt ccacccgttt cctcaggctg agggccagca ggacttttgt ttccttcgtg
     1561 ccaacgaatg caagactggc ttctgccacc tgtacagggt cacagtggaa cttaaaacca
     1621 aggactatga ctggacggaa cccctcagcc ctacagaaga tgagtttaag tgccccatca
     1681 aggaggaggt cgccctgacc agtggcgagt gggaggtctt gtcgaggcat ggctccaaga
     1741 tctgggtcaa cgagcagacg aagctggtgt actttcaagg tacaaaggac acaccgctgg
     1801 aacatcacct ctatgtggtc agctacgagt cagcaggcga gatcgtgcgg ctcaccacgc
     1861 tcggcttctc ccacagctgc tccatgagcc agagcttcga catgttcgtg agtcactaca
     1921 gcagtgtgag cacgccaccc tgtgtacatg tgtacaagct gagcggcccc gatgatgacc
     1981 cactgcacaa gcaaccacgc ttctgggcca gcatgatgga ggcagccaat tgccccccag
     2041 actatgtgcc ccctgagatc ttccacttcc acacccgtgc agacgtgcag ctctacggca
     2101 tgatctacaa gccacacacc ctgcaacctg ggaggaagca ccccactgtg ctctttgtct
     2161 atgggggccc acaggtgcag ttggtgaaca actcctttaa gggcatcaaa tacctgcggc
     2221 taaatacact ggcatccttg ggctatgctg tggtggtgat cgatggtcgg ggctcctgtc
     2281 agcggggcct gcacttcgag ggggccctga aaaatcaaat gggccaggtg gagattgagg
     2341 accaggtgga aggcttgcag tacgtggctg agaagtatgg cttcattgac ttgagccgag
     2401 tcgccatcca tggctggtcc tacggcggct tcctctcact catggggctc atccacaagc
     2461 cacaagtgtt caaggtagcc attgcgggcg ctcctgtcac tgtgtggatg gcctatgaca
     2521 cagggtacac ggaacgatac atggatgtcc ccgaaaataa ccagcaaggc tatgaggcag
     2581 ggtctgtagc cctgcatgtg gagaagctgc ccaatgagcc taaccgcctg cttatcctcc
     2641 acggcttcct ggacgagaac gttcacttct tccacacaaa tttcctggtg tcccagctga
     2701 tccgagcagg aaagccatac cagcttcaga tctacccaaa cgagagacat agcatccgct
     2761 gccgcgagtc cggagagcat tacgaggtga cgctgctgca ctttctgcag gaacacctgt
     2821 gacctcagtc ccgactcctg acgccaccgc tgctcttctt gcgtttttgt aatcttttca
     2881 tttttgaagc ttccaatttg cttgctgctg ctgctgcctg ggggccagga cagaggtagt
     2941 ggcggccccc atgccgccct ccttgagctg gtgaggagaa gtcgccattg agcacacaac
     3001 ctccaccaga ctgccatggc cccgaacctg caattccatc ctagcgcaga agcatgtgcc
     3061 tgccacctgc tgcccctgca gagtcatgtg tgtttgtggt gggcatttta aataattatt
     3121 taaaagacag gaagtaagcg gtaccgagca atgaaactga aggtacagca ctgggcgtct
     3181 ggggacccca cgctctccca acgcccagac tatgtggagc tgccaagccc ctgtctgggc
     3241 acctctgccc tgcctgtctg ctgcccggat cctcctcact tagcacctag gggtgtcagg
     3301 gtcgggagta ggacctgtcc tgacctcagg gttatatata gcccttcccc actccctcct
     3361 acgagagttc tggcataaag aagtaaaaaa gaaaaagaaa aaaacaaaca aaaaaaccaa
     3421 accacctcta catattatgg aaagaaaata tttttgtcaa ttcttattct tttataatta
     3481 tgtggtatgt agactcatta aacaattcc
//
