LOCUS       NM_001401136            6946 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dipeptidylpeptidase 8 (Dpp8), transcript variant 2,
            mRNA.
ACCESSION   NM_001401136 XM_036155360
VERSION     NM_001401136.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6946)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6946)
  AUTHORS   de Vasconcelos,N.M., Vliegen,G., Goncalves,A., De Hert,E.,
            Martin-Perez,R., Van Opdenbosch,N., Jallapally,A.,
            Geiss-Friedlander,R., Lambeir,A.M., Augustyns,K., Van Der Veken,P.,
            De Meester,I. and Lamkanfi,M.
  TITLE     DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome
            hallmarks in murine macrophages
  JOURNAL   Life Sci Alliance 2 (1), e201900313 (2019)
   PUBMED   30718379
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6946)
  AUTHORS   Buljevic,S., Detel,D., Pugel,E.P. and Varljen,J.
  TITLE     The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9
            expression profiles in a mouse model of Crohn's disease
  JOURNAL   J Cell Biochem 119 (8), 6743-6755 (2018)
   PUBMED   29693275
  REMARK    GeneRIF: The effect of CD26-deficiency on dipeptidyl peptidase 8
            and 9 expression profiles in a mouse model of Crohn's disease.
REFERENCE   4  (bases 1 to 6946)
  AUTHORS   Okondo,M.C., Rao,S.D., Taabazuing,C.Y., Chui,A.J., Poplawski,S.E.,
            Johnson,D.C. and Bachovchin,D.A.
  TITLE     Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome
  JOURNAL   Cell Chem Biol 25 (3), 262-267 (2018)
   PUBMED   29396289
REFERENCE   5  (bases 1 to 6946)
  AUTHORS   Kim,M., Minoux,M., Piaia,A., Kueng,B., Gapp,B., Weber,D.,
            Haller,C., Barbieri,S., Namoto,K., Lorenz,T., Wirsching,J.,
            Bassilana,F., Dietrich,W., Rijli,F.M. and Ksiazek,I.
  TITLE     DPP9 enzyme activity controls survival of mouse migratory tongue
            muscle progenitors and its absence leads to neonatal lethality due
            to suckling defect
  JOURNAL   Dev Biol 431 (2), 297-308 (2017)
   PUBMED   28887018
REFERENCE   6  (bases 1 to 6946)
  AUTHORS   Han,R., Wang,X., Bachovchin,W., Zukowska,Z. and Osborn,J.W.
  TITLE     Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte
            differentiation
  JOURNAL   Sci Rep 5, 12348 (2015)
   PUBMED   26242871
  REMARK    GeneRIF: Blocking the expression or activities of DPP8 and DPP9
            attenuates PPARgamma2 induction during preadipocyte
            differentiation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6946)
  AUTHORS   Chowdhury,S., Chen,Y., Yao,T.W., Ajami,K., Wang,X.M., Popov,Y.,
            Schuppan,D., Bertolino,P., McCaughan,G.W., Yu,D.M. and Gorrell,M.D.
  TITLE     Regulation of dipeptidyl peptidase 8 and 9 expression in activated
            lymphocytes and injured liver
  JOURNAL   World J Gastroenterol 19 (19), 2883-2893 (2013)
   PUBMED   23704821
  REMARK    GeneRIF: Suggest roles for DPP8 and DPP9 in lymphocyte activation
            and apoptosis and in hepatocytes during liver disease pathogenesis.
REFERENCE   8  (bases 1 to 6946)
  AUTHORS   Yu,D.M., Ajami,K., Gall,M.G., Park,J., Lee,C.S., Evans,K.A.,
            McLaughlin,E.A., Pitman,M.R., Abbott,C.A., McCaughan,G.W. and
            Gorrell,M.D.
  TITLE     The in vivo expression of dipeptidyl peptidases 8 and 9
  JOURNAL   J Histochem Cytochem 57 (11), 1025-1040 (2009)
   PUBMED   19581630
  REMARK    GeneRIF: DP8 and DP9 tissue and cellular expression
REFERENCE   9  (bases 1 to 6946)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   10 (bases 1 to 6946)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122463.4.
            
            On Feb 2, 2022 this sequence version replaced XM_036155360.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016546.1, SRR10223970.11380.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               AC122463.4         87514-88009
            497-633             AC122463.4         89958-90094
            634-906             AC122463.4         92052-92324
            907-1019            AC122463.4         97347-97459
            1020-1193           AC122463.4         98769-98942
            1194-1362           AC122463.4         100703-100871
            1363-1473           AC122463.4         106473-106583
            1474-1602           AC122463.4         108128-108256
            1603-1664           AC122463.4         108852-108913
            1665-1765           AC122463.4         109502-109602
            1766-1943           AC122463.4         109911-110088
            1944-2103           AC122463.4         110875-111034
            2104-2183           AC122463.4         115286-115365
            2184-2336           AC122463.4         118510-118662
            2337-2472           AC122463.4         118902-119037
            2473-2618           AC122463.4         121434-121579
            2619-2765           AC122463.4         129522-129668
            2766-2918           AC122463.4         130819-130971
            2919-3061           AC122463.4         133046-133188
            3062-3173           AC122463.4         133757-133868
            3174-6946           AC122463.4         135814-139586
FEATURES             Location/Qualifiers
     source          1..6946
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.06 cM"
     gene            1..6946
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /note="dipeptidylpeptidase 8"
                     /db_xref="GeneID:74388"
                     /db_xref="MGI:MGI:1921638"
     exon            1..496
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            497..633
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             618..3296
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /EC_number="3.4.14.5"
                     /note="dipeptidyl peptidase VIII"
                     /codon_start=1
                     /product="dipeptidyl peptidase 8"
                     /protein_id="NP_001388065.1"
                     /db_xref="GeneID:74388"
                     /db_xref="MGI:MGI:1921638"
                     /translation="MKIPSGRCNMAAAMETEQLGVEIFETAECEEGNGESQDRPKLEP
                     FYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRTDPDGPHSDRVYYLAMSGEN
                     RENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGI
                     AAYDYHPGSGTFLFQAGSGIYHIKDGGPHGFTQQPLRPNLVETSCPNIRMDPKLCPAD
                     PDWIAFIHSNDIWISNLVTREERRITYVHNELANMEEDPRSAGVATFVLQEEFDRYSG
                     YWWCPQAERTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPK
                     VTFKMSEIVVDAAGGIIDVIDKELVQPFEILFEGVEYIARAGWTPEGKHAWSILLDRS
                     QTHLQIVLISPELFIPVEDDAMDRQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVF
                     PQTHEDEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEITI
                     TSGEWEVLGRHGSNIWVDEARKLVYFEGTKDSPLEHHLYVTSYANPGEVVRLTDRGYS
                     HSCCLSRHCDFFISKYSNQKNPHCVSLYKLSSPEDDPVHKTKEFWATILDSAGPLPDY
                     TPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFR
                     LNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDL
                     DRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQ
                     GYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQ
                     ERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI"
     exon            634..906
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1019
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1193
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1362
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1473
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1602
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1664
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1765
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1943
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2103
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2183
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2336
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2472
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2618
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2765
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2918
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3061
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3173
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..6946
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3415..3420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /note="hexamer: AGTAAA"
     polyA_site      3438
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /note="major polyA site"
     regulatory      5062..5067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /note="hexamer: ATTAAA"
     polyA_site      5094
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /note="major polyA site"
     regulatory      6924..6929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /note="hexamer: AATAAA"
     polyA_site      6946
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgccg aggcctccgg tgctgtcttc gcctccgccg cttttaagtc ccttcgtccg
       61 ctgcctgggg gccgcggggg ccgccgccga ggaagctgct gtggccccga cgggagcgga
      121 ggcggcgcgg catgaagcgg cgtaggcccg ctccatagcg catccggacg gtccgggcgg
      181 gcccgggggg aaggtgcagt atccgcccgc tctccctccc ctgcgcccgc gaggccacgg
      241 agctccggcc ggccgccctc gggccgctcc cgccgggaga gcgggtggct gggccccgtt
      301 ggccggaaga ggaagcgcac actcggattg cgaggctgcc aacgttcact gggcgcccct
      361 gaacgctggc tgctgcccgc tcggactccc acgtccgtta tcttgataga gcctggcttg
      421 ggttgggatg ccggggacag tccgggcatt cggaggagga aacggaaatc cgcagaggcg
      481 aaggggttcg cctgaggatt ggatggtgag aaaaggaaag attcctgtga gaagagatca
      541 ggatgaacgg agagatctgt gcttaaagtt gggccaggtg aaaatgatct ctttgaaagt
      601 agaagagatc tgagcagatg aaaataccat caggaagatg caacatggca gcagcaatgg
      661 aaacagaaca gctgggtgtc gagatatttg aaactgcaga gtgtgaggag ggaaatggtg
      721 aatcacagga ccgacccaaa ctggagcctt tttatgtcga acggtattct tggagtcagc
      781 tgaaaaagct gcttgctgat accagaaaat accacggcta catgatggct aaggcgccac
      841 atgactttat gtttgtaaag aggacggatc cagatgggcc tcactcagac agggtctatt
      901 accttgccat gtctggtgag aacagagaaa atacactatt ttattctgaa atccctaaaa
      961 ccatcaacag agcagcagtc ttaatgcttt cctggaagcc ccttttggat ctttttcagg
     1021 cgacactaga ctatgggatg tattctcgag aggaagagct actcagagaa agaaagcgca
     1081 ttggaaccgt ggggatcgca gcttatgatt accacccagg aagcggaaca ttcctgtttc
     1141 aagctggcag cggcatttac catatcaaag atggaggacc acatggattt acacaacagc
     1201 ctttgcggcc caatttagtg gaaactagtt gtcccaatat acgaatggat ccaaaattat
     1261 gccctgctga tccagactgg atagctttca ttcacagcaa tgatatttgg atatcaaacc
     1321 tcgtaaccag ggaagagcgg aggatcacat acgtacacaa tgagctagcc aacatggaag
     1381 aggatcccag atcagctggt gttgccacct ttgttcttca agaagaattt gacagatact
     1441 ctggctactg gtggtgtccc caagcggaaa gaactcctag tggtggtaaa attcttagaa
     1501 ttctctatga agaaaatgat gaatctgagg tggagattat tcatgttacg tcccccatgt
     1561 tggaaacaag gagggcagat tcctttcgtt atcccaaaac aggcacagca aacccaaagg
     1621 tcactttcaa gatgtcggag attgttgttg atgctgcagg agggattata gatgtcatag
     1681 ataaagaact ggttcaacct ttcgagattc tgtttgaggg agttgaatat attgccagag
     1741 ccggatggac tccagaggga aaacatgcct ggtccatcct actagaccgt tcccagactc
     1801 acctgcagat agttctgatc tcccctgagt tattcatccc agtagaagat gatgccatgg
     1861 acagacagag acttatagag tcagttcctg actctgtgac accactgatc atctatgaag
     1921 aaacaacaga catctggata aatatccacg atatttttca tgtttttcct caaactcatg
     1981 aagatgaaat tgagtttatt tttgcctctg aatgcaaaac aggttttcgt catctgtata
     2041 aaatcacatc cattttaaag gagagcaaat ataaacggtc cagtggtgga ctacctgccc
     2101 caagtgattt caagtgtcct atcaaagaag aaataacaat taccagtggt gaatgggaag
     2161 tacttggccg gcatggatct aatatctggg ttgatgaagc cagaaagctg gtgtactttg
     2221 aaggcaccaa agactctcct ttggagcatc acctgtacgt gaccagttat gcaaaccctg
     2281 gagaagtggt gaggctgact gaccgtggct actcacactc ctgctgcctc agccggcatt
     2341 gtgacttctt cataagtaag tacagcaacc agaagaatcc acactgtgtg tccctctaca
     2401 aactctcaag tcctgaggat gacccagttc ataaaacaaa ggaattttgg gccaccattt
     2461 tggattcagc aggtcctctt cctgactaca cccctccaga aattttttct tttgaaagta
     2521 ctactggatt tacactgtat ggaatgttgt ataagcctca tgacctacaa cctggaaaga
     2581 aataccccac tgtgttattc atatatggtg gtccccaggt gcagctggtg aacaatcggt
     2641 ttaaaggagt caagtatttc cgcctgaaca ccctggcctc cctgggttat gtggttgtgg
     2701 tgatagacaa caggggatcc tgtcaccgag gacttaaatt tgaaggcgcc tttaaatata
     2761 aaatgggtca aatagaaatc gatgatcaag tggaaggact ccagtaccta gcatctcagt
     2821 atgacttcat tgacttggat cgagtgggca tccacggctg gtcctatggt ggctacctct
     2881 ccctgatggc attaatgcag aggtcggata tcttccgggt ggctattgct ggggccccag
     2941 tcaccctgtg gatcttctat gatacaggat acacggagcg ctatatgggt caccctgacc
     3001 agaatgaaca gggctactac ttaggatctg tggccatgca agcggagaag ttcccctcag
     3061 aaccaaaccg gttactcctc ttgcatgggt tcttggatga gaatgttcac tttgcacaca
     3121 ccagtatatt gctgagtttt ttagtgaggg ctggaaagcc atatgactta cagatctatc
     3181 ctcaggagag gcacagcatc agagttcctg agtctggaga acactatgaa ctgcacctgc
     3241 tccactacct tcaggagaac cttggatcgc gtatcgctgc tctgaaagtg atataactct
     3301 gacgcatgta gaacttggtg tacactgtct aaccaaacaa agagggttag ccaatagaga
     3361 agccagagtt gatgaaccta cttttgtacc tgccacataa gatctatttc tgaaagtaaa
     3421 tttggtgcca tgcagaaatc tgcagttcat ggatagtact ctaatacctt aaccatgcac
     3481 ataaaactga gtgacatgtt cccaaaggat tgaacagtac ctgaggatac tgaaggaatc
     3541 aaggcaccag cgccacatat tcagactagc ctactttcac tttactagca gtataagcct
     3601 cttggactta attagtggac tttacagtat actctgagtt tgttaaaata tgatgatagt
     3661 agtgattggt ttggttcaat tccaggatct ctgactagtt atggatttga tagcacttac
     3721 gtctaattga atagcttatg cttcgtcact tggggtgtat ccagcatgtc atgaactaaa
     3781 tactattaag cttatgactt tcccagtcat taataatttt tcaaggataa cctagtggcc
     3841 tcctaaagat acttacctgg ctggtctctg accagttttt taaccaattt aaacagcatc
     3901 tagtctaagt aattctcctt ttgctttgat gatgtgatgg agtggggttt tcttttacat
     3961 aaaggcaagt aactatgtag catgagttta atcacaagtc tcaagatgtt gacaattata
     4021 aggaaaacat ttttaatcaa attatttgaa agcttgaaaa ttagcaggca agttttttct
     4081 ccttttagga acagaacatg tacacattca catgtattct gaaaatataa tggtgccgtt
     4141 tccatctggc ctttccttaa ttaaagtgtt ccctagtttc caggaggtaa aagggttaca
     4201 gtgggaaggg ggagactcta gtgcagggaa tgaccaggaa agaccaggta gcaaggctct
     4261 gcttcaccat aaatactcat gagaaaaccc agggtaaatg taacccccga gtggctggaa
     4321 accagagcta ggaggtcaag ctttgacagc tacagggtca gtcagtcttt ggagtggtta
     4381 cttttataat tccagctttt tgttattttt ccttttaact ttaaaaacct tacaaatcta
     4441 aactttaact tttttttatt tgaatgtaat ttagatatca ctagcttaaa agaaaaaggt
     4501 ttccagacca cttcttgcgg taagctgatc cctgacaaac catggcactc tttgtgttgg
     4561 aagcctatca agttagttgt gttactcgct cacagcattc tcctgcttca gccttcctgc
     4621 ttgactatga agggaagcat gagctttcaa gtgctggctg gcatctgccc ttccagtatt
     4681 agatgggtcc cactgcagct agccagacac ctgtgggttt gaccctcatt aatcacaccc
     4741 cagtgtttag acagttacca caacttaaaa atcactccaa gaaaagttgc tgtgtttctt
     4801 tctcactgcc acatcaggtc cctttccaag agagcacagt gaagacaggg actgccagaa
     4861 tagaggtgga tgctttggga agcctggaga taaatggcag gtgaccatgg gcttctgtcc
     4921 tggggaggga gggctgggtt tgccagctgt gtgtctatgt tgtatgatag accccacact
     4981 tttctttttg tttatctatt ttgactttca tgcttatgac attttctcgt gccaaaattt
     5041 gtttatattt tttcaagtta aattaaactg atttgggtaa ctttccttcc cctacaaagt
     5101 atttccccca tgacttatgt ctattttgac tgttgagggt ggcattgctg gactagttag
     5161 cctcctgtgg cttcttacgt tctaggtagg catgacatga agtagctcca accacccatt
     5221 tgctttgtac aaagacatct cttattttat gcagacaaat cttagaaaac ctcaattatc
     5281 ctagattctt tctgccttct ctccggctat cacaggagtg catctacaac tgccctttaa
     5341 atgccttctt ccttctctat gagggaaagt gcttgactca cagaaaggtg gcttgaccag
     5401 gcttgtttgt caacaccagt gagaaaggca tcagtcattt ggagcaatca gaaaccactc
     5461 taacactgtc ccatgactgg atgtcagcga aagagacaca cctccctgaa agtacgagta
     5521 tggtgggagc cagagagcat cggtaaggac caaagtgtgg gtttttcaca ggtttggtag
     5581 caagctactc tacgttcaca gcagcaggac tctcaggttc atccaggacc ccacgcacaa
     5641 gtcttgaacc tgctctcaaa ggcatgagct catcagtttg ggtggagacc agagcgcaca
     5701 tttctagcag gatgcgcttc ctgggcactt cagggcgggt ctgcaggctg cttttgtaaa
     5761 ctttctgtaa agaatgcagt cgcagtcaga gaacaggtga cttatatggt ggctggttgt
     5821 taggaaccca taacagtagt caaagaaacg gctcagctgt gatgcaaagc cctctccgtg
     5881 cccctagtct gagaatgtat ttgggcacga tgacttttcg cagtcctggc ccctccaaag
     5941 cctcacacag aaagatgaag ccacgacgca cgcttgctcc tttaaaaccg tgagccacac
     6001 gcatgcgtgc gttcaggtgc ttcctgcctt taccacacag ttctctctgc tggtgggagg
     6061 attccagtca aagcttccat tgctacagaa tcatacattt tccatctgga acaaatcttt
     6121 aacataaccc agtgtcctca tctgctaggg agaaaaaaac caagcttgtg ttctagagag
     6181 gaagaaacac acccaggatc tcacagttag tagtcagaac cagggtctat ctgtggcctg
     6241 cctcatggta gctatgtgat agttaagaaa gatagggttt ttaaagaagt atttattaat
     6301 atattcctat aaaacatttt aaaggaagcc acataaaaat ggttaatgtt tcctttctaa
     6361 gtaaatgcta agcatgctta ttaacgaagc agcactgatg ggtaggtggc atctgaagct
     6421 aatttaagtc attatgttga atgtcttcct tggtgccatg ggacataggg acacagaaca
     6481 tttgcataag cccaggaacc catcttccgt gatgtgagac cagagcctca gcaaggtcta
     6541 cactatgtat gtgagagcat ctcccagcag atggaaggaa ctggaaacat cccgactgtg
     6601 gcctttccag ccccaacccc cccccctcct atctgccctc ctgaccttct acaagtccct
     6661 tgcagacaca ggagctgtgt ttgtgtgttt ggttttgagt aaccctaata caaatttatg
     6721 ttgttttaag caaacttggg aattgggttg ggtggaggtc tttgagttaa gcacttaaag
     6781 tgcctgctgt ctcagcactg acctgtgcag acctgcatgc ctctccagta agcgcacggg
     6841 gctcctcctc ttcagcccca cggcttttaa tcgtgtgatg tgaagcatta gttcgctgca
     6901 ttttattaca ggttcttggt tgcaataaag atgctgctga aatcaa
//
