LOCUS       NP_001388065             892 aa            linear   ROD 02-MAY-2024
DEFINITION  dipeptidyl peptidase 8 [Mus musculus].
ACCESSION   NP_001388065 XP_036011253
VERSION     NP_001388065.1
DBSOURCE    REFSEQ: accession NM_001401136.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 892)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 892)
  AUTHORS   de Vasconcelos,N.M., Vliegen,G., Goncalves,A., De Hert,E.,
            Martin-Perez,R., Van Opdenbosch,N., Jallapally,A.,
            Geiss-Friedlander,R., Lambeir,A.M., Augustyns,K., Van Der Veken,P.,
            De Meester,I. and Lamkanfi,M.
  TITLE     DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome
            hallmarks in murine macrophages
  JOURNAL   Life Sci Alliance 2 (1), e201900313 (2019)
   PUBMED   30718379
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 892)
  AUTHORS   Buljevic,S., Detel,D., Pugel,E.P. and Varljen,J.
  TITLE     The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9
            expression profiles in a mouse model of Crohn's disease
  JOURNAL   J Cell Biochem 119 (8), 6743-6755 (2018)
   PUBMED   29693275
  REMARK    GeneRIF: The effect of CD26-deficiency on dipeptidyl peptidase 8
            and 9 expression profiles in a mouse model of Crohn's disease.
REFERENCE   4  (residues 1 to 892)
  AUTHORS   Okondo,M.C., Rao,S.D., Taabazuing,C.Y., Chui,A.J., Poplawski,S.E.,
            Johnson,D.C. and Bachovchin,D.A.
  TITLE     Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome
  JOURNAL   Cell Chem Biol 25 (3), 262-267 (2018)
   PUBMED   29396289
REFERENCE   5  (residues 1 to 892)
  AUTHORS   Kim,M., Minoux,M., Piaia,A., Kueng,B., Gapp,B., Weber,D.,
            Haller,C., Barbieri,S., Namoto,K., Lorenz,T., Wirsching,J.,
            Bassilana,F., Dietrich,W., Rijli,F.M. and Ksiazek,I.
  TITLE     DPP9 enzyme activity controls survival of mouse migratory tongue
            muscle progenitors and its absence leads to neonatal lethality due
            to suckling defect
  JOURNAL   Dev Biol 431 (2), 297-308 (2017)
   PUBMED   28887018
REFERENCE   6  (residues 1 to 892)
  AUTHORS   Han,R., Wang,X., Bachovchin,W., Zukowska,Z. and Osborn,J.W.
  TITLE     Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte
            differentiation
  JOURNAL   Sci Rep 5, 12348 (2015)
   PUBMED   26242871
  REMARK    GeneRIF: Blocking the expression or activities of DPP8 and DPP9
            attenuates PPARgamma2 induction during preadipocyte
            differentiation.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 892)
  AUTHORS   Chowdhury,S., Chen,Y., Yao,T.W., Ajami,K., Wang,X.M., Popov,Y.,
            Schuppan,D., Bertolino,P., McCaughan,G.W., Yu,D.M. and Gorrell,M.D.
  TITLE     Regulation of dipeptidyl peptidase 8 and 9 expression in activated
            lymphocytes and injured liver
  JOURNAL   World J Gastroenterol 19 (19), 2883-2893 (2013)
   PUBMED   23704821
  REMARK    GeneRIF: Suggest roles for DPP8 and DPP9 in lymphocyte activation
            and apoptosis and in hepatocytes during liver disease pathogenesis.
REFERENCE   8  (residues 1 to 892)
  AUTHORS   Yu,D.M., Ajami,K., Gall,M.G., Park,J., Lee,C.S., Evans,K.A.,
            McLaughlin,E.A., Pitman,M.R., Abbott,C.A., McCaughan,G.W. and
            Gorrell,M.D.
  TITLE     The in vivo expression of dipeptidyl peptidases 8 and 9
  JOURNAL   J Histochem Cytochem 57 (11), 1025-1040 (2009)
   PUBMED   19581630
  REMARK    GeneRIF: DP8 and DP9 tissue and cellular expression
REFERENCE   9  (residues 1 to 892)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   10 (residues 1 to 892)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122463.4.
            
            On Feb 2, 2022 this sequence version replaced XP_036011253.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016546.1, SRR10223970.11380.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..892
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.06 cM"
     Protein         1..892
                     /product="dipeptidyl peptidase 8"
                     /EC_number="3.4.14.5"
                     /note="dipeptidyl peptidase VIII"
                     /calculated_mol_wt=102055
     Region          1..156
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          169..589
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          681..885
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..892
                     /gene="Dpp8"
                     /gene_synonym="2310004I03Rik; 4932434F09Rik; DP8; DPP
                     VIII"
                     /coded_by="NM_001401136.1:618..3296"
                     /db_xref="GeneID:74388"
                     /db_xref="MGI:MGI:1921638"
ORIGIN      
        1 mkipsgrcnm aaameteqlg veifetaece egngesqdrp klepfyvery swsqlkklla
       61 dtrkyhgymm akaphdfmfv krtdpdgphs drvyylamsg enrentlfys eipktinraa
      121 vlmlswkpll dlfqatldyg mysreeellr erkrigtvgi aaydyhpgsg tflfqagsgi
      181 yhikdggphg ftqqplrpnl vetscpnirm dpklcpadpd wiafihsndi wisnlvtree
      241 rrityvhnel anmeedprsa gvatfvlqee fdrysgywwc pqaertpsgg kilrilyeen
      301 deseveiihv tspmletrra dsfrypktgt anpkvtfkms eivvdaaggi idvidkelvq
      361 pfeilfegve yiaragwtpe gkhawsilld rsqthlqivl ispelfipve ddamdrqrli
      421 esvpdsvtpl iiyeettdiw inihdifhvf pqthedeief ifasecktgf rhlykitsil
      481 keskykrssg glpapsdfkc pikeeitits gewevlgrhg sniwvdeark lvyfegtkds
      541 plehhlyvts yanpgevvrl tdrgyshscc lsrhcdffis kysnqknphc vslyklsspe
      601 ddpvhktkef watildsagp lpdytppeif sfesttgftl ygmlykphdl qpgkkyptvl
      661 fiyggpqvql vnnrfkgvky frlntlaslg yvvvvidnrg schrglkfeg afkykmgqie
      721 iddqveglqy lasqydfidl drvgihgwsy ggylslmalm qrsdifrvai agapvtlwif
      781 ydtgyterym ghpdqneqgy ylgsvamqae kfpsepnrll llhgfldenv hfahtsills
      841 flvragkpyd lqiypqerhs irvpesgehy elhllhylqe nlgsriaalk vi
//
