LOCUS       NM_031843               1676 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus dipeptidylpeptidase 7 (Dpp7), transcript variant 1,
            mRNA.
ACCESSION   NM_031843
VERSION     NM_031843.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1676)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1676)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   3  (bases 1 to 1676)
  AUTHORS   Klein,Z.A., Takahashi,H., Ma,M., Stagi,M., Zhou,M., Lam,T.T. and
            Strittmatter,S.M.
  TITLE     Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal
            Dementia-Related Phenotypes in Progranulin-Deficient Mice
  JOURNAL   Neuron 95 (2), 281-296 (2017)
   PUBMED   28728022
REFERENCE   4  (bases 1 to 1676)
  AUTHORS   Mele,D.A., Sampson,J.F. and Huber,B.T.
  TITLE     Th17 differentiation is the default program for DPP2-deficient
            T-cell differentiation
  JOURNAL   Eur J Immunol 41 (6), 1583-1593 (2011)
   PUBMED   21469121
  REMARK    GeneRIF: gene deficiency results in Th17 differentiation and
            peripheral T cells hyperactivation upon TCR stimulation
REFERENCE   5  (bases 1 to 1676)
  AUTHORS   Danilova,O.V., Tai,A.K., Mele,D.A., Beinborn,M., Leiter,A.B.,
            Greenberg,A.S., Perfield,J.W. 2nd, Defuria,J., Singru,P.S.,
            Lechan,R.M. and Huber,B.T.
  TITLE     Neurogenin 3-specific dipeptidyl peptidase-2 deficiency causes
            impaired glucose tolerance, insulin resistance, and visceral
            obesity
  JOURNAL   Endocrinology 150 (12), 5240-5248 (2009)
   PUBMED   19819973
  REMARK    GeneRIF: Data show that an increase in food intake in DPP2 kd mice,
            which was associated with a significant increase in adipose tissue
            mass and enhanced liver steatosis but no difference in body weight.
REFERENCE   6  (bases 1 to 1676)
  AUTHORS   Bista,P., Mele,D.A., Baez,D.V. and Huber,B.T.
  TITLE     Lymphocyte quiescence factor Dpp2 is transcriptionally activated by
            KLF2 and TOB1
  JOURNAL   Mol Immunol 45 (13), 3618-3623 (2008)
   PUBMED   18555530
  REMARK    GeneRIF: KLF2 and TOB1 activate the mouse Dpp2 promoter.
REFERENCE   7  (bases 1 to 1676)
  AUTHORS   Cai,J., Ash,D., Kotch,L.E., Jabs,E.W., Attie-Bitach,T., Auge,J.,
            Mattei,G., Etchevers,H., Vekemans,M., Korshunova,Y., Tidwell,R.,
            Messina,D.N., Winston,J.B. and Lovett,M.
  TITLE     Gene expression in pharyngeal arch 1 during human embryonic
            development
  JOURNAL   Hum Mol Genet 14 (7), 903-912 (2005)
   PUBMED   15703188
REFERENCE   8  (bases 1 to 1676)
  AUTHORS   Araki,H., Li,Y., Yamamoto,Y., Haneda,M., Nishi,K., Kikkawa,R. and
            Ohkubo,I.
  TITLE     Purification, molecular cloning, and immunohistochemical
            localization of dipeptidyl peptidase II from the rat kidney and its
            identity with quiescent cell proline dipeptidase
  JOURNAL   J Biochem 129 (2), 279-288 (2001)
   PUBMED   11173530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732557.4.
            
            On Mar 24, 2023 this sequence version replaced NM_031843.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027205.1, SRR7345562.4321294.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AL732557.4         29004-29126         c
            124-237             AL732557.4         28802-28915         c
            238-377             AL732557.4         28587-28726         c
            378-541             AL732557.4         28331-28494         c
            542-677             AL732557.4         27666-27801         c
            678-759             AL732557.4         27514-27595         c
            760-926             AL732557.4         27241-27407         c
            927-987             AL732557.4         27006-27066         c
            988-1106            AL732557.4         26381-26499         c
            1107-1263           AL732557.4         26133-26289         c
            1264-1328           AL732557.4         25926-25990         c
            1329-1399           AL732557.4         25459-25529         c
            1400-1676           AL732557.4         25063-25339         c
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.19 cM"
     gene            1..1676
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /note="dipeptidylpeptidase 7"
                     /db_xref="GeneID:83768"
                     /db_xref="MGI:MGI:1933213"
     exon            1..123
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1547
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /EC_number="3.4.14.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; dipeptidyl peptidase II; dipeptidyl peptidase
                     2; DPP II; dipeptidyl aminopeptidase II; quiescent cell
                     proline dipeptidase"
                     /codon_start=1
                     /product="dipeptidyl peptidase 2 isoform 1 precursor"
                     /protein_id="NP_114031.2"
                     /db_xref="CCDS:CCDS15766.1"
                     /db_xref="GeneID:83768"
                     /db_xref="MGI:MGI:1933213"
                     /translation="MNFHPCYPVDHGVPSWILVLLLSLGLCNLQARADRVLDPDFHEN
                     YFEQYMDHFNFESFGNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSFANNSGFMV
                     ELAAQQEALLVFAEHRYYGKSLPFGVQSTQRGYTQLLTVEQALADFAVLLQALRQDLG
                     VHDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVVAVAGLGDSYQFFRDVTAD
                     FYGQSPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDLTQLFGFARNAF
                     TVLAMMDYPYPTDFLGPLPANPVKVGCQRLLNEGQRIMGLRALAGLVYNSSGTEPCYD
                     IYRLYQSCADPTGCGTGSDARAWDYQACTEINLTFDSNNVTDMFPEIPFSEELRQQYC
                     LDTWGVWPRQDWLQTSFWGGDLKAASNIIFSNGDLDPWAGGGIQSNLSTSVIAVTIQG
                     GAHHLDLRASNSEDPPSVVEVRKLESTLIREWVAAARLKQPAMPRWPGPKKQHPSR"
     exon            124..237
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            238..377
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            378..541
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            542..677
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            678..759
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            760..926
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            927..987
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1106
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1263
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1328
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1399
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1676
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1655..1660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /note="hexamer: AATAAA"
     polyA_site      1676
                     /gene="Dpp7"
                     /gene_synonym="Dpp2; DPPII; QPP"
                     /note="major polyA site"
ORIGIN      
        1 agtcagcgcc cggctcagaa tcaagcatga acttccatcc ttgttaccct gtggaccatg
       61 gtgtcccctc ctggatcctg gtcctgctgc tgtcactggg actgtgcaac ctccaggcca
      121 gagccgacag agttctagac cctgactttc atgagaatta ttttgagcaa tacatggacc
      181 atttcaactt tgagagtttc ggcaacaaaa cctttggcca gcggttccta gtgtcagata
      241 agttctggaa gatgggcgaa gggcccatct ttttctacac agggaatgag ggggatatct
      301 ggtccttcgc taacaactct ggcttcatgg tggaactggc agcccagcag gaggccctgc
      361 ttgtctttgc tgagcaccgg tactatggga aatcgcttcc gttcggtgtc cagtccacac
      421 agcggggata tacacagctg ctgactgtgg agcaggcgct ggccgacttt gctgtgctgc
      481 tccaggccct gcggcaggac cttggggtcc atgatgcccc caccatagcc tttggaggga
      541 gttatggggg gatgctgagt gcctacatga ggatgaagta cccccacctg gtggctgggg
      601 cactggcagc cagcgctcct gttgtagctg ttgcaggcct tggggactcc taccaattct
      661 tccgagatgt cacagcggac ttttatggcc agagtcccaa gtgcgcccag gctgtgcggg
      721 atgcctttca gcaaatcaaa gacttgttcc tccagggagc ctatgacacc atcagccaga
      781 actttggtac ctgtcaatca ctttccagcc caaaggacct gactcagctc tttgggtttg
      841 cccgaaatgc atttactgtg ctcgccatga tggactaccc gtatcctact gactttctag
      901 ggccccttcc tgccaaccct gtcaaggtgg gctgtcaacg gctgttgaat gagggccaga
      961 ggatcatggg tctacgggca ctggcagggc tggtctacaa ctcctctggc acggaaccct
     1021 gttatgacat ctaccggtta taccaaagct gtgctgaccc cactggctgt ggcactggct
     1081 ctgacgctag ggcttgggac taccaggcct gtacggagat caatctgacc tttgacagca
     1141 acaatgtgac agacatgttt cctgaaatcc cattctctga agaactccgc cagcaatact
     1201 gtctggatac atggggcgtg tggcctcggc aagactggct gcagaccagc ttctggggtg
     1261 gtgaccttaa agcagccagc aacatcattt tctccaacgg tgacctagac ccctgggcag
     1321 ggggcgggat ccagagcaac ctgagtacat cagtcattgc tgtcaccatc caggggggag
     1381 cacatcacct agatctcaga gcatctaact cagaagaccc cccatctgtc gtggaggtgc
     1441 gtaagctgga atctaccctc attcgtgagt gggtagcagc agccagacta aagcaaccag
     1501 caatgccacg gtggcctggg cctaagaagc agcacccttc cagataagat gcagcaaacc
     1561 ccagacatcc cttgttttat gtgatctaca gtggtgtgac aacttgcctt gtatctgatg
     1621 gactgtccag atttatggta gatggaagaa actgaataaa cacatgttaa tgtgtc
//
