LOCUS       NM_001159543            3654 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus dipeptidylpeptidase 4 (Dpp4), transcript variant 2,
            mRNA.
ACCESSION   NM_001159543
VERSION     NM_001159543.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3654)
  AUTHORS   Traynor,S., Bhattacharya,S., Batmanov,K., Cheng,L., Weller,A.,
            Moore,N., Flesher,C. and Merrick,D.
  TITLE     Developmental regulation of dermal adipose tissue by BCL11b
  JOURNAL   Genes Dev 38 (15-16), 772-783 (2024)
   PUBMED   39266447
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3654)
  AUTHORS   Shi,J., Hu,S., Wei,H., Zhang,L., Lan,Y., Guan,J., Zhao,K., Gao,F.,
            He,W. and Li,Z.
  TITLE     Dipeptidyl peptidase 4 interacts with porcine coronavirus PHEV
            spikes and mediates host range expansion
  JOURNAL   J Virol 98 (7), e0075324 (2024)
   PUBMED   38829136
  REMARK    GeneRIF: Dipeptidyl peptidase 4 interacts with porcine coronavirus
            PHEV spikes and mediates host range expansion.
REFERENCE   3  (bases 1 to 3654)
  AUTHORS   Zhang,M., Yue,X., Xu,S., Piao,J., Zhao,L., Shu,S., Kuzuya,M.,
            Li,P., Hong,L., Kim,W., Liu,B. and Cheng,X.W.
  TITLE     Dipeptidyl peptidase-4 disturbs adipocyte differentiation via the
            negative regulation of the glucagon-like
            peptide-1/adiponectin-cathepsin K axis in mice under chronic stress
            conditions
  JOURNAL   FASEB J 38 (10), e23684 (2024)
   PUBMED   38795334
  REMARK    GeneRIF: Dipeptidyl peptidase-4 disturbs adipocyte differentiation
            via the negative regulation of the glucagon-like
            peptide-1/adiponectin-cathepsin K axis in mice under chronic stress
            conditions.
REFERENCE   4  (bases 1 to 3654)
  AUTHORS   Martinez,D.R., Moreira,F.R., Catanzaro,N.J., Diefenbacher,M.V.,
            Zweigart,M.R., Gully,K.L., De la Cruz,G., Brown,A.J., Adams,L.E.,
            Yount,B., Baric,T.J., Mallory,M.L., Conrad,H., May,S.R., Dong,S.,
            Scobey,D.T., Nguyen,C., Montgomery,S.A., Perry,J.K., Babusis,D.,
            Barrett,K.T., Nguyen,A.H., Nguyen,A.Q., Kalla,R., Bannister,R.,
            Feng,J.Y., Cihlar,T., Baric,R.S., Mackman,R.L., Bilello,J.P.,
            Schafer,A. and Sheahan,T.P.
  TITLE     The oral nucleoside prodrug GS-5245 is efficacious against
            SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses
  JOURNAL   Sci Transl Med 16 (748), eadj4504 (2024)
   PUBMED   38776389
REFERENCE   5  (bases 1 to 3654)
  AUTHORS   Li,W., Yao,C., Guo,H., Ni,X., Zhu,R., Wang,Y., Yu,B., Feng,X.,
            Gu,Z. and Da,Z.
  TITLE     Macrophages communicate with mesangial cells through the
            CXCL12/DPP4 axis in lupus nephritis pathogenesis
  JOURNAL   Cell Death Dis 15 (5), 344 (2024)
   PUBMED   38762508
  REMARK    GeneRIF: Macrophages communicate with mesangial cells through the
            CXCL12/DPP4 axis in lupus nephritis pathogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3654)
  AUTHORS   Mentzel,S., Dijkman,H.B., Van Son,J.P., Koene,R.A. and Assmann,K.J.
  TITLE     Organ distribution of aminopeptidase A and dipeptidyl peptidase IV
            in normal mice
  JOURNAL   J Histochem Cytochem 44 (5), 445-461 (1996)
   PUBMED   8627002
REFERENCE   7  (bases 1 to 3654)
  AUTHORS   Bernard,A.M., Mattei,M.G., Pierres,M. and Marguet,D.
  TITLE     Structure of the mouse dipeptidyl peptidase IV (CD26) gene
  JOURNAL   Biochemistry 33 (50), 15204-15214 (1994)
   PUBMED   7999781
REFERENCE   8  (bases 1 to 3654)
  AUTHORS   David,F., Bernard,A.M., Pierres,M. and Marguet,D.
  TITLE     Identification of serine 624, aspartic acid 702, and histidine 734
            as the catalytic triad residues of mouse dipeptidyl-peptidase IV
            (CD26). A member of a novel family of nonclassical serine
            hydrolases
  JOURNAL   J Biol Chem 268 (23), 17247-17252 (1993)
   PUBMED   8102366
REFERENCE   9  (bases 1 to 3654)
  AUTHORS   Marguet,D., Bernard,A.M., Vivier,I., Darmoul,D., Naquet,P. and
            Pierres,M.
  TITLE     cDNA cloning for mouse thymocyte-activating molecule. A
            multifunctional ecto-dipeptidyl peptidase IV (CD26) included in a
            subgroup of serine proteases
  JOURNAL   J Biol Chem 267 (4), 2200-2208 (1992)
   PUBMED   1370813
REFERENCE   10 (bases 1 to 3654)
  AUTHORS   Vivier,I., Marguet,D., Naquet,P., Bonicel,J., Black,D., Li,C.X.,
            Bernard,A.M., Gorvel,J.P. and Pierres,M.
  TITLE     Evidence that thymocyte-activating molecule is mouse CD26
            (dipeptidyl peptidase IV)
  JOURNAL   J Immunol 147 (2), 447-454 (1991)
   PUBMED   1712807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163085.1, AK085370.1 and AL928804.5.
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct C-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK163085.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1194              AK163085.1         6-1199
            1195-2547           AK085370.1         778-2130
            2548-3252           AK163085.1         2553-3257
            3253-3654           AL928804.5         66843-67244         c
FEATURES             Location/Qualifiers
     source          1..3654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 35.85 cM"
     gene            1..3654
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /note="dipeptidylpeptidase 4"
                     /db_xref="GeneID:13482"
                     /db_xref="MGI:MGI:94919"
     exon            1..446
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..2630
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /EC_number="3.4.14.5"
                     /note="isoform 2 is encoded by transcript variant 2; DPP
                     IV; dipeptidyl peptidase IV; thymocyte-activating
                     molecule; T-cell activation antigen CD26"
                     /codon_start=1
                     /product="dipeptidyl peptidase 4 isoform 2"
                     /protein_id="NP_001153015.1"
                     /db_xref="GeneID:13482"
                     /db_xref="MGI:MGI:94919"
                     /translation="MKTPWKVLLGLLGVAALVTIITVPIVLLSKDEAAADSRRTYSLA
                     DYLKSTFRVKSYSLWWVSDFEYLYKQENNILLLNAEHGNSSIFLENSTFESFGYHSVS
                     PDRLFVLLEYNYVKQWRHSYTASYNIYDVNKRQLITEEKIPNNTQWITWSPEGHKLAY
                     VWKNDIYVKVEPHLPSHRITSTGEENVIYNGITDWVYEEEVFGAYSALWWSPNNTFLA
                     YAQFNDTGVPLIEYSFYSDESLQYPKTVWIPYPKAGAVNPTVKFFIVNIDSLSSSSSA
                     APIQIPAPASVARGDHYLCDVVWATEERISLQWLRRIQNYSVMAICDYDKINLTWNCP
                     SEQQHVEMSTTGWVGRFRPAEPHFTSDGSSFYKIISDKDGYKHICHFPKDKKDCTFIT
                     KGAWEVISIEALTSDYLYYISNQYKEMPGGRNLYKIQLTDHTNVKCLSCDLNPERCQY
                     YAVSFSKEAKYYQLGCWGPGLPLYTLHRSTDHKELRVLEDNSALDRMLQDVQMPSKKL
                     DFIVLNETRFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADASFRLNWATYLASTEN
                     IIVASFDGRGSGYQGDKIMHAINRRLGTLEVEDQIEAARQFVKMGFVDSKRVAIWGWS
                     YGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPIPEDNLDHYRNSTV
                     MSRAEHFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQAMVY"
     exon            447..531
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            532..627
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            628..719
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            720..788
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            789..841
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            842..914
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1035
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1196
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1309
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1445
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1490
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1598
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1666
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1720
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1842
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1890
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1989
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2059
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2254
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2309
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2409
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2474
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2547
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..3654
                     /gene="Dpp4"
                     /gene_synonym="Cd26; Dpp-4; THAM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactgacaga cctctcaggg aaggggacaa gagaactggc agctagtttc tgcagtgagc
       61 cgtgaatctg ccaaactcca tgcctgcttg aacctcagct gcctcgatta tccacgcaag
      121 ggagcaacag ttaaacctca atgtgcaatg tctcttttag caaagggggt tcgctgttcc
      181 ccttatccct cactcatggg ggccctgcgt gctacttcct ggctcgccta gtggtcctac
      241 cgcgctgggt cggctgcccc gcgctcacac tgtgcaccga agcccgcctt gcgctaacta
      301 atgtttaact caggccgaaa cttggcggcg agctcagggt gactgcgtgc agagcagccg
      361 cgcaggacgt ccgtctctgc gcgcagtgac ttctgcctgc gctcaagctt cagagttcag
      421 tttcaaggag ccgcccgacc atgaagacac cgtggaaggt tcttctggga ctgcttggtg
      481 tcgctgcgct tgtcaccatc atcaccgtgc caatagttct gctgagcaaa gatgaagcgg
      541 cagctgacag ccgcagaacg tattcactag ctgactattt aaagagtacc tttcgggtca
      601 agtcctactc tttgtggtgg gtttcagact ttgaatacct ctacaaacaa gagaacaata
      661 tcttgctgct caatgctgaa catggaaaca gctccatttt cttggagaac agtacctttg
      721 aaagctttgg atatcattca gtgtcacctg accgactgtt tgttctcttg gaatacaact
      781 acgtgaagca atggagacat tcctacacag cttcatacaa catttatgat gtgaataaaa
      841 gacagctgat cacagaagag aagattccaa ataatacaca gtggatcaca tggtcaccag
      901 aaggtcataa gttggcatat gtctggaaga atgatattta cgttaaagtt gaaccacact
      961 tacctagtca taggatcaca tcgacaggag aagaaaatgt aatatataat ggaataactg
     1021 actgggttta tgaagaggaa gtcttcggtg cctactctgc actgtggtgg tctccaaaca
     1081 acacgtttct agcttatgcc cagtttaacg acacaggagt gccgctcatt gaatactcct
     1141 tctattctga tgagtcactg cagtacccca agacagtgtg gattccatac ccaaaggcag
     1201 gagctgtgaa tccaactgta aagttcttta ttgtaaatat agactctctc agctcatcct
     1261 ctagtgcggc tcccatccaa atccctgctc ctgcatctgt ggcaagaggg gatcactatt
     1321 tatgtgatgt ggtgtgggct acagaagaaa gaatttcact acagtggctc aggaggattc
     1381 agaactattc cgtgatggct atctgtgact atgataagat caacctaacg tggaactgtc
     1441 catccgagca gcagcatgtt gaaatgagta ccacaggctg ggtcggaaga tttaggcccg
     1501 cagaacctca cttcacctct gatggaagca gcttctataa gatcatcagc gacaaagatg
     1561 gctacaaaca catctgccac ttcccgaaag ataagaaaga ctgtacattt attacaaaag
     1621 gagcctggga agtcattagt atcgaagctc tgaccagcga ttatctatac tacattagta
     1681 accaatataa agaaatgcca ggaggaagaa atctctataa aattcaactt actgaccaca
     1741 caaatgtgaa gtgccttagt tgtgacctga atccagaaag atgtcagtat tatgcggtat
     1801 catttagtaa agaggcaaag tactatcagc tgggatgttg gggccccggt ctgcccctct
     1861 acactctaca tcgtagcacg gatcataaag agctgcgagt cctggaagac aattctgctt
     1921 tggatagaat gctgcaggat gtccagatgc cttcaaaaaa attggacttc attgttttga
     1981 atgaaacaag attttggtat caaatgatct tgccccctca ttttgataaa tccaagaaat
     2041 atcctctact attagatgta tatgcaggtc cctgtagtca aaaagcagat gcttccttca
     2101 gactgaactg ggccacttac cttgcaagta cagaaaacat catagtagct agctttgacg
     2161 gcagaggaag tggttaccaa ggagataaga tcatgcatgc aatcaacaga agattgggaa
     2221 cactggaagt tgaagatcaa attgaagcag ccaggcaatt tgtaaaaatg ggatttgtgg
     2281 atagcaagcg agttgcaatt tggggctggt catatggagg gtatgtaacc tcaatggtcc
     2341 tgggatcggg aagtggcgtg ttcaagtgcg gaatagctgt ggcacctgtg tcacggtggg
     2401 agtactatga ctcagtgtac acagagcgtt acatgggtct cccaattcca gaagacaacc
     2461 ttgaccatta caggaactca acagtcatga gcagagctga acattttaaa caagttgagt
     2521 acctccttat tcatggaacg gcagatgata atgttcactt tcagcagtca gctcagatct
     2581 ccaaagccct ggtggatgct ggtgtggatt tccaagcaat ggtatactaa gactttgttc
     2641 agggggaaca aaatatctag tgggtctagt ttcccctttg gcagttactt tttcccaagg
     2701 aagtctcaga tgacaggaag agaagagagg ccccttatca ttccgctgtg aagttggaga
     2761 cgtgctatcc ttgagtcata cacagagtaa atattagaca gtttgaggtt gagaaacaca
     2821 gtattacata tcctgggagt gtcaaaacac cattcttcta ttcctgtgat ggttcagtct
     2881 ctccctgttt tgattcgaaa gtaatcactt attctgtaaa tgtgtggcag agtaattcta
     2941 aagtgaaacc agcatgataa tagctgaaat gtaaaatcca ttctgttatt atgattacta
     3001 gccatcctaa caacagtggg gtattaatag ttagcatgct tcagctcttg cagtcgctac
     3061 attatctttt gttgaacaac tgcaggcagc aaacaattag gcttgtttat aaagtcagaa
     3121 atggctgggg ctgggtttgc ctgtatagag gaggttttgg gtatttagtc taactcatct
     3181 tcttcattag aattcttcat cagactttat acatacatac atatatatat atatatatat
     3241 atatatatat atatatatat atatatatat atatatgtgc atcttgcact aataatacaa
     3301 tgctataaaa caacacaact ttcttaactg ttttggctag aaaatagtgt ccctccactt
     3361 ctgacacata attagctgtg tgctccgctt caatagtgcc cacctatgta agagtggatt
     3421 ttttattttg tactgagaaa acctgccata tattttggac cagattctca gaagaagttg
     3481 aggtttgttt tttccatgtt taaagcaaag ttatataata cttgaggcat gattaaaatt
     3541 aacttatgtc tcaggaatat gtacctgcct gacataaatg tcagatatac agagttctta
     3601 atttccagtg taaaatttaa atgttggtaa ataaaacatt tgtcttttgg cttc
//
